116666-63-8
[1]Patent:US4808605,1989,A
[1]Patent:WO2018/152317,2018,A1.Locationinpatent:Page/Pagecolumn51-52
Title: Epigallocatechin-3-gallate induces mesothelioma cell death via H2 O2 -dependent T-type Ca2+ channel opening.
Journal: Journal of cellular and molecular medicine 20121101
Title: Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.
Journal: British journal of pharmacology 20121001
Title: Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa.
Journal: International journal of andrology 20121001
Title: T-type Ca²⁺ signalling downregulates MEK1/2 phosphorylation and cross-talk with the RAAS transcriptional response in cardiac myocytes.
Journal: Journal of molecular and cellular cardiology 20120801
Title: The CatSper channel: a polymodal chemosensor in human sperm.
Journal: The EMBO journal 20120404
Title: Functional expression of voltage-gated calcium channels in human melanoma.
Journal: Pigment cell & melanoma research 20120301
Title: [Impact of calcium channel antagonists for estrogen action on the endometrial carcinoma HEC-1A cells].
Journal: Zhonghua fu chan ke za zhi 20120301
Title: Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes.
Journal: British journal of pharmacology 20120201
Title: Retrieval of context-associated memory is dependent on the Ca(v)3.2 T-type calcium channel.
Journal: PloS one 20120101
Title: Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-n-[(1r)-1-(4-fluorophenyl)-2-methylpropyl]acetamide Derivatives as Novel Antihypertensive Agents.
Journal: Chemical & pharmaceutical bulletin 20120101
Title: On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20111101
Title: Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats.
Journal: Pflugers Archiv : European journal of physiology 20111101
Title: Coding movement direction by burst firing in electrosensory neurons.
Journal: Journal of neurophysiology 20111001
Title: Sodium influx induced by external calcium chelation decreases human sperm motility.
Journal: Human reproduction (Oxford, England) 20111001
Title: Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry letters 20111001
Title: The sound of silence: ionic mechanisms encoding sound termination.
Journal: Neuron 20110908
Title: Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.
Journal: Hypertension (Dallas, Tex. : 1979) 20110901
Title: Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831
Title: Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats.
Journal: Fundamental & clinical pharmacology 20110801
Title: Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.
Journal: The Journal of clinical investigation 20110801
Title: Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: Quantitative prediction of mechanism-based inhibition caused by mibefradil in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: Synaptically driven state transitions in distal dendrites of striatal spiny neurons.
Journal: Nature neuroscience 20110701
Title: Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.
Journal: Cancer investigation 20110601
Title: The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.
Journal: Nature 20110317
Title: T-type voltage-gated calcium channels regulate the tone of mouse efferent arterioles.
Journal: Kidney international 20110201
Title: Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.
Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101
Title: Inhibitory actions of mibefradil on steroidogenesis in mouse Leydig cells: involvement of Ca(2+) entry via the T-type Ca(2+) channel.
Journal: Asian journal of andrology 20101101
Title: Voltage-gated divalent currents in descending vasa recta pericytes.
Journal: American journal of physiology. Renal physiology 20101001
Title: Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice.
Journal: Psychopharmacology 20101001
Title: Biophysical properties of human medulloblastoma cells.
Journal: The Journal of membrane biology 20101001
Title: Altered protein kinase C regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry after chronic hypoxia.
Journal: The Journal of pharmacology and experimental therapeutics 20100901
Title: Comparative effects of T-type and L-type Ca(2+)-antagonists against noradrenaline-induced contractions of human vas deferens.
Journal: BJU international 20100801
Title: Alpha1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium.
Journal: American journal of physiology. Lung cellular and molecular physiology 20100701
Title: Changes in aortic stiffness related to elastic fiber network anomalies in the Brown Norway rat during maturation and aging.
Journal: American journal of physiology. Heart and circulatory physiology 20100701
Title: Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide.
Journal: Journal of neurochemistry 20100701
Title: Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.
Journal: Pain 20100701
Title: Synaptic integration of rhythmogenic neurons in the locomotor circuitry: the case of Hb9 interneurons.
Journal: Annals of the New York Academy of Sciences 20100601
Title: Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.
Journal: Biochemical and biophysical research communications 20100514
Title: T-type Ca(2+) channel modulation by otilonium bromide.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501
Title: Electrophysiological effects of neuropeptide S on rat ventromedial hypothalamic neurons in vitro.
Journal: Peptides 20100401
Title: Electrical stimulation induces calcium-dependent release of NGF from cultured Schwann cells.
Journal: Glia 20100401
Title: Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis.
Journal: The Journal of biological chemistry 20100305
Title: Effects of T-type calcium channel blockers and thalidomide on contractions of rat vas deferens.
Journal: British journal of pharmacology 20100301
Title: The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia.
Journal: Pharmacology 20100101
Title: Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2.
Journal: Channels (Austin, Tex.) 20100101
Title: Voltage-dependent Ca2+ currents contribute to spontaneous Ca2+ waves in rabbit corpus cavernosum myocytes.
Journal: The journal of sexual medicine 20091101
Title: A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation.
Journal: Oncology reports 20091101
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Journal: Nature chemical biology 20091001
Title: T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.
Journal: Circulation 20090901
Title: Evaluating patients with persistent chest pain and no obstructive coronary artery disease.
Journal: JAMA 20090812
Title: Is combined L- and T-channel blockade better than L-channel blockade in therapy?
Journal: Hypertension (Dallas, Tex. : 1979) 20090701
Title: Luminal hydrogen sulfide plays a pronociceptive role in mouse colon.
Journal: Gut 20090601
Title: Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.
Journal: Gut 20090601
Title: Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade.
Journal: Hypertension (Dallas, Tex. : 1979) 20090401
Title: Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.
Journal: Pain 20090301
Title: Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels.
Journal: Neuroscience 20090218
Title: Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs.
Journal: The Journal of pharmacology and experimental therapeutics 20090201
Title: T-type calcium channels mediate rebound firing in intact deep cerebellar neurons.
Journal: Neuroscience 20090123
Title: The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes.
Journal: Journal of cellular and molecular medicine 20090101
Title: Excitatory effects of low-level lead exposure on action potential firing of pyramidal neurons in CA1 region of rat hippocampal slices.
Journal: Journal of neuroscience research 20081201
Title: Effects of distension on airway inflammation and venular P-selectin expression.
Journal: American journal of physiology. Lung cellular and molecular physiology 20081101
Title: Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels.
Journal: Pflugers Archiv : European journal of physiology 20081001
Title: Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis.
Journal: Molecular and cellular biochemistry 20080801
Title: Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry letters 20080801
Title: Involvement of T-type Ca2+ channels in the potentiation of synaptic and visual responses during the critical period in rat visual cortex.
Journal: The European journal of neuroscience 20080801
Title: The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701
Title: Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes.
Journal: Pflugers Archiv : European journal of physiology 20080601
Title: A selective T-type Ca2+ channel blocker R(-) efonidipine.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080601
Title: The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay.
Journal: The Journal of pharmacology and experimental therapeutics 20080601
Title: T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites.
Journal: Nature neuroscience 20080601
Title: Contributions of voltage- and Ca2+-activated conductances to GABA-induced depolarization in spider mechanosensory neurons.
Journal: Journal of neurophysiology 20080401
Title: In vivo approach for the evaluation of mechanism-based inhibition of cytochrome P450 3A in rats.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080401
Title: Participation of low-threshold Ca2+ spike in the Purkinje cells complex spike.
Journal: Neuroreport 20080212
Title: Voltage-gated Ca2+ currents are necessary for slow-wave propagation in the canine gastric antrum.
Journal: American journal of physiology. Cell physiology 20071101
Title: T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.
