[1]CurrentPatentAssignee:LIGANDPHARMACEUTICALSINC-WO2007/41362,2007,A1Locationinpatent:Page/Pagecolumn59;69
[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2009/97578,2009,A1Locationinpatent:Page/Pagecolumn181;183-184
[1]McBride,ChristopherM.;Levine,Barry;Xia,Yi;Bellamacina,Cornelia;Machajewski,Timothy;Gao,Zhenhai;Renhowe,Paul;Antonios-Mccrea,William;Barsanti,Paul;Brinner,Kristin;Costales,Abran;Doughan,Brandon;Lin,Xiaodong;Louie,Alicia;McKenna,Maureen;Mendenhall,Kris;Poon,Daniel;Rico,Alice;Wang,Michael;Williams,TeresaE.;Abrams,Tinya;Fong,Susan;Hendrickson,Thomas;Lei,Dachuan;Lin,Julie;Menezes,Daniel;Pryer,Nancy;Taverna,Pietro;Xu,Yongjin;Zhou,Yasheen;Shafer,CynthiaM.[JournalofMedicinalChemistry,2014,vol.57,#21,p.9124-9129]
1034297-69-2
[1]JournalofMedicinalChemistry,2014,vol.57,p.9124-9129
[1]McBride,ChristopherM.;Levine,Barry;Xia,Yi;Bellamacina,Cornelia;Machajewski,Timothy;Gao,Zhenhai;Renhowe,Paul;Antonios-Mccrea,William;Barsanti,Paul;Brinner,Kristin;Costales,Abran;Doughan,Brandon;Lin,Xiaodong;Louie,Alicia;McKenna,Maureen;Mendenhall,Kris;Poon,Daniel;Rico,Alice;Wang,Michael;Williams,TeresaE.;Abrams,Tinya;Fong,Susan;Hendrickson,Thomas;Lei,Dachuan;Lin,Julie;Menezes,Daniel;Pryer,Nancy;Taverna,Pietro;Xu,Yongjin;Zhou,Yasheen;Shafer,CynthiaM.[JournalofMedicinalChemistry,2014,vol.57,#21,p.9124-9129]
Title: Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120701
Title: The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases.
Journal: European journal of haematology 20120501
Title: The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo.
Journal: Molecular cancer therapeutics 20120301
Title: Preclinical activity of the novel orally bioavailable HSP90 inhibitor NVP-HSP990 against multiple myeloma cells.
Journal: Anticancer research 20120201
Title: Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma.
Journal: Molecular cancer therapeutics 20111001
Title: Menezes DL, et al. The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. Mol Cancer Ther. 2012 Mar;11(3):730-9.
Title: McBride CM, et al. Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990. J Med Chem. 2014 Nov 13;57(21):9124-9.
Title: Lamottke B, et al. The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases. Eur J Haematol. 2012 May;88(5):406-15.
