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93882-12-3,MFCD00057683
Catalog No.:AA00H8GF

93882-12-3 | 8-CPT-cAMP

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10mg
≥98%
in stock  
$82.00   $57.00
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25mg
≥98%
in stock  
$150.00   $105.00
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50mg
≥98%
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$276.00   $193.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00H8GF
Chemical Name:
8-CPT-cAMP
CAS Number:
93882-12-3
Molecular Formula:
C16H14ClN5NaO6PS
Molecular Weight:
493.7938
MDL Number:
MFCD00057683
SMILES:
O[C@@H]1[C@@H]2OP(=O)([O-])OC[C@H]2O[C@H]1n1c(Sc2ccc(cc2)Cl)nc2c1ncnc2N.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
227 - 232°C  
Storage:
Keep in dry area;-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
699  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Literature

Title: Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.

Journal: Neurotoxicology 20150101

Title: Receptor-mediated modulation of activity-dependent adenosine release in rat cerebellum.

Journal: Neuropharmacology 20120201

Title: 8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanism.

Journal: American journal of physiology. Endocrinology and metabolism 20111101

Title: Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.

Journal: Cellular signalling 20111001

Title: Guanine-nucleotide exchange factors (RAPGEF3/RAPGEF4) induce sperm membrane depolarization and acrosomal exocytosis in capacitated stallion sperm.

Journal: Biology of reproduction 20110701

Title: Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Journal: American journal of physiology. Renal physiology 20110501

Title: Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes.

Journal: Endocrinology 20110501

Title: Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model.

Journal: BMC cancer 20110101

Title: In vitro analyses of endothelial cell permeability.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: cAMP/PKA antagonizes thrombin-induced inactivation of endothelial myosin light chain phosphatase: role of CPI-17.

Journal: Cardiovascular research 20100715

Title: ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms.

Journal: The Journal of biological chemistry 20100625

Title: cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.

Journal: American journal of physiology. Renal physiology 20100301

Title: 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties.

Journal: American journal of physiology. Renal physiology 20100201

Title: Pharmacological activation of guanine nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity beta1 integrins as coreceptors for parvovirus B19: improved ex vivo gene transfer to human erythroid progenitor cells.

Journal: Human gene therapy 20091201

Title: Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Follistatin gene expression by gonadotropin-releasing hormone: a role for cyclic AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells.

Journal: Molecular and cellular endocrinology 20090813

Title: Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats.

Journal: Journal of vascular research 20090101

Title: L-type channel inhibition by CB1 cannabinoid receptors is mediated by PTX-sensitive G proteins and cAMP/PKA in GT1-7 hypothalamic neurons.

Journal: Cell calcium 20090101

Title: Modeling of the adrenergic response of the human IKs current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells.

Journal: American journal of physiology. Heart and circulatory physiology 20081101

Title: Dobutamine inhibits vasopressin-mediated water transport across toad bladder epithelium.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080701

Title: Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080625

Title: Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings.

Journal: Journal of neurophysiology 20080601

Title: Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901.

Journal: World journal of gastroenterology 20080227

Title: [cAMP analogue 8-CPT-cAMP inducing differentiation in the M2b subtype of acute myeloid leukemia cell line Kasumi-1].

Journal: Zhongguo shi yan xue ye xue za zhi 20080201

Title: Ile481 from the guinea pig alpha-subunit plays a major role in the activation of ENaC by cpt-cAMP.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

Title: Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line.

Journal: American journal of physiology. Endocrinology and metabolism 20071201

Title: The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool.

Journal: Traffic (Copenhagen, Denmark) 20070901

Title: Downregulation of vasopressin V2 receptor promoter activity via V1a receptor pathway.

Journal: American journal of physiology. Renal physiology 20070501

Title: Direct modulation of Ca(2+)-activated K(+) current by H-89 in rabbit coronary arterial smooth muscle cells.

Journal: Vascular pharmacology 20070201

Title: Lordosis facilitation by LHRH, PGE2 or db-cAMP requires activation of the kinase A signaling pathway in estrogen primed rats.

Journal: Pharmacology, biochemistry, and behavior 20070101

Title: Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.

Journal: Analytical chemistry 20061215

Title: Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway.

Journal: Brain research 20061003

Title: PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists.

Journal: American journal of physiology. Lung cellular and molecular physiology 20061001

Title: Ischemic preconditioning prevents calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion.

Journal: Cardiovascular research 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effect of cAMP on porcine ciliary transepithelial short-circuit current, sodium transport, and chloride transport.

