Home Other Building Blocks 1156-19-0
1156-19-0,MFCD00083504
Catalog No.:AA000G65

1156-19-0 | Tolazamide

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1mg
98%
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$7.00   $5.00
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10mg
98%
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$19.00   $14.00
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25mg
98%(HPLC)
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$43.00   $30.00
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100mg
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$60.00   $42.00
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250mg
98%
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$87.00   $61.00
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1g
98%
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$217.00   $152.00
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5g
98%
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$713.00   $499.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000G65
Chemical Name:
Tolazamide
CAS Number:
1156-19-0
Molecular Formula:
C14H21N3O3S
Molecular Weight:
311.3998
MDL Number:
MFCD00083504
SMILES:
O=C(NS(=O)(=O)c1ccc(cc1)C)NN1CCCCCC1
Properties
Computed Properties
 
Complexity:
431  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
1.5  

Downstream Synthesis Route
1156-19-0   
3,3-Hexamethylen-1-(4-tolylsulfonyl)-triazen 

[1]ArchivderPharmazie,1993,vol.326,p.925-927

[2]ArchivderPharmazie,1993,vol.326,p.925-927

[1]CurrentPatentAssignee:WUXISANGGEERBIOTECHNOLOGY-CN113683584,2021,ALocationinpatent:Paragraph0027;0032-0055

Literature

Title: Epac2: a sulfonylurea receptor?

Journal: Biochemical Society transactions 20120201

Title: The management of type 2 diabetic patients with hypoglycaemic agents.

Journal: ISRN endocrinology 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones.

Journal: Diabetes & metabolism journal 20110801

Title: Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study.

Journal: Diabetes care 20110601

Title: Primary language, income and the intensification of anti-glycemic medications in managed care: the (TRIAD) study.

Journal: Journal of general internal medicine 20110501

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Glucose biosensors: an overview of use in clinical practice.

Journal: Sensors (Basel, Switzerland) 20100101

Title: Accuracy of Veterans Affairs databases for diagnoses of chronic diseases.

Journal: Preventing chronic disease 20091001

Title: The second-meal phenomenon in type 2 diabetes.

Journal: Diabetes care 20090701

Title: A review of exenatide as adjunctive therapy in patients with type 2 diabetes.

Journal: Drug design, development and therapy 20090101

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

Journal: PloS one 20090101

Title: Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

Journal: BMJ (Clinical research ed.) 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

Journal: Diabetes care 20081101

Title: Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Journal: Nature chemical biology 20080501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.

Journal: Journal of medicinal chemistry 20050407

Title: Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes.

Journal: Kidney international 20050201

Title: Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105

Title: Efficacy of sulfonylureas with insulin in type 2 diabetes mellitus.

Journal: The Annals of pharmacotherapy 20031101

Title: Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030801

Title: Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: a cross sectional study.

Journal: BMC health services research 20030101

Title: [A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus].

Journal: Yakushigaku zasshi 20030101

Title: Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020615

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.

Journal: Journal of molecular endocrinology 19990401

Title: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.

Journal: Science (New York, N.Y.) 19951117

Title: Oral hypoglycemic agents in the treatment of type II diabetes.

Journal: American family physician 19931101

Title: Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy.

Journal: Neurology 19861101

Title: A case of chronic liver disease due to tolazamide.

Journal: Gastroenterology 19850701

Title: Wernicke's encephalopathy induced by tolazamide.

Journal: The New England journal of medicine 19830908

Title: The effect of chlorpropamide hyponatremia on mental status in a nursing home population.

Journal: The Journal of family practice 19830501

Title: Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats.

Journal: Diabetes 19830301

Title: Tolazamide-induced cholestasis.

Journal: Southern medical journal 19800801

Title: Reduction of the severity of nephropathy in aging Fischer 344 rats treated with analogs of arylsulfonyluria.

Journal: Toxicology and applied pharmacology 19790701

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