Home Quinolines 91-21-4
91-21-4,MFCD00006896
Catalog No.:AA003D7G

91-21-4 | 1,2,3,4-Tetrahydroisoquinoline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$8.00   $5.00
- +
5g
98%
in stock  
$9.00   $6.00
- +
10g
98%
in stock  
$16.00   $11.00
- +
25g
98%
in stock  
$23.00   $16.00
- +
100g
98%
in stock  
$68.00   $47.00
- +
500g
98%
in stock  
$267.00   $187.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003D7G
Chemical Name:
1,2,3,4-Tetrahydroisoquinoline
CAS Number:
91-21-4
Molecular Formula:
C9H11N
Molecular Weight:
133.1903
MDL Number:
MFCD00006896
SMILES:
N1CCc2c(C1)cccc2
NSC Number:
15312
Properties
Properties
 
BP:
232-233°C at 760 mmHg  
Form:
Solid  
MP:
-25 °C  
Refractive Index:
n20/D 1.568(lit.)  
Solubility:
20g/l  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
111  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
1.6  

Literature

Title: The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20140902

Title: Bioactive alkaloid extracts from Narcissus broussonetii: mass spectral studies.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: Regiochemistry of the condensation of 2-aroyl-cyclohexanones and 2-cyanoacetamide: 13C-labeling studies and semiempirical MO calculations.

Journal: The Journal of organic chemistry 20120907

Title: Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.

Journal: European journal of medicinal chemistry 20120801

Title: (S)-4-tert-Butyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.

Journal: Acta crystallographica. Section E, Structure reports online 20120801

Title: Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists.

Journal: Bioorganic & medicinal chemistry letters 20120601

Title: First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours.

Journal: British journal of cancer 20120410

Title: MCR synthesis of praziquantel derivatives.

Journal: Chemical biology & drug design 20120401

Title: Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.

Journal: Current opinion in chemical biology 20120401

Title: Concise route to 3-arylisoquinoline skeleton by Lewis acid catalyzed C(sp3)-H bond functionalization and its application to formal synthesis of (±)-tetrahydropalmatine.

Journal: Organic letters 20120316

Title: Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.

Journal: ACS combinatorial science 20120312

Title: (S)-Benzyl 3-phenyl-carbamoyl-1,2,3,4-tetra-hydro-isoquinoline-2-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

Journal: Journal of medicinal chemistry 20120223

Title: Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.

Journal: The Journal of biological chemistry 20120210

Title: Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies.

Journal: Cancer chemotherapy and pharmacology 20120201

Title: Monitoring on-chip Pictet-Spengler reactions by integrated analytical separation and label-free time-resolved fluorescence.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120123

Title: Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.

Journal: ACS combinatorial science 20120109

Title: (S)-4-Phenyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.

Journal: Acta crystallographica. Section E, Structure reports online 20120101

Title: The role of circulating serotonin in the development of chronic obstructive pulmonary disease.

Journal: PloS one 20120101

Title: Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells.

Journal: PloS one 20120101

Title: Genome expression profile analysis of the immature maize embryo during dedifferentiation.

Journal: PloS one 20120101

Title: Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids.

Journal: Cancer cell international 20120101

Title: A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma.

Journal: PloS one 20120101

Title: Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats.

Journal: PloS one 20120101

Title: Trabectedin as a new chemotherapy option in the treatment of relapsed platinum sensitive ovarian cancer.

Journal: Current pharmaceutical design 20120101

Title: Acceleration of anaerobic cysteine transformations to sulfane sulfur consequent to γ-glutamyl transpeptidase inhibition.

Journal: TheScientificWorldJournal 20120101

Title: Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities.

Journal: Pharmacognosy reviews 20120101

Title: A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson's disease.

Journal: Parkinson's disease 20120101

Title: The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase.

Journal: Methods in enzymology 20120101

Title: Electrochemical synthesis and chemistry of chiral 1-cyanotetrahydroisoquinolines. An approach to the asymmetric syntheses of the alkaloid (-)-crispine a and its natural (+)-antipode.

Journal: The Journal of organic chemistry 20111202

Title: Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: Anticancer research 20111201

Title: (1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carbothio-amide.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling.

Journal: Immune network 20111201

Title: Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743.

Journal: ACS chemical biology 20111118

Title: Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms.

Journal: The Journal of organic chemistry 20111104

Title: A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an iridium catalyst.

Journal: Angewandte Chemie (International ed. in English) 20111104

Title: Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Journal: Bioorganic & medicinal chemistry 20111101

Title: Expedient entry to the piperazinohydroisoquinoline ring system using a sequential Ugi/Pictet-Spengler/reductive methylation reaction protocol.

Journal: Chemical communications (Cambridge, England) 20111014

Title: Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: 2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: 2-(2-Hy-droxy-phen-yl)-3,4-dihydro-iso-quinolin-1(2H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: 2-(4-Bromo-phen-yl)-3,4-dihydro-isoquinolin-2-ium thio-cyanate hemihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20111001

Title: Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Journal: Organic letters 20110902

Title: XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.

Journal: Chemistry & biology 20110826

Title: Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.

