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115103-85-0,MFCD00878420
Catalog No.:AA000G84

115103-85-0 | Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, sodium salt, (E)- (9CI)

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000G84
Chemical Name:
Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, sodium salt, (E)- (9CI)
CAS Number:
115103-85-0
Molecular Formula:
C26H26ClN2NaO3S2
Molecular Weight:
537.0690
MDL Number:
MFCD00878420
SMILES:
[O-]C(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C.[Na+]
Properties
Computed Properties
 
Complexity:
700  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
1  

Literature

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Title: Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).

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Title: Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells.

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Title: Transcellular transport of aconitine across human intestinal Caco-2 cells.

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Title: Absorption mechanism of ginsenoside compound K and its butyl and octyl ester prodrugs in Caco-2 cells.

Journal: Journal of agricultural and food chemistry 20121017

Title: Characterization of efflux transport of the PDE5 inhibitors, vardenafil and sildenafil.

Journal: The Journal of pharmacy and pharmacology 20120801

Title: Fasitibant chloride, a kinin B₂ receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats.

Journal: British journal of pharmacology 20120601

Title: Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin.

Journal: European journal of pharmacology 20120415

Title: The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia.

Journal: Leukemia & lymphoma 20120401

Title: A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120201

Title: Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes.

Journal: The Journal of biological chemistry 20120102

Title: The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes.

Journal: Journal of neurochemistry 20120101

Title: Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium.

Journal: PloS one 20120101

Title: ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium.

Journal: Cellular signalling 20111201

Title: Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes.

Journal: Biochimica et biophysica acta 20111101

Title: Development of a double-layer microfluidic chip with flow medium for chemotherapy resistance analysis of lung cancer.

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Title: Multidrug resistance-associated protein 1 mediates 15-deoxy-Δ(12,14)-prostaglandin J2-induced expression of glutamate cysteine ligase expression via Nrf2 signaling in human breast cancer cells.

Journal: Chemical research in toxicology 20110815

Title: Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.

Journal: Journal of the American College of Cardiology 20110809

Title: Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110601

Title: Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110401

Title: Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401

Title: Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats.

Journal: Biological chemistry 20110401

Title: Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201

Title: Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20110117

Title: Preclinical pharmacokinetics of PDE-310, a novel PDE4 inhibitor.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Role of the multidrug resistance protein-1 (MRP1) for endothelial progenitor cell function and survival.

Journal: Journal of molecular and cellular cardiology 20100901

Title: Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.

Journal: International journal of pharmaceutics 20100816

Title: cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter.

Journal: Molecular human reproduction 20100701

Title: Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy.

Journal: Neuropharmacology 20100601

Title: Multidrug resistance protein transporter and Ins(1,4,5)P₃-sensitive Ca²+-signaling involved in adenosine triphosphate export via Gq protein-coupled NK₂-receptor stimulation with neurokinin A.

Journal: Journal of pharmacological sciences 20100101

Title: Montelukast is a potent and durable inhibitor of multidrug resistance protein 2-mediated efflux of taxol and saquinavir.

Journal: Biological & pharmaceutical bulletin 20091201

Title: Extracellular redox modulation by regulatory T cells.

Journal: Nature chemical biology 20091001

Title: Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20091001

Title: Inhibition of multidrug/xenobiotic resistance transporter by MK571 improves dye (Fura 2) accumulation in crustacean tissues from lobster, shrimp, and isopod.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090901

Title: Culture period-dependent change of function and expression of ATP-binding cassette transporters in Caco-2 cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090901

Title: Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes.

Journal: The Journal of biological chemistry 20090807

Title: Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

Journal: Pharmaceutical research 20090801

Title: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090801

Title: The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090712

Title: Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins.

Journal: Pharmaceutical research 20090401

Title: Saturation of multidrug-resistant protein 2 (mrp2/abcc2)-mediated hepatobiliary secretion: nonlinear pharmacokinetics of a heterocyclic compound in rats after intravenous bolus administration.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401

Title: Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090401

Title: Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line.

Journal: Journal of neuroscience research 20090301

Title: Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215

Title: Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells.

Journal: Life sciences 20090213

Title: Formation and efflux of ATP-binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments.

Journal: Molecular pharmaceutics 20090101

Title: The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium.

Journal: Molecular pharmaceutics 20090101

Title: Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides.

Journal: Molecular pharmaceutics 20090101

Title: Avian renal proximal tubule epithelium urate secretion is mediated by Mrp4.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20081201

Title: Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer.

