Title: Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).
Journal: Journal of medicinal chemistry 20120426
Title: Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121).
Journal: Molecules (Basel, Switzerland) 20111205
Title: Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.
Journal: Bioorganic & medicinal chemistry letters 20100415
Title: The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Grand challenges in pharmacotherapy of inflammation for the first decades of the 21st century.
Journal: Frontiers in pharmacology 20100101
Title: Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Journal: Journal of medicinal chemistry 20081225
Title: Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
Journal: Journal of medicinal chemistry 20080911
