[1]Weiss;Raizman[JournaloftheAmericanChemicalSociety,1958,vol.80,p.4657]
[2]Park,Jin;Li,Qian;Chang,Young-Tae;Kim,TaeSung[BioorganicandMedicinalChemistry,2005,vol.13,#7,p.2589-2595]
[3]Chang,Young-Tae;Choi,Jaehwa;Ding,Sheng;Prieschl,EvaE.;Baumruker,Thomas;Lee,Jae-Mok;Chung,Sung-Kee;Schultz,PeterG.[JournaloftheAmericanChemicalSociety,2002,vol.124,#9,p.1856-1857]
[1]Weiss;Raizman[JournaloftheAmericanChemicalSociety,1958,vol.80,p.4657]
[2]Park,Jin;Li,Qian;Chang,Young-Tae;Kim,TaeSung[BioorganicandMedicinalChemistry,2005,vol.13,#7,p.2589-2595]
[3]Chang,Young-Tae;Choi,Jaehwa;Ding,Sheng;Prieschl,EvaE.;Baumruker,Thomas;Lee,Jae-Mok;Chung,Sung-Kee;Schultz,PeterG.[JournaloftheAmericanChemicalSociety,2002,vol.124,#9,p.1856-1857]
[1]Julina,Radomir;Herzig,Thomas;Bernet,Bruno;Vasella,Andrea[HelveticaChimicaActa,1986,vol.69,p.368-373]
Title: Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment.
Journal: Archives of toxicology 20170201
Title: Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
Journal: British journal of pharmacology 20170101
Title: Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160301
Title: A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells.
Journal: Chemico-biological interactions 20150725
Title: FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.
Journal: Toxicology letters 20150702
Title: Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20150601
Title: FTY720 Phosphate Activates Sphingosine-1-Phosphate Receptor 2 and Selectively Couples to Gα12/13/Rho/ROCK to Induce Myofibroblast Contraction.
Journal: Molecular pharmacology 20150601
Title: Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.
Journal: Journal of lipid research 20150601
Title: Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.
Journal: Chemico-biological interactions 20150525
Title: Lysophospholipid receptors in drug discovery.
Journal: Experimental cell research 20150501
Title: Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Journal: Journal of neuroinflammation 20150101
Title: Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway.
Journal: International journal of clinical and experimental pathology 20150101
Title: Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.
Journal: Neurotoxicology 20140901
Title: Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells.
Journal: Molecular neurobiology 20140801
Title: FTY720 attenuates paraquat-induced lung injury in mice.
Journal: International immunopharmacology 20140801
Title: Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
Journal: Nature neuroscience 20140701
Title: ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
Journal: PloS one 20140101
Title: Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod.
Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20130601
Title: Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20130401
Title: Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors.
Journal: Analytical biochemistry 20130315
Title: Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.
Journal: British journal of pharmacology 20130301
Title: Early tolerability and safety of fingolimod in clinical practice.
Journal: Journal of the neurological sciences 20121215
Title: Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts.
Journal: European journal of pharmacology 20121205
Title: Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway.
Journal: Biochimie 20121201
Title: Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃.
Journal: Molecular and cellular biochemistry 20121201
Title: Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes.
Journal: International journal of molecular medicine 20121201
Title: Effect of alkyl chain length on sphingosine kinase 2 selectivity.
Journal: Bioorganic & medicinal chemistry letters 20121115
Title: Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.
Journal: International journal of cancer 20121101
Title: Withdrawal of fingolimod treatment for relapsing-remitting multiple sclerosis: report of six cases.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121101
Title: Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts.
Journal: The Biochemical journal 20121101
Title: Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis.
Journal: Journal of neurochemistry 20121101
Title: A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor.
Journal: Bioresource technology 20121101
Title: Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat.
Journal: Basic research in cardiology 20121101
Title: Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity.
Journal: Endocrinology 20121101
Title: High density lipoprotein biogenesis, cholesterol efflux, and immune cell function.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20121101
Title: Switching therapy from natalizumab to fingolimod in relapsing-remitting multiple sclerosis: clinical and magnetic resonance imaging findings.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Emerging tumefactive multiple sclerosis after switching therapy from natalizumab to fingolimod.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121101
Title: Focus on molecules: Sphingosine 1 Phosphate (S1P).
Journal: Experimental eye research 20121001
Title: Sudden unexpected death on fingolimod.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20121001
Title: Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome.
Journal: The Journal of surgical research 20121001
Title: Effects of FTY720 and rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat.
Journal: Pancreas 20121001
Title: Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway.
Journal: Archives of dermatological research 20121001
Title: Sphingosine 1-phosphate-primed astrocytes enhance differentiation of neuronal progenitor cells.
Journal: Journal of neuroscience research 20121001
Title: Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus.
Journal: Journal of clinical immunology 20121001
Title: Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation.
Journal: Prostaglandins & other lipid mediators 20121001
Title: Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
Journal: Biochimica et biophysica acta 20121001
Title: Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.
Journal: The Biochemical journal 20121001
Title: New disease-modifying therapies and new challenges for MS.
Journal: Current neurology and neuroscience reports 20121001
Title: Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway.
Journal: Fertility and sterility 20121001
Title: Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.
Journal: Archives of biochemistry and biophysics 20121001
Title: Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels.
Journal: American journal of physiology. Heart and circulatory physiology 20121001
Title: Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women.
Journal: The Journal of clinical endocrinology and metabolism 20121001
Title: Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells.
Journal: Endocrine-related cancer 20121001
Title: A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1.
Journal: Therapeutic advances in cardiovascular disease 20121001
Title: The functional roles of S1P in immunity.
Journal: Journal of biochemistry 20121001
Title: Stereoselective synthesis of C18-guggultetrol and C18-phytosphingosine analogues from D-fructose.
Journal: Carbohydrate research 20121001
Title: Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.
Journal: Birth defects research. Part A, Clinical and molecular teratology 20121001
Title: Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure.
Journal: Heart failure clinics 20121001
Title: Bcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120926
Title: Diastereodivergent hydroxyfluorination of cyclic and acyclic allylic amines: synthesis of 4-deoxy-4-fluorophytosphingosines.
Journal: The Journal of organic chemistry 20120907
Title: The safety risks of innovation: the FDA's Expedited Drug Development Pathway.
Journal: JAMA 20120905
Title: A randomized, controlled trial of fingolimod (FTY720) in Japanese patients with multiple sclerosis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120901
Title: Evaluation of pathological effects in broilers during fumonisins and clays exposure.
Journal: Mycopathologia 20120901
Title: A patient with Leiden V mutation, multiple sclerosis, psoriasis, and sicca syndrome: could celecoxib and fingolimod adversely affect the heart?
Journal: Cardiovascular toxicology 20120901
Title: Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case.
Journal: Traffic (Copenhagen, Denmark) 20120901
Title: The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death.
Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901
Title: Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.
Journal: Glia 20120901
Title: Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
Journal: Journal of neurophysiology 20120901
Title: The hydrophobic mismatch determines the miscibility of ceramides in lipid monolayers.
Journal: Chemistry and physics of lipids 20120901
Title: 4-aminopyridine toxicity: a case report and review of the literature.
Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20120901
Title: First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
Journal: Molecular cancer therapeutics 20120901
Title: Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes.
Journal: Acta neuropathologica 20120901
Title: Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat.
Journal: Lipids 20120901
Title: Reporting of subgroup analyses from clinical trials.
Journal: The Lancet. Neurology 20120901
Title: The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis.
Journal: Lymphatic research and biology 20120901
Title: Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.
Journal: Chemistry & biology 20120824
Title: Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice.
Journal: Vascular pharmacology 20120819
Title: Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Journal: Cell 20120817
Title: S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma.
Journal: Blood 20120816
Title: [Infections and fingolimod].
Journal: Revista de neurologia 20120816
Title: Ethylene signaling pathway and MAPK cascades are required for AAL toxin-induced programmed cell death.
Journal: Molecular plant-microbe interactions : MPMI 20120801
Title: PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.
Journal: Molecular and cellular biochemistry 20120801
Title: Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease.
Journal: Human molecular genetics 20120801
Title: Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.
Journal: The Journal of pharmacology and experimental therapeutics 20120801
Title: Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.
Journal: Transplant immunology 20120801
Title: Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.
Journal: Journal of lipid research 20120801
Title: A fluorescent assay for ceramide synthase activity.
Journal: Journal of lipid research 20120801
Title: Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans.
Journal: The Journal of clinical endocrinology and metabolism 20120801
Title: Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model.
Journal: The American journal of pathology 20120801
Title: Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
Journal: EMBO molecular medicine 20120801
Title: Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage.
Journal: Stroke 20120801
Title: Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.
Journal: International journal of clinical pharmacology and therapeutics 20120801
Title: Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes.
Journal: Investigative ophthalmology & visual science 20120801
Title: Labeling Golgi with fluorescent ceramides.
Journal: Cold Spring Harbor protocols 20120801
Title: Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Journal: International journal of rheumatic diseases 20120801
Title: [Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils].
Journal: Zhongguo shi yan xue ye xue za zhi 20120801
Title: The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.
Journal: Biochemical and biophysical research communications 20120720
Title: Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.
Journal: Proceedings of the American Thoracic Society 20120715
Title: Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.
Journal: Circulation 20120710
Title: Population pharmacokinetics of fingolimod phosphate in healthy participants.
Journal: Journal of clinical pharmacology 20120701
Title: Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model.
Journal: Breast cancer research and treatment 20120701
Title: The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120701
Title: A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.
Journal: Leukemia 20120701
Title: Metabolic engineering of the non-conventional yeast Pichia ciferrii for production of rare sphingoid bases.
Journal: Metabolic engineering 20120701
Title: Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?
Journal: International journal of pharmaceutics 20120701
Title: IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120701
Title: The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4+CD25+ T cells in vitro.
Journal: International journal of molecular medicine 20120701
Title: The role of sphingosine-1-phosphate transporter Spns2 in immune system function.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20120701
Title: [Basic mechanisms of action of fingolimod in relation to multiple sclerosis].
Journal: Revista de neurologia 20120701
Title: Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet.
Journal: Clinical nephrology 20120701
Title: Cost-effectiveness of early initiation of fingolimod versus delayed initiation after 1 year of intramuscular interferon beta-1a in patients with multiple sclerosis.
Journal: Clinical therapeutics 20120701
Title: Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors.
Journal: Journal of Zhejiang University. Science. B 20120701
Title: [Effect of ceramide on GSTA1 in Caco-2 cells].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120701
Title: [Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator FTY720 (fingolimod) in combination with betamethasone ointment in NC/Nga mice].
Journal: Arerugi = [Allergy] 20120701
Title: Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression.
Journal: Cancer letters 20120628
Title: Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Journal: Biochemical and biophysical research communications 20120622
Title: Species-specific activity of glycolipid ligands for invariant NKT cells.
Journal: Chembiochem : a European journal of chemical biology 20120618
Title: First-line disease-modifying therapies in paediatric multiple sclerosis: a comprehensive overview.
Journal: Drugs 20120618
Title: Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.
Journal: Biochemical and biophysical research communications 20120615
Title: In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20120610
Title: Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers.
Journal: Circulation 20120605
Title: Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.
Journal: Circulation 20120605
Title: SRC regulates sphingosine-1-phosphate mediated smooth muscle cell migration.
Journal: The Journal of surgical research 20120601
Title: Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.
Journal: British journal of pharmacology 20120601
Title: Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome.
Journal: Endocrine 20120601
Title: FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.
Journal: British journal of pharmacology 20120601
Title: Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells.
Journal: Journal of cellular biochemistry 20120601
Title: Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure.
Journal: Advances in medical sciences 20120601
Title: H-Ras increases release of sphingosine resulting in down-regulation of TSP-1 in non-transformed cells.
Journal: International journal of experimental pathology 20120601
Title: Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis.
Journal: Coronary artery disease 20120601
Title: Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium.
Journal: Allergology international : official journal of the Japanese Society of Allergology 20120601
Title: Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection.
Journal: Cardiovascular drugs and therapy 20120601
Title: Ethanol triggers sphingosine 1-phosphate elevation along with neuroapoptosis in the developing mouse brain.
Journal: Journal of neurochemistry 20120601
Title: FTY720 mediates activation suppression and G(0)/G (1) cell cycle arrest in a concanavalin A-induced mouse lymphocyte pan-activation model.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120601
Title: Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.
Journal: Angiogenesis 20120601
Title: Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle.
Journal: Allergology international : official journal of the Japanese Society of Allergology 20120601
Title: Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis.
Journal: Neurochemical research 20120601
Title: Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.
Journal: Journal of lipid research 20120601
Title: IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model.
Journal: Pulmonary pharmacology & therapeutics 20120601
Title: Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.
Journal: Critical care medicine 20120601
Title: Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis.
Journal: Development (Cambridge, England) 20120601
Title: Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.
Journal: Analytical and bioanalytical chemistry 20120601
Title: [Assessment of the clinical and MRI results of the FREEDOMS and TRANSFORMS phase III. clinical trials].
Journal: Ideggyogyaszati szemle 20120530
Title: The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment.
Journal: Transplantation 20120527
Title: The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
Journal: Molecular cell 20120525
Title: Structure of the first sphingosine 1-phosphate receptor.
Journal: Science signaling 20120522
Title: FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells.
Journal: Neuroscience letters 20120516
Title: Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
Journal: The Biochemical journal 20120515
Title: Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible.
Journal: American journal of physiology. Heart and circulatory physiology 20120515
Title: Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients.
Journal: Journal of neuroimmunology 20120515
Title: Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20120515
Title: Building a better sphingosine kinase-1 inhibitor.
Journal: The Biochemical journal 20120515
Title: [Multiple sclerosis: beyong first line therapies].
Journal: Revue medicale suisse 20120502
Title: Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury.
Journal: Kidney international 20120501
Title: Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.
Journal: Journal of cell science 20120501
Title: Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells.
Journal: International journal of oncology 20120501
Title: S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.
Journal: Experimental cell research 20120501
Title: Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.
Journal: Cancer biology & therapy 20120501
Title: Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity.
Journal: Neurochemistry international 20120501
Title: Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.
Journal: Molecular endocrinology (Baltimore, Md.) 20120501
Title: An efficient synthesis of the polar part of sulfamisterin and its analogs.
Journal: Carbohydrate research 20120501
Title: Annualized relapse rate of first-line treatments for multiple sclerosis: a meta-analysis, including indirect comparisons versus fingolimod.
Journal: Current medical research and opinion 20120501
Title: Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C.
Journal: Journal of neuropathology and experimental neurology 20120501
Title: MS clinical trials: what can subgroup analyses teach us?
Journal: The Lancet. Neurology 20120501
Title: Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.
Journal: The Lancet. Neurology 20120501
Title: Harnessing regulatory T cells for therapeutic purposes.
Journal: Kidney international 20120501
Title: Immunotherapies in neurologic disorders.
Journal: The Medical clinics of North America 20120501
Title: Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
Journal: Nature 20120426
Title: Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.
Journal: Oncogene 20120419
Title: [New disease-modifying and symptomatic therapies for multiple sclerosis].
Journal: MMW Fortschritte der Medizin 20120419
Title: Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120415
Title: Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells.
Journal: The Journal of biological chemistry 20120413
Title: Drugs: An injection of hope.
Journal: Nature 20120412
Title: Autophagy induced by FTY720 promotes apoptosis in U266 cells.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411
Title: CCR7/CCL19 controls expression of EDG-1 in T cells.
Journal: The Journal of biological chemistry 20120406
Title: The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
Journal: The Journal of clinical investigation 20120402
Title: Treatments for relapsing-remitting multiple sclerosis: summarising current information by network meta-analysis.
Journal: European journal of clinical pharmacology 20120401
Title: Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers.
Journal: European journal of clinical pharmacology 20120401
Title: Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation.
Journal: Journal of cellular biochemistry 20120401
Title: Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells.
Journal: Molecular and cellular biochemistry 20120401
Title: Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats.
Journal: Molecular and cellular biochemistry 20120401
Title: Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans.
Journal: Cellular microbiology 20120401
Title: Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.
Journal: The Journal of pathology 20120401
Title: A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression.
Journal: International journal of biological macromolecules 20120401
Title: Pharmacological mechanisms of black cohosh in Sprague-Dawley rats.
Journal: Fitoterapia 20120401
Title: Phytosphingosine-phosphate is a signal for AtMPK6 activation and Arabidopsis response to chilling.
Journal: The New phytologist 20120401
Title: Sphingosine pathway deregulation in endometriotic tissues.
Journal: Fertility and sterility 20120401
Title: Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120401
Title: Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.
Journal: Experimental cell research 20120401
Title: Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
Journal: The American journal of pathology 20120401
Title: An efficient and convenient formal synthesis of Jaspine B from D-xylose.
Journal: Carbohydrate research 20120401
Title: Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma.
Journal: Neuro-oncology 20120401
Title: Evidence that sphingolipid signaling is involved in responding to low temperature.
Journal: The New phytologist 20120401
Title: Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer.
Journal: Bioorganic & medicinal chemistry letters 20120401
Title: FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.
Journal: The American journal of pathology 20120401
Title: Network analysis of randomized controlled trials in multiple sclerosis.
Journal: Clinical therapeutics 20120401
Title: [2012: Update on diagnosis and treatment of multiple sclerosis].
Journal: Deutsche medizinische Wochenschrift (1946) 20120401
Title: Fingolimod: cardiovascular deaths.
Journal: Prescrire international 20120401
Title: Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis.
Journal: Future medicinal chemistry 20120401
Title: Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
Journal: The Journal of biological chemistry 20120323
Title: Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis.
Journal: Biochemical and biophysical research communications 20120323
Title: Severe multiple sclerosis relapse under fingolimod therapy: incident or coincidence?
Journal: Neurology 20120320
Title: S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.
Journal: Blood 20120315
Title: Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis.
Journal: European journal of pharmacology 20120315
Title: Synthesis of amino core compounds of galactosyl phytosyl ceramide analogs for developing iNKT-cell inducers.
Journal: Molecules (Basel, Switzerland) 20120312
Title: Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis.
Journal: The Journal of biological chemistry 20120309
Title: Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis.
Journal: Biochemical and biophysical research communications 20120309
Title: Local delivery of FTY720 accelerates cranial allograft incorporation and bone formation.
Journal: Cell and tissue research 20120301
Title: Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Journal: European journal of immunology 20120301
Title: High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii.
Journal: Metabolic engineering 20120301
Title: Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac.
Journal: The American journal of pathology 20120301
Title: Prevention of GVHD and graft rejection by a new S1P receptor agonist, W-061, in rat small bowel transplantation.
Journal: Transplant immunology 20120301
Title: Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves.
Journal: Cardiovascular research 20120301
Title: Targeting sphingosine kinase-1 to inhibit melanoma.
Journal: Pigment cell & melanoma research 20120301
Title: Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes.
Journal: Plant molecular biology 20120301
Title: Terpene alcohols inhibit de novo sphingolipid biosynthesis.
Journal: Planta medica 20120301
Title: Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120301
Title: LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301
Title: FTY720-induced blockage of autophagy enhances anticancer efficacy of milatuzumab in mantle cell lymphoma: is FTY720 the next autophagy-blocking agent in lymphoma treatment?
Journal: Autophagy 20120301
Title: FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120301
Title: Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice.
Journal: Blood 20120301
Title: [Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120301
Title: [Ca2+ and sphingolipids as modulators for apoptosis and cancer].
Journal: Investigacion clinica 20120301
Title: Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys.
Journal: Avian diseases 20120301
Title: Immunological function of sphingosine 1-phosphate in the intestine.
Journal: Nutrients 20120301
Title: Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.
Journal: Experimental & molecular medicine 20120227
Title: Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection.
Journal: British journal of cancer 20120227
Title: Fingolimod-associated macular edema: incidence, detection, and management.
Journal: Neurology 20120227
Title: Agency is under fire for refusing to supply details of sudden deaths after first dose of multiple sclerosis drug.
Journal: BMJ (Clinical research ed.) 20120223
Title: ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate.
Journal: Clinica chimica acta; international journal of clinical chemistry 20120218
Title: FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).
Journal: The Journal of biological chemistry 20120217
Title: Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors.
Journal: Developmental biology 20120215
Title: Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.
Journal: Oncogene 20120202
Title: Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase.
Journal: Inflammation 20120201
Title: Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
Journal: Acta physiologica (Oxford, England) 20120201
Title: Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.
Journal: International journal of cancer 20120201
Title: Integration of transient receptor potential canonical channels with lipids.
Journal: Acta physiologica (Oxford, England) 20120201
Title: Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis.
Journal: British journal of pharmacology 20120201
Title: Targeting synaptic pathology in multiple sclerosis: fingolimod to the rescue?
Journal: British journal of pharmacology 20120201
Title: [Fingolimod treatment for multiple sclerosis patients. Infectiological aspects and recommendations for vaccinations].
Journal: Der Nervenarzt 20120201
Title: Inhibitors of specific ceramide synthases.
Journal: Biochimie 20120201
Title: Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells.
Journal: Neuropharmacology 20120201
Title: Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions.
