Catalog No.:AA0039UV

917879-39-1 | MK-2461

Name: Name:MK-2461
Brand: AABLOCKS
SKU: AA0039UV
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

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1mg

98+%

in stock

$87.00 $61.00

- +

2mg

98+%

in stock

$156.00 $110.00

- +

5mg

98+%

in stock

$233.00 $164.00

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100mg

98% by HPLC

in stock

$4,243.00 $2,970.00

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500mg

98% by HPLC

in stock

$13,562.00 $9,493.00

- +

1000mg

98% by HPLC

in stock

$21,663.00 $15,164.00

- +

Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA0039UV

Chemical Name:

MK-2461

CAS Number:

917879-39-1

Molecular Formula:

C24H25N5O5S

Molecular Weight:

495.5508

MDL Number:

MFCD11977739

SMILES:

Cn1ncc(c1)c1cnc2c(c1)c(=O)c1cc(ccc1cc2)NS(=O)(=O)N(C[C@@H]1COCCO1)C

Properties

Computed Properties

Complexity:

895

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.2

Literature

Title: Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

Journal: Journal of medicinal chemistry 20110623

Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Journal: European journal of medicinal chemistry 20110601

Title: MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

Journal: Cancer research 20100215

Title: Pan BS, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.

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SDS