Journal: The Journal of organic chemistry 20110819

Title: Eosin Y catalyzed visible light oxidative C-C and C-P bond formation.

Journal: Organic letters 20110805

Title: Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release.

Journal: Neurotoxicity research 20110801

Title: Modulation of leukotriene D4 attenuates the development of seizures in mice.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20110801

Title: 2-(4-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: Structure-based design of novel boronic acid-based inhibitors of autotaxin.

Journal: Journal of medicinal chemistry 20110714

Title: Comparison of enveloping distribution sampling and thermodynamic integration to calculate binding free energies of phenylethanolamine N-methyltransferase inhibitors.

Journal: The Journal of chemical physics 20110714

Title: Dietary inhibitors of monoamine oxidase A.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20110701

Title: Asymmetric total synthesis of (-)-saframycin A from L-tyrosine.

Journal: The Journal of organic chemistry 20110701

Title: Ortho-rhom-bic polymorph of (6,7-dimeth-oxy-1,2,3,4-tetra-hydro-isoquinolin-1-yl)methanol.

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110601

Title: 6,7-Dimeth-oxy-3-meth-oxy-carbonyl-1-(2-meth-oxy-phen-yl)-3,4-dihydro-isoquinoline 2-oxide.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: (1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: 2-(2-Iodo-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-1-carbonitrile.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: (1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: Chiral capillary electrophoresis-mass spectrometry of tetrahydroisoquinoline-derived neurotoxins: observation of complex stereoisomerism.

Journal: Journal of chromatography. A 20110520

Title: 1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: (S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110501

Title: Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities.

Journal: Journal of medicinal chemistry 20110428

Title: A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110418

Title: Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach.

Journal: Journal of medicinal chemistry 20110414

Title: Methyl 1-cyclo-hexyl-6,7-dimeth-oxy-3,4-dihydro-isoquinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20110401

Title: Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids.

Journal: Chemical communications (Cambridge, England) 20110321

Title: The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.

Journal: Bioorganic & medicinal chemistry letters 20110315

Title: Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Optically active diaryl tetrahydroisoquinoline derivatives.

Journal: Acta crystallographica. Section C, Crystal structure communications 20110301

Title: [Design, synthesis, and PPARalpha/gamma agonistic activity of novel tetrahydroisoquinoline derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110301

Title: Synthesis of anisotropic CdS nanostructures via a single-source route.

Journal: Journal of nanoscience and nanotechnology 20110201

Title: Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Liposarcoma: molecular genetics and therapeutics.

Journal: Sarcoma 20110101

Title: In silico quantitative structure-activity relationship studies on P-gp modulators of tetrahydroisoquinoline-ethyl-phenylamine series.

Journal: BMC structural biology 20110101

Title: Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells.

Journal: Anticancer research 20110101

Title: Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences 20110101

Title: 1-(2-Bromobenzoyl)-6,7-(methylene-dioxy)isoquinoline.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: N-(9,11-Dimeth-oxy-4-oxo-2,3,4,6,7,11b-hexa-hydro-1H-pyrido[2,1-a]isoquinolin-3-yl)benzamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: (3S)-2-Benzyl-3-carb-oxy-1,2,3,4-tetra-hydro-isoquinolinium chloride monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: (S)-N-Benzyl-2-methyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20110101

Title: Feasibility Assessment of Micro-Electrode Chip Assay as a Method of Detecting Neurotoxicity in vitro.

Journal: Frontiers in neuroengineering 20110101

Title: Global diversity of Ascidiacea.

Journal: PloS one 20110101

Title: Synthesis and pharmacological evaluation of 1-isopropyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel antihypertensive agents.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.

Journal: Frontiers in molecular neuroscience 20110101

Title: Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

Journal: Marine drugs 20110101

Title: Investigational approaches for mesothelioma.

Journal: Frontiers in oncology 20110101

Title: Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants.

Journal: Chemical & pharmaceutical bulletin 20101201

Title: (1R,3S)-Methyl 6,7-dimeth-oxy-1-(4-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: 4-Chloro-N-methyl-2-(1,2,3,4-tetra-hydro-isoquinolin-1-yl)aniline.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds.

Journal: Journal of combinatorial chemistry 20101108

Title: A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst.

Journal: Molecular diversity 20101101

Title: The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors.

Journal: Molecular pharmacology 20101101

Title: PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.

Journal: British journal of pharmacology 20101101

Title: Total synthesis of (+)-korupensamine B via an atropselective intermolecular biaryl coupling.

Journal: Journal of the American Chemical Society 20101013

Title: A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

Journal: Nature communications 20101005

Title: An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides.

Journal: Organic & biomolecular chemistry 20100921

Title: Specific inhibitors of the breast cancer resistance protein (BCRP).

Journal: ChemMedChem 20100903

Title: Synthesis, structure and DNA cleavage studies of coumarin analogues of tetrahydroisoquinoline and protoberberine alkaloids.

Journal: European journal of medicinal chemistry 20100901

Title: Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Synthesis of novel tetrahydroisoquinoline bronchodilators.

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Neurotoxic effects of tetrahydroisoquinolines and underlying mechanisms.

Journal: Experimental neurobiology 20100901

Title: Recent synthetic approaches to 6,15-iminoisoquino[3,2-b]3-benzazocine compounds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100823

Title: Synthesis of tetrahydroisoquinoline alkaloids via anodic cyanation as the key step.

Journal: The Journal of organic chemistry 20100820

Title: Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.

Journal: Journal of medicinal chemistry 20100812

Title: Derivatives of tetrahydroisoquinoline: synthesis and initial evaluation of novel non-peptide antagonists of the alpha(IIb)beta(3)-integrin.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: A review of trabectedin (ET-743): a unique mechanism of action.

Journal: Molecular cancer therapeutics 20100801

Title: Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation.

Journal: Chemical & pharmaceutical bulletin 20100801

Title: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae).

Journal: Natural product communications 20100701

Title: Catechol-O-methyltransferase: potential relationship to idiopathic hypertension.

Journal: Archives of medical science : AMS 20100630

Title: 4-[(2,4-Dimethyl-1,3-oxazol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: 2'-Methyl-3,5-diphenyl-spiro-[4,6-dioxa-2-aza-bicyclo-[3.2.0]hept-2-ene-7,4'-iso-quinoline]-1',3'(2'H,4'H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: 4-[(2,4-Dimethyl-thia-zol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: 4-[(2,5-Dimethyl-1,3-thia-zol-4-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: Catalytic enantioselective 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines with alpha,beta-unsaturated aldehydes.

Journal: Journal of the American Chemical Society 20100331

Title: Preventative effects of 1,3-dimethyl- and 1,3-dimethyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline on MPTP-induced Parkinson's disease-like symptoms in mice.

Journal: Brain research 20100319

Title: Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: Enantiospecific stereodivergent synthesis of trans- and cis-N(2),3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolines.

Journal: Chemistry, an Asian journal 20100301

Title: {(1R,3S)-2-Benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl}diphenyl-methanol.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: Trabectedin: a review of its use in soft tissue sarcoma and ovarian cancer.

Journal: Drugs 20100212

Title: Pictet-Spengler reactions for the synthesis of pharmaceutically relevant heterocycles.

Journal: Current opinion in drug discovery & development 20100101

Title: Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures.

Journal: BMC plant biology 20100101

Title: Trabectedin for metastatic soft tissue sarcoma: a retrospective single center analysis.

Journal: Marine drugs 20100101

Title: Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells.

Journal: Journal of neuroinflammation 20100101

Title: New developments in treatment of ovarian carcinoma: focus on trabectedin.

Journal: Cancer management and research 20100101

Title: [Bioactivity diversity and functional mechanism of tetrahydroisoquinoline alkaloids].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100101

Title: Biochemistry and occurrence of o-demethylation in plant metabolism.

Journal: Frontiers in physiology 20100101

Title: A highly enantioselective access to tetrahydroisoquinoline and beta-carboline alkaloids with simple noyori-type catalysts in aqueous media.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20091207

Title: Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells.

Journal: Atherosclerosis 20091201

Title: A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis.

Journal: European journal of medicinal chemistry 20091201

Title: (1R,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20091101

Title: Graphite-supported gold nanoparticles as efficient catalyst for aerobic oxidation of benzylic amines to imines and N-substituted 1,2,3,4-tetrahydroisoquinolines to amides: synthetic applications and mechanistic study.

Journal: Chemistry, an Asian journal 20091005

Title: Selective functionalization of sp(3) C-H bonds adjacent to nitrogen using (diacetoxyiodo)benzene (DIB).

Journal: The Journal of organic chemistry 20091002

Title: Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells.

Journal: European journal of medicinal chemistry 20091001

Title: Estimation of relationship between descriptors and cytotoxicity of newly synthesized 1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: Anticancer research 20091001

Title: Oxaziridine-mediated intramolecular amination of sp(3)-hybridized C-H bonds.

Journal: Journal of the American Chemical Society 20090909

Title: The use of positron emission tomography in soft tissue sarcoma patients under therapy with trabectedin.

Journal: Marine drugs 20090901

Title: Bioactivity-guided mapping and navigation of chemical space.

Journal: Nature chemical biology 20090801

Title: Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.

Journal: Anticancer research 20090801

Title: Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution.

Journal: International journal of molecular sciences 20090801

Title: Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.

Journal: Biochemical pharmacology 20090715

Title: Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.

Journal: Molecular cancer therapeutics 20090701

Title: (S)-Methyl 2-[(3R,4R)-2-benzyl-3-(2-fur-yl)-1-oxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxamido]-3-(1H-indol-3-yl)propanoate.

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090601

Title: Estimation of relationship between the structure of 1,2,3,4-tetrahydroisoquinoline derivatives determined by a semiempirical molecular-orbital method and their cytotoxicity.

Journal: Anticancer research 20090601

Title: Methyl trans-(±)-1-oxo-2-phenethyl-3-(thio-phen-2-yl)-1,2,3,4-tetra-hydro-isoquinoline-4-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Fast and sensitive liquid chromatography/electrospray mass spectrometry method to study ocular penetration of EDL-155, a novel antitumor agent for retinoblastoma in rats.

Journal: Journal of mass spectrometry : JMS 20090501

Title: Capillary electrophoretic study of small, highly sulfated, non-sugar molecules interacting with antithrombin.

Journal: Electrophoresis 20090501

Title: Biosynthesis of 3-hydroxy-5-methyl-o-methyltyrosine in the saframycin/ safracin biosynthetic pathway.

Journal: Journal of microbiology and biotechnology 20090501

Title: Facile synthesis of a benzindenoazepine alkaloid, bulgaramine, via samarium diiodide promoted ring expansion of an alpha-aminocarbonyl compound.

Journal: Organic letters 20090416

Title: Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Enantioselective synthesis of schulzeines B and C via a beta-lactone-derived surrogate for bishomoserine aldehyde.

Journal: Organic letters 20090305

Title: The synthesis of N-phenoxyethyl-1-substituted-1,2,3,4-tetrahydroisoquinolines and their alpha1-adrenoceptor blocking activity.

Journal: European journal of medicinal chemistry 20090301

Title: Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

Journal: Natural product reports 20090301

Title: The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease.

Journal: Journal of neurochemistry 20090101

Title: Application of the statistical methods in systematic structure-activity relationship analysis of thiazole, benzothiazole and tetrahydroisoquinoline derivatives with biological activity.

Journal: Acta poloniae pharmaceutica 20090101

Title: Solution-phase parallel annulation of (thio)hydantoins to tetrahydroisoquinolines and tetrahydro-beta-carbolines containing the 2-arylethyl amine scaffold.

Journal: Journal of combinatorial chemistry 20090101

Title: ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.

Journal: PloS one 20090101

Title: Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain.

Journal: Pharmacological reports : PR 20090101

Title: Possible treatment concepts for the levodopa-related hyperhomocysteinemia.

Journal: Cardiovascular psychiatry and neurology 20090101

Title: Role of trabectedin in the treatment of soft tissue sarcoma.

Journal: OncoTargets and therapy 20090101

Title: Trabectedin: the evidence for its place in therapy in the treatment of soft tissue sarcoma.

Journal: Core evidence 20090101

Title: A concise total synthesis of (-)-quinocarcin via aryne annulation.

Journal: Journal of the American Chemical Society 20081224

Title: Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis.

Journal: The Journal of organic chemistry 20081219

Title: Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain.

Journal: Journal of neurochemistry 20081201

Title: Recent progress in the total synthesis of naphthyridinomycin and lemonomycin tetrahydroisoquinoline antitumor antibiotics (TAAs).

Journal: Chemical Society reviews 20081201

Title: Pharmacological modulation of leukotriene D(4) attenuates the development of opioid dependence in a mouse model of naloxone-induced opioid withdrawal syndrome.

Journal: European journal of pharmacology 20081119

Title: Synthesis of chiral 3-methyl- and 3-methyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline and prevention of MPP+ -induced cytotoxicity.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101

Title: Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer.

Journal: European journal of medicinal chemistry 20081001

Title: HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

Journal: Cellular signalling 20081001

Title: Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma.

Journal: Anti-cancer drugs 20081001

Title: Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site.

Journal: The Journal of biological chemistry 20080905

Title: Copper-catalyzed oxidative sp3 C-H bond arylation with aryl boronic acids.

Journal: Organic letters 20080904

Title: N-Methyl-isosalsoline from Hammada scoparia.

Journal: Acta crystallographica. Section E, Structure reports online 20080901

Title: Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: Concise synthesis of the CDE ring system of tetrahydroisoquinoline alkaloids using carbophilic Lewis acid-catalyzed hydroamidation and oxidative Friedel-Crafts cyclization.

Journal: The Journal of organic chemistry 20080704

Title: Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer.

Journal: Bioorganic & medicinal chemistry letters 20080615

Title: Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells.

Journal: European journal of medicinal chemistry 20080601

Title: Simultaneous analysis of 1,2,3,4-tetrahydroisoquinolines by high-performance liquid chromatography using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride as a fluorescent labeling reagent.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

Title: SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure.

Journal: Bioorganic & medicinal chemistry 20080301

Title: New 1,2,3,4-tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SKCa channel imaging agents.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20080201

Title: Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents.

Journal: Chemical & pharmaceutical bulletin 20080201

Title: Trabectedin and its potential in the treatment of soft tissue sarcoma.

Journal: Therapeutics and clinical risk management 20080201

Title: Metabolism of praziquantel in kingfish Seriola lalandi.

Journal: Diseases of aquatic organisms 20080124

Title: Discovery of a potent and long-acting bronchorelaxing capsazepinoid, RESPIR 4-95.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.

Journal: Bioorganic & medicinal chemistry 20080101

Title: Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.

Journal: Bioorganic & medicinal chemistry 20080101

Title: Selective androgen receptor modulators in preclinical and clinical development.

Journal: Nuclear receptor signaling 20080101

Title: A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens.

Journal: British journal of cancer 20071217

Title: Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo.

Journal: The Journal of pharmacy and pharmacology 20071201

Title: Synthesis and antifungal activities of novel 2-aminotetralin derivatives.