Journal: Neuropharmacology 20070901
Title: Mutation of delta-sarcoglycan is associated with Ca(2+) -dependent vascular remodeling in the Syrian hamster.
Journal: The American journal of pathology 20070701
Title: Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.
Journal: The FEBS journal 20070601
Title: Cav3.1 (alpha1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070401
Title: Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches.
Journal: Assay and drug development technologies 20070401
Title: Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells.
Journal: The Journal of endocrinology 20070301
Title: Mibefradil-sensitive component involved in the plateau potential in submucosal interstitial cells of the murine proximal colon.
Journal: Biochemical and biophysical research communications 20070202
Title: Lead discovery and optimization of T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry 20070201
Title: Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.
Journal: Behavioural pharmacology 20070201
Title: T-type Ca2+ channels mediate propagation of odor-induced Ca2+ transients in rat olfactory receptor neurons.
Journal: Neuroscience 20070119
Title: Synthesis and biological evaluation of novel T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry letters 20070115
Title: 3D pharmacophore based virtual screening of T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry 20070115
Title: Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry letters 20070115
Title: Resonance (approximately 10 Hz) of excitatory networks in motor cortex: effects of voltage-dependent ion channel blockers.
Journal: The Journal of physiology 20070101
Title: T-type Ca2+ channels contribute to IBMX/forskolin- and K(+)-induced Ca(2+) transients in porcine olfactory receptor neurons.
Journal: Neuroscience research 20070101
Title: Long-term calcium antagonist treatment of human hypertension with mibefradil or amlodipine increases sympathetic nerve activity.
Journal: Journal of hypertension 20070101
Title: Fractal michaelis-menten kinetics under steady state conditions: Application to mibefradil.
Journal: Pharmaceutical research 20061201
Title: An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.
Journal: Molecular pharmacology 20061101
Title: Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus.
Journal: Circulation 20060926
Title: Haloperidol induces calcium ion influx via L-type calcium channels in hippocampal HN33 cells and renders the neurons more susceptible to oxidative stress.
Journal: Molecules and cells 20060831
Title: Mibefradil, a T-type Ca2+ channel blocker, protects against mesenteric ischemia-reperfusion-induced oxidative injury and histologic alterations in intestinal mucosa in rats.
Journal: Digestive diseases and sciences 20060801
Title: Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats.
Journal: Endocrinology 20060701
Title: Sodium-, chloride-, and mibefradil-sensitive calcium channels in intestinal pacing in wild-type and W/WV mice.
Journal: Canadian journal of physiology and pharmacology 20060601
Title: Synthesis and SAR studies of a novel series of T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry 20060515
Title: Inhibitory effects of L- and T-type calcium antagonists on contractions of human detrusor muscle.
Journal: European journal of clinical pharmacology 20060501
Title: T-type CaV3.3 calcium channels produce spontaneous low-threshold action potentials and intracellular calcium oscillations.
Journal: The European journal of neuroscience 20060501
Title: A role for voltage gated T-type calcium channels in mediating 'capacitative' calcium entry?
Journal: Cell calcium 20060401
Title: Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.
Journal: Molecular pharmacology 20060301
Title: Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.
Journal: Circulation research 20060106
Title: Relaxant responses to calcium channel antagonists and potassium channel opener in human saphenous vein.
Journal: Autonomic & autacoid pharmacology 20060101
Title: Early activation of internal medial smooth muscle cells in the rabbit aorta after mechanical injury: relationship with intimal thickening and pharmacological applications.
Journal: Clinical and experimental pharmacology & physiology 20060101
Title: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms.
Journal: Pharmacology 20060101
Title: Role of high-voltage-activated calcium channels in glucose-regulated beta-cell calcium homeostasis and insulin release.
Journal: American journal of physiology. Endocrinology and metabolism 20051101
Title: Pathophysiological significance of T-type Ca2+ channels: T-type Ca2+ channels and drug development.