Journal: Biochimica et biophysica acta 20120201
Title: S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis.
Journal: Molecular pharmacology 20120201
Title: Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury.
Journal: Journal of the American Society of Nephrology : JASN 20120201
Title: Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.
Journal: Thorax 20120201
Title: Therapeutic dosing of fingolimod (FTY720) prevents cell infiltration, rapidly suppresses ocular inflammation, and maintains the blood-ocular barrier.
Journal: The American journal of pathology 20120201
Title: Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.
Journal: Archives of biochemistry and biophysics 20120201
Title: Immune regulation by sphingosine 1-phosphate and its receptors.
Journal: Archivum immunologiae et therapiae experimentalis 20120201
Title: Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors.
Journal: Biochimica et biophysica acta 20120201
Title: Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization.
Journal: Reproductive biomedicine online 20120201
Title: Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo.
Journal: Journal of dermatological science 20120201
Title: Does fingolimod in multiple sclerosis patients cause macular edema?
Journal: Journal of neurology 20120201
Title: Sphingosine 1-phosphate signalling in cancer.
Journal: Biochemical Society transactions 20120201
Title: Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
Journal: Cell cycle (Georgetown, Tex.) 20120201
Title: Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry.
Journal: Chemistry and physics of lipids 20120201
Title: Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription.
Journal: Journal of separation science 20120201
Title: Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Journal: Cancer research 20120201
Title: Fingolimod for multiple sclerosis.
Journal: Drug and therapeutics bulletin 20120201
Title: Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.
Journal: Archives of neurology 20120201
Title: Synthesis and immunomodulating activity of new analogues of fingolimod.
Journal: Archiv der Pharmazie 20120201
Title: [Role of S1P acting both inside and outside the cells].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20120201
Title: [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20120201
Title: Fingolimod for multiple sclerosis.
Journal: The New England journal of medicine 20120126
Title: Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20120125
Title: Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.
Journal: Blood 20120119
Title: PBSCs Sphingoling along S1P/S1P1 axis.
Journal: Blood 20120119
Title: Bioactive lipids from the sponge Spirastrella abata.
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: [Neurology].
Journal: Revue medicale suisse 20120111
Title: Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells.
Journal: Molecular and cellular endocrinology 20120102
Title: Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.
Journal: Clinical immunology (Orlando, Fla.) 20120101
Title: Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.
Journal: Journal of hepatology 20120101
Title: Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors.
Journal: Leukemia 20120101
Title: Sphingosine 1-phosphate in coagulation and inflammation.
Journal: Seminars in immunopathology 20120101
Title: The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.
Journal: Molecular biology reports 20120101
Title: Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists.
Journal: Cellular signalling 20120101
Title: Nuclear sphingolipid metabolism.
Journal: Annual review of physiology 20120101
Title: Role of FAK in S1P-regulated endothelial permeability.
Journal: Microvascular research 20120101
Title: Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.
Journal: Cellular signalling 20120101
Title: The natural cardioprotective particle HDL modulates connexin43 gap junction channels.
Journal: Cardiovascular research 20120101
Title: Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.
Journal: American journal of respiratory and critical care medicine 20120101
Title: Sphingosine-1-phosphate signaling and its role in disease.
Journal: Trends in cell biology 20120101
Title: CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy.
Journal: The American journal of pathology 20120101
Title: Sphingosine in plants--more riddles from the Sphinx?
Journal: The New phytologist 20120101
Title: Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20120101
Title: Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
Journal: Bioorganic & medicinal chemistry 20120101
Title: Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn.
Journal: Acta pharmacologica Sinica 20120101
Title: Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20120101
Title: Clinical pharmacokinetics of fingolimod.
Journal: Clinical pharmacokinetics 20120101
Title: Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.
Journal: Annual review of immunology 20120101
Title: Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.
Journal: Bioorganic & medicinal chemistry letters 20120101
Title: Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.
Journal: Cellular immunology 20120101
Title: Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi.
Journal: Molecular and biochemical parasitology 20120101
Title: The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines.
Journal: Current pharmaceutical design 20120101
Title: Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin.
Journal: PloS one 20120101
Title: FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells.
Journal: PloS one 20120101
Title: Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis.
Journal: Indian journal of ophthalmology 20120101
Title: [Research progress of the selective sphingosine-1-phosphate receptor 1 agonists].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120101
Title: Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.
Journal: Cellular immunology 20120101
Title: Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice.
Journal: Molecular vision 20120101
Title: Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Isoform-selective assays for sphingosine kinase activity.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: A cleanup method for mass spectrometry of sphingosine-1-phosphate in blood and solid tissues using a phosphate capture molecule.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Sphingosine-1-phosphate signaling in skeletal muscle cells.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Sphingosine-1-phosphate signaling in neural progenitors.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries.
Journal: PloS one 20120101
Title: Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swine.
Journal: PloS one 20120101
Title: Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.
Journal: PloS one 20120101
Title: Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.
Journal: PloS one 20120101
Title: Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures.
Journal: PloS one 20120101
Title: Sphingosine-1-phosphate signaling in physiology and diseases.
Journal: BioFactors (Oxford, England) 20120101
Title: Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells.
Journal: Clinical and experimental obstetrics & gynecology 20120101
Title: [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101
Title: The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes.
Journal: PloS one 20120101
Title: Topographical and biological evidence revealed FTY720-mediated anergy-polarization of mouse bone marrow-derived dendritic cells in vitro.
Journal: PloS one 20120101
Title: Oral FTY720 administration induces immune tolerance and inhibits early development of atherosclerosis in apolipoprotein E-deficient mice.
Journal: International journal of immunopathology and pharmacology 20120101
Title: Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells.
Journal: PloS one 20120101
Title: Effect of FTY720 on some physiological indexes of Non-Obese Diabetic (NOD) Mice.
Journal: International journal of molecular sciences 20120101
Title: Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis.
Journal: PloS one 20120101
Title: Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Journal: Asian Pacific journal of cancer prevention : APJCP 20120101
Title: Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
Journal: PloS one 20120101
Title: Therapeutic approach to steroid-resistant dermatitis using novel immunomodulator FTY720 (Fingolimod) in combination with betamethasone ointment in NC/Nga mice.
Journal: Biological & pharmaceutical bulletin 20120101
Title: The essential structures of ISP-I that influence serine palmitoyltransferase inhibition in Chinese hamster ovary cells.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Dealing with excess of zeros in the statistical analysis of magnetic resonance imaging lesion count in multiple sclerosis.
Journal: Pharmaceutical statistics 20120101
Title: Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, fingolimod will change therapeutic paradigm approach.
Journal: Drug design, development and therapy 20120101
Title: Fingolimod in the treatment algorithm of relapsing remitting multiple sclerosis: a statement of the Central and East European (CEE) MS Expert Group.
Journal: Wiener medizinische Wochenschrift (1946) 20120101
Title: 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin.
Journal: Lipids in health and disease 20120101
Title: [Changes in content of glycolipids, sphingosine and cytokines in the rat brain with experimental edema].
Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101
Title: Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A.
Journal: PloS one 20120101
Title: Synthesis of a key intermediate for the preparation of FTY720 analogs.
Journal: Chemical & pharmaceutical bulletin 20120101
Title: Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.
Journal: The Journal of biological chemistry 20111230
Title: FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.
Journal: Blood 20111222
Title: Effects of sphingosine 2N- and 3O-methylation on palmitoyl ceramide properties in bilayer membranes.
Journal: Biophysical journal 20111221
Title: Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.
Journal: The Biochemical journal 20111215
Title: The in vitro metabolism of sphingosine-1-phosphate: identification; inhibition and pharmacological implications.
Journal: European journal of pharmacology 20111215
Title: Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Journal: Circulation 20111213
Title: Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.
Journal: The Journal of biological chemistry 20111209
Title: Asymmetric synthesis and cytotoxic activity of isomeric phytosphingosine derivatives.
Journal: Organic & biomolecular chemistry 20111207
Title: Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions.
Journal: Clinical science (London, England : 1979) 20111201
Title: ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium.
Journal: Cellular signalling 20111201
Title: Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.
Journal: Biochimica et biophysica acta 20111201
Title: Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.
Journal: Cellular signalling 20111201
Title: Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana.
Journal: The New phytologist 20111201
Title: Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.
Journal: Pharmacology & therapeutics 20111201
Title: Integral hair lipid in human hair follicle.
Journal: Journal of dermatological science 20111201
Title: Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20111201
Title: Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism.
Journal: Atherosclerosis 20111201
Title: Complex modulation of peptidolytic activity of cathepsin D by sphingolipids.
Journal: Biochimica et biophysica acta 20111201
Title: Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.
Journal: Molecular endocrinology (Baltimore, Md.) 20111201
Title: Extracellular and intracellular sphingosine-1-phosphate in cancer.
Journal: Cancer metastasis reviews 20111201
Title: Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Journal: Molecular endocrinology (Baltimore, Md.) 20111201
Title: Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regeneration.
Journal: The Journal of pathology 20111201
Title: The debut of a rational treatment for an inherited neuropathy?
Journal: The Journal of clinical investigation 20111201
Title: Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.
Journal: The Journal of clinical investigation 20111201
Title: [Bone and calcium update; bone research update. Trafficking of osteoclast precursors visualized by intravital imaging technology].
Journal: Clinical calcium 20111201
Title: Role of the sphingosine rheostat in the regulation of cnidarian-dinoflagellate symbioses.
Journal: The Biological bulletin 20111201
Title: Cardioprotective role of sphingosine-1-phosphate.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20111201
Title: Setting the clock for recirculating lymphocytes.
Journal: Science signaling 20111108
Title: Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction.
Journal: Journal of cellular and molecular medicine 20111101
Title: Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells.
Journal: Journal of cellular physiology 20111101
Title: Exercise increases plasma levels of sphingoid base-1 phosphates in humans.
Journal: Acta physiologica (Oxford, England) 20111101
Title: FTY720-induced conversion of conventional Foxp3- CD4+ T cells to Foxp3+ regulatory T cells in NOD mice.
Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20111101
Title: Delayed fingolimod-associated asystole.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20111101
Title: Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.
Journal: Neurochemical research 20111101
Title: Sphingolipid metabolism and leukemia: a potential for novel therapeutic approaches.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: Hypoxia-inducible factors and sphingosine 1-phosphate signaling.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: Regulation of autophagy by sphingolipids.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: S1P regulation of macrophage functions in the context of cancer.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: Targeting sphingosine-1-phosphate receptors in cancer.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: Targeting sphingosine-1-phosphate in hematologic malignancies.
Journal: Anti-cancer agents in medicinal chemistry 20111101
Title: Oral fingolimod (FTY720) in relapsing multiple sclerosis: impact on health-related quality of life in a phase II study.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20111101
Title: Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.
Journal: Journal of cellular biochemistry 20111101
Title: Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions.
Journal: Experimental dermatology 20111101
Title: Sphingosine-1-phospate receptor 4 (S1P₄) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111101
Title: The involvement of jasmonates and ethylene in Alternaria alternata f. sp. lycopersici toxin-induced tomato cell death.
Journal: Journal of experimental botany 20111101
Title: FTY720 combined with tacrolimus in de novo renal transplantation: 1-year, multicenter, open-label randomized study.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101
Title: Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Journal: Cancer research 20111101
Title: Background and rationale for mechanism of action, efficacy, and safety of fingolimod (Gilenya), the first oral therapy for remitting-relapsing multiple sclerosis: with special emphasis upon visual safety.
Journal: Current opinion in ophthalmology 20111101
Title: Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols.
Journal: European journal of medicinal chemistry 20111101
Title: A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.
Journal: Basic research in cardiology 20111101
Title: Oral treatment for multiple sclerosis.
Journal: The Lancet. Neurology 20111101
Title: Short-term immunossupressive treatment of the donor does not prevent ischemia-reperfusion kidney damage in the rat.
Journal: Transplantation proceedings 20111101
Title: [Multiple sclerosis: current therapies and future perspectives].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101
Title: C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides.
Journal: Molecules and cells 20111031
Title: Syntheses of sulfur and selenium analogues of pachastrissamine via double displacements of cyclic sulfate.
Journal: Organic & biomolecular chemistry 20111021
Title: Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.
Journal: Chemical reviews 20111012
Title: Lysosomal storage causes cellular dysfunction in mucolipidosis II skin fibroblasts.
Journal: The Journal of biological chemistry 20111007
Title: Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation.
Journal: Cell biology international 20111001
Title: Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.
Journal: Cellular and molecular neurobiology 20111001
Title: (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Journal: Cellular signalling 20111001
Title: G-protein-coupled receptors in control of natural killer cell migration.
Journal: Trends in immunology 20111001
Title: Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia.
Journal: Journal of clinical immunology 20111001
Title: Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury.
Journal: American journal of physiology. Heart and circulatory physiology 20111001
Title: Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
Title: GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels.
Journal: Cell calcium 20111001
Title: Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats.
Journal: Diabetes research and clinical practice 20111001
Title: Fingolimod for multiple sclerosis: mechanism of action, clinical outcomes, and future directions.
Journal: Current neurology and neuroscience reports 20111001
Title: Mechanisms involved in α1B-adrenoceptor desensitization.
Journal: IUBMB life 20111001
Title: The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism.
Journal: Critical reviews in biochemistry and molecular biology 20111001
Title: The role of sphingolipids in respiratory disease.
Journal: Therapeutic advances in respiratory disease 20111001
Title: Reactive oxygen species as transducers of sphinganine-mediated cell death pathway.
Journal: Plant signaling & behavior 20111001
Title: Fingolimod treatment for multiple sclerosis patients What do we do with varicella?
Journal: Annals of neurology 20111001
Title: [The study of FTY720 on inducing apoptosis and autophagy in multiple myeloma cell line U266].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20111001
Title: GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Journal: Science (New York, N.Y.) 20110930
Title: A facile synthesis of D-ribo-C(20)-phytosphingosine and its C2 epimer from D-ribose.
Journal: Carbohydrate research 20110927
Title: Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia.
Journal: Biochemical and biophysical research communications 20110923
Title: The sphingosine-1-phosphate derivative NHOBTD inhibits angiogenesis both in vitro and in vivo.
Journal: Biochemical and biophysical research communications 20110923
Title: The effect of FTY720 in the Theiler's virus model of multiple sclerosis.
Journal: Journal of the neurological sciences 20110915
Title: Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C.
Journal: Bioorganic & medicinal chemistry 20110915
Title: Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer.
Journal: Nature reviews. Urology 20110913
Title: Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia.
Journal: Blood 20110908
Title: FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2.
Journal: The Journal of biological chemistry 20110902
Title: There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells.
Journal: Neurochemical research 20110901
Title: The sphingosine 1-phosphate receptor modulator FTY720 prevents iodide-induced autoimmune thyroiditis in non-obese diabetic mice.
Journal: Autoimmunity 20110901
Title: MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis.
Journal: The New phytologist 20110901
Title: TLR2 and TLR4 expression after kidney ischemia and reperfusion injury in mice treated with FTY720.
Journal: International immunopharmacology 20110901
Title: Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.
Journal: The Journal of pharmacology and experimental therapeutics 20110901
Title: Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.
Journal: Journal of cellular physiology 20110901
Title: Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation.
Journal: Journal of cellular physiology 20110901
Title: P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels.
Journal: American journal of physiology. Heart and circulatory physiology 20110901
Title: PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.
Journal: Protein science : a publication of the Protein Society 20110901
Title: Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
Journal: American journal of physiology. Cell physiology 20110901
Title: Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.
Journal: Molecular and cellular neurosciences 20110901
Title: FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110901
Title: Branch retinal vein occlusion during fingolimod treatment in a patient with multiple sclerosis.
Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20110901
Title: New insights into cell death induced by long chain bases in Arabidopsis.
Journal: The New phytologist 20110901
Title: Post-translational modification of 14-3-3 isoforms and regulation of cellular function.
Journal: Seminars in cell & developmental biology 20110901
Title: A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).
Journal: Discovery medicine 20110901
Title: Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution.
Journal: The Journal of biological chemistry 20110826
Title: NICE rules out NHS prescription of fingolimod for multiple sclerosis.
Journal: BMJ (Clinical research ed.) 20110810
Title: Sphingosine-1-phosphate: a potential therapeutic target for rheumatoid arthritis.
Journal: Molecular biology reports 20110801
Title: Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.
Journal: American journal of respiratory cell and molecular biology 20110801
Title: Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism.
Journal: Cell death and differentiation 20110801
Title: Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.
Journal: Digestive diseases and sciences 20110801
Title: The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
Journal: Pulmonary pharmacology & therapeutics 20110801
Title: Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20110801
Title: Translational aspects of sphingosine 1-phosphate biology.
Journal: Trends in molecular medicine 20110801
Title: Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol.
Journal: Biochimica et biophysica acta 20110801
Title: Sphingolipid modulation of angiogenic factor expression in neuroblastoma.
Journal: Cancer prevention research (Philadelphia, Pa.) 20110801
Title: Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.
Journal: Journal of neurochemistry 20110801
Title: Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain.
Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110801
Title: Serine palmitoyltransferase inhibitor myriocin induces growth inhibition of B16F10 melanoma cells through G(2) /M phase arrest.
Journal: Cell proliferation 20110801
Title: Oral fingolimod for the treatment of patients with relapsing forms of multiple sclerosis.
Journal: International journal of clinical practice 20110801
Title: Natural product drug discovery: the successful optimization of ISP-1 and halichondrin B.
Journal: Current opinion in chemical biology 20110801
Title: Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases.
Journal: Cell calcium 20110801
Title: Activation of matriptase zymogen.
Journal: Journal of biochemistry 20110801
Title: Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.
Journal: Critical reviews in biochemistry and molecular biology 20110801
Title: Fingolimod: a review of its use in the management of relapsing-remitting multiple sclerosis.
Journal: CNS drugs 20110801
Title: Melanoma occurring during treatment with fingolimod for multiple sclerosis: a case report.
Journal: Archives of dermatology 20110801
Title: Multiple sclerosis treatment: First oral drug, new antibody therapies.
Journal: JAAPA : official journal of the American Academy of Physician Assistants 20110801
Title: [The study on protective effect of sphingosine-1-phosphate in cardiomyocytes].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110801
Title: Redirected tumor-specific allogeneic T cells for universal treatment of cancer.
Journal: Blood 20110728
Title: Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors.
Journal: Life sciences 20110718
Title: Targeting lymphangiogenesis after islet transplantation prolongs islet allograft survival.
Journal: Transplantation 20110715
Title: Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.
Journal: Neuroscience letters 20110715
Title: Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.
Journal: The Journal of biological chemistry 20110715
Title: Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS.
Journal: Nature reviews. Neurology 20110712
Title: Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants.
Journal: Biochemical and biophysical research communications 20110708
Title: Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence.
Journal: Biomedical chromatography : BMC 20110701
Title: FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.
Journal: The European respiratory journal 20110701
Title: S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis.
Journal: Rheumatology international 20110701
Title: Dissecting the role of the S1P/S1PR axis in health and disease.
Journal: Journal of dental research 20110701
Title: Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.
Journal: British journal of pharmacology 20110701
Title: CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells.
Journal: The Journal of investigative dermatology 20110701
Title: Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110701
Title: FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells.
Journal: Autophagy 20110701
Title: A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate.
Journal: American journal of physiology. Renal physiology 20110701
Title: Role of sphingosine-1-phosphate in the renal medulla.
Journal: American journal of physiology. Renal physiology 20110701
Title: High 1,3-trans stereoselectivity in nucleophilic substitution at the anomeric position and β-fragmentation of the primary alkoxyl radical in 3-amino-3-deoxy-ribofuranose derivatives: application to the synthesis of 2-epi-(-)-jaspine B.
Journal: The Journal of organic chemistry 20110701
Title: A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels.
Journal: Cell calcium 20110701
Title: Reduction of the peripheral blood CD56(bright) NK lymphocyte subset in FTY720-treated multiple sclerosis patients.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110701
Title: Discovery of S1P agonists with a dihydronaphthalene scaffold.
Journal: Bioorganic & medicinal chemistry letters 20110701
Title: Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq coupling.
Journal: Journal of cell science 20110701
Title: [Pharmacological targets in multiple sclerosis].
Journal: Revista de neurologia 20110701
Title: Differentiation of adult stem cells into smooth muscle for vascular tissue engineering.
Journal: The Journal of surgical research 20110615
Title: Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.
Journal: Biochemical and biophysical research communications 20110610
Title: Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
Journal: Blood 20110602
Title: Exogenous gangliosides increase the release of brain-derived neurotrophic factor.
Journal: Neuropharmacology 20110601
Title: Cloning and characterization of a wheat neutral ceramidase gene Ta-CDase.
Journal: Molecular biology reports 20110601
Title: Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility.
Journal: Journal of hepatology 20110601
Title: Sphingosine 1-phosphate receptor modulator FTY720 suppresses rat experimental autoimmune prostatitis.
Journal: Scandinavian journal of immunology 20110601
Title: Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
Journal: Hepatology (Baltimore, Md.) 20110601
Title: Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20110601
Title: Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.
