Home Amines 96865-92-8
96865-92-8,MFCD00055115
Catalog No.:AA005SGA

96865-92-8 | Xanthine amine congener

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5mg
≥98%
in stock  
$116.00   $81.00
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10mg
≥98%
in stock  
$218.00   $152.00
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25mg
≥98%
in stock  
$509.00   $356.00
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50mg
≥98%
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$903.00   $632.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005SGA
Chemical Name:
Xanthine amine congener
CAS Number:
96865-92-8
Molecular Formula:
C21H28N6O4
Molecular Weight:
428.4848
MDL Number:
MFCD00055115
SMILES:
CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN
Properties
Properties
 
Storage:
2-8℃;Keep in dry area;  

Computed Properties
 
Complexity:
639  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
2.7  

Literature

Title: Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001

Title: Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.

Journal: Structure (London, England : 1993) 20110907

Title: Biophysical mapping of the adenosine A2A receptor.

Journal: Journal of medicinal chemistry 20110714

Title: T-cell specific defect in expression of the NTPDase CD39 as a biomarker for lupus.

Journal: Cellular immunology 20110101

Title: Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions.

Journal: Molecular pharmacology 20100401

Title: Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.

Journal: British journal of pharmacology 20100201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.

Journal: Bioorganic & medicinal chemistry 20090701

Title: N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.

Journal: Journal of medicinal chemistry 20090423

Title: Synthesis of eudistomin D analogues and its effects on adenosine receptors.

Journal: Bioorganic & medicinal chemistry 20080401

Title: A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.

Journal: Brain research 20070907

Title: Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors.

Journal: Bioorganic & medicinal chemistry 20070501

Title: Protective effect of adenosine and purine nucleos(t)ides against the death by hydrogen peroxide and glucose deprivation in rat primary astrocytes.

Journal: Neuroscience research 20050101

Title: [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors.

Journal: Biochemical pharmacology 20040715

Title: Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists.

Journal: Journal of medicinal chemistry 20021024

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Adenosine receptor-mediated control of in vitro release of pain-related neuropeptides from the rat spinal cord.

Journal: European journal of pharmacology 20020419

Title: Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020401

Title: 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 20020328

Title: Adenosine receptor antagonists and retinal neovascularization in vivo.

Journal: Investigative ophthalmology & visual science 20011201

Title: Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

Journal: Journal of medicinal chemistry 20011122

Title: [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors.

Journal: Biochemical pharmacology 20010315

Title: Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 20010301

Title: Why are A(2B) receptors low-affinity adenosine receptors? Mutation of Asn273 to Tyr increases affinity of human A(2B) receptor for 2-(1-Hexynyl)adenosine.

Journal: Molecular pharmacology 20001201

Title: [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

Journal: Molecular pharmacology 20000501

Title: Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.

Journal: Journal of medicinal chemistry 20000323

Title: Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.

Journal: Drug design and discovery 19991101

Title: Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.

Journal: Molecular pharmacology 19991001

Title: Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19980101

Title: Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261.

Journal: British journal of pharmacology 19970501

Title: Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells.

Journal: British journal of pharmacology 19961101

Title: Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.

Journal: The Journal of biological chemistry 19950609

Title: Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor.

Journal: The Journal of biological chemistry 19941223

Title: Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.

Journal: The Journal of biological chemistry 19941007

Title: Molecular cloning and characterization of the human A3 adenosine receptor.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19931101

Title: Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).

Journal: Life sciences 19890101

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