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93-14-1,MFCD00016873
Catalog No.:AA006I85

93-14-1 | Guaifenesin

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1mg
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10g
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25g
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100g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006I85
Chemical Name:
Guaifenesin
CAS Number:
93-14-1
Molecular Formula:
C10H14O4
Molecular Weight:
198.2158
MDL Number:
MFCD00016873
SMILES:
OCC(COc1ccccc1OC)O
Properties
Properties
 
BP:
215°C (19 mmHg)  
Form:
Solid  
MP:
77-81°C  
Refractive Index:
1.5550 (estimate)  
Solubility:
50g/l (experimental)  
Storage:
Room Temperature;Keep in dry area;  

Computed Properties
 
Complexity:
151  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.4  

Literature

Title: Alfaxalone compared with ketamine for induction of anaesthesia in horses following xylazine and guaifenesin.

Journal: Veterinary anaesthesia and analgesia 20121101

Title: Application of hollow fiber-supported liquid-phase microextraction coupled with HPLC for the determination of guaifenesin enantiomer-protein binding.

Journal: Biomedical chromatography : BMC 20120701

Title: Evaluation of the clinical efficacy of two partial intravenous anesthetic protocols, compared with isoflurane alone, to maintain general anesthesia in horses.

Journal: American journal of veterinary research 20120701

Title: Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20120601

Title: Optimization of an improved single-column chromatographic process for the separation of enantiomers.

Journal: Journal of chromatography. A 20120330

Title: Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells.

Journal: Respiratory research 20120101

Title: Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111215

Title: Clinical evaluation of total intravenous anesthesia using a combination of propofol and medetomidine following anesthesia induction with medetomidine, guaifenesin and propofol for castration in Thoroughbred horses.

Journal: The Journal of veterinary medical science 20111201

Title: Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells.

Journal: Experimental lung research 20111201

Title: Anesthetic induction with guaifenesin and propofol in adult horses.

Journal: American journal of veterinary research 20111201

Title: Using dispersive liquid-liquid microextraction and liquid chromatography for determination of guaifenesin enantiomers in human urine.

Journal: Journal of separation science 20111101

Title: Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20110901

Title: The pharmacokinetics and pharmacodynamics of the injectable anaesthetic alfaxalone in the horse.

Journal: Veterinary anaesthesia and analgesia 20110901

Title: Salivary cortisol in obstructive sleep apnea: the effect of CPAP.

Journal: Endocrine 20110801

Title: The role of decongestants, cromolyn, guafenesin, saline washes, capsaicin, leukotriene antagonists, and other treatments on rhinitis.

Journal: Immunology and allergy clinics of North America 20110801

Title: Clinical evaluation of detomidine-butorphanol-guaifenesin-ketamine as short term TIVA in Spiti ponies.

Journal: Pakistan journal of biological sciences : PJBS 20110601

Title: Modulating the synthetase activity of penicillin G acylase in organic media by addition of N-methylimidazole: using vinyl acetate as activated acyl donor.

Journal: Journal of biotechnology 20110520

Title: Nitric oxide donors improve prednisone effects on muscular dystrophy in the mdx mouse diaphragm.

Journal: American journal of physiology. Cell physiology 20110501

Title: A new technique for spectrophotometric determination of pseudoephedrine and guaifenesin in syrup and synthetic mixture.

Journal: Drug testing and analysis 20110501

Title: Recommendations for the proper use of nonprescription cough suppressants and expectorants in solid-organ transplant recipients.

Journal: Progress in transplantation (Aliso Viejo, Calif.) 20110301

Title: Simultaneous determination of potassium guaiacolsulfonate, guaifenesin, diphenhydramine HCl and carbetapentane citrate in syrups by using HPLC-DAD coupled with partial least squares multivariate calibration.

Journal: Talanta 20110215

Title: Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Influence of modified open lung concept ventilation on the cardiovascular and pulmonary function of horses during total intravenous anaesthesia.

Journal: The Veterinary record 20101225

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Blockade of MUC1 expression by glycerol guaiacolate inhibits proliferation of human breast cancer cells.

Journal: Anti-cancer agents in medicinal chemistry 20101001

Title: Simultaneous determination of diclofenac potassium and methocarbamol in ternary mixture with guaifenesin by reversed phase liquid chromatography.

