Title: Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
Journal: Journal of medicinal chemistry 20120614
Title: Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans.
Journal: Clinical pharmacology and therapeutics 20110401
Title: The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast.
Journal: European journal of clinical pharmacology 20110201
Title: CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091201
Title: Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091001
Title: Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition.
Journal: Chemical research in toxicology 20090701
Title: The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo.
Journal: Clinical pharmacology and therapeutics 20080901
Title: Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101
Title: The effects of the phytoestrogenic isoflavone genistein on the hepatic disposition of preformed and hepatically generated gemfibrozil 1-O-acyl glucuronide in the isolated perfused rat liver.
Journal: The Journal of pharmacy and pharmacology 20031001
Title: Self-micellization of gemfibrozil 1-O-beta acyl glucuronide in aqueous solution.
Journal: Pharmaceutical research 20030301
Title: Shitara Y, et al. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2(OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36.
Title: Baer BR, et al. Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition. Chem Res Toxicol. 2009 Jul;22(7):1298-309.
