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Title: Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers.
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Title: Tamoxifen-DNA adduct formation in human endometrium.
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Title: Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives.
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Title: Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.
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Title: Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen.
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Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.
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Title: Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa.
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Title: Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells.
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Title: Biotransformation of tamoxifen in a human endometrial explant culture model.
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Title: Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.
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Title: Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.
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Title: The mutational signature of alpha-hydroxytamoxifen at Hprt locus in Chinese hamster cells.
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Title: Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats.
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Title: Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen.
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Title: Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells.
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Title: Short-term dosing of alpha-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han rats.
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