Journal: Talanta 20100915

Title: [The relationship between the lung function and the level of TNF-α in serum in COPD department of respiratory].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100901

Title: The influence of heterogeneous nucleation on the surface crystallization of guaifenesin from melt extrudates containing Eudragit L10055 or Acryl-EZE.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100501

Title: Efficacy, safety and tolerability of salbutamol + guaiphenesin + bromhexine (Ascoril) expectorant versus expectorants containing salbutamol and either guaiphenesin or bromhexine in productive cough: a randomised controlled comparative study.

Journal: Journal of the Indian Medical Association 20100501

Title: A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the simultaneous determination of pentoxyverine citrate and guaifenesin in human plasma---application to pharmacokinetic and bioequivalence studies.

Journal: Biomedical chromatography : BMC 20100401

Title: Laccase catalyzed covalent coupling of fluorophenols increases lignocellulose surface hydrophobicity.

Journal: Bioresource technology 20100401

Title: Effects of adding butorphanol to a balanced anaesthesia protocol during arthroscopic surgery in horses.

Journal: The Veterinary record 20100313

Title: [A prospective multicenter randomized controlled clinical study on the efficacy and safety of Guaifenesin compound pseudoephedrine hydrochloride oral solution].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20100301

Title: Aqueous film coating to reduce recrystallization of guaifenesin from hot-melt extruded acrylic matrices.

Journal: Drug development and industrial pharmacy 20100201

Title: Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.

Journal: International journal of analytical chemistry 20100101

Title: Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis.

Journal: International journal of chronic obstructive pulmonary disease 20100101

Title: Implementation of an automated on-line high-performance liquid chromatography monitoring system for 'cycle to cycle' control of simulated moving beds.

Journal: Journal of chromatography. A 20091211

Title: Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane.

Journal: Journal of the South African Veterinary Association 20091201

Title: Case report: anaphylactic reaction to guaifenesin.

Journal: Hospital practice (1995) 20091201

Title: Oxidation of the erythro and threo forms of the phenolic lignin model compound 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol by laccases and model oxidants.

Journal: Bioorganic chemistry 20091001

Title: Do OTC remedies relieve cough in acute URIs?

Journal: The Journal of family practice 20091001

Title: Best drugs for what ails you: the brands to buy--and those to skip.

Journal: Consumer reports 20090901

Title: Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough.

Journal: Respiratory medicine 20090601

Title: Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model.

Journal: Pulmonary pharmacology & therapeutics 20090601

Title: Simultaneous determination of pseudoephdrine, pheniramine, guaifenisin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography.

Journal: Talanta 20090515

Title: Safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for adjunctive symptom relief of acute respiratory infections.

Journal: Postgraduate medicine 20090501

Title: Guaifenesin in rhinitis.

Journal: Current allergy and asthma reports 20090301

Title: Identification of aquaporin 4 inhibitors using in vitro and in silico methods.

Journal: Bioorganic & medicinal chemistry 20090101

Title: Effects of changing body position on oxygenation and arterial blood pressures in foals anesthetized with guaifenesin, ketamine, and xylazine.

Journal: Veterinary anaesthesia and analgesia 20090101

Title: Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.

Journal: Molecular pharmaceutics 20090101

Title: Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice.

Journal: Neuro endocrinology letters 20090101

Title: A randomized, double-blind, parallel-group, multicenter, placebo-controlled study of the safety and efficacy of extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections.

Journal: Postgraduate medicine 20080701

Title: Disassembly of lignin and chemical recovery in supercritical water and p-cresol mixture. Studies on lignin model compounds.

Journal: Bioresource technology 20080401

Title: Simultaneous determination of multi drug components Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride by validated RP-HPLC method in liquid dosage form.

Journal: Pakistan journal of pharmaceutical sciences 20080401

Title: New validated liquid chromatographic and chemometrics-assisted UV spectroscopic methods for the determination of two multicomponent cough mixtures in syrup.

Journal: Journal of AOAC International 20080101

Title: Simultaneous determination of phenylephrine hydrochloride, guaifenesin, and chlorpheniramine maleate in cough syrup by gradient liquid chromatography.

Journal: Journal of AOAC International 20080101

Title: Cardiopulmonary effects of administration of a combination solution of xylazine, guaifenesin, and ketamine or inhaled isoflurane in mechanically ventilated calves.

Journal: American journal of veterinary research 20071201

Title: Enantiomer separation of the four diastereomers of guaiacyl glycerol from Hydnocarpus annamensis by capillary electrophoresis with HP-beta-CD as a chiral selector.

Journal: Journal of chromatographic science 20071001

Title: Experimental implementation of automatic 'cycle to cycle' control of a chiral simulated moving bed separation.