Journal: Journal of pharmacological sciences 20051101
Title: The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.
Journal: European journal of pharmacology 20051003
Title: Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.
Journal: Indian journal of experimental biology 20050901
Title: T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells.
Journal: Brain research 20050823
Title: Characterization of a proton-activated, outwardly rectifying anion channel.
Journal: The Journal of physiology 20050815
Title: Effect of mibefradil on sodium and calcium currents.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20050801
Title: Involvement of different calcium channels in the depolarization-evoked release of noradrenaline from sympathetic neurones in rabbit carotid artery.
Journal: Basic & clinical pharmacology & toxicology 20050801
Title: Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.
Journal: Endocrinology 20050701
Title: Developmental downregulation of low-voltage-activated Ca2+ channels in Cajal-Retzius cells of the mouse visual cortex.
Journal: The European journal of neuroscience 20050601
Title: Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney.
Journal: The Keio journal of medicine 20050601
Title: Inhibition of in vitro contractions of human myometrium by mibefradil, a T-type calcium channel blocker: support for a model using excitation-contraction coupling, and autocrine and paracrine signaling mechanisms.
Journal: Journal of the Society for Gynecologic Investigation 20050501
Title: Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.
Journal: Circulation research 20050429
Title: Dendritic sodium spikelets and low-threshold calcium spikes in turtle olfactory bulb granule cells.
Journal: Journal of neurophysiology 20050301
Title: Pacemaker potentials generated by interstitial cells of Cajal in the murine intestine.
Journal: American journal of physiology. Cell physiology 20050301
Title: Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking.
Journal: American journal of physiology. Heart and circulatory physiology 20050201
Title: Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells.
Journal: Cell calcium 20050201
Title: Modulation of oral squamous cell carcinoma incidence in rats via diet and a novel calcium channel antagonist.
Journal: Toxicologic pathology 20050101
Title: Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396.
Journal: Cardiovascular drug reviews 20050101
Title: The effects of mibefradil, a T-type Ca2+ channels blocker, on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Journal: Renal failure 20050101
Title: State-dependent mibefradil block of Na+ channels.
Journal: Molecular pharmacology 20041201
Title: The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits.
Journal: Biochemical and biophysical research communications 20041105
Title: Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.
Journal: The American journal of cardiology 20041101
Title: Calcium channel blockers, either amlodipine or mibefradil, ameliorate renal injury in experimental diabetes.
Journal: Kidney international 20040901
Title: Michaelis-Menten kinetics under spatially constrained conditions: application to mibefradil pharmacokinetics.
Journal: Biophysical journal 20040901
Title: Ca2+ flux through voltage-gated channels with flow cessation in pulmonary microvascular endothelial cells.
Journal: Microcirculation (New York, N.Y. : 1994) 20040901
Title: Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats.
Journal: Journal of cardiovascular pharmacology 20040801
Title: Testosterone enhances calcium reabsorption by the kidney.
Journal: Molecular and cellular endocrinology 20040730
Title: The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon.
Journal: Journal of the American College of Cardiology 20040707
Title: 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Journal: Bioorganic & medicinal chemistry letters 20040705
Title: Induction of apoptosis by the calcium antagonist mibefradil correlates with depolarization of the membrane potential and decreased integrin expression in human lens epithelial cells.
Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20040701
Title: Effects of calcium channel blockers on 'dynamic' and 'steady-state step' renal autoregulation.
Journal: American journal of physiology. Renal physiology 20040601
Title: Comparison of cardioprotective effects of mibefradil and ramipril in stroke-prone spontaneously hypertensive rats.
Journal: Acta pharmacologica Sinica 20040601
Title: Depolarization-induced calcium influx in rat mesenteric small arterioles is mediated exclusively via mibefradil-sensitive calcium channels.
Journal: British journal of pharmacology 20040601
Title: Characterization of T-type calcium current and its contribution to electrical activity in rabbit urethra.