Journal: Journal of medicinal chemistry 20071101

Title: Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

Journal: Journal of medicinal chemistry 20071004

Title: Synthesis of carbon-11 labeled biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues as new potential PET glioma tumor imaging agents.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20071001

Title: Fatty acyl amides of endogenous tetrahydroisoquinolines are active at the recombinant human TRPV1 receptor.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Cardioprotective effects of novel tetrahydroisoquinoline analogs of nitrobenzylmercaptopurine riboside in an isolated perfused rat heart model of acute myocardial infarction.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Determination of a potent non-competitive AMPA receptor antagonist in rat brain.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for sigma receptors.

Journal: Bioorganic & medicinal chemistry letters 20070501

Title: Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer.

Journal: Bioorganic & medicinal chemistry letters 20070501

Title: Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.

Journal: Bioorganic & medicinal chemistry letters 20070201

Title: Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.

Journal: Bioorganic & medicinal chemistry 20070201

Title: The effect of modulation of gamma-glutamyl transpeptidase and nitric oxide synthase activity on GSH homeostasis in HepG2 cells.

Journal: Fundamental & clinical pharmacology 20070201

Title: Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.

Journal: Journal of medicinal chemistry 20070125

Title: Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition.

Journal: Neurotoxicology 20070101

Title: Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation.

Journal: Thrombosis research 20070101

Title: Quantitative structure-activity relationship modeling of growth hormone secretagogues agonist activity of some tetrahydroisoquinoline 1-carboxamides.

Journal: Chemical biology & drug design 20070101

Title: Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

Journal: PloS one 20070101

Title: IBX-mediated oxidative Ugi-type multicomponent reactions: application to the N and C1 functionalization of tetrahydroisoquinoline.

Journal: Angewandte Chemie (International ed. in English) 20070101

Title: Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.

Journal: PloS one 20070101

Title: Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?

Journal: Behavioral and brain functions : BBF 20070101

Title: Stereochemical diversity in asymmetric cyclization via memory of chirality.

Journal: Journal of the American Chemical Society 20061206

Title: Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.

Journal: Journal of medicinal chemistry 20061130

Title: Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia.

Journal: The Journal of organic chemistry 20061027

Title: Solid-phase synthesis of tetrahydro-beta-carbolines and tetrahydroisoquinolines by stereoselective intramolecular N-carbamyliminium Pictet-Spengler reactions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20061025

Title: Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi.

Journal: Bioorganic & medicinal chemistry letters 20061015

Title: Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries.

Journal: Biochemical and biophysical research communications 20061013

Title: De novo biosynthesis of morphine in animal cells: an evidence-based model.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20061001

Title: Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.

Journal: Journal of medicinal chemistry 20060921

Title: Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.

Journal: Journal of medicinal chemistry 20060907

Title: Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.

Journal: Journal of medicinal chemistry 20060907

Title: Random chemistry as a new tool for the generation of small-compound libraries.

Journal: Archiv der Pharmazie 20060901

Title: Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex.

Journal: European journal of medicinal chemistry 20060801

Title: [Asymmetric intramolecular conjugate addition of chiral enolates via non-equilibrium].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801

Title: Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine.

Journal: Organic letters 20060720

Title: Synthesis and SAR of novel histamine H3 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20060701

Title: 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.

Journal: Archiv der Pharmazie 20060701

Title: Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G.

Journal: Bioorganic & medicinal chemistry letters 20060615

Title: Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability.

Journal: Bioorganic & medicinal chemistry letters 20060515

Title: The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties and inhibition of glutamate-induced excitotoxicity.

Journal: Journal of neurochemistry 20060501

Title: Acetylcholinesterase inhibitors from Stephania venosa tuber.

Journal: The Journal of pharmacy and pharmacology 20060501

Title: Development of the Pictet-Spengler reaction catalyzed by AuCl3/AgOTf.

Journal: The Journal of organic chemistry 20060317

Title: 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060315

Title: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for beta-adrenoceptor subtypes.

Journal: Bioorganic & medicinal chemistry 20060315

Title: The solution to a deep stereochemical conundrum: studies toward the tetrahydroisoquinoline alkaloids.

Journal: Angewandte Chemie (International ed. in English) 20060303

Title: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline passes through the blood-brain barrier of rat brain: an in vivo microdialysis study.

Journal: Neuroscience letters 20060227

Title: Synthesis and in vitro cytotoxicity of 1,2,3,4-tetrahydroisoquinoline derivatives.

Journal: European journal of medicinal chemistry 20060201

Title: Capillary liquid chromatography-tandem mass spectrometry of tetrahydroisoquinoline derived neurotoxins: a study on the blood-brain barrier of rat brain.

Journal: Journal of chromatography. A 20060127

Title: Trabectedin: Ecteinascidin 743, Ecteinascidin-743, ET 743, ET-743, NSC 684766.

Journal: Drugs in R&D 20060101

Title: [Syntheses and ring-closures of difunctional tetrahydroisoquinolines].

Journal: Acta pharmaceutica Hungarica 20060101

Title: [Synthesis of isothioureas derived from tetrahydroisoquinoline and NOS inhibitory activity].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051101

Title: Synthesis of the tetrahydroisoquinoline alkaloid (+/-)-renieramycin G and A (+/-)-lemonomycinone analogue from a common intermediate.

