Title: Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines.
Journal: Molecules (Basel, Switzerland) 20140217
Title: A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer.
Journal: Disease models & mechanisms 20120501
Title: In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract.
Journal: Journal of ethnopharmacology 20110902
Title: A phase I pharmacokinetics study of 9-nitrocamptothecin in patients with advanced solid tumors.
Journal: Cancer chemotherapy and pharmacology 20110401
Title: 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Journal: Journal of medicinal chemistry 20110324
Title: Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees.
Journal: PloS one 20110101
Title: A novel preparation method for camptothecin (CPT) loaded folic acid conjugated dextran tumor-targeted nanoparticles.
Journal: International journal of molecular sciences 20110101
Title: Preparation and in vitro characterization of 9-nitrocamptothecin-loaded long circulating nanoparticles for delivery in cancer patients.
Journal: International journal of nanomedicine 20100101
Title: Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts.
Journal: Macromolecular bioscience 20091110
Title: Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
Journal: Journal of neuro-oncology 20090701
Title: Phase II study of 9-aminocamptothecin in previously treated lymphomas: results of Cancer and Leukemia Group B 9551.
Journal: Cancer chemotherapy and pharmacology 20090401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090401
Title: The role side effects play in the choice of antiepileptic therapy in brain tumor-related epilepsy: a comparative study on traditional antiepileptic drugs versus oxcarbazepine.
Journal: Journal of experimental & clinical cancer research : CR 20090101
Title: Tumor, tissue, and plasma pharmacokinetic studies and antitumor response studies of docetaxel in combination with 9-nitrocamptothecin in mice bearing SKOV-3 human ovarian xenografts.
Journal: Cancer chemotherapy and pharmacology 20080801
Title: Tumor-targeting prodrug-activating bacteria for cancer therapy.
Journal: Cancer gene therapy 20080601
Title: Key role of topoisomerase I inhibitors in the treatment of recurrent and refractory epithelial ovarian carcinoma.
Journal: Expert review of anticancer therapy 20080501
Title: Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.
Journal: Journal of medicinal chemistry 20080327
Title: Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats.
Journal: Pharmaceutical research 20080101
Title: Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin.
Journal: Cancer chemotherapy and pharmacology 20070601
Title: Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20070212
Title: Membrane-localized activation of glucuronide prodrugs by beta-glucuronidase enzymes.
Journal: Cancer gene therapy 20070201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061201
Title: Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes.
Journal: Investigational new drugs 20060901
Title: Phase I trial of continuous infusion 9-aminocamptothecin in patients with advanced solid tumors: 21-day infusion is an active well-tolerated regimen.
Journal: Anti-cancer drugs 20060601
Title: Pre-irradiation 9-amino [20s] camptothecin (9-AC) in patients with newly diagnosed glioblastoma multiforme.
Journal: Investigational new drugs 20060501
Title: Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors.
Journal: Cancer chemotherapy and pharmacology 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Identification of a small topoisomerase I-binding peptide that has synergistic antitumor activity with 9-aminocamptothecin.
Journal: Molecular cancer therapeutics 20060301
Title: Risk assessment of human myelotoxicity of anticancer drugs: a predictive model and the in vitro colony forming unit granulocyte/macrophage (CFU-GM) assay.
Journal: Die Pharmazie 20060201
Title: Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20060110
Title: Rubitecan.
Journal: Expert opinion on investigational drugs 20060101
Title: Relationship between plasma exposure of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite and antitumor response in mice bearing human colon carcinoma xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050701
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050301
Title: Alternative administration of camptothecin analogues.
Journal: Expert opinion on drug delivery 20050301
Title: Phase II evaluation of 9-aminocamptothecin (9-AC, NSC #603071) in platinum-resistant ovarian and primary peritoneal carcinoma: a Gynecologic Oncology Group Study.
Journal: Gynecologic oncology 20050101
Title: Topoisomerases in the treatment of metastatic or recurrent squamous carcinoma of the head and neck.
Journal: Expert opinion on pharmacotherapy 20050101
Title: Pharmacokinetic studies of 9-nitrocamptothecin on intermittent and continuous schedules of administration in patients with solid tumors.
Journal: Cancer chemotherapy and pharmacology 20041201
Title: Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1-5 of a 3-weekly cycle in patients with advanced solid tumours.
Journal: British journal of cancer 20041018
Title: A predictive model of human myelotoxicity using five camptothecin derivatives and the in vitro colony-forming unit granulocyte/macrophage assay.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041001
Title: Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration.
Journal: Clinical colorectal cancer 20040901
Title: 9-Aminocamptothecin (9-AC) given as a 120-hour continuous infusion in patients with advanced adenocarcinomas of the stomach and gastroesophageal junction: A phase II trial of the University of Chicago phase II consortium.
Journal: Investigational new drugs 20040801
Title: Phase I and pharmacologic study of intermittently administered 9-nitrocamptothecin in patients with advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040801
Title: Cytotoxic pyrroloiminoquinones from four new species of South African latrunculid sponges.