Journal: American journal of physiology. Cell physiology 20040501
Title: Expression and differential cell distribution of low-threshold Ca(2+) channels in mammalian male germ cells and sperm.
Journal: FEBS letters 20040409
Title: NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels.
Journal: The Journal of pharmacology and experimental therapeutics 20040401
Title: Identification of channels promoting calcium spikes and waves in HT1080 tumor cells: their apparent roles in cell motility and invasion.
Journal: Cancer research 20040401
Title: Mibefradil is more effective than verapamil for restoring post-ischemic function of isolated hearts of guinea pigs with acute renal failure.
Journal: European journal of pharmacology 20040319
Title: T-type calcium channels in the regulation of afferent and efferent arterioles in rats.
Journal: American journal of physiology. Renal physiology 20040201
Title: Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells.
Journal: Journal of molecular and cellular cardiology 20040101
Title: Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.
Journal: Neuroscience 20040101
Title: The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens.
Journal: The Journal of physiology 20031201
Title: Cellular mechanism for mibefradil-induced vasodilation of renal microcirculation: studies in the isolated perfused hydronephrotic kidney.
Journal: Journal of cardiovascular pharmacology 20031201
Title: Mechanism of active repolarization of inhibitory junction potential in murine colon.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20031101
Title: Thalamic control of visceral nociception mediated by T-type Ca2+ channels.
Journal: Science (New York, N.Y.) 20031003
Title: Effect of mibefradil on CYP3A4 in vivo.
Journal: Journal of clinical pharmacology 20031001
Title: Reversal of experimental neuropathic pain by T-type calcium channel blockers.
Journal: Pain 20030901
Title: Cav3.1 (alpha1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation.
Journal: Circulation research 20030822
Title: A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
Journal: Nature neuroscience 20030701
Title: Mibefradil: 'Has the baby been thrown out with the bath water?'.
Journal: American heart journal 20030701
Title: Inhibition of collateral artery growth by mibefradil: possible role of volume-regulated chloride channels.
Journal: Endothelium : journal of endothelial cell research 20030101
Title: Different effects of mibefradil and amlodipine on coronary vessels and during beta-adrenergic stimulation in conscious dogs.
Journal: Journal of cardiovascular pharmacology 20021201
Title: Effects of mibefradil on uterine contractility.
Journal: European journal of pharmacology 20021122
Title: Ca2+ entry via P/Q-type Ca2+ channels and the Na+/Ca2+ exchanger in rat and human neocortical synaptosomes.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021101
Title: Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries.
Journal: British journal of pharmacology 20021101
Title: Involvement of T-type calcium channels in the mechanism of action of 5-HT in rat glomerulosa cells: a novel signaling pathway for the 5-HT7 receptor.
Journal: Endocrine research 20021101
Title: Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker.
Journal: Brain research 20021004
Title: Modulation by mibefradil of the histamine-induced Ca2+ entry in human aortic endothelial cells.
Journal: Japanese journal of pharmacology 20021001
Title: Blood pressure response to antihypertensive agents related to baseline blood pressure.
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20021001
Title: Local electric stimulation causes conducted calcium response in rat interlobular arteries.
Journal: American journal of physiology. Renal physiology 20020901
Title: Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Journal: Acta physiologica Scandinavica 20020901
Title: Differential involvement of Ca(2+) channels in survival and neurite outgrowth of cultured embryonic cockroach brain neurons.
Journal: Journal of neurophysiology 20020901
Title: [Functional analysis of the alpha1G subunit of the T-type calcium channel in cellular proliferation].
Journal: Shi yan sheng wu xue bao 20020901
Title: Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815
Title: The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.
Journal: Molecular pharmacology 20020801
Title: Fractal pharmacokinetics of the drug mibefradil in the liver.
Journal: Physical review. E, Statistical, nonlinear, and soft matter physics 20020801
Title: T-Type calcium channel alpha1G and alpha1H subunits in human retinoblastoma cells and their loss after differentiation.