Journal: International journal of oncology 20081201

Title: P-gp inhibition potential in cell-based models: which 'calculation' method is the most accurate?

Journal: The AAPS journal 20081201

Title: Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus.

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Title: ABCC1: a gateway for pharmacological compounds to the ischaemic brain.

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Title: A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.

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Title: Application and limitation of inhibitors in drug-transporter interactions studies.

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Title: Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model.

Journal: European journal of pharmacology 20071201

Title: Agonist- and T(H)2 cytokine-induced up-regulation of cysteinyl leukotriene receptor messenger RNA in human monocytes.

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Title: ABCC transporter inhibition reduces zymosan-induced peritonitis.

Journal: Journal of leukocyte biology 20070901

Title: Acetylcholine-mediated axon-glia signaling in the developing insect olfactory system.

Journal: The European journal of neuroscience 20070901

Title: Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.

Journal: Journal of pharmacological sciences 20070901

Title: Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801

Title: Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor.

Journal: International journal of pharmaceutics 20070718

Title: Mechanistic study on the intestinal absorption and disposition of baicalein.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

Title: Transepithelial transport of fusariotoxin nivalenol: mediation of secretion by ABC transporters.

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Title: Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

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Title: Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.

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Title: Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin.

Journal: Neuroscience 20070209

Title: Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters.

Journal: British journal of pharmacology 20070201

Title: Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells.

Journal: Experimental eye research 20070101

Title: Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.

Journal: The Journal of allergy and clinical immunology 20070101

Title: Modulatory effects of heparin on cellular accumulation and cytotoxicity of doxorubicin in MRP1-overexpressing HL60/doxo cells.

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Title: Sulfasalazine-induced reduction of glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin.

Journal: Chemotherapy 20070101

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Journal: Molecular membrane biology 20070101

Title: Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20070101

Title: An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers.

Journal: Toxicology and applied pharmacology 20061201

Title: Formation and rapid export of the monochlorobimane-glutathione conjugate in cultured rat astrocytes.

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Title: The complexity of intestinal absorption and exsorption of digoxin in rats.

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Title: The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2.

Journal: Pharmaceutical research 20060801

Title: Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.

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Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060501

Title: Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis.

Journal: Journal of neurochemistry 20060501

Title: Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

Title: Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.

Journal: Molecular pharmacology 20060401

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Journal: Journal of neurochemistry 20060401

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Journal: International immunopharmacology 20060201

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Title: Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats.

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Title: Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets.

Journal: The Journal of experimental biology 20051201

Title: Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery.

Journal: Clinical and experimental pharmacology & physiology 20051201

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Title: Role of cysteinyl leukotrienes in airway inflammation and responsiveness following RSV infection in BALB/c mice.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20051101

Title: Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.

Journal: Life sciences 20050826

Title: Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae.

Journal: Pharmaceutical research 20050701

Title: Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2.

Journal: The Journal of pharmacology and experimental therapeutics 20050501

Title: Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.

Journal: Immunology 20050401

Title: P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Transepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayers.

Journal: Bioscience, biotechnology, and biochemistry 20050301

Title: Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells.

Journal: Journal of agricultural and food chemistry 20050209

Title: Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050201

Title: Endogenous thiols and MRP transporters contribute to Hg2+ efflux in HgCl2-treated tubular MDCK cells.

Journal: Toxicology 20050105

Title: P2X7 receptor activation in rat brain cultured astrocytes increases the biosynthetic release of cysteinyl leukotrienes.

Journal: International journal of immunopathology and pharmacology 20050101

Title: Relation between the ability of some compounds to modulate the MRP1-mediated efflux of glutathione and to inhibit the MRPl-mediated efflux of daunorubicin.

Journal: Biochemical pharmacology 20041201

Title: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

Journal: British journal of pharmacology 20041201

Title: Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041001

Title: Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy.

Journal: American journal of physiology. Renal physiology 20040901

Title: Disposition mechanisms of raloxifene in the human intestinal Caco-2 model.

Journal: The Journal of pharmacology and experimental therapeutics 20040701

Title: The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin.

Journal: Blood 20040601

Title: Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators in leukemic cell lines.

Journal: Leukemia research 20040601

Title: Identification of multidrug resistance-associated protein 1 and glutathione as multidrug resistance mechanisms in human prostate cancer cells: chemosensitization with leukotriene D4 antagonists and buthionine sulfoximine.

Journal: BJU international 20040601

Title: Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.

Journal: Biochemical pharmacology 20040101

Title: Bodipy-FL-verapamil: a fluorescent probe for the study of multidrug resistance proteins.

Journal: Cellular oncology : the official journal of the International Society for Cellular Oncology 20040101

Title: Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

Journal: Chemical research in toxicology 20031201

Title: Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis.

Journal: Biochemical and biophysical research communications 20031121

Title: The role of breast cancer resistance protein in acute lymphoblastic leukemia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031101

Title: Stereoselective hepatic disposition of a diastereomeric pair of alphavbeta3 antagonists in rat.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20031101

Title: Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients.

Journal: Matrix biology : journal of the International Society for Matrix Biology 20031101

Title: Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Title: Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model.

Journal: The Journal of pharmacology and experimental therapeutics 20031001

Title: cGMP and glutathione-conjugate transport in human erythrocytes.

Journal: European journal of biochemistry 20030901

Title: Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601

Title: Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells.

Journal: Pharmaceutical research 20030601

Title: Cysteinyl leukotrienes in porcine acute allergic airway reactions: bronchial and vascular effects.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030501

Title: Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20030401

Title: Kinetic analysis of fluorescein and dihydrofluorescein effluxes in tumour cells expressing the multidrug resistance protein, MRP1.

Journal: Biochemical pharmacology 20030315

Title: Sulfate conjugating and transport functions of MDCK distal tubular cells.

Journal: Kidney international 20030301

Title: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).

Journal: Molecular pharmacology 20030201

Title: Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

Journal: European journal of pharmacology 20030110

Title: Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.

Journal: Chemico-biological interactions 20030106

Title: Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers.

Journal: European journal of pharmacology 20030101

Title: Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.

Journal: European journal of pharmacology 20030101

Title: A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles.

Journal: Analytical biochemistry 20021101

Title: Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.

Journal: Journal of cellular physiology 20020801

Title: Glutathione release from cultured brain cells: multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells.

Journal: Journal of neuroscience research 20020801

Title: Mrp2 modulates the activity of chloride channels in isolated hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20020701

Title: Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils.

Journal: The Journal of allergy and clinical immunology 20020601

Title: Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes.

Journal: Biological chemistry 20020601

Title: Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020501

Title: Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells.

Journal: International journal of cancer 20020220

Title: 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes.

Journal: Gastroenterology 20020201

Title: Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma.

Journal: European journal of pharmacology 20020201

Title: Cysteinyl leukotrienes modulate angiotensin II constrictor effects on aortas from streptozotocin-induced diabetic rats.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20011101

Title: Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011001

Title: An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea.

Journal: British journal of pharmacology 20010801

Title: Cysteinyl leukotrienes mediate enhanced vasoconstriction to angiotensin II but not endothelin-1 in SHR.

Journal: American journal of physiology. Heart and circulatory physiology 20010701

Title: Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice.

Journal: Biochemical and biophysical research communications 20010622

Title: SCF-induced airway hyperreactivity is dependent on leukotriene production.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010601

Title: Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1.

Journal: Blood 20010601

Title: Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells.

Journal: European journal of pharmacology 20010601

Title: Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus.

Journal: Life sciences 20010511

Title: Mechanisms for the transport of unconjugated bilirubin in human trophoblastic BeWo cells.

Journal: FEBS letters 20010420

Title: Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes.

Journal: Biochimica et biophysica acta 20010216

Title: The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress.

Journal: Journal of neurochemistry 20010101

Title: Comparison of the properties of human breast cancer cells: MCF-7 and MCF-7 cells selected for resistance to etoposide.

Journal: Advances in enzyme regulation 20010101

Title: The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro.

Journal: Journal of submicroscopic cytology and pathology 20010101

Title: Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.

Journal: Molecular pharmacology 19991201

Title: Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells.

Journal: FEBS letters 19990129

Title: Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor.

Journal: Receptors & signal transduction 19960101

Title: The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Journal: The Journal of biological chemistry 19941111

Title: BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes.

Journal: European journal of pharmacology 19941103

Title: Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.

Journal: The Journal of pharmacology and experimental therapeutics 19940601

Title: Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects.

Journal: Thorax 19931201

Title: Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung.

Journal: European journal of pharmacology 19930215

Title: A second cysteinyl leukotriene receptor in human lung.

Journal: The Journal of pharmacology and experimental therapeutics 19921101

Title: Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

Journal: Inflammation 19920601

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Tags:115103-85-0 Molecular Formula|115103-85-0 MDL|115103-85-0 SMILES|115103-85-0 Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-, sodium salt, (E)- (9CI)