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92-78-4,MFCD00021639
Catalog No.:AA0033WQ

92-78-4 | N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0033WQ
Chemical Name:
N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide
CAS Number:
92-78-4
Molecular Formula:
C17H12ClNO2
Molecular Weight:
297.7357
MDL Number:
MFCD00021639
SMILES:
Clc1ccc(cc1)NC(=O)c1cc2ccccc2cc1O
Properties
Properties
 
Form:
Solid  
MP:
255°C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
368  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
4.8  

Downstream Synthesis Route

[1]Dikshitetal.[Proceedings-IndianAcademyofSciences,SectionA,1953,#37,p.92,94]

[1]Kos,Jiri;Zadrazilova,Iveta;Pesko,Matus;Keltosova,Stanislava;Tengler,Jan;Gonec,Tomas;Bobal,Pavel;Kauerova,Tereza;Oravec,Michal;Kollar,Peter;Cizek,Alois;Kralova,Katarina;Jampilek,Josef[Molecules,2013,vol.18,#7,p.7977-7997]

[2]Fujita,Satoshi;Momiyama,Masayoshi;Kondo,Yasumitsu;Kagiyama,Naoto;Hori,SamuelH.;Toru,Takeshi[AnalyticalChemistry,1994,vol.66,#8,p.1347-1353]

[3]Vaillancourt,ValerieA;Cudahy,MicheleM.;Staley,SandraA.;Brideau,RogerJ.;Conrad,StevenJ.;Knechtel,MaryL.;Oien,NanceeL.;Wieber,JanetL.;Yagi,Yoshihiko;Wathen,MichaelW.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#18,p.2079-2081]

[4]Kos,Jiri;Kapustikova,Iva;Clements,Carol;Gray,AlexanderI.;Jampilek,Josef[MonatsheftefurChemie,2018,vol.149,#5,p.887-892]

[5]CurrentPatentAssignee:Chem.Fabr.Griesheim-Elekron-DE293897

[6]CurrentPatentAssignee:Chem.Fabr.Griesheim-Elekron-DE293897

[1]CurrentPatentAssignee:I.G.FARBENINDUSTRIEAG(historic)-DE506837,1927,C[Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.17,p.696][Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.17,p.696]

[1]Kekre,J.S.;Sunthankar,S.V.[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1976,vol.14,p.212-213]

92-78-4   
3-(4-chlorophenyl)carbamoyl-naphthalen-2-yldihydrogenphosphate 

[1]Fujita,Satoshi;Momiyama,Masayoshi;Kondo,Yasumitsu;Kagiyama,Naoto;Hori,SamuelH.;Toru,Takeshi[AnalyticalChemistry,1994,vol.66,#8,p.1347-1353]

Literature

Title: Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription.

Journal: Bioorganic & medicinal chemistry 20121201

Title: Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.

Journal: Bioorganic & medicinal chemistry letters 20000918

Title: Fuchun Xie, et al. Synthesis and Evaluation of an O-Aminated Naphthol AS-E as a Prodrug of CREB-mediated Gene Transcription Inhibition. Lett Org Chem. 2013 Jun;10(5):380-384.

Title: Bingbing X Li, et al. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10(17):2721-4.

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