Home Amines 97151-02-5
97151-02-5,MFCD02101152
Catalog No.:AA01CBQ6

97151-02-5 | Benzeneethanol,b-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-a-methyl-,(bE)-

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1mg
≥98%
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$82.00   $57.00
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5mg
≥98%
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$306.00   $214.00
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10mg
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$479.00   $335.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CBQ6
Chemical Name:
Benzeneethanol,b-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-a-methyl-,(bE)-
CAS Number:
97151-02-5
Molecular Formula:
C26H29NO2
Molecular Weight:
387.5140
MDL Number:
MFCD02101152
SMILES:
CC(C(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3)O
Properties
Computed Properties
 
Complexity:
495  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.9  

Literature

Title: Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120201

Title: Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.

Journal: Cancer letters 20071118

Title: Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101

Title: Tamoxifen-DNA adduct formation in human endometrium.

Journal: Chemical research in toxicology 20051001

Title: Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives.

Journal: Chemical research in toxicology 20051001

Title: Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.

Journal: Mutagenesis 20050701

Title: Formation of tamoxifen-DNA adducts in human endometrial explants exposed to alpha-hydroxytamoxifen.

Journal: Chemical research in toxicology 20050501

Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.

Journal: Pharmacology & therapeutics 20050401

Title: Interactions of the stereoisomers of alpha-hydroxytamoxifen with human hydroxysteroid sulfotransferase SULT2A1 and rat hydroxysteroid sulfotransferase STa.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20041201

Title: Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells.

Journal: Chemical research in toxicology 20040501

Title: Biotransformation of tamoxifen in a human endometrial explant culture model.

Journal: Chemico-biological interactions 20031215

Title: Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.

Journal: Chemical research in toxicology 20030901

Title: Identification of human CYP forms involved in the activation of tamoxifen and irreversible binding to DNA.

Journal: Carcinogenesis 20021101

Title: The mutational signature of alpha-hydroxytamoxifen at Hprt locus in Chinese hamster cells.

Journal: Carcinogenesis 20021101

Title: Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats.

Journal: Carcinogenesis 20021001

Title: Induction of lacI mutations in Big Blue rats treated with tamoxifen and alpha-hydroxytamoxifen.

Journal: Cancer letters 20020208

Title: Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells.

Journal: Chemical research in toxicology 20010701

Title: Short-term dosing of alpha-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han rats.

Journal: Carcinogenesis 20010401

Title: Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res. 1994 Nov 1;54(21):5518-22.

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Tags:97151-02-5 Molecular Formula|97151-02-5 MDL|97151-02-5 SMILES|97151-02-5 Benzeneethanol,b-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-a-methyl-,(bE)-