Journal: Journal of the American Chemical Society 20050914

Title: P2X(7) receptor: Death or life?

Journal: Purinergic signalling 20050901

Title: Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson's disease.

Journal: Biological & pharmaceutical bulletin 20050801

Title: Alkaloids from Alangium javanicum and Alangium grisolleoides that mediate Cu2+-dependent DNA strand scission.

Journal: Journal of natural products 20050801

Title: Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine.

Journal: Journal of medicinal chemistry 20050728

Title: 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity.

Journal: Brain research 20050727

Title: Treatment with 1,2,3,4-tetrahydroisoquinolone affects the levels of nitric oxide, S-nitrosothiols, glutathione and the enzymatic activity of gamma-glutamyl transpeptidase in the dopaminergic structures of rat brain.

Journal: Brain research 20050712

Title: SPE-HPLC determination of new tetrahydroisoquinoline derivatives in rat plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705

Title: Synthesis of a novel class of fatty acids-derived isoquinolines.

Journal: Chemistry and physics of lipids 20050601

Title: Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.

Journal: Journal of natural products 20050601

Title: Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring.

Journal: Journal of medicinal chemistry 20050519

Title: Decrease in cytosolic phospholipase A2alpha mRNA levels by reactive oxygen species via MAP kinase pathways in PC12 cells: effects of dopaminergic neurotoxins.

Journal: Cellular signalling 20050501

Title: Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues.

Journal: Bioorganic & medicinal chemistry letters 20050401

Title: Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers.

Journal: Bioorganic & medicinal chemistry 20050215

Title: QSAR of estrogen receptor modulators: exploring selectivity requirements for ER(alpha) versus ER(beta) binding of tetrahydroisoquinoline derivatives using E-state and physicochemical parameters.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Chiral CE separation of dopamine-derived neurotoxins.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050201

Title: Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands.

Journal: Journal of medicinal chemistry 20050127

Title: Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20050103

Title: [Effect of 1,2,3,4-tetrahydroimidazo[4,5-c]pyridine and 1,2,3,4-tetrahydroisoquinoline derivatives on the behavior and the brain receptor system in rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20050101

Title: Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20041206

Title: Alkaloidal constituents of Mucuna pruriens seeds.

Journal: Phytochemistry 20040901

Title: Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder.

Journal: Dialogues in clinical neuroscience 20040901

Title: New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'.

Journal: Journal of medicinal chemistry 20040826

Title: Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias.

Journal: Molecules (Basel, Switzerland) 20040731

Title: Synthesis of some novel 11b-substituted pyrimido[6,1-a]-isoquinoline derivatives.

Journal: Molecules (Basel, Switzerland) 20040731

Title: Stereoselective synthesis of atropisomeric korupensamines A and B utilizing planar chiral arene chromium complex.

Journal: The Journal of organic chemistry 20040611

Title: Enantioselective total syntheses of the Ipecacuanha alkaloid emetine, the Alangium alkaloid tubulosine and a novel benzoquinolizidine alkaloid by using a domino process.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040607

Title: Pivotal role of an endogenous tetrahydroisoquinoline, salsolinol, in stress- and suckling-induced release of prolactin.

Journal: Annals of the New York Academy of Sciences 20040601

Title: Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system.

Journal: Brain research 20040529

Title: Structure of hydrated clusters of tetrahydroisoquinoline [THIQ-(H2O)(n=1,3)] investigated by jet spectroscopy.

Journal: The Journal of chemical physics 20040522

Title: Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline.

Journal: Free radical biology & medicine 20040501

Title: Carbazates as potent inhibitors of hormone-sensitive lipase.

Journal: Bioorganic & medicinal chemistry letters 20040405

Title: Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as potent and selective dopamine D3 receptor ligands.

Journal: Chembiochem : a European journal of chemical biology 20040402

Title: Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.

Journal: Cancer chemotherapy and pharmacology 20040401

Title: In vivo bioconversion of tetrahydroisoquinoline by recombinant coclaurine N-methyltransferase.

Journal: Bioscience, biotechnology, and biochemistry 20040401

Title: Ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes.

Journal: Journal of the American Chemical Society 20040310

Title: New imide 5-HT1A receptor ligands - modification of terminal fragment geometry.

Journal: Molecules (Basel, Switzerland) 20040227

Title: Disposition of 1,2,3,4,-tetrahydroisoquinoline in the brain of male Wistar and Dark Agouti rats.

Journal: Brain research 20040123

Title: Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives.

Journal: Farmaco (Societa chimica italiana : 1989) 20040101

Title: Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids.

Journal: Journal of combinatorial chemistry 20040101

Title: Solid-phase synthesis of 1,2,3,4-tetrahydroisoquinoline derivatives employing support-bound tyrosine esters in the Pictet-Spengler reaction.

Journal: Journal of combinatorial chemistry 20040101

Title: A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction.

Journal: Molecular diversity 20040101

Title: Inhibition of rodent brain monoamine oxidase and tyrosine hydroxylase by endogenous compounds - 1,2,3,4-tetrahydro-isoquinoline alkaloids.

Journal: Polish journal of pharmacology 20040101

Title: In vitro interaction between ecteinascidin 743 (ET-743) and radiation, in relation to its cell cycle effects.