Journal: American journal of physiology. Lung cellular and molecular physiology 20110601
Title: The outs and the ins of sphingosine-1-phosphate in immunity.
Journal: Nature reviews. Immunology 20110601
Title: New drugs 2011 part 2.
Journal: Nursing 20110601
Title: Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice.
Journal: The Journal of clinical investigation 20110601
Title: Transforming multiple sclerosis trials into practical reality.
Journal: The Lancet. Neurology 20110601
Title: Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study.
Journal: The Lancet. Neurology 20110601
Title: Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants.
Journal: Pediatric transplantation 20110601
Title: Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I.
Journal: Human mutation 20110601
Title: Determination of sphingosine kinase 2 activity using fluorescent sphingosine by capillary electrophoresis.
Journal: Electrophoresis 20110601
Title: [Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia].
Journal: Zhongguo shi yan xue ye xue za zhi 20110601
Title: [Cardiovascular function of sphingosine 1-phosphate signaling].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20110601
Title: The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy.
Journal: Molecules and cells 20110531
Title: FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Journal: The Journal of biological chemistry 20110527
Title: Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.
Journal: Journal of medicinal chemistry 20110526
Title: HDL and sphingosine-1-phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion.
Journal: The Prostate 20110515
Title: Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.
Journal: The Journal of biological chemistry 20110506
Title: BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504
Title: Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function.
Journal: Digestive diseases and sciences 20110501
Title: Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB.
Journal: Cellular and molecular life sciences : CMLS 20110501
Title: Magnetic resonance imaging as surrogate for clinical endpoints in multiple sclerosis: data on novel oral drugs.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20110501
Title: Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501
Title: S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
Journal: American journal of physiology. Cell physiology 20110501
Title: Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
Journal: Kidney international 20110501
Title: Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages.
Journal: Microbiology (Reading, England) 20110501
Title: Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.
Journal: Biochimica et biophysica acta 20110501
Title: S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.
Journal: American journal of physiology. Heart and circulatory physiology 20110501
Title: Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination.
Journal: Analytical and bioanalytical chemistry 20110501
Title: Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110501
Title: Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts.
Journal: Endocrinology 20110501
Title: The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.
Journal: Molecular immunology 20110501
Title: Managing MS in a changing treatment landscape.
Journal: Journal of neurology 20110501
Title: Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells.
Journal: Plant signaling & behavior 20110501
Title: Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.
Journal: Annals of neurology 20110501
Title: Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease.
Journal: Future medicinal chemistry 20110501
Title: [Genetic dissection of cardiac morphogenesis in zebrafish].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20110501
Title: Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts.
Journal: Biochemical and biophysical research communications 20110429
Title: Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite.
Journal: Journal of natural products 20110425
Title: Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720.
Journal: The Journal of biological chemistry 20110422
Title: A rapid assay for assessment of sphingosine kinase inhibitors and substrates.
Journal: Analytical biochemistry 20110415
Title: A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110415
Title: Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.
Journal: Biochemical pharmacology 20110415
Title: Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
Journal: The Journal of biological chemistry 20110415
Title: Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS.
Journal: Neurology 20110405
Title: Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer.
Journal: Investigational new drugs 20110401
Title: Sphingosine kinase and sphingosine 1-phosphate in asthma.
Journal: Bioscience reports 20110401
Title: Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids.
Journal: British journal of pharmacology 20110401
Title: G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20110401
Title: Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation.
Journal: Journal of thrombosis and haemostasis : JTH 20110401
Title: Redox regulation of ERK1/2 activation induced by sphingosine 1-phosphate in fibroblasts: involvement of NADPH oxidase and platelet-derived growth factor receptor.
Journal: Biochimica et biophysica acta 20110401
Title: S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells.
Journal: American journal of physiology. Cell physiology 20110401
Title: Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
Journal: Journal of cellular biochemistry 20110401
Title: Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.
Journal: Glia 20110401
Title: Anti-ageing effects of a new synthetic sphingolipid (K6EAA-L12) on aged murine skin.
Journal: Experimental dermatology 20110401
Title: Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110401
Title: Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20110401
Title: Fingolimod: an oral disease-modifying therapy for relapsing multiple sclerosis.
Journal: Advances in therapy 20110401
Title: Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.
Journal: Molecular cancer therapeutics 20110401
Title: Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.
Journal: The American journal of pathology 20110401
Title: [An active lipid signaling molecule: sphingosine-1-phosphate and its biological characteristics].
Journal: Sheng li ke xue jin zhan [Progress in physiology] 20110401
Title: Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor α and interleukin 1α: interaction with follicle-stimulating hormone/adenosine 3',5'-cyclic phosphate signalling.
Journal: Molecular and cellular endocrinology 20110330
Title: Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers via η3-allylpalladium intermediates.
Journal: Organic & biomolecular chemistry 20110321
Title: Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells.
Journal: Archives of biochemistry and biophysics 20110315
Title: Local inactivation of sphingosine 1-phosphate in lymph nodes induces lymphopenia.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110315
Title: In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates.
Journal: Fertility and sterility 20110315
Title: Primary varicella zoster infection associated with fingolimod treatment.
Journal: Neurology 20110315
Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers -- Letter.
Journal: Cancer research 20110315
Title: Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
Journal: The Journal of biological chemistry 20110304
Title: Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.
Journal: Autoimmunity 20110301
Title: Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth.
Journal: Tissue engineering. Part A 20110301
Title: Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase.
Journal: Cell death and differentiation 20110301
Title: Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis.
Journal: International immunopharmacology 20110301
Title: Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1.
Journal: Biology of reproduction 20110301
Title: Circulating sphingolipid biomarkers in models of type 1 diabetes.
Journal: Journal of lipid research 20110301
Title: Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.
Journal: British journal of pharmacology 20110301
Title: Involvement of sphingosine-1-phosphate/RhoA/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats.
Journal: The journal of sexual medicine 20110301
Title: Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator.
Journal: Biochemical pharmacology 20110301
Title: The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue.
Journal: Experimental dermatology 20110301
Title: Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes.
Journal: Biochimica et biophysica acta 20110301
Title: Aerobic training in rats increases skeletal muscle sphingomyelinase and serine palmitoyltransferase activity, while decreasing ceramidase activity.
Journal: Lipids 20110301
Title: Dihydrosphingosine-induced programmed cell death in tobacco BY-2 cells is independent of H₂O₂ production.
Journal: Molecular plant 20110301
Title: Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
Journal: Pain 20110301
Title: Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
Journal: Cancer biology & therapy 20110301
Title: Simultaneous determination of sphingosine and sphingosine 1-phosphate in biological samples by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110301
Title: Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: [Encounter of cancer cells with bone. In vivo imaging of osteoclasts and their precursors in intact bone tissues].
Journal: Clinical calcium 20110301
Title: The role of reactive oxygen species and autophagy in safingol-induced cell death.
Journal: Cell death & disease 20110301
Title: [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20110301
Title: Sphingosine-1-phosphate decreases melanin synthesis via microphthalmia-associated transcription factor phosphorylation through the S1P3 receptor subtype.
Journal: The Journal of pharmacy and pharmacology 20110301
Title: Embryonic pig pancreatic tissue for the treatment of diabetes: potential role of immune suppression with 'off-the-shelf' third-party regulatory T cells.
Journal: Transplantation 20110227
Title: Impact of sphingosine 1-phosphate modulation on immune outcomes.
Journal: Neurology 20110222
Title: Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis.
Journal: Neurology 20110222
Title: Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy.
Journal: Neurology 20110222
Title: Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.
Journal: Neurology 20110222
Title: The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators.
Journal: Neurology 20110222
Title: Modulation of sphingosine 1-phosphate signaling in neurologic disease.
Journal: Neurology 20110222
Title: [Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells].
Journal: Zhonghua yi xue za zhi 20110215
Title: Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis.
Journal: Circulation research 20110204
Title: Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.
Journal: Cell death and differentiation 20110201
Title: [Oral fingolimod in multiple sclerosis: therapeutic modulation of the sphingosine-1-phosphate system].
Journal: Der Nervenarzt 20110201
Title: Emerging disease-modifying oral therapies for multiple sclerosis.
Journal: Journal of neuroimmunology 20110201
Title: Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation.
Journal: Autoimmunity reviews 20110201
Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201
Title: Roles for lysophospholipid S1P receptors in multiple sclerosis.
Journal: Critical reviews in biochemistry and molecular biology 20110201
Title: Absorption and disposition of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in healthy volunteers: a case of xenobiotic biotransformation following endogenous metabolic pathways.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: Sphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling.
Journal: Cytokine & growth factor reviews 20110201
Title: Modulation of sphingosine 1-phosphate and tyrosine hydroxylase in the stress-induced anxiety.
Journal: Neurochemical research 20110201
Title: Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.
Journal: Archives of biochemistry and biophysics 20110201
Title: Fingolimod for the treatment of relapsing multiple sclerosis.
Journal: Expert review of neurotherapeutics 20110201
Title: Systemic influence of immunosuppressive drugs on small and large bowel transport and barrier function.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20110201
Title: The ceramide-enriched trans-Golgi compartments reorganize together with other parts of the Golgi apparatus in response to ATP-depletion.
Journal: Histochemistry and cell biology 20110201
Title: Sphingosine-1-phosphate reduces hepatic ischaemia/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice.
Journal: Nephrology (Carlton, Vic.) 20110201
Title: High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry.
Journal: Journal of biomolecular screening 20110201
Title: Multiple sclerosis in 2010: Advances in monitoring and treatment of multiple sclerosis.
Journal: Nature reviews. Neurology 20110201
Title: S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism.
Journal: Cell death & disease 20110201
Title: Identification and evaluation of neutral sphingomyelinase 2 inhibitors.
Journal: Archives of pharmacal research 20110201
Title: Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients.
Journal: Annals of neurology 20110201
Title: [Current treatment of multiple sclerosis].
Journal: Lege artis medicinae : uj magyar orvosi hirmondo 20110201
Title: The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.
Journal: The Journal of biological chemistry 20110121
Title: Regioselective inversion of the hydroxyl group in D-ribo-phytosphingosine via a cyclic sulfate and bis-sulfonate intermediate.
Journal: The Journal of organic chemistry 20110121
Title: Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.
Journal: Biochemical and biophysical research communications 20110107
Title: Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110101
Title: Possible roles of phospholipase A(2) in the biological activities of Acanthamoeba castellanii (T4 Genotype).
Journal: Protist 20110101
Title: CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110101
Title: Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Journal: Biochimie 20110101
Title: Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal.
Journal: Analytical biochemistry 20110101
Title: Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis.
Journal: The Journal of investigative dermatology 20110101
Title: Differential responses of human microglia and blood-derived myeloid cells to FTY720.
Journal: Journal of neuroimmunology 20110101
Title: Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis.
Journal: American journal of physiology. Cell physiology 20110101
Title: Sphingosine kinase localization in the control of sphingolipid metabolism.
Journal: Advances in enzyme regulation 20110101
Title: Lipid component quantitation by thin layer chromatography.
Journal: Methods in molecular biology (Clifton, N.J.) 20110101
Title: Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved.
Journal: CNS drugs 20110101
Title: Sphingosine-1-phosphate and immune regulation: trafficking and beyond.
Journal: Trends in pharmacological sciences 20110101
Title: Dose-dependent effect of sphingosine-1-phosphate in mouse oocyte maturation medium on subsequent embryo development.
Journal: Gynecologic and obstetric investigation 20110101
Title: Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.
Journal: Microcirculation (New York, N.Y. : 1994) 20110101
Title: Therapeutic approach to multiple sclerosis by novel oral drug.
Journal: Recent patents on inflammation & allergy drug discovery 20110101
Title: Investigation of the molecular structure of the human stratum corneum ceramides [NP] and [EOS] by mass spectrometry.
Journal: Skin pharmacology and physiology 20110101
Title: New drugs: dabigatran etexilate mesylate, fingolimod hydrochloride, and ulipristal acetate.
Journal: Journal of the American Pharmacists Association : JAPhA 20110101
Title: A matter of fat: interaction between nitric oxide and sphingolipid signaling in plant cold response.
Journal: Plant signaling & behavior 20110101
Title: Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls.
Journal: Current topics in medicinal chemistry 20110101
Title: Fingolimod provides long-term protection in rodent models of cerebral ischemia.
Journal: Annals of neurology 20110101
Title: Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase.
Journal: PloS one 20110101
Title: Potential of D-erythro-C14-Sphingosine as an adjuvant for a fungal pesticide of Nomuraea rileyi.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: Genetic evidence for involvement of neuronally expressed S1P₁ receptor in nociceptor sensitization and inflammatory pain.
Journal: PloS one 20110101
Title: [Immunosuppressive agents in kidney transplantation].
Journal: Nihon Jinzo Gakkai shi 20110101
Title: Current disease-modifying treatment of multiple sclerosis.
Journal: The Mount Sinai journal of medicine, New York 20110101
Title: Multiple sclerosis therapeutic pipeline: opportunities and challenges.
Journal: The Mount Sinai journal of medicine, New York 20110101
Title: Chemotherapy-induced late transgenerational effects in mice.
Journal: PloS one 20110101
Title: Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells.
Journal: Nutrition and cancer 20110101
Title: The effect of amino acids on the C₁₄-sphingosine-triggered germination of Nomuraea rileyi, and surface amino acids on Spodoptera litura fabricius.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease.
Journal: Lipids in health and disease 20110101
Title: S1P is associated with protection in human and experimental cerebral malaria.
Journal: Molecular medicine (Cambridge, Mass.) 20110101
Title: Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
Journal: PloS one 20110101
Title: Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells.
Journal: Methods in molecular biology (Clifton, N.J.) 20110101
Title: Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension.
Journal: BMC genetics 20110101
Title: Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice.
Journal: Pharmacological reports : PR 20110101
Title: Inverse relationship between adipocyte differentiation and ceramide level in 3T3-L1 cells.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Relapse of experimental autoimmune encephalomyelitis after discontinuation of FTY720 (Fingolimod) treatment, but not after combination of FTY720 and pathogenic autoantigen.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6.
Journal: PloS one 20110101
Title: Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions.
Journal: Journal of biomedical science 20110101
Title: The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development.
Journal: BMC developmental biology 20110101
Title: Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.
Journal: PloS one 20110101
Title: Mechanism of sphingosine 1-phosphate- and lysophosphatidic acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.
Journal: International journal of molecular sciences 20110101
Title: Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery.
Journal: PloS one 20110101
Title: FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
Journal: PloS one 20110101
Title: Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection.
Journal: Cellular immunology 20110101
Title: An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.
Journal: Advances in experimental medicine and biology 20110101
Title: FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice.
Journal: Acta neurochirurgica. Supplement 20110101
Title: Fingolimod modulates microglial activation to augment markers of remyelination.
Journal: Journal of neuroinflammation 20110101
Title: CREST--a large and diverse superfamily of putative transmembrane hydrolases.
Journal: Biology direct 20110101
Title: Fingolimod.
Journal: Prescrire international 20110101
Title: Cost-effectiveness of natalizumab versus fingolimod for the treatment of relapsing multiple sclerosis.
Journal: Journal of medical economics 20110101
Title: Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide.
Journal: PloS one 20110101
Title: Orally administered glucosylceramide improves the skin barrier function by upregulating genes associated with the tight junction and cornified envelope formation.
Journal: Bioscience, biotechnology, and biochemistry 20110101
Title: A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders.
Journal: PloS one 20110101
Title: Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects.
Journal: Journal of biomedical science 20110101
Title: Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Journal: Lipids in health and disease 20110101
Title: Novel therapeutic approaches to autoimmune demyelinating disorders.
Journal: Current pharmaceutical design 20110101
Title: Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Title: Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes.
Journal: Reproduction, fertility, and development 20110101
Title: Heart sphingolipids in health and disease.
Journal: Advances in experimental medicine and biology 20110101
Title: Blood sphingolipids in homeostasis and pathobiology.
Journal: Advances in experimental medicine and biology 20110101
Title: [A plan for risk management in the treatment of multiple sclerosis with gilenia (fingolimod)].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101
Title: Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells.
Journal: BMC cancer 20110101
Title: Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
Journal: PloS one 20110101
Title: Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia.
Journal: PloS one 20110101
Title: The immunosuppressant FTY720 (fingolimod) enhances glycosaminoglycan depletion in articular cartilage.
Journal: BMC musculoskeletal disorders 20110101
Title: LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
Journal: PloS one 20110101
Title: Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.
Journal: Neuroscience 20101229
Title: Oral fingolimod (gilenya) for multiple sclerosis.
Journal: The Medical letter on drugs and therapeutics 20101229
Title: Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
Journal: The Journal of biological chemistry 20101224
Title: Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
Journal: American journal of respiratory cell and molecular biology 20101201
Title: Effects of different dose of FTY720 on lymphocyte cell cycle arrest in cardiac transplantation model of rats.
Journal: Immunopharmacology and immunotoxicology 20101201
Title: Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20101201
Title: Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers.
Journal: Investigative ophthalmology & visual science 20101201
Title: Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis.
Journal: Cellular and molecular life sciences : CMLS 20101201
Title: Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death.
Journal: Neurotoxicology 20101201
Title: Global analysis of circulating metabolites in hibernating ground squirrels.
Journal: Comparative biochemistry and physiology. Part D, Genomics & proteomics 20101201
Title: p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101201
Title: Plasma gelsolin modulates cellular response to sphingosine 1-phosphate.
Journal: American journal of physiology. Cell physiology 20101201
Title: Effects of sphingosine-1-phosphate on acute contractile heart failure (ACHF).
Journal: Cardiovascular drugs and therapy 20101201
Title: Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₁ and S1P₃ and Smad-signalling.
Journal: Cytoskeleton (Hoboken, N.J.) 20101201
Title: Identification of specific inhibitors for a trypanosomatid RNA editing reaction.
Journal: RNA (New York, N.Y.) 20101201
Title: Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20101201
Title: Signal transduction pathways and transcriptional regulation in Th17 cell differentiation.
Journal: Cytokine & growth factor reviews 20101201
Title: Dental pulp stem cell migration.
Journal: Journal of endodontics 20101201
Title: T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract.
Journal: Nature medicine 20101201
Title: Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis.
Journal: Cancer research 20101201
Title: Understanding the effects of FTY720 on leukocyte trafficking.
Journal: Archives of neurology 20101201
Title: Distinct properties of circulating CD8+ T cells in FTY720-treated patients with multiple sclerosis.
Journal: Archives of neurology 20101201
Title: Effect of FTY720 treatment on postischemic pancreatic microhemodynamics.
Journal: Transplantation proceedings 20101201
Title: FDA approves the first oral drug for reducing multiple sclerosis relapses.
Journal: Harvard women's health watch 20101201
Title: Penasins A-E, long-chain cytotoxic sphingoid bases, from a marine sponge Penares sp.
Journal: Journal of natural products 20101129
Title: A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation.
Journal: Organic & biomolecular chemistry 20101121
Title: Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101117
Title: The influences of sphingolipid metabolites on gentamicin-induced hair cell loss of the rat cochlea.
Journal: Neuroscience letters 20101112
Title: Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.
Journal: The Journal of biological chemistry 20101112
Title: Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
Journal: The Journal of biological chemistry 20101112
Title: Importance of the sphingosine base double-bond geometry for the structural and thermodynamic properties of sphingomyelin bilayers.
Journal: Biophysical journal 20101103
Title: SHEP1 partners with CasL to promote marginal zone B-cell maturation.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20101102
Title: Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs.
Journal: Archives of dermatological research 20101101
Title: Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells.
Journal: Journal of bone and mineral metabolism 20101101
Title: Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer.
Journal: Breast cancer research and treatment 20101101
Title: Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels.
Journal: Cardiovascular research 20101101
Title: Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.
Journal: Journal of cellular physiology 20101101
Title: The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver.
Journal: Prostaglandins & other lipid mediators 20101101
Title: Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells.
Journal: Cellular signalling 20101101
Title: Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease.
Journal: Basic research in cardiology 20101101
Title: Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules.
Journal: American journal of physiology. Heart and circulatory physiology 20101101
Title: Selective deuterium labeling of the sphingoid backbone: facile syntheses of 3,4,5-trideuterio-d-erythro-sphingosine and 3-deuterio-d-erythro-sphingomyelin.
Journal: Chemistry and physics of lipids 20101101
Title: The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
Journal: Journal of neurophysiology 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver.
Journal: Prostaglandins & other lipid mediators 20101101
Title: The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.
Journal: Nature immunology 20101101
Title: High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.
Journal: The American journal of pathology 20101101
Title: Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.
Journal: Stroke 20101101
Title: FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.
Journal: Autophagy 20101101
Title: Ethanolamine is a novel STAT-3 dependent cardioprotective agent.
Journal: Basic research in cardiology 20101101
Title: FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
Journal: Cancer research 20101101
Title: Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.
Journal: The Journal of clinical investigation 20101101
Title: Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.
Journal: Nature reviews. Drug discovery 20101101
Title: Novartis eyes oral MS drug as potential blockbuster.
Journal: Nature biotechnology 20101101
Title: [Role of T lymphocytes in ischemic brain injury].
Journal: Rinsho shinkeigaku = Clinical neurology 20101101
Title: Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway.
Journal: Archives of biochemistry and biophysics 20101015
Title: Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.
Journal: The Journal of biological chemistry 20101015
Title: Effect of sphingosine on domain morphology in giant vesicles.
Journal: Journal of colloid and interface science 20101015
Title: Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms.
Journal: Biochemical and biophysical research communications 20101015
Title: Design and synthesis of selective and potent orally active S1P5 agonists.
Journal: ChemMedChem 20101004
Title: Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.
Journal: Progress in lipid research 20101001
Title: Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry.
Journal: Biomedical chromatography : BMC 20101001
Title: Therapeutic applications of bioactive sphingolipids in hematological malignancies.
Journal: International journal of cancer 20101001
Title: Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.
Journal: The Journal of investigative dermatology 20101001
Title: Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma.
Journal: Pharmacological research 20101001
Title: (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
Journal: Cellular signalling 20101001
Title: FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Journal: Cellular signalling 20101001
Title: Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients.
Journal: Clinical immunology (Orlando, Fla.) 20101001
Title: Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate.
Journal: Molecular pharmacology 20101001
Title: The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling.
Journal: Biopharmaceutics & drug disposition 20101001
Title: Permissive role of sphingosine on calcium-dependent endocytosis in chromaffin cells.
Journal: Pflugers Archiv : European journal of physiology 20101001
Title: Sphingosine-1-phosphate signaling in human submandibular cells.
Journal: Journal of dental research 20101001
Title: Sphingosine 1-phosphate (S1P) induces expression of E-selectin and adhesion of monocytes via intracellular signalling pathways in vascular endothelial cells.
Journal: European journal of cell biology 20101001
Title: Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
Journal: Journal of lipid research 20101001
Title: Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction.
Journal: Circulation research 20101001
Title: Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.
Journal: Biomaterials 20101001
Title: Effect of sphingosine-1-phosphate supplementation on follicular integrity of vitrified-warmed mouse ovarian grafts.
Journal: European journal of obstetrics, gynecology, and reproductive biology 20101001
Title: Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
Journal: Carcinogenesis 20101001
Title: FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice.
Journal: The American journal of pathology 20101001
Title: Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II.
Journal: The Journal of hand surgery 20101001
Title: Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis.
Journal: Archives of pharmacal research 20101001
Title: Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.
Journal: Future oncology (London, England) 20101001
Title: Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20101001
Title: Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana.
Journal: FEBS letters 20100924
Title: Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation.
Journal: Circulation 20100914
Title: Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells.
Journal: Life sciences 20100911
Title: Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.
Journal: Progress in biophysics and molecular biology 20100901
Title: Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate.
Journal: Journal of lipid research 20100901
Title: Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation.
Journal: Molecular and cellular biochemistry 20100901
Title: Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.
Journal: Cellular signalling 20100901
Title: Emerging therapies in relapsing-remitting multiple sclerosis.
Journal: Reviews on recent clinical trials 20100901
Title: PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.
Journal: Journal of cellular biochemistry 20100901
Title: HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate.
Journal: Journal of lipid research 20100901
Title: The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein.
Journal: Biopolymers 20100901
Title: UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples.
Journal: Prostaglandins & other lipid mediators 20100901
Title: A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination.
Journal: European journal of immunology 20100901
Title: The enhancement of bone allograft incorporation by the local delivery of the sphingosine 1-phosphate receptor targeted drug FTY720.
Journal: Biomaterials 20100901
Title: Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.
Journal: Glia 20100901
Title: Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20100901
Title: Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation.
Journal: Journal of cellular and molecular medicine 20100901
Title: Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Journal: British journal of pharmacology 20100901
Title: Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.
Journal: Acta pharmacologica Sinica 20100901
Title: Emerging oral agents for multiple sclerosis.
Journal: The American journal of managed care 20100901
Title: Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.
Journal: The Journal of biological chemistry 20100827
Title: Development of a sphingosylphosphorylcholine detection system using RNA aptamers.
Journal: Molecules (Basel, Switzerland) 20100820
Title: Signalling of sphingosine-1-phosphate in Müller glial cells via the S1P/EDG-family of G-protein-coupled receptors.
Journal: Neuroscience letters 20100816
Title: Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells.
Journal: Journal of cellular biochemistry 20100815
Title: Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20100815
Title: Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism.
Journal: Structure (London, England : 1993) 20100811
Title: Asymmetric synthesis of sphinganine and ent-clavaminol [corrected] H.
Journal: The Journal of organic chemistry 20100806
Title: Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis.
Journal: Neurology 20100803
Title: FTY720 and central memory: out of sight, out of mind.
Journal: Neurology 20100803
Title: Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
Journal: The Journal of experimental medicine 20100802
Title: The sphingosine-1-phosphate pathway is upregulated in response to partial urethral obstruction in male rats and activates RhoA/Rho-kinase signalling.
Journal: BJU international 20100801
Title: TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes.
Journal: Journal of neurochemistry 20100801
Title: Effect of combined treatment with FK506, FTY720, and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Pediatric transplantation 20100801
Title: Aquilegia vulgaris L. extract counteracts oxidative stress and cytotoxicity of fumonisin in rats.
Journal: Toxicon : official journal of the International Society on Toxinology 20100801
Title: Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements.
Journal: Annals of biomedical engineering 20100801
Title: Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model.
Journal: Clinical immunology (Orlando, Fla.) 20100801
Title: Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation.
Journal: Laboratory investigation; a journal of technical methods and pathology 20100801
Title: Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells.
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20100801
Title: Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation.
Journal: Endocrinology 20100801
Title: N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF.
Journal: Apoptosis : an international journal on programmed cell death 20100801
Title: Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue-derived stem cells.
Journal: Journal of molecular cell biology 20100801
Title: Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China.
Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100801
Title: FTY720 mediates cytochrome c release from mitochondria during rat thymocyte apoptosis.
Journal: Transplant immunology 20100801
Title: Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Journal: The FEBS journal 20100801
Title: Update on emerging therapies for multiple sclerosis.
Journal: Expert review of neurotherapeutics 20100801
Title: A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis.
Journal: Discovery medicine 20100801
Title: Avoiding infusion therapy prime benefit of new MS drug.
Journal: Managed care (Langhorne, Pa.) 20100801
Title: A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity.
Journal: The Journal of biological chemistry 20100723
Title: Flexible and enantioselective access to jaspine B and biologically active chain-modified analogues thereof.
Journal: Organic & biomolecular chemistry 20100721
Title: CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4.
Journal: The Journal of biological chemistry 20100716
Title: Runx regulation of sphingolipid metabolism and survival signaling.
Journal: Cancer research 20100715
Title: Asymmetric synthesis of D-ribo-phytosphingosine from 1-tetradecyne and (4-methoxyphenoxy)acetaldehyde.
Journal: The Journal of organic chemistry 20100702
Title: L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation.
Journal: The Journal of nutritional biochemistry 20100701
Title: Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells.
Journal: American journal of respiratory cell and molecular biology 20100701
Title: Quantitative sphingosine measurement as a surrogate for total ceramide concentration-preclinical and potential translational applications.
Journal: Biomedical chromatography : BMC 20100701
Title: Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium.
Journal: Microvascular research 20100701
Title: Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100701
Title: Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes.
Journal: Biochemical pharmacology 20100701
Title: Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.
Journal: Arthritis and rheumatism 20100701
Title: Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20100701
Title: S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate.
Journal: American journal of physiology. Lung cellular and molecular physiology 20100701
Title: Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms.
Journal: Journal of neurochemistry 20100701
Title: S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration.
Journal: Endocrinology 20100701
Title: Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway.
Journal: Stroke 20100701
Title: Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.
Journal: Cancer research 20100701
Title: Fingolimod is a potential novel therapy for multiple sclerosis.
Journal: Nature reviews. Neurology 20100701
Title: Printing a tissue: a new engineering strategy for cardiovascular regeneration.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20100701
Title: Sphingosine 1-phosphate and cancer.
Journal: Nature reviews. Cancer 20100701
Title: An update on sphingosine-1-phosphate and other sphingolipid mediators.
Journal: Nature chemical biology 20100701
Title: Anti-scratching behavioral effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in mice.
Journal: Lipids 20100701
Title: Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion.
Journal: British journal of pharmacology 20100701
Title: S1P(1) receptor agonists: Assessment of selectivity and current clinical activity.
Journal: Current opinion in drug discovery & development 20100701
Title: Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100701
Title: Induction of apoptosis by sphingosine, sphinganine, and C(2)-ceramide in human colon cancer cells, but not by C(2)-dihydroceramide.
Journal: Anticancer research 20100701
Title: The effect of a phytosphingosine-like substance isolated from Asterina pectinifera on involucrin expression in mite antigen-stimulated HaCaT cells.
Journal: Natural product communications 20100701
Title: [Fingolimod in the treatment of multiple sclerosis. Novelties presented at the annual congress of the American Academy of Neurology (Toronto, April 2010)].
Journal: Drugs of today (Barcelona, Spain : 1998) 20100701
Title: [Lysophospholipids].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20100701
Title: Enhancement of stability and skin permeation by sucrose stearate and cyclodextrins in progesterone nanoemulsions.
Journal: International journal of pharmaceutics 20100630
Title: Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis.
Journal: Neuroscience letters 20100625
Title: Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Journal: Nature 20100624
Title: FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100615
Title: Critical vasospasm during fingolimod (FTY720) treatment in a patient with multiple sclerosis.
Journal: Neurology 20100615
Title: Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.
Journal: Circulation research 20100611
Title: Stereoselective divergent synthesis of four diastereomers of pachastrissamine (jaspine B).
Journal: The Journal of organic chemistry 20100604
Title: Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of propargyl chlorides and carbonates.
Journal: The Journal of organic chemistry 20100604
Title: [Emerging treatments for multiple sclerosis].
Journal: Revue medicale suisse 20100602
Title: FTY720 promotes local microvascular network formation and regeneration of cranial bone defects.
Journal: Tissue engineering. Part A 20100601
Title: Anaphylaxis: an update on its understanding and management.
Journal: Recent patents on inflammation & allergy drug discovery 20100601
Title: Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: structural characterization and immunoreactivity in cerebrospinal fluid.
Journal: Journal of lipid research 20100601
Title: S1P metabolism in cancer and other pathological conditions.
Journal: Biochimie 20100601
Title: Pannexin-I/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning.
Journal: Journal of cardiovascular pharmacology and therapeutics 20100601
Title: Hemolysis induced by Bacillus cereus sphingomyelinase.
Journal: Biochimica et biophysica acta 20100601
Title: Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.
Journal: Diabetes 20100601
Title: Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting.
Journal: Current molecular pharmacology 20100601
Title: Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Journal: Journal of the American Society of Nephrology : JASN 20100601
Title: The impact of fingolimod (FTY720) in neuroimmunologic diseases: mechanisms beyond immunomodulation.
Journal: The American journal of pathology 20100601
Title: Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices.
Journal: The American journal of pathology 20100601
Title: The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.
Journal: The Journal of clinical investigation 20100601
Title: Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.
Journal: International immunology 20100601
Title: [Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery].
Journal: Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20100601
Title: Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100526
Title: Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.
Journal: European journal of pharmacology 20100525
Title: Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis.
Journal: The Journal of biological chemistry 20100521
Title: A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury.
Journal: The Journal of biological chemistry 20100521
Title: Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets.
Journal: Chemico-biological interactions 20100514
Title: Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis.
Journal: The Journal of biological chemistry 20100507
Title: Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis.
Journal: Biochemical and biophysical research communications 20100507
Title: Oral cladribine and fingolimod for relapsing multiple sclerosis.
Journal: The New England journal of medicine 20100506
Title: Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C.
Journal: Clinica chimica acta; international journal of clinical chemistry 20100502
Title: Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse.
Journal: American journal of respiratory cell and molecular biology 20100501
Title: Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival.
Journal: Journal of lipid research 20100501
Title: Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20100501
Title: Evaluation of experimental autoimmune uveitis in mice treated with FTY720.
Journal: Investigative ophthalmology & visual science 20100501
Title: Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats.
Journal: Acta physiologica (Oxford, England) 20100501
Title: The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep.
Journal: Biology of reproduction 20100501
Title: Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity.
Journal: Cellular and molecular life sciences : CMLS 20100501
Title: Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100501
Title: Relevance of sphingolipids in the pleiotropic protective effects of high-density lipoproteins.
Journal: Current pharmaceutical design 20100501
Title: Inhibition of sodium-calcium exchange by KB-R7943: Dodecylamine and sphingosine in transfected Chinese hamster ovary cells.
Journal: Cell calcium 20100501
Title: Mammalian ceramide synthases.
Journal: IUBMB life 20100501
Title: Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal.
Journal: Stem cells (Dayton, Ohio) 20100501
Title: Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex.
Journal: Leukemia 20100501
Title: Fingolimod for relapsing multiple sclerosis: an update.
Journal: Expert opinion on pharmacotherapy 20100501
Title: Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate.
Journal: Kidney international 20100501
Title: Pecipamide, a new sphingosine derivative from the cultures of Polyporus picipes (Basidiomycetes).
Journal: Lipids 20100501
Title: The riddle of the sphinx redux.
Journal: Kidney international 20100501
Title: Identification of glucosylceramides containing sphingatrienine in maize and rice using ion trap mass spectrometry.
Journal: Lipids 20100501
Title: Oral fingolimod for the treatment of relapsing-remitting multiple sclerosis.
Journal: Drugs of today (Barcelona, Spain : 1998) 20100501
Title: [Updates on clinicopathologic findings of Niemann-Pick disease type C].
Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology 20100501
Title: Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.
Journal: Blood 20100429
Title: Effect of S1P5 on proliferation and migration of human esophageal cancer cells.
Journal: World journal of gastroenterology 20100421
Title: Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate.
Journal: Journal of cellular biochemistry 20100415
Title: A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag.
Journal: Rapid communications in mass spectrometry : RCM 20100415
Title: Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20100415
Title: FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice.
Journal: Biochemical and biophysical research communications 20100409
Title: Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors.
Journal: Journal of medicinal chemistry 20100408
Title: Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
Journal: The Journal of biological chemistry 20100402
Title: Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.
Journal: The Journal of biological chemistry 20100402
Title: Docosahexaenoic acid down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the sphingomyelinase/ceramide pathway.
Journal: The Journal of nutritional biochemistry 20100401
Title: Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147.
Journal: Immunobiology 20100401
Title: Sphingosine-1-phosphate and oligodendrocytes: from cell development to the treatment of multiple sclerosis.
Journal: Prostaglandins & other lipid mediators 20100401
Title: Photoactivable sphingosine as a tool to study membrane microenvironments in cultured cells.
Journal: Journal of lipid research 20100401
Title: FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.
Journal: Cancer immunology, immunotherapy : CII 20100401
Title: Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils.
Journal: Shock (Augusta, Ga.) 20100401
Title: Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase.
Journal: Cellular signalling 20100401
Title: Modulation of the activity of cytosolic phospholipase A2alpha (cPLA2alpha) by cellular sphingolipids and inhibition of cPLA2alpha by sphingomyelin.
Journal: Journal of lipid research 20100401
Title: Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes.
Journal: Cardiovascular research 20100401
Title: Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease.
Journal: Traffic (Copenhagen, Denmark) 20100401
Title: Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake.
Journal: Steroids 20100401
Title: The effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome.
Journal: European journal of clinical nutrition 20100401
Title: Targeting the sphingolipid signaling pathway in stroke.
Journal: Stroke 20100401
Title: Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.
Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20100401
Title: Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate.
Journal: Stem cells (Dayton, Ohio) 20100401
Title: Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation.
Journal: American journal of nephrology 20100401
Title: [How rare is tuberculosis?].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20100401
Title: [Development of oral therapies for multiple sclerosis--fingolimod, cladribine and other drugs].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20100401
Title: C2-ceramide inhibits the prostaglandin E2-induced accumulation of cAMP in human gingival fibroblasts.
Journal: Biomedical research (Tokyo, Japan) 20100401
Title: Multiple sclerosis: closing in on an oral treatment.
Journal: Nature 20100318
Title: Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
Journal: Bioorganic & medicinal chemistry letters 20100315
Title: Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.
Journal: Neuroscience 20100310
Title: FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
Journal: Circulation research 20100305
Title: [Progress of therapy in patients with multiple sclerosis].
Journal: MMW Fortschritte der Medizin 20100304
Title: Deregulation of sphingolipid metabolism in Alzheimer's disease.
Journal: Neurobiology of aging 20100301
Title: Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I.
Journal: Journal of cellular and molecular medicine 20100301
Title: Normalization of diabetic wound healing.
Journal: Surgery 20100301
Title: Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts.
Journal: Cellular signalling 20100301
Title: United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100301
Title: Increased expression of enzymes for sphingosine 1-phosphate turnover and signaling in human decidua during late pregnancy.
Journal: Biology of reproduction 20100301
Title: Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration.
Journal: American journal of physiology. Cell physiology 20100301
Title: High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
Journal: American journal of physiology. Heart and circulatory physiology 20100301
Title: Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation.
Journal: Reproductive biomedicine online 20100301
Title: miR-181a and miR-630 regulate cisplatin-induced cancer cell death.
Journal: Cancer research 20100301
Title: Discovery of a novel series of potent S1P1 agonists.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: S1P receptor mediated activity of FTY720 phosphate mimics.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: New drugs may improve, complicate treatment for multiple sclerosis.
Journal: Nature medicine 20100301
Title: Cell phenotype evaluation at various sites after skin transplantation and FTY720 plus sirolimus therapy.
Journal: Transplantation proceedings 20100301
Title: Leishmania (Leishmania) amazonensis infection in mice treated with FTY720.
Journal: Transplantation proceedings 20100301
Title: Sirolimus in combination with FTY720: analysis of urinary and serum parameters.
Journal: Transplantation proceedings 20100301
Title: Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants.
Journal: Transplantation 20100227
Title: Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition.
Journal: The Journal of biological chemistry 20100226
Title: Influence of a phytosphingosine-containing chlorhexidine shampoo on superficial bacterial counts and bacterial adherence to canine keratinocytes.
Journal: Veterinary microbiology 20100224
Title: Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection.
Journal: Virology 20100220
Title: Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
Journal: American journal of respiratory and critical care medicine 20100215
Title: Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia.
Journal: Neuroscience letters 20100212
Title: A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis.
Journal: The New England journal of medicine 20100204
Title: Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
Journal: The New England journal of medicine 20100204
Title: Oral therapy for multiple sclerosis--sea change or incremental step?
Journal: The New England journal of medicine 20100204
Title: FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses.
Journal: Journal of neuroscience research 20100201
Title: Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors.
Journal: Investigative ophthalmology & visual science 20100201
Title: Sphingosine kinase 1 regulates mucin production via ERK phosphorylation.
Journal: Pulmonary pharmacology & therapeutics 20100201
Title: FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.
Journal: Journal of molecular and cellular cardiology 20100201
Title: Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.
Journal: Stroke 20100201
Title: The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia.
Journal: British journal of pharmacology 20100201
Title: Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20100201
Title: Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae.
Journal: FEMS microbiology letters 20100201
Title: ABC transporters in cancer: more than just drug efflux pumps.
Journal: Nature reviews. Cancer 20100201
Title: HDL lipids and insulin resistance.
Journal: Current diabetes reports 20100201
Title: Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation.
Journal: The Journal of pharmacy and pharmacology 20100201
Title: Sphingosine-1-phosphate and its receptors as a possible therapeutic target in autoimmune diseases of the nervous system.
Journal: Journal of neuroimmunology 20100125
Title: Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
Journal: The Journal of experimental medicine 20100118
Title: Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.
Journal: Experimental cell research 20100115
Title: Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling.
Journal: The Journal of biological chemistry 20100115
Title: Influence of phase separating lipids on supported lipid bilayer formation at SiO2 surfaces.
Journal: Physical chemistry chemical physics : PCCP 20100114
Title: New endogenous regulators of class I histone deacetylases.
Journal: Science signaling 20100105
Title: Analysis of skin penetration of phytosphingosine by fluorescence detection and influence of the thermotropic behaviour of DPPC liposomes.
Journal: International journal of pharmaceutics 20100104
Title: Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen.
Journal: Acta biomaterialia 20100101
Title: Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis.
Journal: Cardiovascular research 20100101
Title: Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice.
Journal: Shock (Augusta, Ga.) 20100101
Title: Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease.
Journal: European heart journal 20100101
Title: A functional role for CCR6 on proallergic T cells in the gastrointestinal tract.
Journal: Gastroenterology 20100101
Title: FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration.
Journal: Laboratory investigation; a journal of technical methods and pathology 20100101
Title: Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells.
Journal: Immunology 20100101
Title: Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice.
Journal: Journal of dermatological science 20100101
Title: Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
Journal: Advances in enzyme regulation 20100101
Title: Phytosphingosine kills Candida albicans by disrupting its cell membrane.