Journal: Journal of neurophysiology 20020701
Title: Selective L-type, T-type, and nonspecific calcium-channel blockers for stable angina pectoris.
Journal: American heart journal 20020701
Title: Randomized comparison of T-type versus L-type calcium-channel blockade on exercise duration in stable angina: results of the Posicor Reduction of Ischemia During Exercise (PRIDE) trial.
Journal: American heart journal 20020701
Title: The role of T-type calcium channels in morphine analgesia, development of antinociceptive tolerance and dependence to morphine, and morphine abstinence syndrome.
Journal: Life sciences 20020628
Title: Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine.
Journal: The Journal of physiology 20020615
Title: Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons.
Journal: Journal of neurophysiology 20020601
Title: A post-marketing observational study to assess the safety of mibefradil in the community in England.
Journal: International journal of clinical pharmacology and therapeutics 20020601
Title: Mibefradil improves beta-adrenergic responsiveness and intracellular Ca(2+) handling in hypertrophied rat myocardium.
Journal: Experimental biology and medicine (Maywood, N.J.) 20020501
Title: Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501
Title: Impaired mechanisms of leukocyte adhesion in vitro by the calcium channel antagonist mibefradil.
Journal: Cardiovascular drugs and therapy 20020501
Title: Impaired mechanisms of leukocyte adhesion in vitro by the calcium channel antagonist mibefradil.
Journal: Cardiovascular drugs and therapy 20020501
Title: Antioxidant effect of T-type calcium channel blockers in gastric injury.
Journal: Digestive diseases and sciences 20020401
Title: Single-channel pharmacology of mibefradil in human native T-type and recombinant Ca(v)3.2 calcium channels.
Journal: Molecular pharmacology 20020301
Title: Effect of nitric oxide synthase inhibitor N(omega) nitro-L-arginine methyl ester on relaxant responses to calcium channel antagonists in isolated aortic rings from Dahl normotensive and hypertensive rats.
Journal: Journal of cardiovascular pharmacology 20020301
Title: [Good and bad fortunes of drugs].
Journal: La Revue du praticien 20020301
Title: Acute effects of L- and T-type calcium channel antagonists on cardiovascular reflexes in conscious rabbits.
Journal: Clinical and experimental pharmacology & physiology 20020101
Title: Comparison of L-type and mixed L- and T-type calcium channel blockers on kidney injury caused by deoxycorticosterone-salt hypertension in rats.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20011201
Title: Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat.
Journal: Pharmacological research 20011201
Title: Low-voltage-activated calcium channels are not involved in capacitation and biological response to progesterone in human sperm.
Journal: International journal of andrology 20011201
Title: Low threshold T-type calcium current in rat embryonic chromaffin cells.
Journal: The Journal of physiology 20011115
Title: State-dependent inhibition of inactivation-deficient Ca(V)1.2 and Ca(V)2.3 channels by mibefradil.
Journal: The Journal of membrane biology 20011115
Title: Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo.
Journal: Journal of hypertension 20011101
Title: Evidence against an action of mibefradil at N-type voltage-operated calcium channels.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011101
Title: T-type Ca(2+) channels mediate neurotransmitter release in retinal bipolar cells.
Journal: Neuron 20011011
Title: Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis.
Journal: Clinical science (London, England : 1979) 20011001
Title: Torsades de pointes caused by Mibefradil.
Journal: European journal of heart failure 20011001
Title: Effect of T-type selective calcium antagonist on renal microcirculation: studies in the isolated perfused hydronephrotic kidney.
Journal: Hypertension (Dallas, Tex. : 1979) 20010901
Title: Selectivity of blocking of low- versus high-voltage activated calcium currents by the dihydropyridine derivatives Bay E5759 and Bay A4339 in neuroblastoma--glioma NG 108-15 cells.
Journal: Pharmacological research 20010801
Title: The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.