Journal: Journal of chromatography. A 20070921

Title: Crystal growth formation in melt extrudates.

Journal: International journal of pharmaceutics 20070816

Title: Clinical inquiries. Is guaifenesin safe during pregnancy?

Journal: The Journal of family practice 20070801

Title: 'Crystal dex:' free-base dextromethorphan.

Journal: The Journal of emergency medicine 20070501

Title: Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: Evaluation of the effects of the sedation with azaperone/acepromazine and immobilization with guaiphenesin/thiopentone in mules.

Journal: Veterinary research communications 20070201

Title: Physicochemical properties of film-coated melt-extruded pellets.

Journal: Journal of microencapsulation 20070201

Title: Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid/liquid extraction and gradient liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20070117

Title: Adjuvant therapies in the treatment of acute and chronic rhinosinusitis.

Journal: Clinical allergy and immunology 20070101

Title: New FDA guidance documents.

Journal: Food and drug law journal 20070101

Title: Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy.

Journal: The Laryngoscope 20061201

Title: Non-enzymatic reduction of quinone methides during oxidative coupling of monolignols: implications for the origin of benzyl structures in lignins.

Journal: Organic & biomolecular chemistry 20060921

Title: Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup.

Journal: Journal of pharmaceutical and biomedical analysis 20060607

Title: Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.

Journal: Journal of pharmaceutical and biomedical analysis 20060503

Title: Wood stimulates the demethoxylation of [O14CH3]-labeled lignin model compounds by the white-rot fungi Phanerochaete chrysosporium and Phlebia radiata.

Journal: Archives of microbiology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effects of incorporated drugs on degradation of novel 2,2'-bis(2-oxazoline) linked poly(lactic acid) films.

Journal: International journal of pharmaceutics 20060309

Title: Beta-galactosidase catalyzed selective galactosylation of aromatic compounds.

Journal: Biotechnology progress 20060101

Title: Spontaneous dissolution of a guaifenesin stone.

Journal: The Canadian journal of urology 20050801

Title: Voltammetric assay of Guaifenesin in pharmaceutical formulation.

Journal: Journal of pharmaceutical and biomedical analysis 20050601

Title: Influence of general anesthesia on pharmacokinetics of intravenous lidocaine infusion in horses.

Journal: American journal of veterinary research 20050401

Title: Sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of paracetamol and guaifenesin in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

Title: The cellulose/lignin assembly assessed by molecular modeling. Part 1: adsorption of a threo guaiacyl beta-O-4 dimer onto a Ibeta cellulose whisker.

Journal: Plant physiology and biochemistry : PPB 20050301

Title: Can Robitussin DM be used to treat cough during pregnancy?

Journal: Medicine and health, Rhode Island 20050301

Title: Dextromethorphan-induced delirium and possible methadone interaction.

Journal: The American journal of geriatric pharmacotherapy 20050301

Title: In brief: Mucinex.

Journal: The Medical letter on drugs and therapeutics 20050214

Title: Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy.

Journal: The Laryngoscope 20050101

Title: Gender differences in psychogenic non-epileptic seizures.

Journal: Seizure 20050101

Title: Pseudoephedrine and guaifenesin urolithiasis: widening the differential diagnosis of radiolucent calculi on abdominal radiograph.

Journal: Abdominal imaging 20050101

Title: Effects of formulation variables and characterization of guaifenesin wax microspheres for controlled release.

Journal: Pharmaceutical development and technology 20050101

Title: On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma.

Journal: European journal of mass spectrometry (Chichester, England) 20050101

Title: Simultaneous determination of some active ingredients in cough and cold preparations by gas chromatography, and method validation.

Journal: Journal of AOAC International 20050101

Title: Ephedrine- and guaifenesin-induced nephrolithiasis.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20041201

Title: High-performance liquid chromatographic analysis of dextromethorphan, guaifenesin and benzoate in a cough syrup for stability testing.

Journal: Journal of chromatography. A 20040910

Title: The influence of guaifenesin and ketoprofen on the properties of hot-melt extruded polyethylene oxide films.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040801

Title: Determination of guaifenesin in human serum by capillary gas chromatography and electron capture detection.

Journal: Journal of pharmaceutical and biomedical analysis 20040629

Title: Conformational study of a guaiacyl beta-O-4 lignin model compound by NMR. Examination of intramolecular hydrogen bonding interactions and conformational flexibility in solution.

Journal: Magnetic resonance in chemistry : MRC 20040301

Title: Microencapsulation of a hydrophilic drug into a hydrophobic matrix using a salting-out procedure. I: Development and optimization of the process using factorial design.