Journal: Journal of natural products 20040801
Title: Plasma and cerebrospinal fluid pharmacokinetic study of BNP1350 in nonhuman primates.
Journal: Cancer chemotherapy and pharmacology 20040601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040301
Title: Development of a bioanalytical liquid chromatography method for quantitation of 9-nitrocamptothecin in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105
Title: Biweekly 72-hour 9-aminocamptothecin infusion as second-line therapy for ovarian carcinoma: phase II study of the New York Gynecologic Oncology Group and the Eastern Cooperative Oncology Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040101
Title: Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2).
Journal: BMC medicine 20040101
Title: Ex vivo analysis of topotecan: advancing the application of laboratory-based clinical therapeutics.
Journal: British journal of cancer 20031103
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031101
Title: Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liquid chromatography with fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005
Title: A phase I study of 9-aminocamptothecin as a colloidal dispersion formulation given as a fortnightly 72-h infusion.
Journal: Cancer chemotherapy and pharmacology 20031001
Title: Stability of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in the presence of human serum albumin.
Journal: Biochemical pharmacology 20031001
Title: Are there any better camptothecins than the ones we have?
Journal: Clinical advances in hematology & oncology : H&O 20031001
Title: The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine.
Journal: Biochemical pharmacology 20030801
Title: Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.
Journal: Cancer research 20030615
Title: Phase I and pharmacological study of oral 9-aminocamptothecin colloidal dispersion (NSC 603071) in patients with advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030601
Title: Intravenous administration of 9-aminocamptothecin to dogs with lymphoma.
Journal: Veterinary and comparative oncology 20030601
Title: Camptothecin analogues and vinblastine in the treatment of renal cell carcinoma: an in vivo study using a human orthotopic renal cancer xenograft.
Journal: Urologic oncology 20030101
Title: Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule.
Journal: Cancer chemotherapy and pharmacology 20021201
Title: Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis.
Journal: British journal of cancer 20021104
Title: Enzyme-activated Prodrug Therapy Enhances Tumor-specific Replication of Adenovirus Vectors.
Journal: Cancer research 20021101
Title: Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
Journal: British journal of cancer 20020909
Title: Novel 20-carbonate linked prodrugs of camptothecin and 9-aminocamptothecin designed for activation by tumour-associated plasmin.
Journal: Bioorganic & medicinal chemistry letters 20020902
Title: Phase I and pharmacologic study of i.p. 9-aminocamptothecin given as six fractions over 14 days.
Journal: Anti-cancer drugs 20020901
Title: Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020805
Title: DNA ligase III is degraded by calpain during cell death induced by DNA-damaging agents.
Journal: The Journal of biological chemistry 20020719
Title: Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme.
Journal: European journal of cancer (Oxford, England : 1990) 20020701
Title: Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice.
Journal: British journal of cancer 20020520
Title: Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma.
Journal: British journal of cancer 20020318
Title: Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Title: Analytical approaches for traditional chinese medicines exhibiting antineoplastic activity.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20011125
Title: A phase I and pharmacologic study of 9-aminocamptothecin administered as a 120-h infusion weekly to adult cancer patients.
Journal: Cancer chemotherapy and pharmacology 20010901
Title: Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecin.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20010810
Title: Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20010801
Title: Topoisomerase I inhibitors in the treatment of head and neck cancer.
Journal: Oncology (Williston Park, N.Y.) 20010701
Title: Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20010601
Title: Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010401
Title: Why drugs fail: of mice and men revisited.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
Title: Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
Title: Modulation of camptothecin analogs in the treatment of cancer: a review.
Journal: Anti-cancer drugs 20010201
Title: Pharmacological determinants of 9-aminocamptothecin cytotoxicity.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010101
Title: Phase II trial of 9-aminocamptothecin as a 72-h infusion in cutaneous T-cell lymphoma.
Journal: Investigational new drugs 20010101
Title: A phase II trial of 9-aminocaptothecin (9-AC) as a 120-h infusion in patients with non-small cell lung cancer.
Journal: Investigational new drugs 20010101
Title: The development of camptothecin analogs in childhood cancers.
Journal: The oncologist 20010101
Title: Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
Journal: Antimicrobial agents and chemotherapy 19991201
Title: Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Journal: Journal of medicinal chemistry 19930903
Title: Inhibitors of human immunodeficiency virus integrase.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930315
Title: Li ML, et al. Pharmacological determinants of 9-aminocamptothecin cytotoxicity. Clin Cancer Res. 2001 Jan;7(1):168-74.
Title: de Souza PL, et al. 9-Aminocamptothecin: a topoisomerase I inhibitor with preclinical activity in prostate cancer. Clin Cancer Res. 1997 Feb;3(2):287-94.
Title: Jeha S, et al. Activity of oral and intravenous 9-aminocamptothecin in SCID mice engrafted with human leukemia. Leuk Lymphoma. 1998 Dec;32(1-2):159-64.