Journal: Biological chemistry 20100101
Title: Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation.
Journal: Biochemical and biophysical research communications 20100101
Title: Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60.
Journal: Leukemia & lymphoma 20100101
Title: A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.
Journal: Glycobiology 20100101
Title: Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells.
Journal: Cell calcium 20100101
Title: Enantioselective syntheses of pachastrissamine and jaspine A via hydroxylactonization of a chiral epoxy ester.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis.
Journal: Clinical neuropharmacology 20100101
Title: Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells.
Journal: Molecules and cells 20100101
Title: [FTY720-induced lymphocyte apoptosis inhibits acute graft versus host disease in rat small bowel transplantation].
Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20100101
Title: Expression, purification, and characterization of a recombinant neutral ceramidase from Mycobacterium tuberculosis.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Revealing a signaling role of phytosphingosine-1-phosphate in yeast.
Journal: Molecular systems biology 20100101
Title: A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow.
Journal: PloS one 20100101
Title: Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
Journal: Arthritis research & therapy 20100101
Title: Synthesis and structure-activity relationships of skin ceramides.
Journal: Current medicinal chemistry 20100101
Title: Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages.
Journal: PloS one 20100101
Title: Spingolipids in Multiple Sclerosis.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Endothelial functions of sphingosine-1-phosphate.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan.
Journal: BMC musculoskeletal disorders 20100101
Title: Characterization of a germination-accelerating factor from the silkworm (Bombyx mori Linnaeus) of entomopathogenic fungus Nomuraea rileyi (Farlow) Samson.
Journal: Bioscience, biotechnology, and biochemistry 20100101
Title: Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.
Journal: PloS one 20100101
Title: Arthritis: where are the T cells?
Journal: Arthritis research & therapy 20100101
Title: An autocrine sphingosine-1-phosphate signaling loop enhances NF-kappaB-activation and survival.
Journal: BMC cell biology 20100101
Title: Identification of targets and new developments in the treatment of multiple sclerosis--focus on cladribine.
Journal: Drug design, development and therapy 20100101
Title: Deoxysphingoid bases as plasma markers in diabetes mellitus.
Journal: Lipids in health and disease 20100101
Title: A novel sphingosine-1-phosphate receptor 1 antagonist prevents the proliferation and relaxation of vascular endothelial cells by sphingosine-1-phosphate.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Multiple sclerosis therapies: molecular mechanisms and future.
Journal: Results and problems in cell differentiation 20100101
Title: Distribution and metabolism of sphingosine in skin after oral administration to mice.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Extracellular and intracellular actions of sphingosine-1-phosphate.
Journal: Advances in experimental medicine and biology 20100101
Title: Cancer treatment strategies targeting sphingolipid metabolism.
Journal: Advances in experimental medicine and biology 20100101
Title: SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice.
Journal: Journal of pharmacological sciences 20100101
Title: Altered expression of signaling genes in Jurkat cells upon FTY720 induced apoptosis.
Journal: International journal of molecular sciences 20100101
Title: FTY720-induced suicidal erythrocyte death.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: New antinociceptive agents related to dihydrosphingosine.
Journal: Pharmacological reports : PR 20100101
Title: Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.
Journal: Journal of pharmacological sciences 20100101
Title: Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury.
Journal: Mediators of inflammation 20100101
Title: [Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis].
Journal: Biomeditsinskaia khimiia 20100101
Title: Functional modulation of mitochondria by eicosapentaenoic acid provides protection against ceramide toxicity to C6 glioma cells.
Journal: Journal of agricultural and food chemistry 20091223
Title: Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo.
Journal: The Journal of biological chemistry 20091204
Title: Ectopic and eutopic stromal endometriotic cells have a damaged ceramide signaling pathway to apoptosis.
Journal: Fertility and sterility 20091201
Title: Lung tumor development in the presence of sphingosine 1-phosphate agonist FTY720.
Journal: Pathology oncology research : POR 20091201
Title: Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury.
Journal: Burns : journal of the International Society for Burn Injuries 20091201
Title: FTY720 reduces inflammation and promotes functional recovery after spinal cord injury.
Journal: Journal of neurotrauma 20091201
Title: Local effects of the sphingosine 1-phosphate on prostaglandin F2alpha-induced luteolysis in the pregnant rat.
Journal: Molecular reproduction and development 20091201
Title: Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin.
Journal: The Journal of investigative dermatology 20091201
Title: Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells.
Journal: Journal of biochemistry 20091201
Title: Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes.
Journal: Experimental eye research 20091201
Title: Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement.
Journal: Cellular signalling 20091201
Title: Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells.
Journal: Journal of neurophysiology 20091201
Title: Lysophospholipids enhance taurine release from rat retinal vascular endothelial cells under hypoosmotic stress.
Journal: Microvascular research 20091201
Title: Pharmacologic therapies on the horizon for acute lung injury/acute respiratory distress syndrome.
Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20091201
Title: Vascular integrity mediated by vascular endothelial cadherin and regulated by sphingosine 1-phosphate and angiopoietin-1.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20091201
Title: The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells.
Journal: International journal of oncology 20091201
Title: Ovarian transplantation for fertility preservation in a sheep model: can follicle loss be prevented by antiapoptotic sphingosine-1-phosphate administration?
Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20091201
Title: T-cell activation in ischemic stroke: a new therapeutic target for delayed infarct expansion?
Journal: Neurosurgery 20091201
Title: Treatment with immunosuppressants FTY720 and tacrolimus promotes functional recovery after spinal cord injury in rats.
Journal: The Tohoku journal of experimental medicine 20091201
Title: Systemically circulating colitogenic memory CD4+T cells may be an ideal target for the treatment of inflammatory bowel diseases.
Journal: The Keio journal of medicine 20091201
Title: Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia.
Journal: Arhiv za higijenu rada i toksikologiju 20091201
Title: Chemotherapy induces ATP release from tumor cells.
Journal: Cell cycle (Georgetown, Tex.) 20091115
Title: Ca2+ waves initiate antigen-stimulated Ca2+ responses in mast cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20091115
Title: The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia.
Journal: Biochemical and biophysical research communications 20091113
Title: Efficient synthesis of D-xylo and D-ribo-phytosphingosines from methyl 2-amino-2-deoxy-beta-D-hexopyranosides.
Journal: Carbohydrate research 20091102
Title: Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.
Journal: Stem cells and development 20091101
Title: Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability.
Journal: Cancer letters 20091101
Title: Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies.
Journal: Journal of lipid research 20091101
Title: Oxytocin stimulates in vitro angiogenesis via a Pyk-2/Src-dependent mechanism.
Journal: Experimental cell research 20091101
Title: Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
Journal: International journal of cancer 20091101
Title: FcepsilonRI-mediated mast cell migration: signaling pathways and dependence on cytosolic free Ca2+ concentration.
Journal: Cellular signalling 20091101
Title: Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
Journal: The Journal of allergy and clinical immunology 20091101
Title: Transforming growth factor-beta1 downregulates caveolin-1 expression and enhances sphingosine 1-phosphate signaling in cultured vascular endothelial cells.
Journal: American journal of physiology. Cell physiology 20091101
Title: Horizontal chromosome transfer, a mechanism for the evolution and differentiation of a plant-pathogenic fungus.
Journal: Eukaryotic cell 20091101
Title: Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in mice.
Journal: British journal of pharmacology 20091101
Title: Sphingosine kinase as a regulator of calcium entry through autocrine sphingosine 1-phosphate signaling in thyroid FRTL-5 cells.
Journal: Endocrinology 20091101
Title: Discovery of novel sphingosine kinase 1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091101
Title: FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system.
Journal: British journal of pharmacology 20091101
Title: [Multiple sclerosis, the therapeutic arsenal of today and tomorrow].
Journal: Soins; la revue de reference infirmiere 20091101
Title: News & views in ... Immunotherapy.
Journal: Immunotherapy 20091101
Title: Sphingosine 1-phosphate induces vascular endothelial growth factor expression in endothelial cells.
Journal: BMB reports 20091031
Title: Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog.
Journal: Transplantation 20091027
Title: T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
Journal: The Journal of experimental medicine 20091026
Title: The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20091020
Title: Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
Journal: Archives of biochemistry and biophysics 20091015
Title: MRP- and BCL-2-mediated drug resistance in human SCLC: effects of apoptotic sphingolipids in vitro.
Journal: Lung cancer (Amsterdam, Netherlands) 20091001
Title: FTY720 attenuates lesional interleukin-17(+) cell accumulation in rat experimental autoimmune neuritis.
Journal: Neuropathology and applied neurobiology 20091001
Title: Modulation of invasive properties of CD133+ glioblastoma stem cells: a role for MT1-MMP in bioactive lysophospholipid signaling.
Journal: Molecular carcinogenesis 20091001
Title: Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091001
Title: Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells.
Journal: The Prostate 20091001
Title: Sphingolipids in inflammation: pathological implications and potential therapeutic targets.
Journal: British journal of pharmacology 20091001
Title: Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum.
Journal: Journal of biochemistry 20091001
Title: Lipids as targets for novel anti-inflammatory therapies.
Journal: Pharmacology & therapeutics 20091001
Title: Sphingosine 1-phosphate: a regulator of arterial lesions.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001
Title: Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.
Journal: The Journal of pharmacology and experimental therapeutics 20091001
Title: Sphingosine-1-phosphate receptor-2 regulates expression of smooth muscle alpha-actin after arterial injury.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001
Title: Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells.
Journal: Endocrinology 20091001
Title: Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20091001
Title: Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2.
Journal: Stroke 20091001
Title: Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning.
Journal: American journal of physiology. Heart and circulatory physiology 20091001
Title: Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis.
Journal: Immunology and cell biology 20091001
Title: Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.
Journal: American journal of physiology. Cell physiology 20091001
Title: Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.
Journal: Kidney international 20091001
Title: Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.
Journal: Cellular and molecular life sciences : CMLS 20091001
Title: Simple dihydrosphyngosine analogues with potent activity against MDR-Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20091001
Title: Susceptibility of Phelipanche and Orobanche species to AAL-toxin.
Journal: Planta 20091001
Title: The future of multiple sclerosis therapy.
Journal: Pharmacological research 20091001
Title: Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation.
Journal: Journal of biomolecular screening 20091001
Title: Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis.
Journal: The American journal of pathology 20091001
Title: Ring-construction/stereoselective functionalization cascade: total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of bromoallenes.
Journal: Organic letters 20091001
Title: Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20091001
Title: Sphingosine kinase-1: a potential mediator of renal fibrosis.
Journal: Kidney international 20091001
Title: [Fingolimod - a new immunomodulator].
Journal: Deutsche medizinische Wochenschrift (1946) 20091001
Title: Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.
Journal: The American journal of tropical medicine and hygiene 20091001
Title: Recognition of lyso-phospholipids by human natural killer T lymphocytes.
Journal: PLoS biology 20091001
Title: New oral drugs for multiple sclerosis.
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20091001
Title: Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.
Journal: Journal of neuroimmunology 20090929
Title: The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.
Journal: The Journal of biological chemistry 20090925
Title: Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling.
Journal: Circulation research 20090925
Title: Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells.
Journal: Circulation research 20090925
Title: Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.
Journal: Journal of medicinal chemistry 20090924
Title: Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity.
Journal: The Journal of biological chemistry 20090918
Title: High-yielding synthesis of sphingoid-type bases.
Journal: The Journal of organic chemistry 20090918
Title: Sphinganine-sphingosine ratio in urine from two Portuguese populations as biomarker to fumonisins exposure.
Journal: Toxicon : official journal of the International Society on Toxinology 20090915
Title: The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20090915
Title: Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system.
Journal: Analytica chimica acta 20090914
Title: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Journal: Science (New York, N.Y.) 20090904
Title: The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.
Journal: Blood 20090903
Title: Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments.
Journal: Biophysical journal 20090902
Title: Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors.
Journal: Investigative ophthalmology & visual science 20090901
Title: Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.
Journal: Journal of lipid research 20090901
Title: The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism.
Journal: Biochemical pharmacology 20090901
Title: Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.
Journal: Cancer science 20090901
Title: Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Journal: Diabetes 20090901
Title: Transcriptional analysis of the response of Neurospora crassa to phytosphingosine reveals links to mitochondrial function.
Journal: Microbiology (Reading, England) 20090901
Title: Role of FTY720 on M1 and M2 macrophages, lymphocytes, and chemokines in 5/6 nephrectomized rats.
Journal: American journal of physiology. Renal physiology 20090901
Title: Fragile maintenance of allograft tolerance induced by lymphocyte sequestration and co-stimulation blockade.
Journal: Transplant immunology 20090901
Title: Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death.
Journal: Journal of neurochemistry 20090901
Title: Effect of dimethyl sulfoxide on the phase behavior of model stratum corneum lipid mixtures.
Journal: Chemistry and physics of lipids 20090901
Title: Lipid signaling in Arabidopsis: no sphingosine? No problem!
Journal: Trends in plant science 20090901
Title: Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20090901
Title: Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Journal: Cancer research 20090901
Title: [Discovery of S1P transporter may uncover the unidentified S1P-regulated signal in circulation, immunity, and bone metabolism].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090901
Title: [Role of sphingosine 1-phosphate receptor signaling in hematopoietic stem/progenitor cell transmigration].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090901
Title: [Sphingolipids in embryonic implantation].
Journal: Ginecologia y obstetricia de Mexico 20090901
Title: N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells.
Journal: Toxicology and applied pharmacology 20090815
Title: Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20090815
Title: Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs.
Journal: Bioorganic & medicinal chemistry 20090815
Title: Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes.
Journal: Archives of biochemistry and biophysics 20090815
Title: Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes.
Journal: The Journal of biological chemistry 20090807
Title: Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers.
Journal: Journal of lipid research 20090801
Title: Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
Journal: The Journal of investigative dermatology 20090801
Title: Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus.
Journal: Genome research 20090801
Title: S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.
Journal: American journal of physiology. Cell physiology 20090801
Title: Trafficking of murine hematopoietic stem and progenitor cells in health and vascular disease.
Journal: Microcirculation (New York, N.Y. : 1994) 20090801
Title: Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.
Journal: Journal of neurochemistry 20090801
Title: (-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts.
Journal: International journal of molecular medicine 20090801
Title: Elevated concentrations of sphingosylphosphorylcholine in cerebrospinal fluid after subarachnoid hemorrhage: a possible role as a spasmogen.
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090801
Title: Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.
Journal: The Journal of investigative dermatology 20090801
Title: Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions and internalization.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20090801
Title: [Molecular target drug development for curing multiple sclerosis].
Journal: Brain and nerve = Shinkei kenkyu no shinpo 20090801
Title: Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion.
Journal: Cardiovascular research 20090715
Title: Phase behavior of an equimolar mixture of N-palmitoyl-D-erythro-sphingosine, cholesterol, and palmitic acid, a mixture with optimized hydrophobic matching.
Journal: Langmuir : the ACS journal of surfaces and colloids 20090707
Title: Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.
Journal: The Journal of biological chemistry 20090703
Title: VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
Journal: Glycoconjugate journal 20090701
Title: Export and functions of sphingosine-1-phosphate.
Journal: Biochimica et biophysica acta 20090701
Title: Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48, and FTY720 enables long-term graft maintenance in mice with only mild ongoing immunosuppression.
Journal: Diabetes 20090701
Title: Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome.
Journal: American journal of physiology. Endocrinology and metabolism 20090701
Title: The lymphocyte migration inhibitor FTY720 attenuates experimental hypertensive nephropathy.
Journal: American journal of physiology. Renal physiology 20090701
Title: A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.
Journal: Journal of dermatological science 20090701
Title: Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from Ascotricha chartarum Berk. SANK 14186.
Journal: The Journal of antibiotics 20090701
Title: Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation.
Journal: Bioorganic & medicinal chemistry letters 20090701
Title: Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090701
Title: Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Journal: International journal of molecular medicine 20090701
Title: Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.
Journal: The Journal of clinical investigation 20090701
Title: Regulation of blood and vascular cell function by bioactive lysophospholipids.
Journal: Journal of thrombosis and haemostasis : JTH 20090701
Title: Immunomodulatory drug FTY720 induces regulatory CD4(+)CD25(+) T cells in vitro.
Journal: Clinical and experimental immunology 20090701
Title: Saturated ceramides from the sponge Dysidea robusta.
Journal: Natural product communications 20090701
Title: Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases.
Journal: Journal of medicinal chemistry 20090625
Title: Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons.
Journal: Bioorganic & medicinal chemistry letters 20090615
Title: Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.
Journal: The Journal of biological chemistry 20090612
Title: The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.
Journal: Blood 20090611
Title: Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.
Journal: Neuron 20090611
Title: FTY720 and lung tumor development.
Journal: International immunopharmacology 20090601
Title: Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601
Title: Entamoeba invadens: sphingolipids metabolic regulation is the main component of a PKC signaling pathway in controlling cell growth and proliferation.
Journal: Experimental parasitology 20090601
Title: TRPC channel lipid specificity and mechanisms of lipid regulation.
Journal: Cell calcium 20090601
Title: High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry.
Journal: Clinical chemistry 20090601
Title: FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090601
Title: Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.
Journal: Journal of hepatology 20090601
Title: Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090601
Title: Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Journal: Nature chemical biology 20090601
Title: Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization.
Journal: Journal of cardiovascular pharmacology 20090601
Title: [New therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090601
Title: Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
Journal: Pathology international 20090601
Title: [FTY720 reduces peritubular micrangium loss in renal interstitial fibrotic rats].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20090601
Title: Inhibition of sphingosine kinase by bovine viral diarrhea virus NS3 is crucial for efficient viral replication and cytopathogenesis.
Journal: The Journal of biological chemistry 20090515
Title: Design and synthesis of piperidine-containing sphingoid base analogues.
Journal: The Journal of organic chemistry 20090515
Title: The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
Journal: Journal of medicinal chemistry 20090514
Title: Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
Journal: The Journal of biological chemistry 20090508
Title: Sphingosine kinase regulation and cardioprotection.
Journal: Cardiovascular research 20090501
Title: Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2.
Journal: Endocrinology 20090501
Title: Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate.
Journal: Cardiovascular research 20090501
Title: Endothelial-mural cell signaling in vascular development and angiogenesis.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090501
Title: The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.
Journal: Cellular signalling 20090501
Title: Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
Journal: Cardiovascular research 20090501
Title: Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts.
Journal: Cardiovascular research 20090501
Title: Sphingosine-1-phosphate and modulation of vascular tone.
Journal: Cardiovascular research 20090501
Title: Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection.
Journal: Cardiovascular research 20090501
Title: Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine.
Journal: American journal of physiology. Heart and circulatory physiology 20090501
Title: Regional heterogeneity in expression of the sphingosine-1-phosphate pathway in the female rat lower urinary tract.
Journal: American journal of obstetrics and gynecology 20090501
Title: The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids.
Journal: European journal of pharmacology 20090501
Title: Sphingosine-1-phosphate increases human alveolar epithelial IL-8 secretion, proliferation and neutrophil chemotaxis.
Journal: European journal of pharmacology 20090501
Title: Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.
Journal: The Journal of biological chemistry 20090501
Title: Lipid signalling in cardiovascular pathophysiology.
Journal: Cardiovascular research 20090501
Title: Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
Journal: Journal of vascular surgery 20090501
Title: Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement.
Journal: Microvascular research 20090501
Title: Sphingosine 1-phosphate induces differentiation of adipose tissue-derived mesenchymal stem cells towards smooth muscle cells.
Journal: Cellular and molecular life sciences : CMLS 20090501
Title: Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling.
Journal: The American journal of pathology 20090501
Title: Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation.
Journal: Journal of cell science 20090501
Title: Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20090501
Title: When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
Journal: Cancer research 20090501
Title: Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Journal: Anti-cancer agents in medicinal chemistry 20090501
Title: Synthesis of 7-aza- and 7-thiasphingosines, and evaluation of their interaction with sphingosine kinases and with T-cells.
Journal: Chemistry & biodiversity 20090501
Title: Synthesis and evaluation of sphingolipid analogues: modification of the hydroxy group at C(1) of 7-oxasphingosine, and of the hydroxy group at C(1) and the amide group of 7-oxaceramides.
Journal: Chemistry & biodiversity 20090501
Title: [Role of S1P in the lipoprotein-induced actions and their signaling mechanism].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20090501
Title: Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.
Journal: Trends in cardiovascular medicine 20090501
Title: Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.
Journal: Biochimica et biophysica acta 20090501
Title: Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons.
Journal: The Journal of biological chemistry 20090424
Title: S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor.
Journal: Cancer letters 20090418
Title: Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
Journal: The Journal of organic chemistry 20090417
Title: Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: pH dependence of sphingosine aggregation.
Journal: Biophysical journal 20090408
Title: FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage.
Journal: Brain pathology (Zurich, Switzerland) 20090401
Title: The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.
Journal: The international journal of biochemistry & cell biology 20090401
Title: Immunosuppressive therapy and post-transplant malignancy.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090401
Title: Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling.