Journal: British journal of cancer 20031215

Title: Synthetic studies on ecteinascidin 743: rapid access to the fully functionalized tetrahydroisoquinoline with a bridged 10-membered sulfur containing macrocycle.

Journal: Chemical communications (Cambridge, England) 20031207

Title: Structural specificity for the inhibitory effect of calmodulin on specific 125I-omega-conotoxin GVIA binding.

Journal: Neurochemical research 20031201

Title: Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline.

Journal: Journal of pharmacological sciences 20031201

Title: Intermolecular, markovnikov hydroamination of vinylarenes with alkylamines.

Journal: Journal of the American Chemical Society 20031126

Title: Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

Journal: Chemical & pharmaceutical bulletin 20031101

Title: The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20031101

Title: The Pictet-Spengler reaction in solid-phase combinatorial chemistry.

Journal: Current opinion in drug discovery & development 20031101

Title: Synthesis and pharmacological evaluation of 1-oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and related analogues as a new class of specific bradycardic agents possessing I(f) channel inhibitory activity.

Journal: Journal of medicinal chemistry 20031023

Title: Organolathanide-catalyzed regioselective intermolecular hydroamination of alkenes, alkynes, vinylarenes, di- and trivinylarenes, and methylenecyclopropanes. Scope and mechanistic comparison to intramolecular cyclohydroaminations.

Journal: Journal of the American Chemical Society 20031015

Title: Debenzylation of tertiary amines using phosgene or triphosgene: an efficient and rapid procedure for the preparation of carbamoyl chlorides and unsymmetrical ureas. Application in carbon-11 chemistry.

Journal: The Journal of organic chemistry 20030919

Title: Presence of reticuline in rat brain: a pathway for morphine biosynthesis.

Journal: Brain research. Molecular brain research 20030910

Title: Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp.

Journal: Journal of natural products 20030801

Title: Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.

Journal: Journal of medicinal chemistry 20030703

Title: Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Journal: Bioorganic & medicinal chemistry letters 20030616

Title: New strategy for the synthesis of tetrahydroisoquinoline alkaloids.

Journal: Organic letters 20030612

Title: New scaffolds in the development of mu opioid-receptor ligands.

Journal: Bioorganic & medicinal chemistry letters 20030505

Title: Tetrahydroisoquinoline alkaloids and 2-deoxyribonolactones from Aristolochia arcuata.

Journal: Phytochemistry 20030401

Title: Synthesis and pharmacological evaluation of 2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline derivatives as specific bradycardic agents.

Journal: Chemical & pharmaceutical bulletin 20030401

Title: The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20030401

Title: Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030401

Title: A short diastereoselective synthesis of the putative alkaloid jamtine, using a tandem pummerer/mannich cyclization sequence.

Journal: The Journal of organic chemistry 20030207

Title: Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists.

Journal: Journal of chemical information and computer sciences 20030101

Title: A possible physiological role for cerebral tetrahydroisoquinolines.

Journal: Neurotoxicity research 20030101

Title: Tetrahydroisoquinoline and beta-carboline alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae).

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: Influence of acute and chronic 1,2,3,4-tetrahydroisoquinoline administration on the expression of proenkephalin mRNA in the rat striatum.

Journal: Polish journal of pharmacology 20030101

Title: A study of the influence of newly synthesized acyclonucleosides and 1,2,3,4-tetrahydroisoquinoline derivatives on deoxythymidine and deoxycytidine kinase activities in human neurofibrosarcoma and ovarian cancer.

Journal: Acta biochimica Polonica 20030101

Title: Cytotoxicity of dopamine-derived tetrahydroisoquinolines on melanoma cells.

Journal: Biochemical pharmacology 20021115

Title: Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure-activity relationship.

Journal: Bioorganic & medicinal chemistry 20021101

Title: [Tetrahydroisoquinoline derivatives as possible Parkinson's disease-inducing substances].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021101

Title: Alkaloids, alcohol and Parkinson's disease.

Journal: Parkinsonism & related disorders 20020901

Title: Two optically active isoquinoline derivatives.

Journal: Acta crystallographica. Section C, Crystal structure communications 20020801

Title: Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.

Journal: Bioorganic & medicinal chemistry 20020601

Title: Tetrahydroisoquinoline derivatives of enkephalins: synthesis and properties.

Journal: Biochemical pharmacology 20020515

Title: 3-D-QSAR analysis of N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline and N-(3-acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thioureas analogues as potent vanilloid receptor ligands.

Journal: Bioorganic & medicinal chemistry 20020501

Title: Further characterization of the stimulus properties of 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline.

Journal: Pharmacology, biochemistry, and behavior 20020501

Title: Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics.

Journal: Chemical reviews 20020501

Title: Active conformation of some arylpiperazine postsynaptic 5-HT(1A) receptor antagonists.

Journal: European journal of medicinal chemistry 20020401

Title: Total synthesis of (+/-)-jamtine using a thionium/N-acyliminium ion cascade.

Journal: Organic letters 20020307

Title: Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020305

Title: Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter.

Journal: Biochemical pharmacology 20020301

Title: Application of a new chiral derivatizing agent to the enantioseparation of secondary amino acids.

