Home Amines 95896-78-9
95896-78-9,MFCD00269903
Catalog No.:AA005WH8

95896-78-9 | 2-Amino-3,4,8-trimethyl-3h-imidazo[4,5-f]quinoxaline

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10mg
~90%
2 weeks  
$1,077.00   $754.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005WH8
Chemical Name:
2-Amino-3,4,8-trimethyl-3h-imidazo[4,5-f]quinoxaline
CAS Number:
95896-78-9
Molecular Formula:
C12H13N5
Molecular Weight:
227.2651
MDL Number:
MFCD00269903
SMILES:
Cc1cnc2c(n1)c1nc(n(c1c(c2)C)C)N
Properties
Properties
 
Form:
Solid  
MP:
>254°C (dec.)  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
297  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
XLogP3:
1.4  

Literature

Title: Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.

Journal: Archives of toxicology 20170901

Title: Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130901

Title: Response surface optimization of effects of some processing variables on carcinogenic/mutagenic heterocyclic aromatic amine (HAA) content in cooked patties.

Journal: Meat science 20120701

Title: Pancreatic cancer risk: associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort.

Journal: Molecular carcinogenesis 20120101

Title: Patterns of meat intake and risk of prostate cancer among African-Americans in a large prospective study.

Journal: Cancer causes & control : CCC 20111201

Title: Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study.

Journal: Breast cancer research and treatment 20111001

Title: [Simultaneous determination of 9 heterocyclic aromatic amine in poultry products by solid-phase extraction-high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20110801

Title: Meat consumption and risk of esophageal and gastric cancer in a large prospective study.

Journal: The American journal of gastroenterology 20110301

Title: Effects of (+)-catechin and (-)-epicatechin on heterocyclic amines-induced oxidative DNA damage.

Journal: Journal of applied toxicology : JAT 20110101

Title: Impact of meat consumption, preparation, and mutagens on aggressive prostate cancer.

Journal: PloS one 20110101

Title: Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort.

Journal: Journal of the National Cancer Institute 20100908

Title: Dietary exposure to heterocyclic amines in high-temperature cooked meat and fish in Malaysia.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100801

Title: Determination of heterocyclic amines in urine samples by capillary liquid chromatography with evaporated light-scattering detection.

Journal: Analytical and bioanalytical chemistry 20100501

Title: A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.

Journal: Cancer research 20100315

Title: A review and meta-analysis of prospective studies of red and processed meat intake and prostate cancer.

Journal: Nutrition journal 20100101

Title: Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Journal: British journal of cancer 20090707

Title: Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090701

Title: Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer.

Journal: Cancer research 20090301

Title: Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk.

Journal: Cancer research 20090201

Title: Optimized HPLC method for analysis of polar and nonpolar heterocyclic amines in cooked meat products.

Journal: Journal of AOAC International 20090101

Title: Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers.

Journal: Nutrition journal 20090101

Title: Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods.

Journal: Journal of agricultural and food chemistry 20080625

Title: Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.

Journal: Chemical research in toxicology 20080401

Title: Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial.

Journal: Molecular nutrition & food research 20080301

Title: Quantitation of 13 heterocyclic aromatic amines in cooked beef, pork, and chicken by liquid chromatography-electrospray ionization/tandem mass spectrometry.

Journal: Journal of agricultural and food chemistry 20080109

Title: Meat and meat mutagens and risk of prostate cancer in the Agricultural Health Study.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080101

Title: Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties.

Journal: Journal of agricultural and food chemistry 20071212

Title: Inhibitory effect of fruit extracts on the formation of heterocyclic amines.

Journal: Journal of agricultural and food chemistry 20071212

Title: Meat intake, preparation methods, mutagens and colorectal adenoma recurrence.

Journal: Carcinogenesis 20070901

Title: Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070801

Title: Heterocyclic amines in griddled beef steak analysed using a single extract clean-up procedure.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070401

Title: Dietary mutagen exposure and risk of pancreatic cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070401

Title: Differential effects of heterocyclic amines on poly(ADP-ribose) polymerase-1 and mono-ADP-ribosyltransferase A.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060901

Title: Effect of pH on binding of mutagenic heterocyclic amines by the natural biopolymer poly(gamma-glutamic acid).

Journal: Journal of agricultural and food chemistry 20060823

Title: Meat mutagens and risk of distal colon adenoma in a cohort of U.S. men.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060601

Title: A prospective study of meat and meat mutagens and prostate cancer risk.

Journal: Cancer research 20051215

Title: Quantitation of carcinogenic heterocyclic aromatic amines and detection of novel heterocyclic aromatic amines in cooked meats and grill scrapings by HPLC/ESI-MS.

Journal: Journal of agricultural and food chemistry 20050420

Title: Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study.

Journal: Carcinogenesis 20050301

Title: Addition of various carbohydrates to beef burgers affects the formation of heterocyclic amines during frying.

Journal: Journal of agricultural and food chemistry 20041215

Title: Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens.

Journal: Archives of toxicology 20041001

Title: Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry.

Journal: Chemical research in toxicology 20040801

Title: Determination of heterocyclic aromatic amines (HAs) content in samples of household-prepared meat dishes.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040325

Title: Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains.

Journal: Carcinogenesis 20031201

Title: Effect of high water-holding capacity on the formation of heterocyclic amines in fried beefburgers.

Journal: Journal of agricultural and food chemistry 20030716

Title: Heterocyclic amines, meat intake, and association with colon cancer in a population-based study.

Journal: American journal of epidemiology 20030301

Title: Development of a short questionnaire to assess the dietary intake of heterocyclic aromatic amines.

Journal: Public health nutrition 20021001

Title: Screening for heterocyclic amines in chicken cooked in various ways.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801

Title: Reactivity and selectivity of the N-acetyl-Glu-P-1, N-acetyl-Glu-P-2, N-acetyl-MeIQx, and N-acetyl-IQx nitrenium ions: comparison to carbocyclic N-arylnitrenium ions.

Journal: Journal of the American Chemical Society 20020710

Title: Effects of soy sauce and sugar on the formation of heterocyclic amines in marinated foods.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020701

Title: Clean-up procedures for the analysis of heterocyclic aromatic amines (aminoazaarenes) from heat-treated meat samples.

Journal: Journal of chromatography. A 20011214

Title: Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.

Journal: Mutation research 20010822

Title: Dietary intake of heterocyclic amines, meat-derived mutagenic activity, and risk of colorectal adenomas.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010501

Title: Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis.

Journal: Journal of experimental & clinical cancer research : CR 20010301

Title: Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

Journal: Cancer research 19900601

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Tags:95896-78-9 Molecular Formula|95896-78-9 MDL|95896-78-9 SMILES|95896-78-9 2-Amino-3,4,8-trimethyl-3h-imidazo[4,5-f]quinoxaline