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1146618-41-8,MFCD16621142
Catalog No.:AA000EWG

1146618-41-8 | SNS-314 Mesylate

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Purity
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1mg
≥98%
in stock  
$116.00   $81.00
- +
5mg
≥98%
in stock  
$205.00   $143.00
- +
10mg
≥98%
in stock  
$345.00   $241.00
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25mg
99%
in stock  
$588.00   $412.00
- +
50mg
≥98%
in stock  
$1,119.00   $783.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000EWG
Chemical Name:
SNS-314 Mesylate
CAS Number:
1146618-41-8
Molecular Formula:
C19H19ClN6O4S3
Molecular Weight:
527.0400
MDL Number:
MFCD16621142
SMILES:
CS(=O)(=O)O.O=C(Nc1ncc(s1)CCNc1ncnc2c1scc2)Nc1cccc(c1)Cl
Properties
Computed Properties
 
Complexity:
625  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

Downstream Synthesis Route
SNS-314 
  75-75-2    1146618-41-8 

[1]CurrentPatentAssignee:SUNESISPHARMACEUTICALSINC-WO2009/114856,2009,A2Locationinpatent:Page/Pagecolumn57-58

[1]CurrentPatentAssignee:SUNESISPHARMACEUTICALSINC-WO2009/114856,2009,A2

[1]CurrentPatentAssignee:SUNESISPHARMACEUTICALSINC-WO2009/114856,2009,A2

[1]CurrentPatentAssignee:SUNESISPHARMACEUTICALSINC-WO2009/114856,2009,A2

2BrH*C11H11N5S2 
  1146618-41-8 

[1]CurrentPatentAssignee:SUNESISPHARMACEUTICALSINC-WO2009/114856,2009,A2

Literature

Title: Aurora kinase inhibitors as anti-cancer therapy.

Journal: Anti-cancer drugs 20100401

Title: SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.

Journal: Cancer chemotherapy and pharmacology 20100301

Title: 2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: Discovery and development of aurora kinase inhibitors as anticancer agents.

Journal: Journal of medicinal chemistry 20090514

Title: The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model.

Journal: Molecular cancer therapeutics 20090401

Title: Water-soluble prodrugs of an Aurora kinase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: Discovery of a potent and selective aurora kinase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20080901

Title: Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4.

Title: Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.

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SDS
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