Home Other Building Blocks 934526-89-3
934526-89-3,MFCD26142605
Catalog No.:AA00GU4N

934526-89-3 | XL147

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$23.00   $16.00
- +
5mg
95%
in stock  
$37.00   $26.00
- +
10mg
95%
in stock  
$54.00   $38.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU4N
Chemical Name:
XL147
CAS Number:
934526-89-3
Molecular Formula:
C25H25ClN6O4S
Molecular Weight:
541.0218
MDL Number:
MFCD26142605
SMILES:
COc1ccc(c(c1)Nc1nc2ccccc2nc1NS(=O)(=O)c1cccc(c1)NC(=O)C(N)(C)C)Cl
Properties
Computed Properties
 
Complexity:
887  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
3.4  

Literature

Title: Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.

Journal: Oncotarget 20170321

Title: Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20140101

Title: Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20120221

Title: Foster P, et al. The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models. Mol Cancer Ther. 2015 Apr;14(4):931-40.

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