Journal: International journal of cardiology 20010801
Title: L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in mice.
Journal: Pain 20010701
Title: Inhibition of lens epithelial cell adhesion by the calcium antagonist Mibefradil correlates with impaired integrin distribution and organization of the cytoskeleton.
Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010701
Title: Novel voltage-dependent non-selective cation conductance in murine colonic myocytes.
Journal: The Journal of physiology 20010601
Title: Inhibition of T-type and L-type calcium channels by mibefradil: physiologic and pharmacologic bases of cardiovascular effects.
Journal: Journal of cardiovascular pharmacology 20010601
Title: Molecular identification of a TTX-sensitive Ca(2+) current.
Journal: American journal of physiology. Cell physiology 20010501
Title: Blocking swelling-activated chloride current inhibits mouse liver cell proliferation.
Journal: The Journal of physiology 20010501
Title: Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model.
Journal: Hypertension (Dallas, Tex. : 1979) 20010501
Title: Role of membrane depolarization and T-type Ca2+ channels in angiotensin II and K+ stimulated aldosterone secretion.
Journal: Molecular and cellular endocrinology 20010425
Title: Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs.
Journal: Cardiovascular research 20010301
Title: Comparison of sympathetic modulation induced by single oral doses of mibefradil, amlodipine, and nifedipine in healthy volunteers.
Journal: Clinical pharmacology and therapeutics 20010301
Title: Conducted vasoconstriction in rat mesenteric arterioles: role for dihydropyridine-insensitive Ca(2+) channels.
Journal: American journal of physiology. Heart and circulatory physiology 20010201
Title: Comparative effects of mibefradil and nifedipine gastrointestinal transport system on autonomic function in patients with mild to moderate essential hypertension.
Journal: Journal of hypertension 20010201
Title: Calcium channel blockade limits cardiac remodeling and improves cardiac function in myocardial infarction-induced heart failure in rats.
Journal: Journal of cardiovascular pharmacology 20010101
Title: Effects of the T-type calcium channel blockade with oral mibefradil on the electrophysiologic properties of the human heart.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101
Title: Effects of mibefradil, a T- and L-type calcium channel blocker, on cardiac remodeling in the UM-X7.1 cardiomyopathic hamster.
Journal: Cardiovascular drugs and therapy 20010101
Title: The evaluation of pharmacologic therapy in humans: a brief summary of the drug evaluation process and guidelines for clinical trials as they related to women.
Journal: The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20010101
Title: Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol.
Journal: Cardiology 20010101
Title: Mibefradil block of cloned T-type calcium channels.
Journal: The Journal of pharmacology and experimental therapeutics 20001001
Title: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.
Journal: Neuropharmacology 20000101
Title: Combination of calcium channel blockers and beta blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. The Netherlands Working Group on Cardiovascular Research (WCN).
Journal: Angiology 19990601
Title: Structure and functional characterization of a novel human low-voltage activated calcium channel.
Journal: Journal of neurochemistry 19990201
Title: Mibefradil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the management of hypertension and angina pectoris.
Journal: Drugs 19971101
Title: Cardiovascular alterations in rat fetuses exposed to calcium channel blockers.
Journal: Reproductive toxicology (Elmsford, N.Y.) 19970101
Title: Comparative antihypertensive effectiveness of once-daily mibefradil and diltiazem CD. Mibefradil Hypertension Study Group.
Journal: Clinical therapeutics 19970101
Title: Comparative efficacy and tolerability of two long-acting calcium antagonists, mibefradil and amlodipine, in essential hypertension. Mibefradil Hypertension Study Group.
Journal: Clinical therapeutics 19970101
Title: Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism.
Journal: Hypertension (Dallas, Tex. : 1979) 19960901
Title: The novel calcium antagonist Ro 40-5967 limits myocardial infarct size in the dog.
Journal: Cardiovascular research 19941001
Title: Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8.
Title: Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35.
Title: Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044.
Title: Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6.