Journal: Journal of lipid research 20090401
Title: Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis.
Journal: Journal of lipid research 20090401
Title: Lipid phosphate phosphatases and signaling.
Journal: Journal of lipid research 20090401
Title: Targeting sphingosine-1-phosphate signalling for cardioprotection.
Journal: Current opinion in pharmacology 20090401
Title: Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts.
Journal: Journal of molecular and cellular cardiology 20090401
Title: Differential regulation of sphingosine kinases 1 and 2 in lung injury.
Journal: American journal of physiology. Lung cellular and molecular physiology 20090401
Title: Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques.
Journal: The Journal of antimicrobial chemotherapy 20090401
Title: Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.
Journal: European journal of immunology 20090401
Title: Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice.
Journal: Cell biology international 20090401
Title: Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090401
Title: Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)).
Journal: British journal of pharmacology 20090401
Title: Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin.
Journal: Thrombosis and haemostasis 20090401
Title: Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats.
Journal: Journal of pediatric surgery 20090401
Title: Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
Journal: Molecular cancer therapeutics 20090401
Title: [A new therapeutic approach for autoimmune diseases by the sphingosine 1-phosphate receptor modulator, fingolimod (FTY720)].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20090401
Title: Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.
Journal: International journal of pharmaceutics 20090331
Title: Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
Journal: Nature 20090326
Title: Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity.
Journal: Chembiochem : a European journal of chemical biology 20090323
Title: B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis.
Journal: Immunity 20090320
Title: Hemorrhaging focal encephalitis under fingolimod (FTY720) treatment: a case report.
Journal: Neurology 20090317
Title: Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog.
Journal: Biochemical pharmacology 20090315
Title: Sphingosine-1-phosphate regulates RGS2 and RGS16 mRNA expression in vascular smooth muscle cells.
Journal: European journal of pharmacology 20090315
Title: Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate.
Journal: Biochemical and biophysical research communications 20090306
Title: Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway.
Journal: Digestive diseases and sciences 20090301
Title: Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.
Journal: Biology of the cell 20090301
Title: Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization.
Journal: Experimental eye research 20090301
Title: Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2.
Journal: Journal of lipid research 20090301
Title: BM88/Cend1 regulates stimuli-induced intracellular calcium mobilization.
Journal: Neuropharmacology 20090301
Title: Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney.
Journal: American journal of physiology. Renal physiology 20090301
Title: Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy.
Journal: The Journal of pharmacology and experimental therapeutics 20090301
Title: Distribution of Foxp3(+) T-regulatory cells in experimental autoimmune neuritis rats.
Journal: Experimental neurology 20090301
Title: Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20090301
Title: Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090301
Title: The jasmonate signaling pathway in tomato regulates susceptibility to a toxin-dependent necrotrophic pathogen.
Journal: Planta 20090301
Title: Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G.
Journal: Apoptosis : an international journal on programmed cell death 20090301
Title: Effect of Asparagus racemosus extract on transdermal delivery of carvedilol: a mechanistic study.
Journal: AAPS PharmSciTech 20090301
Title: Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.
Journal: Molecular cancer research : MCR 20090301
Title: Sphingosine kinase and sphingosine 1-phosphate in cardioprotection.
Journal: Journal of cardiovascular pharmacology 20090301
Title: Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine.
Journal: Molecular cancer research : MCR 20090301
Title: Effects of synthetic sphingosine-1-phosphate analogs on cytosolic phospholipase A2alpha-independent release of arachidonic acid and cell toxicity in L929 fibrosarcoma cells: the structure-activity relationship.
Journal: Journal of pharmacological sciences 20090301
Title: [Advances in thrombin-protease-activated receptor 1-sphingosine 1-phosphate pathway during sepsis].
Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090301
Title: Sphingosine-1 phosphate: a new player in osteoimmunology.
Journal: Developmental cell 20090301
Title: FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.
Journal: Transplantation proceedings 20090301
Title: Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2.
Journal: The Journal of biological chemistry 20090227
Title: FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
Journal: The Journal of biological chemistry 20090227
Title: Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
Journal: Oncogene 20090226
Title: Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.
Journal: The Journal of biological chemistry 20090220
Title: Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation.
Journal: Journal of cell science 20090215
Title: Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen.
Journal: Journal of cell science 20090215
Title: Cell biology. The ABCs of lipophile transport.
Journal: Science (New York, N.Y.) 20090213
Title: Identification of tight junction modulating lipids.
Journal: Journal of pharmaceutical sciences 20090201
Title: Role for sphingosine kinase 1 in colon carcinogenesis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090201
Title: Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis.
Journal: Journal of cellular physiology 20090201
Title: Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells.
Journal: Histochemistry and cell biology 20090201
Title: Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090201
Title: Ceramide production associated with retinal apoptosis after retinal detachment.
Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090201
Title: Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.
Journal: Cellular signalling 20090201
Title: Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3.
Journal: American journal of physiology. Cell physiology 20090201
Title: N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation.
Journal: Bioorganic & medicinal chemistry letters 20090201
Title: Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.
Journal: Autophagy 20090201
Title: Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition.
Journal: Journal of clinical pharmacology 20090201
Title: Trial watch: Phase III promise for oral multiple sclerosis therapy.
Journal: Nature reviews. Drug discovery 20090201
Title: [Sphingolipids and their medical impact].
Journal: Deutsche medizinische Wochenschrift (1946) 20090201
Title: [An additional role of FTY720 in chronic colitis].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20090201
Title: Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells.
Journal: Biomedical and environmental sciences : BES 20090201
Title: [The effects of Sphing-1-phosphate(S1P) on the potassium channel of the ventricular myocytes].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090201
Title: The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.
Journal: Science (New York, N.Y.) 20090123
Title: Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study.
Journal: Neurology 20090106
Title: Endothelial cell migration in human plasma is enhanced by a narrow range of added sphingosine 1-phosphate: implications for biomaterials design.
Journal: Journal of biomedical materials research. Part A 20090101
Title: Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system.
Journal: Cellular signalling 20090101
Title: Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I.
Journal: Endocrine journal 20090101
Title: Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease.
Journal: Cellular signalling 20090101
Title: Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization.
Journal: Journal of cellular physiology 20090101
Title: A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090101
Title: A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
Journal: Analytical biochemistry 20090101
Title: The influence of sphingosine-1-phosphate receptor signaling on lymphocyte trafficking: how a bioactive lipid mediator grew up from an 'immature' vascular maturation factor to a 'mature' mediator of lymphocyte behavior and function.
Journal: Immunologic research 20090101
Title: Use of an exposure-response model to aid early drug development of an oral sphingosine 1-phosphate receptor modulator.
Journal: Journal of clinical pharmacology 20090101
Title: Effect of double bond geometry in sphingosine base on the antioxidant function of sphingomyelin.
Journal: Archives of biochemistry and biophysics 20090101
Title: Regulation by sphingolipids of the fate of FRTL-5 cells.
Journal: Journal of biochemistry 20090101
Title: Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Journal: Kidney international 20090101
Title: Regulation of vascular permeability by sphingosine 1-phosphate.
Journal: Microvascular research 20090101
Title: Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis.
Journal: Plant physiology 20090101
Title: RTA2 is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans.
Journal: Cellular and molecular life sciences : CMLS 20090101
Title: Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature.
Journal: American journal of physiology. Heart and circulatory physiology 20090101
Title: Muscarinic receptor regulation of osmosensitive taurine transport in human SH-SY5Y neuroblastoma cells.
Journal: Journal of neurochemistry 20090101
Title: An efficient and general enantioselective synthesis of sphingosine, phythosphingosine, and 4-substituted derivatives.
Journal: Organic letters 20090101
Title: Enhanced detection of sphingoid bases via divalent ruthenium bipyridine complex derivatization and electrospray ionization tandem mass spectrometry.
Journal: Analytical chemistry 20090101
Title: Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.
Journal: Bioorganic & medicinal chemistry 20090101
Title: An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation.
Journal: Clinical and experimental immunology 20090101
Title: Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration.
Journal: Surgery 20090101
Title: Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling.
Journal: International journal of oncology 20090101
Title: Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.
Journal: PloS one 20090101
Title: Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61.
Journal: Molecular cancer research : MCR 20090101
Title: [Lysophospholipid mediators].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20090101
Title: Concepts in microvascular endothelial barrier regulation in health and disease.
Journal: Microvascular research 20090101
Title: Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.
Journal: Cellular & molecular biology letters 20090101
Title: The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells.
Journal: Cellular & molecular biology letters 20090101
Title: GPR3 receptor, a novel actor in the emotional-like responses.
Journal: PloS one 20090101
Title: Exploiting immunotherapy in Mycobacterium tuberculosis-infected mice: sphingosine 1-phosphate treatment results in a protective or detrimental effect depending on the stage of infection.
Journal: International journal of immunopathology and pharmacology 20090101
Title: Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁.
Journal: International journal of molecular sciences 20090101
Title: Hematopoietic stem and progenitor cells: their mobilization and homing to bone marrow and peripheral tissue.
Journal: Immunologic research 20090101
Title: Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18.
Journal: PloS one 20090101
Title: Achieving molecular complexity by organocatalytic one-pot strategies - a fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated alpha-amino acids.
Journal: Angewandte Chemie (International ed. in English) 20090101
Title: The influence of commonly used immunosuppressive drugs on the small bowel functions - a comparative experimental study.
Journal: Annals of transplantation 20090101
Title: Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis.
Journal: International journal of medical sciences 20090101
Title: New aspects of sphingosine 1-phosphate signaling in mammalian cells.
Journal: Advances in enzyme regulation 20090101
Title: Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma.
Journal: Immunology and cell biology 20090101
Title: Mammalian Diaphanous (mDia) may be involved in the signal transduction of sphingosine-1-phosphate on developing actin stress fiber of human fibroblasts.
Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20090101
Title: Regulation of macrophage function by sphingosine-1-phosphate.
Journal: Immunobiology 20090101
Title: Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava.
Journal: Journal of oleo science 20090101
Title: FTY720 and everolimus in de novo renal transplant patients at risk for delayed graft function: results of an exploratory one-yr multicenter study.
Journal: Clinical transplantation 20090101
Title: Lipid generation and signaling in ovarian cancer.
Journal: Cancer treatment and research 20090101
Title: Lysophosphatidic acid and invasion.
Journal: Cancer treatment and research 20090101
Title: Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery.
Journal: PloS one 20090101
Title: Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms.
Journal: Oncology research 20090101
Title: The discovery of novel experimental therapies for inflammatory arthritis.
Journal: Mediators of inflammation 20090101
Title: Choices and outcomes: Extending basic biology to clinical care.
Journal: Oxidative medicine and cellular longevity 20090101
Title: Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning.
Journal: Oxidative medicine and cellular longevity 20090101
Title: Asymmetric sulfur ylide based enantioselective synthesis of D-erythro-sphingosine.
Journal: Organic & biomolecular chemistry 20081221
Title: The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.
Journal: Current biology : CB 20081209
Title: Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells.
Journal: Stem cells and development 20081201
Title: Impaired initiation of contact hypersensitivity by FTY720.
Journal: The Journal of investigative dermatology 20081201
Title: Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain.
Journal: Stroke 20081201
Title: Diacylglyceride lipase activity in rod outer segments depends on the illumination state of the retina.
Journal: Neurochemistry international 20081201
Title: Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis.
Journal: American journal of physiology. Heart and circulatory physiology 20081201
Title: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow.
Journal: European journal of immunology 20081201
Title: RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20081201
Title: Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20081201
Title: Evaluation of four topical preparations for the treatment of cannon hyperkeratosis in a horse.
Journal: Veterinary dermatology 20081201
Title: Treatment of chronic allograft nephropathy at late stages using everolimus or FTY720 in combination with cyclosporine.
Journal: Transplantation proceedings 20081201
Title: Retinal flavoprotein autofluorescence as a measure of retinal health.
Journal: Transactions of the American Ophthalmological Society 20081201
Title: Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.
Journal: Bulletin of experimental biology and medicine 20081201
Title: Effects of ethanol and lipopolysaccharide on the sphingomyelin cycle in rat hepatocytes.
Journal: Bulletin of experimental biology and medicine 20081201
Title: Sphingosine 1-phosphate modulates spinal nociceptive processing.
Journal: The Journal of biological chemistry 20081121
Title: Synthesis of alpha-galactosyl ceramide (KRN7000) and analogues thereof via a common precursor and their preliminary biological assessment.
Journal: The Journal of organic chemistry 20081121
Title: Central nervous system-directed effects of FTY720 (fingolimod).
Journal: Journal of the neurological sciences 20081115
Title: WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.
Journal: Blood 20081115
Title: Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20081115
Title: WASp stings mature lymphocytes.
Journal: Blood 20081115
Title: Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.
Journal: Circulation research 20081107
Title: Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Journal: Breast cancer research and treatment 20081101
Title: Central nervous system effects of current and emerging multiple sclerosis-directed immuno-therapies.
Journal: Clinical neurology and neurosurgery 20081101
Title: Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha.
Journal: Journal of lipid research 20081101
Title: Potential role of sphingosine 1-phosphate in the pathogenesis of rheumatoid arthritis.
Journal: Journal of lipid research 20081101
Title: Sphingosine 1-phosphate receptor agonism impairs skin dendritic cell migration and homing to secondary lymphoid tissue: association with prolonged allograft survival.
Journal: Transplant immunology 20081101
Title: High-throughput screening of cell lysates for ganglioside synthesis.
Journal: Analytical biochemistry 20081101
Title: S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing.
Journal: Molecular immunology 20081101
Title: Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices.
Journal: American journal of physiology. Heart and circulatory physiology 20081101
Title: Sphingosine-1-phosphate acts as a developmental stage specific inhibitor of platelet-derived growth factor-induced chemotaxis of osteoblasts.
Journal: Journal of cellular biochemistry 20081101
Title: Expression patterns of the lysophospholipid receptor genes during mouse early development.
Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20081101
Title: Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease.
Journal: Biological chemistry 20081101
Title: The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis.
Journal: Current opinion in investigational drugs (London, England : 2000) 20081101
Title: Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
Journal: Nature medicine 20081101
Title: Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo.
Journal: Translational research : the journal of laboratory and clinical medicine 20081101
Title: Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells.
Journal: Archives of pharmacal research 20081101
Title: Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study.
Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20081101
Title: Arabidopsis AAL-toxin-resistant mutant atr1 shows enhanced tolerance to programmed cell death induced by reactive oxygen species.
Journal: Biochemical and biophysical research communications 20081031
Title: A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
Journal: Biochemical and biophysical research communications 20081031
Title: Nerve growth factor, sphingomyelins, and sensitization in sensory neurons.
Journal: Sheng li xue bao : [Acta physiologica Sinica] 20081025
Title: Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia.
Journal: Biochemical and biophysical research communications 20081024
Title: FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis.
Journal: Neurology 20081014
Title: Microwave-assisted synthesis of near-infrared fluorescent sphingosine derivatives.
Journal: Chemical communications (Cambridge, England) 20081007
Title: Divergent syntheses of all stereoisomers of phytosphingosine and their use in the construction of a ceramide library.
Journal: Bioorganic chemistry 20081001
Title: K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin.
Journal: Experimental dermatology 20081001
Title: Involvement of sphingosine kinase in plant cell signalling.
Journal: The Plant journal : for cell and molecular biology 20081001
Title: Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.
Journal: Cardiovascular research 20081001
Title: Lipid content of brain, brain membrane lipid domains, and neurons from acid sphingomyelinase deficient mice.
Journal: Journal of neurochemistry 20081001
Title: Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye.
Journal: Experimental eye research 20081001
Title: Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20081001
Title: Lipid metabolism: sources and stability of plasma sphingosine-1-phosphate.
Journal: Current opinion in lipidology 20081001
Title: Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod.
Journal: The American journal of pathology 20081001
Title: The suppressive effect that myriocin has on hepatitis C virus RNA replication is independent of inhibition of serine palmitoyl transferase.
Journal: The Journal of infectious diseases 20081001
Title: The alliance of sphingosine-1-phosphate and its receptors in immunity.
Journal: Nature reviews. Immunology 20081001
Title: Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates.
Journal: Acta pharmacologica Sinica 20081001
Title: Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20081001
Title: Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2.
Journal: Molecular cancer research : MCR 20081001
Title: Human cytomegalovirus regulates bioactive sphingolipids.
Journal: The Journal of biological chemistry 20080919
Title: Sphingosine kinase inhibitor suppresses IL-18-induced interferon-gamma production through inhibition of p38 MAPK activation in human NK cells.
Journal: Biochemical and biophysical research communications 20080912
Title: A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells.
Journal: Circulation research 20080912
Title: High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function.
Journal: The Journal of biological chemistry 20080905
Title: Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor.
Journal: American journal of respiratory cell and molecular biology 20080901
Title: Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity.
Journal: Biochimica et biophysica acta 20080901
Title: K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling.
Journal: The Journal of investigative dermatology 20080901
Title: Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.
Journal: Biochimica et biophysica acta 20080901
Title: G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.
Journal: Cardiovascular research 20080901
Title: FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice.
Journal: Diabetes, obesity & metabolism 20080901
Title: A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
Journal: Analytical biochemistry 20080901
Title: Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
Journal: Biochimica et biophysica acta 20080901
Title: Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination.
Journal: Biochimica et biophysica acta 20080901
Title: Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight.
Journal: Biochimica et biophysica acta 20080901
Title: Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza.
Journal: Molecular pharmacology 20080901
Title: Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate.
Journal: Biochimica et biophysica acta 20080901
Title: Sphingosine 1-phosphate chemical biology.
Journal: Biochimica et biophysica acta 20080901
Title: S1P and eNOS regulation.
Journal: Biochimica et biophysica acta 20080901
Title: The vascular S1P gradient-cellular sources and biological significance.
Journal: Biochimica et biophysica acta 20080901
Title: Sphingosine-1-phosphate regulation of mammalian development.
Journal: Biochimica et biophysica acta 20080901
Title: Transdermal delivery of carvedilol containing glycyrrhizin and chitosan as permeation enhancers: biochemical, biophysical, microscopic and pharmacodynamic evaluation.
Journal: Drug delivery 20080901
Title: Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2.
Journal: Endocrinology 20080901
Title: Emerging oral drugs for multiple sclerosis.
Journal: Expert opinion on emerging drugs 20080901
Title: N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.
Journal: Molecular cancer therapeutics 20080901
Title: Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness.
Journal: Molecular cancer research : MCR 20080901
Title: [Mitochondrial changes in apoptosis of HT-29 cells induced by C2-ceramide].
Journal: Wei sheng yan jiu = Journal of hygiene research 20080901
Title: A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Journal: Blood 20080815
Title: Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways.
Journal: Blood 20080815
Title: TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity.
Journal: Bioorganic & medicinal chemistry 20080815
Title: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Journal: Cancer research 20080815
Title: Immunology: Surprising side effects.
Journal: Nature 20080814
Title: Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection.
Journal: Nature 20080814
Title: Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
Journal: Cancer letters 20080808
Title: Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a 'come-and-get-me' signal.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801
Title: Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.
Journal: Cardiovascular research 20080801
Title: K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling.
Journal: Journal of dermatological science 20080801
Title: Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
Journal: Human molecular genetics 20080801
Title: HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080801
Title: Biodiversity of sphingoid bases ('sphingosines') and related amino alcohols.
Journal: Journal of lipid research 20080801
Title: Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn.
Journal: Cellular signalling 20080801
Title: Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20080801
Title: The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects.
Journal: British journal of clinical pharmacology 20080801
Title: S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac.
Journal: Gynecologic oncology 20080801
Title: Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080801
Title: Understanding the mechanisms of anaphylaxis.
Journal: Current opinion in allergy and clinical immunology 20080801
Title: Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness.
Journal: Circulation research 20080801
Title: Cell-culture-dependent change of Ca2+ response of rat aortic myocytes to sphingosine-1-phosphate.
Journal: Journal of pharmacological sciences 20080801
Title: Anti-tumor activity of phenoxodiol: from bench to clinic.
Journal: Future oncology (London, England) 20080801
Title: Infections cast cloud over Novartis' MS therapy.
Journal: Nature biotechnology 20080801
Title: Molecular targeting of acid ceramidase: implications to cancer therapy.
Journal: Current drug targets 20080801
Title: Azathioprine in multiple sclerosis.
Journal: Mini reviews in medicinal chemistry 20080801
Title: [SphK-1/S1P signal pathway in CML cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20080801
Title: Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.
Journal: Biophysical journal 20080715
Title: Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to tissues from patients with Niemann-Pick disease types A and C, and Gaucher disease.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080715
Title: Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Journal: Biochemical and biophysical research communications 20080711
Title: Increased resistance of complex I mutants to phytosphingosine-induced programmed cell death.
Journal: The Journal of biological chemistry 20080711
Title: Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway.
Journal: The Journal of biological chemistry 20080711
Title: Skeletal muscle wastage in Crohn's disease: a pathway shared with heart failure?
Journal: International journal of cardiology 20080704
Title: Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype.
