Home Amines 89796-99-6
89796-99-6,MFCD00864296
Catalog No.:AA003NJD

89796-99-6 | 2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid

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Purity
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250mg
98%
in stock  
$7.00   $5.00
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25g
98%
in stock  
$15.00   $11.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003NJD
Chemical Name:
2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid
CAS Number:
89796-99-6
Molecular Formula:
C16H13Cl2NO4
Molecular Weight:
354.1847
MDL Number:
MFCD00864296
SMILES:
OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Properties
Properties
 
BP:
486°C at 760 mmHg  
Form:
Solid  
MP:
149-153°C  
Solubility:
Soluble in DMSO  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
411  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.3  

Upstream Synthesis Route

[1]Patent:CN108383745,2018,A,.Locationinpatent:Paragraph0029-0031;0032-0034;0035-0037;0038-0069

[2]Patent:US2004/24057,2004,A1,.Locationinpatent:Page/Pagecolumn53

[1]JournalofCrystallographicandSpectroscopicResearch,1992,vol.22,#3,p.323-328

[1]JournalofCrystallographicandSpectroscopicResearch,1992,vol.22,#3,p.323-328

Downstream Synthesis Route

[1]JournalofCrystallographicandSpectroscopicResearch,1992,vol.22,p.323-328

89796-99-6   
C16H13Cl2NO5 
 
C14H11Cl2NO3 
  15307-78-5 

[1]Pharmazie,2007,vol.62,p.337-341

[1]JournalofCrystallographicandSpectroscopicResearch,1992,vol.22,p.323-328

[2]Patent:CN110143891,2019,A

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Title: Aceclofenac vs paracetamol in the management of symptomatic osteoarthritis of the knee: a double-blind 6-week randomized controlled trial.

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Title: Fixed drug eruption due to aceclofenac.

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Title: Photodegradation and in vitro phototoxicity of aceclofenac.

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Title: Influence of amorphous cyclodextrin derivatives on aceclofenac release from directly compressible tablets.

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Title: Immunomodulatory effect of nonsteroidal anti-inflammatory drugs (NSAIDs) at the clinically available doses.

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Title: The efficacy and safety of aceclofenac versus placebo and naproxen in women with primary dysmenorrhoea.

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Title: Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations.

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Title: Allergic contact dermatitis due to aceclofenac.

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Title: Topical delivery of aceclofenac from lecithin organogels: preformulation study.

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Journal: The Korean journal of hepatology 20060901

Title: Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac.

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Title: Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems.

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Title: Analgesic efficacy of aceclofenac after surgical extraction of impacted lower third molars.

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Title: Physicochemical characterization and dissolution enhancement of aceclofenac-hydroxypropyl beta-cyclodextrin binary systems.

Journal: PDA journal of pharmaceutical science and technology 20060101

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Journal: International journal of pharmaceutics 20050930

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Journal: Archives of pharmacal research 20050901

Title: Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.

Journal: Biochemical pharmacology 20050701

Title: Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes.

Journal: Archives of dermatology 20050701

Title: Separation of aceclofenac and diclofenac in human plasma by free zone capillary electrophoresis using N-methyl-D-glucamine as an effective electrolyte additive.

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Journal: BMC medicine 20050101

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Journal: BMC medical research methodology 20050101

Title: Comparative efficacy of aceclofenac and etoricoxib in post extraction pain control: randomized control trial.

Journal: Indian journal of dental research : official publication of Indian Society for Dental Research 20050101

Title: Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.

Journal: Biochemical and biophysical research communications 20041224

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Journal: Fogorvosi szemle 20041201

Title: Polarographic behaviour of Aceclofenac, Tenoxicam and Droxicam in a methanol-water mixture.

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Journal: Current opinion in rheumatology 20040901

Title: Risk of breast cancer among users of aspirin and other anti-inflammatory drugs.

Journal: British journal of cancer 20040802

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Journal: Expert opinion on pharmacotherapy 20040601

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Journal: Alternatives to laboratory animals : ATLA 20040601

Title: [Determination of aceclofenac in human plasma by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20040501

Title: Bioequivalence evaluation of two brands of aceclofenac 100 mg tablets (Aceclofar and Bristaflam) in healthy human volunteers.

Journal: Biopharmaceutics & drug disposition 20040401

Title: Upper gastrointestinal bleeding associated with the use of NSAIDs: newer versus older agents.

Journal: Drug safety 20040101

Title: Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac.

Journal: Clinical pharmacology and therapeutics 20030901

Title: [Intramuscular aceclofenac and necrosis at the point of injection with fatal outcome].

Journal: Atencion primaria 20030630

Title: Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography.

Journal: Biomedical chromatography : BMC 20030601

Title: A double-blind, multicentre, randomised clinical trial comparing the efficacy and tolerability of aceclofenac with diclofenac resinate in patients with acute low back pain.

Journal: Clinical rheumatology 20030501

Title: [Exudative erythema multiforme with transition to a toxic epidermal necrolysis after taking aceclofenac (Beofenac)].

Journal: Deutsche medizinische Wochenschrift (1946) 20030307

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Journal: Farmaco (Societa chimica italiana : 1989) 20030201

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Journal: MMW Fortschritte der Medizin 20021128

Title: Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.

Journal: The Journal of biological chemistry 20021011

Title: Preparation and evaluation of aceclofenac microemulsion for transdermal delivery system.

Journal: Archives of pharmacal research 20020801

Title: Dose-effect relationships of nonsteroidal anti-inflammatory drugs: a literature review.

Journal: Clinical therapeutics 20020801

Title: Regulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes.

Journal: Osteoarthritis and cartilage 20020701

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Journal: Inflammation 20020601

Title: Stability-indicating spectrophotometric and densitometric methods for determination of aceclofenac.

Journal: Drug development and industrial pharmacy 20020501

Title: Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugs.

Journal: The Journal of rheumatology 20020401

Title: Determination of aceclofenac in bulk and pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: Comparative incidence of upper gastrointestinal bleeding associated with individual non-steroidal anti-inflammatory drugs.

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Title: Patient and physician satisfaction with aceclofenac: results of the European Observational Cohort Study (experience with aceclofenac for inflammatory pain in daily practice). Aceclofenac is the treatment of choice for patients and physicians in the management of inflammatory pain.

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Title: Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.

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Title: Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro.

Journal: Journal of hand surgery (Edinburgh, Scotland) 20010601

Title: In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs).

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Title: Bioequivalence of two aceclofenac tablet formulations after a single oral dose to healthy male Korean volunteers.

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Title: Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor.

Journal: Journal of hepatology 20010101

Title: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.

Journal: BMC clinical pharmacology 20010101

Title: Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease.

Journal: Drugs 20010101

Title: Iatrogenic cost factors incorporating mild and moderate adverse events in the economic comparison of aceclofenac and other NSAIDs.

Journal: PharmacoEconomics 20010101

Title: Hypersensitivity vasculitis related to aceclofenac.

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Title: Aceclofenac. A review of its pharmacodynamic properties and therapeutic potential in the treatment of rheumatic disorders and in pain management.

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Title: Aceclofenac, a new nonsteroidal antiinflammatory drug, decreases the expression and function of some adhesion molecules on human neutrophils.

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Title: The efficacy and tolerability of aceclofenac compared to indomethacin in patients with rheumatoid arthritis.

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Title: Leukocytoclastic vasculitis and hemoptysis after treatment with aceclofenac.

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Tags:89796-99-6 Molecular Formula|89796-99-6 MDL|89796-99-6 SMILES|89796-99-6 2-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]acetic acid