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Home Amines 1228690-19-4
1228690-19-4,MFCD20486575
Catalog No.:AA000JKV

1228690-19-4 | [1,1'-Biphenyl]-4-acetic acid, 4'-[4-[[[(1R)-1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$21.00   $15.00
- +
2mg
98%
in stock  
$32.00   $22.00
- +
5mg
98%
in stock  
$46.00   $32.00
- +
10mg
98%
in stock  
$70.00   $49.00
- +
1g
98%
in stock  
$1,074.00   $752.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000JKV
Chemical Name:
[1,1'-Biphenyl]-4-acetic acid, 4'-[4-[[[(1R)-1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]-
CAS Number:
1228690-19-4
Molecular Formula:
C27H23ClN2O5
Molecular Weight:
490.9349
MDL Number:
MFCD20486575
SMILES:
OC(=O)Cc1ccc(cc1)c1ccc(cc1)c1onc(c1NC(=O)O[C@@H](c1ccccc1Cl)C)C
Properties
Computed Properties
 
Complexity:
708  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
5.6  

Upstream Synthesis Route

[1]Patent:US2010/152257,2010,A1,.Locationinpatent:Page/Pagecolumn23-24

Literature

Title: Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model.

Journal: British journal of pharmacology 20100801

Title: Swaney, JS, et al. A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model. Br J Pharmacol. 2010 Aug;160(7):1699-713.

Title: Olianas MC, et al. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015 Jun 15;95(4):311-23.

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SDS
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Tags:1228690-19-4 Molecular Formula|1228690-19-4 MDL|1228690-19-4 SMILES|1228690-19-4 [1,1'-Biphenyl]-4-acetic acid, 4'-[4-[[[(1R)-1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]-