Journal: The Journal of investigative dermatology 20080701
Title: Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701
Title: Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments.
Journal: Neurochemical research 20080701
Title: Phosphorylation by sphingosine kinase 2 is essential for in vivo potency of FTY720 analogues.
Journal: ChemMedChem 20080701
Title: Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling.
Journal: Journal of lipid research 20080701
Title: Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering.
Journal: Biomaterials 20080701
Title: Overexpression of TRPC3 reduces the content of intracellular calcium stores in HEK-293 cells.
Journal: Journal of cellular physiology 20080701
Title: Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway.
Journal: The Journal of physiology 20080701
Title: Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts.
Journal: Molecular and cellular biochemistry 20080701
Title: Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20080701
Title: Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease.
Journal: European journal of immunology 20080701
Title: Fungicidal activity of truncated analogues of dihydrosphingosine.
Journal: Bioorganic & medicinal chemistry letters 20080701
Title: Plasma sphingosine-1-phosphate measurement in healthy subjects: close correlation with red blood cell parameters.
Journal: Annals of clinical biochemistry 20080701
Title: Sphingobacterium kitahiroshimense sp. nov., isolated from soil.
Journal: International journal of systematic and evolutionary microbiology 20080701
Title: Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin.
Journal: Thrombosis and haemostasis 20080701
Title: N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes.
Journal: Journal of pharmacological sciences 20080701
Title: Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.
Journal: Molecular cancer therapeutics 20080701
Title: S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.
Journal: Molecular cancer therapeutics 20080701
Title: Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis.
Journal: Biochemical and biophysical research communications 20080620
Title: Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080615
Title: FTY720 inhibits S1P-mediated endothelial healing: relationship to S1P1-receptor surface expression.
Journal: Biochemical and biophysical research communications 20080613
Title: Early attenuation of lesional interleukin-16 up-regulation by dexamethasone and FTY720 in experimental traumatic brain injury.
Journal: Neuropathology and applied neurobiology 20080601
Title: Ceramide inhibits development and cytokinesis and induces apoptosis in preimplantation bovine embryos.
Journal: Molecular reproduction and development 20080601
Title: Lysophospholipid receptor-mediated calcium signaling in human keratinocytes.
Journal: The Journal of investigative dermatology 20080601
Title: S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.
Journal: Journal of cellular biochemistry 20080601
Title: Biosynthesis of sphinganine-analog mycotoxins.
Journal: Journal of industrial microbiology & biotechnology 20080601
Title: An essential role for Rac1 in endothelial cell function and vascular development.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080601
Title: C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3.
Journal: Journal of neuroscience research 20080601
Title: Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate.
Journal: Cellular signalling 20080601
Title: Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.
Journal: Prostaglandins & other lipid mediators 20080601
Title: Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease.
Journal: Kidney international 20080601
Title: Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage.
Journal: Cell death and differentiation 20080601
Title: Retina development in zebrafish requires the heparan sulfate proteoglycan agrin.
Journal: Developmental neurobiology 20080601
Title: Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
Journal: American journal of physiology. Lung cellular and molecular physiology 20080601
Title: Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages.
Journal: Prostaglandins & other lipid mediators 20080601
Title: Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model.
Journal: Prostaglandins & other lipid mediators 20080601
Title: Functional complementation of fumonisin biosynthesis in FUM1-disrupted fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici.
Journal: Journal of natural products 20080601
Title: Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation.
Journal: Prostaglandins & other lipid mediators 20080601
Title: Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080601
Title: Antinociceptive activity of the S1P-receptor agonist FTY720.
Journal: Journal of cellular and molecular medicine 20080601
Title: Interactions between sphingosine-1-phosphate and vascular endothelial growth factor signalling in ML-1 follicular thyroid carcinoma cells.
Journal: Endocrine-related cancer 20080601
Title: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Journal: Biological & pharmaceutical bulletin 20080601
Title: 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets.
Journal: Pharmacological reviews 20080601
Title: Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080601
Title: Activity of nuclear factor of activated T cells is independent of the number of peripheral lymphocytes in FTY720-treated patients.
Journal: Transplantation proceedings 20080601
Title: Antiproliferative and overadditive effects of rapamycin and FTY720 in pancreatic cancer cells in vitro.
Journal: Transplantation proceedings 20080601
Title: Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death.
Journal: Biochemical and biophysical research communications 20080530
Title: Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury?
Journal: Journal of neuroscience research 20080515
Title: New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Journal: Biochemical pharmacology 20080515
Title: Asymmetric synthesis of vicinal amino alcohols: xestoaminol C, sphinganine and sphingosine.
Journal: Organic & biomolecular chemistry 20080507
Title: Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition.
Journal: Organic & biomolecular chemistry 20080507
Title: S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses.
Journal: The Journal of biological chemistry 20080502
Title: Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors.
Journal: The Journal of biological chemistry 20080502
Title: Changes in iNOS, GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress.
Journal: Neurochemical research 20080501
Title: The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice.
Journal: Cardiovascular research 20080501
Title: Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.
Journal: Cardiovascular research 20080501
Title: The effect on heart rate of combining single-dose fingolimod with steady-state atenolol or diltiazem in healthy subjects.
Journal: European journal of clinical pharmacology 20080501
Title: Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells.
Journal: Histochemistry and cell biology 20080501
Title: The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin.
Journal: Journal of lipid research 20080501
Title: Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.
Journal: Blood 20080501
Title: Blebbistatin inhibits the chemotaxis of vascular smooth muscle cells by disrupting the myosin II-actin interaction.
Journal: American journal of physiology. Heart and circulatory physiology 20080501
Title: Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.
Journal: International immunology 20080501
Title: FTY720 (fingolimod) for relapsing multiple sclerosis.
Journal: Expert review of neurotherapeutics 20080501
Title: Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1.
Journal: The Journal of biological chemistry 20080425
Title: Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.
Journal: Circulation research 20080425
Title: Sphingosine 1-phosphate attenuates H2O2-induced apoptosis in endothelial cells.
Journal: Biochemical and biophysical research communications 20080418
Title: Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells.
Journal: Journal of cellular biochemistry 20080415
Title: Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.
Journal: Blood 20080415
Title: A fluorescent plate reader assay for ceramide kinase.
Journal: Analytical biochemistry 20080415
Title: The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080415
Title: Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080415
Title: Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity.
Journal: The Journal of biological chemistry 20080411
Title: Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction.
Journal: The British journal of nutrition 20080401
Title: Fungal growth inhibitory properties of new phytosphingolipid analogues.
Journal: Journal of applied microbiology 20080401
Title: Ceramides modulate cell-surface acetylcholine receptor levels.
Journal: Biochimica et biophysica acta 20080401
Title: Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells.
Journal: The Journal of pharmacology and experimental therapeutics 20080401
Title: Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.
Journal: Blood 20080401
Title: FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves.
Journal: Experimental neurology 20080401
Title: Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells.
Journal: International journal of hematology 20080401
Title: Functions of sphingolipid metabolism in mammals--lessons from genetic defects.
Journal: Biochimica et biophysica acta 20080401
Title: Mechanisms of organogenesis of primary lymphoid follicles.
Journal: International immunology 20080401
Title: Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis.
Journal: Pancreas 20080401
Title: Synthesis of the key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the immunomodulatory agent FTY720 (fingolimod).
Journal: Chemical & pharmaceutical bulletin 20080401
Title: TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells.
Journal: European journal of immunology 20080401
Title: Skin allograft survival and analysis of renal parameters after FTY720 + tacrolimus treatment in mice.
Journal: Transplantation proceedings 20080401
Title: Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.
Journal: European journal of pharmacology 20080331
Title: Vascular endothelium as a contributor of plasma sphingosine 1-phosphate.
Journal: Circulation research 20080328
Title: The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases.
Journal: Circulation research 20080328
Title: The role of sphingosine kinase in a murine model of allergic asthma.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080315
Title: Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.
Journal: FEBS letters 20080305
Title: Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
Journal: Fertility and sterility 20080301
Title: Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes.
Journal: Osteoarthritis and cartilage 20080301
Title: Sphingolipid therapy in myocardial ischemia-reperfusion injury.
Journal: Biochimica et biophysica acta 20080301
Title: Sphingosylphosphorylcholine as a novel calmodulin inhibitor.
Journal: The Biochemical journal 20080301
Title: Plasma sphingosine 1-phosphate metabolism and analysis.
Journal: Biochimica et biophysica acta 20080301
Title: Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures.
Journal: Biochimica et biophysica acta 20080301
Title: Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages.
Journal: Prostaglandins & other lipid mediators 20080301
Title: Determination of sphingosine kinase activity for cellular signaling studies.
Journal: Analytical chemistry 20080301
Title: Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells.
Journal: American journal of physiology. Heart and circulatory physiology 20080301
Title: Ovarian tissue viability following whole ovine ovary cryopreservation: assessing the effects of sphingosine-1-phosphate inclusion.
Journal: Human reproduction (Oxford, England) 20080301
Title: A mechanistic study to assess whether isoproterenol can reverse the negative chronotropic effect of fingolimod.
Journal: Journal of clinical pharmacology 20080301
Title: Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins.
Journal: Thrombosis and haemostasis 20080301
Title: The role of sphingosine-1-phosphate and its receptors in asthma.
Journal: Drug news & perspectives 20080301
Title: [Therapeutic effect of S1P receptor modifying drugs for autoimmune diseases].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20080301
Title: Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83.
Journal: Circulation research 20080227
Title: Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.
Journal: The Journal of biological chemistry 20080227
Title: S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Journal: Biochemical and biophysical research communications 20080222
Title: Efficient and selective synthesis of D-arabino-, D-lyxo-, and D-xylo-phytosphingosine from D-ribo-phytosphingosine.
Journal: The Journal of organic chemistry 20080215
Title: FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.
Journal: Cancer research 20080215
Title: Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1.
Journal: Molecular and cellular endocrinology 20080213
Title: Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells.
Journal: FEBS letters 20080206
Title: Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography.
Journal: ChemMedChem 20080201
Title: Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69.
Journal: Diabetes 20080201
Title: Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes.
Journal: American journal of physiology. Heart and circulatory physiology 20080201
Title: An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate.
Journal: Chemistry and physics of lipids 20080201
Title: Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry.
Journal: Hypertension (Dallas, Tex. : 1979) 20080201
Title: Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080201
Title: Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080201
Title: Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat.
Journal: Critical care medicine 20080201
Title: Principles of bioactive lipid signalling: lessons from sphingolipids.
Journal: Nature reviews. Molecular cell biology 20080201
Title: Lipid signalling in disease.
Journal: Nature reviews. Molecular cell biology 20080201
Title: Targeting lipid metabolism in the treatment of hepatitis C virus infection.
Journal: The Journal of infectious diseases 20080201
Title: Sphingolipid receptors.
Journal: Biochemistry. Biokhimiia 20080201
Title: Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii.
Journal: Archives of pharmacal research 20080201
Title: Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.
Journal: British journal of cancer 20080115
Title: Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron.
Journal: The Journal of physiology 20080115
Title: Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080115
Title: Cell-nonautonomous function of ceramidase in photoreceptor homeostasis.
Journal: Neuron 20080110
Title: [Physiologically active substances derived from activated platelets: overview in clinical medicine].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20080110
Title: Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in cell suspension cultures and in isolated nuclei of tobacco.
Journal: Cell calcium 20080101
Title: Sphingosine kinase activity is required for myogenic differentiation of C2C12 myoblasts.
Journal: Journal of cellular physiology 20080101
Title: FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.
Journal: Blood 20080101
Title: Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate.
Journal: Biophysical journal 20080101
Title: Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets.
Journal: Biochimica et biophysica acta 20080101
Title: FTY720 modulates human oligodendrocyte progenitor process extension and survival.
Journal: Annals of neurology 20080101
Title: Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle.
Journal: American journal of physiology. Cell physiology 20080101
Title: Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis.
Journal: Pharmacology & therapeutics 20080101
Title: Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20080101
Title: Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
Journal: British journal of pharmacology 20080101
Title: Follicular shuttling of marginal zone B cells facilitates antigen transport.
Journal: Nature immunology 20080101
Title: The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Journal: Nature immunology 20080101
Title: The multi-functional role of sphingosylphosphorylcholine.
Journal: Progress in lipid research 20080101
Title: Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080101
Title: A role for S1P signalling in axon guidance in the Xenopus visual system.
Journal: Development (Cambridge, England) 20080101
Title: Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases.
Journal: The American journal of pathology 20080101
Title: Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Surgery today 20080101
Title: Antibody-mediated rejection with a striking interstitial monocyte/macrophage infiltration in a renal allograft under FTY720 treatment.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20080101
Title: Reversible cystoid macular edema secondary to fingolimod in a renal transplant recipient.
Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20080101
Title: Tug of war at the exit door.
Journal: Immunity 20080101
Title: N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells.
Journal: Archives of pharmacal research 20080101
Title: T-cell-targeted signaling inhibitors.
Journal: International reviews of immunology 20080101
Title: Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.
Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20080101
Title: Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate.
Journal: Journal of biochemical and molecular toxicology 20080101
Title: Sphingolipids in macroautophagy.
Journal: Methods in molecular biology (Clifton, N.J.) 20080101
Title: FTY720 treatment in experimentally urethane-induced lung tumors.
Journal: Journal of experimental therapeutics & oncology 20080101
Title: Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine.
Journal: Reviews on recent clinical trials 20080101
Title: Biological effects of lysophospholipids.
Journal: Reviews of physiology, biochemistry and pharmacology 20080101
Title: Investigation on C2-ceramide complexes with transition metal ions using electrospray ionization tandem mass spectrometry.
Journal: European journal of mass spectrometry (Chichester, England) 20080101
Title: Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies.
Journal: The Mount Sinai journal of medicine, New York 20080101
Title: Lysophosphatidic acid (LPA) and angiogenesis.
Journal: Angiogenesis 20080101
Title: Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway.
Journal: Cerebrovascular diseases (Basel, Switzerland) 20080101
Title: Stratification of sphingosine kinase-1 expression and activity in rat kidney.
Journal: Cells, tissues, organs 20080101
Title: The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology.
Journal: Endothelium : journal of endothelial cell research 20080101
Title: Cell cycle arrest effects of large-dose FTY720 on lymphocytes in mouse skin transplantation models.
Journal: Immunopharmacology and immunotoxicology 20080101
Title: Glycosylceramides obtain from the starfish Asterias amurensis Lütken.
Journal: Journal of oleo science 20080101
Title: Lysophospholipid activation of G protein-coupled receptors.
Journal: Sub-cellular biochemistry 20080101
Title: Multiple roles for sphingolipids in steroid hormone biosynthesis.
Journal: Sub-cellular biochemistry 20080101
Title: Roles of bioactive sphingolipids in cancer biology and therapeutics.
Journal: Sub-cellular biochemistry 20080101
Title: Sphingolipid metabolizing enzymes as novel therapeutic targets.
Journal: Sub-cellular biochemistry 20080101
Title: New insights on mast cell activation via the high affinity receptor for IgE.
Journal: Advances in immunology 20080101
Title: Sphingosylphosphorylcholine induces mitochondria-mediated apoptosis in neuro 2a cells: involvement of protein kinase C.
Journal: Acta neurobiologiae experimentalis 20080101
Title: Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol.
Journal: BioFactors (Oxford, England) 20080101
Title: [Cordyceps sinensis, a fungi used in the Chinese traditional medicine].
Journal: Revista iberoamericana de micologia 20071231
Title: An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers.
Journal: Analytical biochemistry 20071215
Title: Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus).
Journal: Chemico-biological interactions 20071215
Title: Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury.
Journal: International immunopharmacology 20071215
Title: Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.
Journal: Journal of medicinal chemistry 20071213
Title: Novel neurotrophic effects of sphingosylphosphorylcholine in cerebellar granule neurons and in PC12 cells.
Journal: Biochemical and biophysical research communications 20071207
Title: Structural confirmation of the dihydrosphinganine and fatty acid constituents of the dental pathogen Porphyromonas gingivalis.
Journal: Organic & biomolecular chemistry 20071207
Title: HDL and its sphingosine-1-phosphate content in cardioprotection.
Journal: Heart failure reviews 20071201
Title: S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.
Journal: Neurochemistry international 20071201
Title: Maternal alcohol consumption increases sphingosine levels in the brains of progeny mice.
Journal: Neurochemical research 20071201
Title: Reorganization of prion protein membrane environment during low potassium-induced apoptosis in primary rat cerebellar neurons.
Journal: Journal of neurochemistry 20071201
Title: Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.
Journal: Glia 20071201
Title: Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways.
Journal: American journal of physiology. Renal physiology 20071201
Title: Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20071201
Title: Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy.
Journal: Bioorganic & medicinal chemistry letters 20071201
Title: Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.
Journal: Journal of neurochemistry 20071201
Title: Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.
Journal: Nature immunology 20071201
Title: Finding a way out: lymphocyte egress from lymphoid organs.
Journal: Nature immunology 20071201
Title: Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells.
Journal: Stem cells and development 20071201
Title: Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.
Journal: Cell research 20071201
Title: [Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review].
Journal: Zhongguo shi yan xue ye xue za zhi 20071201
Title: FTY720 reduces extracellular matrix expansion associated with ischemia-reperfusion induced injury.
Journal: Transplantation proceedings 20071201
Title: Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes.
Journal: Transplantation proceedings 20071201
Title: Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
Journal: Journal of vascular surgery 20071201
Title: Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.
Journal: Inflammation & allergy drug targets 20071201
Title: The signaling mechanism of the sphingosylphosphorylcholine-induced contraction in cat esophageal smooth muscle cells.
Journal: Archives of pharmacal research 20071201
Title: [Effect of FTY720 on glomerulosclerosis and expression of cell cycle regulatory proteins in subtotally nephrectomized rats].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20071201
Title: Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.
Journal: The Journal of biological chemistry 20071123
Title: Validation of fumonisin biomarkers in F344 rats.
Journal: Toxicology and applied pharmacology 20071115
Title: Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720.
Journal: European journal of pharmacology 20071114
Title: Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts.
Journal: FEBS letters 20071113
Title: Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.
Journal: FEBS letters 20071113
Title: Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries.
Journal: Circulation research 20071109
Title: Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds.
Journal: Molecular and cellular biochemistry 20071101
Title: Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).
Journal: Blood 20071101
Title: Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis.
Journal: The Journal of pharmacology and experimental therapeutics 20071101
Title: Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells.
Journal: American journal of physiology. Cell physiology 20071101
Title: HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects.
Journal: Journal of lipid research 20071101
Title: S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells.
Journal: Gynecologic oncology 20071101
Title: The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
Journal: The Journal of pharmacology and experimental therapeutics 20071101
Title: Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20071101
Title: Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.
Journal: The Prostate 20071101
Title: Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20071101
Title: Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20071101
Title: Constituents of Crinoidea. 5. Isolation and structure of a new glycosyl inositolphosphoceramide-type ganglioside from the feather star Comanthina schlegeli.
Journal: Chemical & pharmaceutical bulletin 20071101
Title: A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC).
Journal: Prostaglandins & other lipid mediators 20071101
Title: Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells.
Journal: Prostaglandins & other lipid mediators 20071101
Title: Paucity of pericytes in germinal matrix vasculature of premature infants.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20071031
Title: Synthesis and spectral properties of cholesterol- and FTY720-containing boron dipyrromethene dyes.
Journal: The Journal of organic chemistry 20071026
Title: FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis.
Journal: Brain research bulletin 20071019
Title: Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.
Journal: Cancer letters 20071018
Title: Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Journal: Expert reviews in molecular medicine 20071015
Title: FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study.
Journal: Transplantation 20071015
Title: Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity.
Journal: FEBS letters 20071002
Title: Ceramide inhibits LPS-induced production of IL-5, IL-10, and IL-13 from mast cells.
Journal: Journal of cellular physiology 20071001
Title: Trypanosoma cruzi epimastigotes: regulation of myo-inositol transport by effectors of protein kinases A and C.
Journal: Experimental parasitology 20071001
Title: Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways.
Journal: Journal of lipid research 20071001
Title: A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury.
Journal: Cardiovascular research 20071001
Title: Distribution of sphingosine kinase activity and mRNA in rodent brain.
Journal: Journal of neurochemistry 20071001
Title: Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism.
Journal: The Journal of pharmacology and experimental therapeutics 20071001
Title: The acylation of lipophilic alcohols by lysosomal phospholipase A2.
Journal: Journal of lipid research 20071001
Title: Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.
Journal: American journal of physiology. Heart and circulatory physiology 20071001
Title: Cell-specific expression of neutral glycosphingolipids in vertebrate brain: immunochemical localization of 3-O-acetyl-sphingosine-series glycolipid(s) in myelin and oligodendrocytes.
Journal: Journal of neuroscience research 20071001
Title: Sphingosine 1-phosphate accelerates wound healing in diabetic mice.
Journal: Journal of dermatological science 20071001
Title: Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes.
Journal: European journal of pharmacology 20071001
Title: [FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis].
Journal: Der Nervenarzt 20071001
Title: Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase.