Journal: Journal of microencapsulation 20040301

Title: Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion.

Journal: International journal of pharmaceutics 20040128

Title: Bilateral guaifenesin ureteral calculi.

Journal: Urology 20040101

Title: Cardiopulmonary effects of combined xylazine-guaiphenesin-ketamine infusion and extradural (inter-coccygeal lidocaine) anaesthesia in calves.

Journal: Veterinary anaesthesia and analgesia 20040101

Title: Microencapsulation of a hydrophilic drug into a hydrophobic matrix using a salting-out procedure. II. Effects of adsorbents on microsphere properties.

Journal: Drug development and industrial pharmacy 20040101

Title: Guaifenesin as a treatment for primary dysmenorrhea.

Journal: The Journal of the American Board of Family Practice 20040101

Title: Effect of guaifenesin on cough reflex sensitivity.

Journal: Chest 20031201

Title: Identification and prediction of promiscuous aggregating inhibitors among known drugs.

Journal: Journal of medicinal chemistry 20031009

Title: Detection and characterization of a novel extracellular fungal enzyme that catalyzes the specific and hydrolytic cleavage of lignin guaiacylglycerol beta-aryl ether linkages.

Journal: European journal of biochemistry 20030601

Title: Resolution of ephedrine stones with dissolution therapy.

Journal: Urology 20030501

Title: The cardiopulmonary effects of severe blood loss in anesthetized horses.

Journal: Veterinary anaesthesia and analgesia 20030401

Title: Guaiacylglycerol-7'-O-methyl 8'-vanillic acid ether and related compounds from Boreava orientalis.

Journal: Phytochemical analysis : PCA 20030101

Title: Polymerization of guaiacol and a phenolic beta-O-4-substructure by Trametes hirsuta laccase in the presence of ABTS.

Journal: Biotechnology progress 20030101

Title: Solubility of guaifenesin in the presence of common pharmaceutical additives.

Journal: Pharmaceutical development and technology 20030101

Title: Guaifenesin enhances the analgesic potency of paracetamol in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021201

Title: Comparison of the cardiopulmonary effects of anesthesia maintained by continuous infusion of romifidine, guaifenesin, and ketamine with anesthesia maintained by inhalation of halothane in horses.

Journal: American journal of veterinary research 20021201

Title: Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses.

Journal: American journal of veterinary research 20021201

Title: Infusion of guaifenesin, ketamine, and medetomidine in combination with inhalation of sevoflurane versus inhalation of sevoflurane alone for anesthesia of horses.

Journal: Journal of the American Veterinary Medical Association 20021015

Title: Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20020617

Title: [Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20020601

Title: [Comparative study of two antitussive drugs in the treatment of acute dry cough of infectious origin (prospective, randomized, single blind study)].

Journal: Therapie 20020101

Title: Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

Journal: Immunopharmacology and immunotoxicology 20011101

Title: Comparison of thiopentone/guaifenesin, ketamine/guaifenesin and ketamine/midazolam for the induction of horses to be anaesthetised with isoflurane.

Journal: The Veterinary record 20010804

Title: Efficacy and safety of Ascoril in the management of cough--National Study Group report.

Journal: Journal of the Indian Medical Association 20010201

Title: Guaifenesin- and ephedrine-induced stones.

Journal: Journal of endourology 19991101

Title: Abuse of guaifenesin-containing medications generates an excess of a carboxylate salt of beta-(2-methoxyphenoxy)-lactic acid, a guaifenesin metabolite, and results in urolithiasis.

Journal: Urology 19990701

Title: Fulminant hepatic failure associated with clarithromycin.

Journal: The American journal of gastroenterology 19960201

Title: Affective disorder following use of phenylpropanolamine.

Journal: The American journal of psychiatry 19900301

Title: Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination.

Journal: American journal of veterinary research 19860701

Title: Potentiating effects of chlorpromazine on the paralysis and toxicity induced by guaiacal glyceryl ether in rats.

Journal: Toxicology and applied pharmacology 19721201

Title: Bennett, S., N. Hoffman, and M. Monga, Ephedrine- and guaifenesin-induced nephrolithiasis. J Altern Complement Med, 2004. 10(6): p. 967-9.

Title: Dicpinigaitis PV, et, al. Effect of guaifenesin on cough reflex sensitivity. Chest. 2003 Dec;124(6):2178-81.

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Tags:93-14-1 Molecular Formula|93-14-1 MDL|93-14-1 SMILES|93-14-1 Guaifenesin