Name: Name:Bms-687453
Brand: AABLOCKS
SKU: AA0000U3
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA0000U3

Chemical Name: Bms-687453

CAS Number: 1000998-59-3

Molecular Formula: C22H21ClN2O6

Molecular Weight: 444.8649

MDL Number: MFCD18251482

SMILES: COC(=O)N(Cc1cccc(c1)OCc1nc(oc1C)c1ccc(cc1)Cl)CC(=O)O

Properties

Complexity: 601

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 31

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 1

Rotatable Bond Count: 9

XLogP3: 3.8

Literature fold

Title: Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Journal: Bioorganic & medicinal chemistry letters20100501

Title: Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Journal: Journal of medicinal chemistry20100408

Title: Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20091001

Title: Li J, et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53(7):2854-64.

Title: Mukherjee R, et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.

Title: Vassallo JD, et al. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 Oct;111(2):402-12.

1000998-59-3 | Bms-687453