Home Other Building Blocks 940908-79-2
940908-79-2,MFCD22572932
Catalog No.:AA00GU36

940908-79-2 | R7128

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1mg
≥98%
in stock  
$186.00   $130.00
- +
5mg
≥98%
in stock  
$454.00   $318.00
- +
10mg
≥98%
in stock  
$604.00   $423.00
- +
25mg
≥98%
in stock  
$806.00   $564.00
- +
50mg
≥98%
in stock  
$1,472.00   $1,030.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU36
Chemical Name:
R7128
CAS Number:
940908-79-2
Molecular Formula:
C18H26FN3O6
Molecular Weight:
399.4139
MDL Number:
MFCD22572932
SMILES:
O=C(C(C)C)O[C@@H]1[C@@H](COC(=O)C(C)C)O[C@H]([C@]1(C)F)n1ccc(nc1=O)N
Properties
Computed Properties
 
Complexity:
707  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
1.3  

Literature

Title: The combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti-hepatitis C virus activity without detectable cross-resistance.

Journal: Antimicrobial agents and chemotherapy 20140601

Title: Intracellular effects of the Hepatitis C virus nucleoside polymerase inhibitor RO5855 (Mericitabine Parent) and Ribavirin in combination.

Journal: Antimicrobial agents and chemotherapy 20140501

Title: Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors.

Journal: Hepatology (Baltimore, Md.) 20140201

Title: Tetrazole and triazole as bioisosteres of carboxylic acid: discovery of diketo tetrazoles and diketo triazoles as anti-HCV agents.

Journal: Bioorganic & medicinal chemistry letters 20130815

Title: Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128).

Journal: Hepatology (Baltimore, Md.) 20120401

Title: Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C.

Journal: Gastroenterology 20120401

Title: Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase.

Journal: Antiviral therapy 20120101

Title: The HCV NS5B nucleoside and non-nucleoside inhibitors.

Journal: Clinics in liver disease 20110801

Title: RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) Replication and selection of resistant variants in HCV-infected patients.

Journal: The Journal of infectious diseases 20101115

Title: Isolation and identification of ester impurities in RG7128, an HCV polymerase inhibitor.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: Management of untreated and nonresponder patients with chronic hepatitis C.

Journal: Seminars in liver disease 20101101

Title: Curing hepatitis C with pills: a step toward global control.

Journal: Lancet (London, England) 20101030

Title: Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial.

Journal: Lancet (London, England) 20101030

Title: Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Journal: Journal of medicinal chemistry 20101014

Title: Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.

Journal: Journal of medicinal chemistry 20090910

Title: Le Pogam S, et al. Characterization of HCV quasispecies dynamics upon short term dual-therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir. Antimicrob Agents Chemother. 2012 Nov;56(11):5494-5

Title: Soriano V, et al. Directly acting antivirals against hepatitis C virus. J Antimicrob Chemother. 2011 Aug;66(8):1673-86

Title: Guedj J, et al. Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128). Hepatology. 2012 Apr;55(4):1030-7.

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Tags:940908-79-2 Molecular Formula|940908-79-2 MDL|940908-79-2 SMILES|940908-79-2 R7128