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Title: Generation of the potent anti-malarial drug artemisinin in tobacco.
Journal: Nature biotechnology 20111208
Title: Identification and microbial production of a terpene-based advanced biofuel.
Journal: Nature communications 20110927
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Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801
Title: [Biosynthesis of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli through introducing mevalonate pathway].
Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20110701
Title: The production of artemisinin precursors in tobacco.
Journal: Plant biotechnology journal 20110501
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Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20110201
Title: A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene.
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Title: Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L.
Journal: BMC plant biology 20110101
Title: How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?
Journal: Malaria journal 20110101
Title: Carotenoid β-ring hydroxylase and ketolase from marine bacteria-promiscuous enzymes for synthesizing functional xanthophylls.
Journal: Marine drugs 20110101
Title: Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system.
Journal: Microbial cell factories 20110101
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Journal: Pharmacognosy reviews 20110101
Title: Triterpenoid biosynthesis and engineering in plants.
Journal: Frontiers in plant science 20110101
Title: Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua.
Journal: Plant physiology 20101001
Title: Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites.
Journal: Protein & cell 20100701
Title: Improved computational performance of MFA using elementary metabolite units and flux coupling.
Journal: Metabolic engineering 20100301
Title: Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study.
Journal: Phytochemistry 20100201
Title: Designing and engineering evolutionary robust genetic circuits.
Journal: Journal of biological engineering 20100101
Title: Survey of artemisinin production by diverse Artemisia species in northern Pakistan.
Journal: Malaria journal 20100101
Title: Nicotiana benthamiana as a production platform for artemisinin precursors.
Journal: PloS one 20100101
Title: Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis.
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Title: Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.
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Title: A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).
Journal: ACS chemical biology 20090417
Title: The improvement of amorpha-4,11-diene production by a yeast-conform variant.
Journal: Journal of applied microbiology 20090301
Title: Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene.
Journal: Metabolic engineering 20090101
Title: Engineering prokaryotic gene circuits.
Journal: FEMS microbiology reviews 20090101
Title: High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli.
Journal: PloS one 20090101
Title: An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli.
Journal: Microbial cell factories 20090101
Title: Evolution, ecology and the engineered organism: lessons for synthetic biology.
Journal: Genome biology 20090101
Title: Expression of a synthetic Artemesia annua amorphadiene synthase in Aspergillus nidulans yields altered product distribution.
Journal: Journal of industrial microbiology & biotechnology 20081001
Title: Identification of optimal measurement sets for complete flux elucidation in metabolic flux analysis experiments.
Journal: Biotechnology and bioengineering 20080815
Title: The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.
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Title: Heterologous production of secondary metabolites as pharmaceuticals in Saccharomyces cerevisiae.
Journal: Biotechnology letters 20080701
Title: Production of artemisinin by genetically-modified microbes.
Journal: Biotechnology letters 20080401
Title: Tissue specificity and developmental pattern of amorpha-4,11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana.
Journal: Planta medica 20080201
Title: Yeast cell factories for fine chemical and API production.
Journal: Microbial cell factories 20080101
Title: Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid.
Journal: BMC biotechnology 20080101
Title: [Increase of copy number of HMG-CoA reductase and FPP synthase genes improves the amorpha4,11-diene production in engineered yeast].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071201
Title: Functional genomics and the biosynthesis of artemisinin.
Journal: Phytochemistry 20070701
Title: Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis.
Journal: Applied microbiology and biotechnology 20070701
Title: Engineering Escherichia coli for production of functionalized terpenoids using plant P450s.
Journal: Nature chemical biology 20070501
Title: Metabolic flux elucidation for large-scale models using 13C labeled isotopes.
Journal: Metabolic engineering 20070101
Title: Synthetic biology: promises and challenges.
Journal: Molecular systems biology 20070101
Title: High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli.
Journal: Biotechnology and bioengineering 20061105
Title: Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants.
Journal: Nature biotechnology 20061101
Title: Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis.
Journal: Journal of natural products 20060501
Title: Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate.
Journal: Archives of biochemistry and biophysics 20060415
Title: Production of the antimalarial drug precursor artemisinic acid in engineered yeast.
Journal: Nature 20060413
Title: Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae.
Journal: Biotechnology letters 20060401
Title: Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.
Journal: FEBS letters 20060220
Title: Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L.
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Title: Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua.
Journal: Planta medica 20050101
Title: Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin.
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