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89203-64-5,MFCD01318700
Catalog No.:AA00367D

89203-64-5 | 3-Pyrrolidineacetic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$178.00   $125.00
- +
1g
97.0%
in stock  
$322.00   $225.00
- +
5g
97.0%
in stock  
$877.00   $614.00
- +
10g
97.0%
in stock  
$1,719.00   $1,203.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00367D
Chemical Name:
3-Pyrrolidineacetic acid
CAS Number:
89203-64-5
Molecular Formula:
C6H11NO2
Molecular Weight:
129.1570
MDL Number:
MFCD01318700
SMILES:
OC(=O)CC1CNCC1
Properties
Properties
 
BP:
272.3°C at 760 mmHg  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
114  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-2.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2007/8140,2007,A1Locationinpatent:Page/Pagecolumn244

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2008/4946,2008,A1Locationinpatent:Page/Pagecolumn113-114

[1]Patent:US2008/176827,2008,A1.Locationinpatent:Page/Pagecolumn18

Literature

Title: Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification.

Journal: Organic & biomolecular chemistry 20120328

Title: Ruthenium-catalysed synthesis of fluorinated bicyclic amino esters through tandem carbene addition/cyclopropanation of enynes.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110816

Title: Is β-homo-proline a pseudo-γ-turn forming element of β-peptides? An IR and VCD spectroscopic study on Ac-β-HPro-NHMe in cryogenic matrices and solutions.

Journal: Physical chemistry chemical physics : PCCP 20101107

Title: Synthesis of alpha-cyclopropyl-beta-homoprolines.

Journal: The Journal of organic chemistry 20090605

Title: Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid.

Journal: The Journal of organic chemistry 20080704

Title: Three-component synthesis of polysubstituted homoproline analogs.

Journal: Molecules (Basel, Switzerland) 20050831

Title: Synthesis and biological evaluation of new GABA-uptake inhibitors derived from proline and from pyrrolidine-2-acetic acid.

Journal: European journal of medicinal chemistry 20050301

Title: GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.

Journal: Current pharmaceutical design 20000801

Title: 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.

Journal: British journal of pharmacology 19970301

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SDS
Tags:89203-64-5 Molecular Formula|89203-64-5 MDL|89203-64-5 SMILES|89203-64-5 3-Pyrrolidineacetic acid