Journal: Investigative ophthalmology & visual science 20060501

Title: Direct inhibition of a PKA inhibitor, H-89 on KV channels in rabbit coronary arterial smooth muscle cells.

Journal: Biochemical and biophysical research communications 20060324

Title: Luteinizing hormone inhibits Fas-induced apoptosis in ovarian surface epithelial cell lines.

Journal: The Journal of endocrinology 20060201

Title: Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.

Journal: Pulmonary pharmacology & therapeutics 20060101

Title: cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

Journal: Circulation research 20051209

Title: The cross talk between protein kinase A- and RhoA-mediated signaling in cancer cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20051101

Title: Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway.

Journal: Biochemical pharmacology 20050901

Title: Relaxin and prostaglandin E(2) regulate interleukin 11 during human endometrial stromal cell decidualization.

Journal: The Journal of clinical endocrinology and metabolism 20050601

Title: Cyclic AMP prevents retraction of axon terminals in photoreceptors prepared for transplantation: an in vitro study.

Journal: Investigative ophthalmology & visual science 20050301

Title: Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

Title: cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.

Journal: The Journal of biological chemistry 20041119

Title: Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control.

Journal: Circulation 20041019

Title: Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040701

Title: Regulation of photoreceptor Per1 and Per2 by light, dopamine and a circadian clock.

Journal: The European journal of neuroscience 20040701

Title: Redox modulation of basal and beta-adrenergically stimulated cardiac L-type Ca(2+) channel activity by phenylarsine oxide.

Journal: British journal of pharmacology 20040601

Title: Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells.

Journal: Free radical research 20040601

Title: Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5'-monophosphate-responsive element in the proximal SH2D2A promoter.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040515

Title: The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells.

Journal: The Journal of biological chemistry 20040514

Title: The neuroendocrine protein VGF is sorted into dense-core granules and is secreted apically by polarized rat thyroid epithelial cells.

Journal: Experimental cell research 20040415

Title: Regulation of Ca(2+)-activated chloride channels by cAMP and CFTR in parotid acinar cells.

Journal: Biochemical and biophysical research communications 20040409

Title: Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.

Journal: Journal of neurophysiology 20040301

Title: Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors.

Journal: Neuropharmacology 20031001

Title: Cloning of a protein binding to the most proximal Pit-1 binding element of prolactin gene from human pituitary cDNA library.

Journal: Molecular and cellular endocrinology 20030930

Title: The cAMP pathway sensitizes VR1 expressed in oocytes from Xenopus laevis and in CHO cells.

Journal: Pharmacology 20030901

Title: Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells.

Journal: Biological chemistry 20030901

Title: cAMP-independent olfactory transduction of amino acids in Xenopus laevis tadpoles.

Journal: The Journal of physiology 20030815

Title: Parathyroid hormone (PTH) down-regulates PTH/PTH-related protein receptor gene expression in UMR-106 osteoblast-like cells via a 3',5'-cyclic adenosine monophosphate-dependent, protein kinase A-independent pathway.

Journal: The Journal of endocrinology 20030801

Title: Mitochondrial-targeted fatty acid analog induces apoptosis with selective loss of mitochondrial glutathione in promyelocytic leukemia cells.

Journal: Chemistry & biology 20030701

Title: cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030601

Title: [The effect of SP-8-CPT-cAMP on the tracer coupling between the retinal ganglion cells and amacrine cells].

Journal: Yan ke xue bao = Eye science 20030601

Title: Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.

Journal: The Journal of physiology 20030401

Title: Ca2+ transient evoked by chemical stimulation is enhanced by PGE2 in vagal sensory neurons: role of cAMP/PKA signaling pathway.

Journal: Journal of neurophysiology 20030401

Title: Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons.

Journal: Molecular and cellular neurosciences 20030101

Title: [In vitro study of the effects of arsenic trioxide combined with 8-CPT-cAMP on differentiation induction in retinoic acid resistant acute promyelocytic leukemia cells].

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20030101

Title: 4-aminopyridine decreases progesterone production by porcine granulosa cells.

Journal: Reproductive biology and endocrinology : RB&E 20030101

Title: ENaC plays a role in regulated antibody secretion by hybridomas.

Journal: American journal of physiology. Cell physiology 20021101

Title: Regulation of endothelin-A receptor sensitivity by cyclic adenosine monophosphate in rat hepatic stellate cells.

Journal: Hepatology (Baltimore, Md.) 20021001

Title: Trypanosoma brucei: in vitro slender-to-stumpy differentiation of culture-adapted, monomorphic bloodstream forms.

