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960374-59-8,MFCD26794217
Catalog No.:AA00IJOO

960374-59-8 | (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide

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1mg
≥98%
in stock  
$89.00   $62.00
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5mg
≥98%
in stock  
$238.00   $166.00
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10mg
≥98%
in stock  
$386.00   $270.00
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25mg
98% by HPLC
in stock  
$746.00   $522.00
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50mg
98% by HPLC
in stock  
$1,225.00   $858.00
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100mg
98% by HPLC
in stock  
$2,074.00   $1,452.00
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500mg
98% by HPLC
in stock  
$6,554.00   $4,588.00
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1000mg
98% by HPLC
in stock  
$10,449.00   $7,314.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IJOO
Chemical Name:
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide
CAS Number:
960374-59-8
Molecular Formula:
C31H40N4O7
Molecular Weight:
580.6719
MDL Number:
MFCD26794217
SMILES:
COc1ccc(cc1)C[C@@H](C(=O)N[C@H](C(=O)[C@@]1(C)CO1)Cc1ccccc1)NC(=O)[C@@H](NC(=O)CN1CCOCC1)C
Properties
Computed Properties
 
Complexity:
928  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
14  
XLogP3:
1.9  

Literature

Title: Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.

Journal: Viruses 20170801

Title: Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice.

Journal: Clinical and experimental immunology 20120601

Title: Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.

Journal: The Journal of pharmacology and experimental therapeutics 20120401

Title: Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

Journal: Cell 20120217

Title: Immunoproteasome-specific inhibitors and their application.

Journal: Methods in molecular biology (Clifton, N.J.) 20120101

Title: A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

Journal: Nature medicine 20090701

Title: Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis [published correction appears in Nat Med. 2009 Nov;15(11):1333 Nat Med. 2009;15(7):781-787.

Title: Rožman K, et al. Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome. Molecules. 2020;25(6):1305. Published 2020 Mar 12.

Title: Lin J, et al. PR-957, a selective immunoproteasome inhibitor, reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1. Biochem Pharmacol. 2018;156:511-523.

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SDS
Tags:960374-59-8 Molecular Formula|960374-59-8 MDL|960374-59-8 SMILES|960374-59-8 (2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide