Title: Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.
Journal: Journal of medicinal chemistry 20111222
Title: Molecular structure, harmonic and anharmonic frequency calculations of 2,4-dichloropyrimidine and 4,6-dichloropyrimidine by HF and density functional methods.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110501
Title: Expanding the diversity of allosteric bcr-abl inhibitors.
Journal: Journal of medicinal chemistry 20101014
Title: meso-Pyrimidinyl-substituted A2B- and A3-corroles.
Journal: The Journal of organic chemistry 20100319
Title: Synthesis and highly selective bromination of Azacalix[4]pyrimidine macrocycles.
Journal: The Journal of organic chemistry 20100205
Title: 1,4-Bis(6-chloro-pyrimidin-4-yl-oxy)benzene.
Journal: Acta crystallographica. Section E, Structure reports online 20090201
Title: Comparative computational and experimental study on the thermochemistry of the chloropyrimidines.
Journal: The journal of physical chemistry. B 20070201
Title: Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
Journal: Nature chemical biology 20060201
Title: 5-Pyrimidylboronic acid and 2-methoxy-5-pyrimidylboronic acid: new heteroarylpyrimidine derivatives via Suzuki cross-coupling reactions.
Journal: Organic & biomolecular chemistry 20040321
4,6-Dichloropyrimidine is utilized as a versatile building block in organic synthesis, serving as a key intermediate in the preparation of various functionalized pyrimidine derivatives. Its reactivity allows for the synthesis of N-substituted azacalix[4]pyrimidines, which are important compounds in supramolecular chemistry and molecular recognition studies. Additionally, 4,6-Dichloropyrimidine serves as a starting material for the synthesis of disubstituted pyrimidines via tandem amination and Suzuki-Miyaura cross-coupling reactions. These synthetic routes enable the introduction of diverse substituents onto the pyrimidine scaffold, expanding the structural diversity and utility of the resulting compounds. Furthermore, 4,6-Dichloropyrimidine is employed in biarylpyrimidine synthesis through biaryl cross-coupling reactions, facilitating the construction of biaryl-containing pyrimidine derivatives with potential applications in medicinal chemistry and materials science. Overall, the versatility of 4,6-Dichloropyrimidine makes it a valuable tool in organic synthesis, enabling the efficient preparation of diverse pyrimidine-based compounds with tailored properties for various applications.