Journal: Experimental parasitology 20020801

Title: Differentiation of adult bone marrow stem cells into neuroprogenitor cells in vitro.

Journal: Neuroreport 20020702

Title: Complexity of agonist- and cyclic AMP-mediated downregulation of the human beta 1-adrenergic receptor: role of internalization, degradation, and mRNA destabilization.

Journal: Biochemistry 20020625

Title: A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells.

Journal: The Journal of biological chemistry 20020607

Title: Postsynaptic application of a cAMP analogue reverses long-term potentiation in hippocampal CA1 pyramidal neurons.

Journal: Journal of neurophysiology 20020601

Title: Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases.

Journal: Circulation research 20020517

Title: Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction.

Journal: British journal of pharmacology 20020401

Title: [Experimental study of low dose arsenic trioxide in treatment of patients with acute promyelocytic leukemia].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20020401

Title: Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins.

Journal: European journal of pharmacology 20020202

Title: ACTH-induced Cl(-) current in bovine adrenocortical cells: correlation with cortisol secretion.

Journal: American journal of physiology. Endocrinology and metabolism 20020201

Title: Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk.

Journal: Blood 20020201

Title: cGMP-dependent protein kinase expression restores contractile function in cultured vascular smooth muscle cells.

Journal: Journal of vascular research 20020101

Title: Outward currents in olfactory receptor neurons activated by odorants and by elevation of cyclic AMP.

Journal: Cell biochemistry and biophysics 20020101

Title: Urocortin relaxes rat tail arteries by a PKA-mediated reduction of the sensitivity of the contractile apparatus for calcium.

Journal: British journal of pharmacology 20011201

Title: PACAP has a neurotrophic effect on cultured basal forebrain cholinergic neurons from adult rats.

Journal: Brain research. Developmental brain research 20011126

Title: Nongenomic regulation of ENaC by aldosterone.

Journal: American journal of physiology. Cell physiology 20011001

Title: Effects of chronic lesions of the anteroventral region of the third ventricle on cardiac beta-adrenoceptor function in conscious rats.

Journal: Brain research 20010914

Title: Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP.

Journal: American journal of physiology. Cell physiology 20010901

Title: Differential regulation of IGF-binding protein gene expression by cAMP in rat C6 glioma cells.

Journal: Endocrinology 20010901

Title: Effects of 8-cpt-cAMP on the epithelial sodium channel expressed in Xenopus oocytes.

Journal: The Journal of membrane biology 20010901

Title: Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes.

Journal: Circulation research 20010831

Title: Physiological modulation of rabphilin phosphorylation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010801

Title: Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010801

Title: Involvement of mitogen-activated protein kinase in cyclic adenosine 3',5'-monophosphate-induced hormone gene expression in rat pituitary GH(3) cells.

Journal: Endocrinology 20010701

Title: 5HT increases excitability of nociceptor-like rat dorsal root ganglion neurons via cAMP-coupled TTX-resistant Na(+) channels.

Journal: Journal of neurophysiology 20010701

Title: Proteolytic degradation and impaired secretion of an apolipoprotein A-I mutant associated with dominantly inherited hypoalphalipoproteinemia.

Journal: The Journal of biological chemistry 20010615

Title: Inhibition of rat cardiac fibroblast growth by cAMP--but not by cGMP-dependent protein kinase.

Journal: Basic research in cardiology 20010401

Title: Herpesvirus quiescence in neuronal cells IV: virus activation induced by pituitary adenylate cyclase-activating polypeptide (PACAP) involves the protein kinase A pathway.

Journal: Journal of neurovirology 20010401

Title: The cAMP responsive element and CREB partially mediate the response of the tyrosine hydroxylase gene to phorbol ester.

Journal: Journal of neurochemistry 20010301

Title: Functional integrity of the vesicle transporting machinery is required for complete activation of cFTR expressed in xenopus laevis oocytes.

Journal: Pflugers Archiv : European journal of physiology 20010301

Title: beta-Adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity.

Journal: FEBS letters 20010202

Title: Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway.

Journal: Chemico-biological interactions 20010130

Title: cAMP and excitability in neuroendocrine cells during reproductive senescence.

Journal: Neurobiology of aging 20010101

Title: The CFTR-mediated protein secretion defect: pharmacological correction.

Journal: Pflugers Archiv : European journal of physiology 20010101

Title: Blocking cytochrome c activity within intact neurons inhibits apoptosis.

Journal: The Journal of cell biology 19980921

Title: Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.

Journal: Journal of neurochemistry 19980701

Title: Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid.

Journal: Molecular and cellular biochemistry 19931101

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