Journal: Journal of chromatography. A 20020301

Title: A convenient synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines via Pictet-Spengler reaction using titanium(IV) isopropoxide and acetic-formic anhydride.

Journal: Chemical & pharmaceutical bulletin 20020201

Title: Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay.

Journal: Biochemistry 20020122

Title: The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT(1A)/5-HT(2A) receptor activities of its 1-adamantoyloaminoalkyl derivatives.

Journal: Bioorganic & medicinal chemistry 20020101

Title: Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies.

Journal: Polish journal of pharmacology 20020101

Title: Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.

Journal: Arzneimittel-Forschung 20020101

Title: N-methylation underlying Parkinson's disease.

Journal: Neurotoxicology and teratology 20020101

Title: Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines.

Journal: Polish journal of pharmacology 20020101

Title: Synthesis and in vivo pharmacology of new derivatives of isothiazolo[5,4-b]pyridine of Mannich base type.

Journal: Farmaco (Societa chimica italiana : 1989) 20011201

Title: Synthesis of isoquinolines and pyridines by the palladium-catalyzed iminoannulation of internal alkynes.

Journal: The Journal of organic chemistry 20011130

Title: Total syntheses of conformationally constrained didemnin B analogues. replacements of N,O-dimethyltyrosine with L-1,2,3,4-tetrahydroisoquinoline and L-1,2,3,4-tetrahydro-7-methoxyisoquinoline.

Journal: The Journal of organic chemistry 20011116

Title: Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents.

Journal: Bioorganic & medicinal chemistry 20011101

Title: Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D(2) receptors in the mouse striatum.

Journal: Journal of neurochemistry 20011101

Title: ET-743 (PharmaMar/NCI/Ortho Biotech).

Journal: Current opinion in investigational drugs (London, England : 2000) 20011101

Title: Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anti-cancer agents.

Journal: Current medicinal chemistry. Anti-cancer agents 20011101

Title: Intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins: a new method for the preparation of tetrahydroisoquinolines, tetrahydro-3-benzazepines, and hexahydro-3-benzazocines.

Journal: Organic letters 20011018

Title: Parallel synthesis and biological activity of a new class of high affinity and selective delta-opioid ligand.

Journal: Bioorganic & medicinal chemistry 20011001

Title: Stress-related polyketide metabolism of Dioncophyllaceae and Ancistrocladaceae.

Journal: Journal of experimental botany 20011001

Title: Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson's disease.

Journal: Brain research bulletin 20010901

Title: Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines.

Journal: Bioorganic & medicinal chemistry 20010801

Title: An unusual decarboxylative Maillard reaction between L-DOPA and D-glucose under biomimetic conditions: factors governing competition with Pictet-Spengler condensation.

Journal: The Journal of organic chemistry 20010727

Title: Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties.

Journal: Journal of neurochemistry 20010701

Title: Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.

Journal: Bioorganic & medicinal chemistry letters 20010618

Title: Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid.

Journal: Free radical biology & medicine 20010615

Title: Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine.

Journal: The Journal of organic chemistry 20010504

Title: Chromatographic separation and spectrometric identification of the oxidation products from a tetrahydro-isoquinoline alkaloid.

Journal: Journal of pharmaceutical and biomedical analysis 20010501

Title: Pictet-Spengler condensation of the antiparkinsonian drug L-DOPA with D-glyceraldehyde. Opposite kinetic effects of Fe3+ and Cu2+ ions and possible implications for the origin of therapeutic side effects.

Journal: Bioorganic & medicinal chemistry 20010401

Title: Salsolinol, a naturally occurring tetrahydroisoquinoline alkaloid, induces DNA damage and chromosomal aberrations in cultured Chinese hamster lung fibroblast cells.

Journal: Mutation research 20010301

Title: Synthesis and structure-activity relationships of potential anticonvulsants based on 2-piperidinecarboxylic acid and related pharmacophores.

Journal: European journal of medicinal chemistry 20010301

Title: Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010210

Title: Reduction of rat brain levels of the endogenous dopaminergic proneurotoxins 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-beta-carboline by cigarette smoke.

Journal: Neuroscience letters 20010209

Title: Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010201

Title: Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

Journal: European journal of cancer (Oxford, England : 1990) 20010101

Title: Benzolactam derivatives and their affinity for alpha 1- and alpha 2-adrenoreceptors.

Journal: Archiv der Pharmazie 20010101

Title: Opposite effect of simple tetrahydroisoquinolines on amphetamine- and morphine-stimulated locomotor activity in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Effects of single and repeated administration of 1,2,3,4-tetrahydroisoquinoline analogs on the binding of [11C]raclopride to dopamine D2 receptors in the mouse brain.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101

Title: Effect of acute administration of 1,2,3,4-tetrahydroisoquinoline on the levels of glutathione and reactive oxygen species, and on the enzymatic activity of gamma-glutamyl transpeptidase in dopaminergic structures of rat brain.

Journal: Neuroscience 20010101

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:91-21-4 Molecular Formula|91-21-4 MDL|91-21-4 SMILES|91-21-4 1,2,3,4-Tetrahydroisoquinoline |Organic_Building_Blocks