Journal: American journal of physiology. Cell physiology 20071001
Title: Agonist potency at P2X7 receptors is modulated by structurally diverse lipids.
Journal: British journal of pharmacology 20071001
Title: Fingolimod: a novel immunosuppressant for multiple sclerosis.
Journal: The Annals of pharmacotherapy 20071001
Title: The thymus is required for the ability of FTY720 to prolong skin allograft survival across different histocompatibility MHC barriers.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20071001
Title: Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.
Journal: The Journal of clinical investigation 20071001
Title: Biomarkers of exposure to fumonisin mycotoxins: a review.
Journal: Food additives and contaminants 20071001
Title: Autocrine and paracrine roles of sphingosine-1-phosphate.
Journal: Trends in endocrinology and metabolism: TEM 20071001
Title: Effect of FTY720 on apoptosis of smooth muscle cells.
Journal: Transplantation proceedings 20071001
Title: Sphingolipid signaling pathways as potential therapeutic targets in gliomas.
Journal: Mini reviews in medicinal chemistry 20071001
Title: Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines.
Journal: Autonomic & autacoid pharmacology 20071001
Title: [Association between murine double minute 2 expression and AngII and ceramide induced endothelial cells apoptosis].
Journal: Zhonghua xin xue guan bing za zhi 20071001
Title: Sphingosine 1-phosphate promotes antigen processing and presentation to CD4+ T cells in Mycobacterium tuberculosis-infected monocytes.
Journal: Biochemical and biophysical research communications 20070928
Title: Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its synthesis to its degradation.
Journal: The Journal of biological chemistry 20070928
Title: Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila.
Journal: Developmental biology 20070915
Title: Ceramide-induced cell death in lens epithelial cells.
Journal: Molecular vision 20070910
Title: FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.
Journal: Cancer letters 20070908
Title: Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
Journal: Nature 20070906
Title: FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
Journal: The Journal of clinical investigation 20070904
Title: Recent advances in the glycosylation of sphingosines and ceramides.
Journal: Carbohydrate research 20070903
Title: Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation.
Journal: Atherosclerosis 20070901
Title: Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070901
Title: Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.
Journal: Journal of molecular graphics & modelling 20070901
Title: Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation.
Journal: Journal of lipid research 20070901
Title: Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells.
Journal: Journal of biochemistry 20070901
Title: Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.
Journal: Pharmacology & therapeutics 20070901
Title: Chronic toxicity of fumonisins in turkeys.
Journal: Poultry science 20070901
Title: Sphingosine 1-phosphate as a novel immune regulator of dendritic cells.
Journal: Journal of biosciences 20070901
Title: Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts.
Journal: The Journal of physiology 20070815
Title: Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase.
Journal: Molecular and cellular endocrinology 20070815
Title: HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate.
Journal: Biochemical and biophysical research communications 20070803
Title: Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine [jaspine B].
Journal: The Journal of organic chemistry 20070803
Title: A concise and scalable synthesis of high enantiopurity (-)-D-erythro-sphingosine using peptidyl thiol ester-boronic acid cross-coupling.
Journal: Organic letters 20070802
Title: Previously postulated 'ligand-independent' signaling of GPR4 is mediated through proton-sensing mechanisms.
Journal: Cellular signalling 20070801
Title: Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.
Journal: Cellular signalling 20070801
Title: Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.
Journal: Journal of neurochemistry 20070801
Title: Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action.
Journal: Molecular pharmacology 20070801
Title: The impact of FTY720 (fingolimod) on vasodilatory function and arterial elasticity in renal transplant patients.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801
Title: Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy.
Journal: Critical reviews in oncology/hematology 20070801
Title: Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070801
Title: A higher plant delta8 sphingolipid desaturase with a preference for (Z)-isomer formation confers aluminum tolerance to yeast and plants.
Journal: Plant physiology 20070801
Title: New sphingolipids with a previously unreported 9-methyl-C20-sphingosine moiety from a marine algous endophytic fungus Aspergillus niger EN-13.
Journal: Lipids 20070801
Title: A rice dihydrosphingosine C4 hydroxylase (DSH1) gene, which is abundantly expressed in the stigmas, vascular cells and apical meristem, may be involved in fertility.
Journal: Plant & cell physiology 20070801
Title: Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070801
Title: Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells.
Journal: Journal of neurochemistry 20070801
Title: Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070801
Title: Sevoflurane, but not propofol, prevents Rho kinase-dependent contraction induced by sphingosylphosphorylcholine in the porcine coronary artery.
Journal: Anesthesia and analgesia 20070801
Title: Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease.
Journal: The European journal of neuroscience 20070801
Title: Enantioselective synthesis of pachastrissamine (jaspin B) using dirhodium(II)-catalyzed C-H amination and asymmetric dihydroxylation as key steps.
Journal: Chemical & pharmaceutical bulletin 20070801
Title: FTY720: a most promising immunosuppressant modulating immune cell functions.
Journal: Mini reviews in medicinal chemistry 20070801
Title: FTY720 improves survival after transient ischemia and reperfusion of the hind limbs.
Journal: The Journal of trauma 20070801
Title: (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.
Journal: Molecular cancer research : MCR 20070801
Title: Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai.
Journal: Memorias do Instituto Oswaldo Cruz 20070801
Title: Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice.
Journal: Archives of pharmacal research 20070801
Title: The immunomodulator FTY720 is phosphorylated and released from platelets.
Journal: European journal of pharmacology 20070730
Title: Reduction of ischemia-reperfusion injury in the rat kidney by FTY720, a synthetic derivative of sphingosine.
Journal: Transplantation 20070727
Title: Fluid shear stress enhances the sphingosine 1-phosphate responses in cell-cell interactions between platelets and endothelial cells.
Journal: Biochemical and biophysical research communications 20070713
Title: Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway.
Journal: The Journal of biological chemistry 20070713
Title: Membrane microdomain formation is crucial in epiboly during gastrulation of medaka.
Journal: Biochemical and biophysical research communications 20070706
Title: The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701
Title: Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12.
Journal: Immunology 20070701
Title: Modulation of human arterial tone during pregnancy: the effect of the bioactive metabolite sphingosine-1-phosphate.
Journal: Biology of reproduction 20070701
Title: Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts.
Journal: Stem cells (Dayton, Ohio) 20070701
Title: FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Journal: Molecular immunology 20070701
Title: Validation of a rapid, non-radioactive method to quantify internalisation of G-protein coupled receptors.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070701
Title: Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines.
Journal: European journal of immunology 20070701
Title: Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.
Journal: Pharmacology & therapeutics 20070701
Title: Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine.
Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20070701
Title: Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors.
Journal: The Journal of pharmacy and pharmacology 20070701
Title: Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries.
Journal: Neurological research 20070701
Title: Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance.
Journal: Biochemical pharmacology 20070630
Title: Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells.
Journal: Neuroscience letters 20070629
Title: FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.
Journal: FEBS letters 20070626
Title: Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage.
Journal: Biochemical and biophysical research communications 20070622
Title: Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury.
Journal: American journal of physiology. Heart and circulatory physiology 20070601
Title: Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation.
Journal: Cellular signalling 20070601
Title: Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness.
Journal: American journal of respiratory cell and molecular biology 20070601
Title: Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.
Journal: American journal of physiology. Heart and circulatory physiology 20070601
Title: Sphingosine 1-phosphate stimulation of NADPH oxidase activity: relationship with platelet-derived growth factor receptor and c-Src kinase.
Journal: Biochimica et biophysica acta 20070601
Title: S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis.
Journal: American journal of physiology. Renal physiology 20070601
Title: Differential effects of G protein coupled receptors on hematopoietic progenitor cell growth depend on their signaling capacities.
Journal: Annals of the New York Academy of Sciences 20070601
Title: The suppressive effect of sphingosine 1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins alpha(5)beta(1) and alpha(v)beta(3).
Journal: Journal of thrombosis and haemostasis : JTH 20070601
Title: Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601
Title: The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma.
Journal: International immunology 20070601
Title: Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver.
Journal: Prostaglandins & other lipid mediators 20070601
Title: Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070601
Title: Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis.
Journal: Expert opinion on pharmacotherapy 20070601
Title: Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation.
Journal: Molecular cancer research : MCR 20070601
Title: Very early alloantigen-independent trafficking of lymphocytes during ischemic acute kidney injury.
Journal: Kidney international 20070601
Title: Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration.
Journal: The Journal of biological chemistry 20070525
Title: Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
Journal: The Journal of biological chemistry 20070525
Title: Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes.
Journal: Biochemical and biophysical research communications 20070525
Title: Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
Journal: Cancer letters 20070518
Title: Synthesis and SAR studies of a novel class of S1P1 receptor antagonists.
Journal: Bioorganic & medicinal chemistry 20070515
Title: Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs.
Journal: Bioorganic & medicinal chemistry letters 20070515
Title: Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.
Journal: The Journal of biological chemistry 20070511
Title: Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation.
Journal: Journal of cellular physiology 20070501
Title: The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.
Journal: Journal of cellular biochemistry 20070501
Title: Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
Journal: Blood 20070501
Title: Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070501
Title: Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts.
Journal: Journal of cellular physiology 20070501
Title: Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
Journal: Journal of dermatological science 20070501
Title: Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms.
Journal: Journal of vascular surgery 20070501
Title: Characterization of novel myelin components 3-O-acetyl-sphingosine galactosylceramides by electrospray ionization Q-TOF MS and MS/CID-MS of Li+ adducts.
Journal: Journal of mass spectrometry : JMS 20070501
Title: Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness.
Journal: Experimental cell research 20070501
Title: basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans.
Journal: Genetics 20070501
Title: Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070501
Title: Novel oral agents for multiple sclerosis.
Journal: Current neurology and neuroscience reports 20070501
Title: Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells.
Journal: The European journal of neuroscience 20070501
Title: [Host-selective toxins and their receptors].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20070501
Title: The role of lysosphingolipids in the regulation of biological processes.
Journal: Biochemistry. Biokhimiia 20070501
Title: Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins.
Journal: Experimental & molecular medicine 20070430
Title: S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
Journal: Biochemical and biophysical research communications 20070427
Title: Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.
Journal: The Journal of biological chemistry 20070420
Title: Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3.
Journal: Biochemical and biophysical research communications 20070420
Title: Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells.
Journal: Life sciences 20070417
Title: Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK.
Journal: Journal of cellular biochemistry 20070415
Title: The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells.
Journal: Gene 20070415
Title: Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells.
Journal: The Journal of biological chemistry 20070413
Title: Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.
Journal: Science (New York, N.Y.) 20070413
Title: Immunology. The sources of a lipid conundrum.
Journal: Science (New York, N.Y.) 20070413
Title: Fumonisin B(1): oxidative status and DNA damage in rats.
Journal: Toxicology 20070411
Title: Letter by Xia regarding article, 'High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor'.
Journal: Circulation 20070410
Title: Deafness and stria vascularis defects in S1P2 receptor-null mice.
Journal: The Journal of biological chemistry 20070406
Title: Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.
Journal: Cellular signalling 20070401
Title: Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences.
Journal: American journal of physiology. Endocrinology and metabolism 20070401
Title: Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement.
Journal: Molecular & cellular proteomics : MCP 20070401
Title: Erythrocytes store and release sphingosine 1-phosphate in blood.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070401
Title: Sphingosine-1-phosphate signaling in the cardiovascular system.
Journal: Current opinion in pharmacology 20070401
Title: Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway.
Journal: The Journal of biological chemistry 20070401
Title: Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells.
Journal: International immunology 20070401
Title: Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
Journal: Cardiovascular research 20070401
Title: Mechanism of mitochondrial 7A6 antigen exposure triggered by distinct apoptotic pathways: involvement of caspases.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070401
Title: FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.
Journal: British journal of pharmacology 20070401
Title: Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.
Journal: Cardiovascular research 20070401
Title: Anti-angiogenic effect of tetraacetyl-phytosphingosine.
Journal: Experimental dermatology 20070401
Title: Current perspectives on FTY720.
Journal: Expert opinion on investigational drugs 20070401
Title: Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain.
Journal: Alcoholism, clinical and experimental research 20070401
Title: Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors.
Journal: Neuropharmacology 20070401
Title: Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070401
Title: Sphingosine 1-phosphate in neural signalling and function.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20070401
Title: Vascular effects of sphingolipids.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20070401
Title: Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity.
Journal: Acta paediatrica (Oslo, Norway : 1992) 20070401
Title: Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
Journal: Journal of pharmacological sciences 20070401
Title: Novel therapies for microvascular permeability in sepsis.
Journal: Current drug targets 20070401
Title: [Involvement of Fyn tyrosine kinase and membrane rafts in the signal transduction in Ca2+-sensitization of vascular smooth muscle contraction].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401
Title: Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.
Journal: Journal of Korean medical science 20070401
Title: Development of a simple and robust assay to screen for inhibitors of sphingosine kinases.
Journal: Assay and drug development technologies 20070401
Title: Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development.
Journal: Archives of pharmacal research 20070401
Title: [Measurement of sphingosine 1-phosphate as a biomarker of atherosclerosis].
Journal: Rinsho byori. The Japanese journal of clinical pathology 20070401
Title: Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
Journal: The Journal of biological chemistry 20070323
Title: MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival.
Journal: The Journal of biological chemistry 20070316
Title: Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070315
Title: Impact of long-term therapy with FTY720 or mycophenolate mofetil on cardiac conduction and rhythm in stable adult renal transplant patients.
Journal: Transplantation 20070315
Title: Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
Journal: The Journal of biological chemistry 20070309
Title: Ceramidase enhances phospholipase C-induced hemolysis by Pseudomonas aeruginosa.
Journal: The Journal of biological chemistry 20070302
Title: Synthesis of borondipyrromethene (BODIPY)-labeled sphingosine derivatives by cross-metathesis reaction.
Journal: The Journal of organic chemistry 20070302
Title: The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070301
Title: Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium.
Journal: Journal of lipid research 20070301
Title: Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects.
Journal: Biopharmaceutics & drug disposition 20070301
Title: Tipping the gatekeeper: S1P regulation of endothelial barrier function.
Journal: Trends in immunology 20070301
Title: FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis.
Journal: Expert opinion on investigational drugs 20070301
Title: Ceramide induces apoptosis in human lung adenocarcinoma A549 cells through mitogen-activated protein kinases.
Journal: Acta pharmacologica Sinica 20070301
Title: Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells.
Journal: Journal of neurochemistry 20070301
Title: On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase.
Journal: Biological chemistry 20070301
Title: The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis.
Journal: Immunity 20070301
Title: Sphingosine-1-phosphate and FTY720 as anti-atherosclerotic lipid compounds.
Journal: European journal of clinical investigation 20070301
Title: Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again.
Journal: Cell cycle (Georgetown, Tex.) 20070301
Title: FTY720 application following isolated warm liver ischemia improves long-term survival and organ protection in a mouse model.
Journal: Transplantation proceedings 20070301
Title: FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia; impact on long-term survival and T-lymphocyte tissue infiltration.
Journal: Transplantation proceedings 20070301
Title: A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations.
Journal: Molecular cancer therapeutics 20070301
Title: PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070301
Title: Chemokines and chemokine receptors in renal transplantation--from bench to bedside.
Journal: Acta physiologica Hungarica 20070301
Title: Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
Journal: Progress in lipid research 20070301
Title: FTY720 attenuates accumulation of EMAP-II+ and MHC-II+ monocytes in early lesions of rat traumatic brain injury.
Journal: Journal of cellular and molecular medicine 20070301
Title: Multiple actions of dimethylsphingosine in 1321N1 astrocytes.
Journal: Molecules and cells 20070227
Title: Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells.
Journal: World journal of gastroenterology 20070221
Title: FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070215
Title: Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death.
Journal: Cancer research 20070215
Title: Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo.
Journal: Oncogene 20070208
Title: Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207
Title: Hydrogen peroxide induces S1P1 receptors and sensitizes vascular endothelial cells to sphingosine 1-phosphate, a platelet-derived lipid mediator.
Journal: American journal of physiology. Cell physiology 20070201
Title: Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.
Journal: Cellular signalling 20070201
Title: The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells.
Journal: Cellular signalling 20070201
Title: Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors.
Journal: American journal of physiology. Heart and circulatory physiology 20070201
Title: The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Journal: Blood 20070201
Title: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
Journal: Gynecologic oncology 20070201
Title: Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.
Journal: The Journal of pharmacology and experimental therapeutics 20070201
Title: Coregulator exchange and sphingosine-sensitive cooperativity of steroidogenic factor-1, general control nonderepressed 5, p54, and p160 coactivators regulate cyclic adenosine 3',5'-monophosphate-dependent cytochrome P450c17 transcription rate.
Journal: Molecular endocrinology (Baltimore, Md.) 20070201
Title: Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid.
Journal: Chemistry and physics of lipids 20070201
Title: Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070201
Title: Steroidogenic factor-1 is a sphingolipid binding protein.
Journal: Molecular and cellular endocrinology 20070201
Title: Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.
Journal: International journal of oncology 20070201
Title: Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats.
Journal: Journal of veterinary pharmacology and therapeutics 20070201
Title: Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins.
Journal: British journal of pharmacology 20070201
Title: TRP channels activated by extracellular hypo-osmoticity in epithelia.
Journal: Biochemical Society transactions 20070201
Title: Bipolar phospholipid sensing by TRPC5 calcium channel.
Journal: Biochemical Society transactions 20070201
Title: Regulation and functional roles of sphingosine kinases.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070201
Title: Synthesis of pachastrissamine from phytosphingosine: a comparison of cyclic sulfate vs an epoxide intermediate in cyclization.
Journal: Organic letters 20070201
Title: Pioglitazone induces de novo ceramide synthesis in the rat heart.
Journal: Prostaglandins & other lipid mediators 20070201
Title: Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells.
Journal: Diabetes 20070201
Title: Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells.
Journal: Cellular and molecular life sciences : CMLS 20070201
Title: Ethnic sensitivity study of fingolimod in white and Asian subjects.
Journal: International journal of clinical pharmacology and therapeutics 20070201
Title: [Effect of mono and combination therapy with FTY720 and ICAM-1 mAb for mouse-to-rat cardiac xenotransplantation].
Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070201
Title: Stereoselective synthesis of L-threo-sphingosine, L-threo-sphinganine, D-threo-sphingosine, and D-threo-sphinganine via oxazoline formation and olefin cross-metathesis; potent protein kinase C inhibitor analogues.
Journal: Archives of pharmacal research 20070201
Title: Lysophospholipid receptors in cell signaling.
Journal: Biochemistry. Biokhimiia 20070201
Title: [The effects of sphingosine-1 1-phosphate (SIP) on the action potential and contractile in guinea pig ventricular myocardium].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201
Title: FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.
Journal: Circulation 20070130
Title: Identification of the hydrophobic ligand binding pocket of the S1P1 receptor.
Journal: The Journal of biological chemistry 20070126
Title: Functions of the multifaceted family of sphingosine kinases and some close relatives.
Journal: The Journal of biological chemistry 20070126
Title: Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha.
Journal: The Journal of biological chemistry 20070119
Title: Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors.
Journal: The Journal of biological chemistry 20070119
Title: Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
Journal: Bioorganic & medicinal chemistry letters 20070115
Title: Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector?
Journal: Free radical biology & medicine 20070115
Title: Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols.
Journal: Free radical biology & medicine 20070115
Title: Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases.
Journal: Cancer research 20070115
Title: Dihydroxylation of 2-vinylaziridine: efficient synthesis of D-ribo-phytosphingosine.
Journal: Chemical communications (Cambridge, England) 20070107
Title: Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase.
Journal: Toxicology 20070105
Title: Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis.
Journal: Circulation research 20070105
Title: Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate.
Journal: Circulation research 20070105
Title: Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms.
Journal: American journal of physiology. Cell physiology 20070101
Title: Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.
Journal: Stem cells (Dayton, Ohio) 20070101
Title: Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?
Journal: Autophagy 20070101
Title: SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.
Journal: Genetics 20070101
Title: Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo.
Journal: Fertility and sterility 20070101
Title: Aberrant Gi protein coupled receptor-mediated cell survival signaling in rheumatoid arthritis B cell lines.
Journal: Frontiers in bioscience : a journal and virtual library 20070101
Title: Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5.
Journal: Oncology reports 20070101
Title: Sphingosine-1-phosphate and calcium signaling in cerebellar astrocytes and differentiated granule cells.
Journal: Neurochemical research 20070101
Title: FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease.
Journal: European journal of immunology 20070101
Title: Cytochemical alterations in the rat retina by LPS administration.
Journal: Neurochemical research 20070101
Title: Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipients.
Journal: International immunopharmacology 20070101
Title: Multiple sclerosis: new insights and therapeutic progress.
Journal: The Lancet. Neurology 20070101
Title: Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling.
Journal: The American journal of pathology 20070101
Title: Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells.
Journal: Scandinavian journal of immunology 20070101
Title: Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells.
Journal: Molecular cancer therapeutics 20070101
Title: Effects of LPA and S1P on the nervous system and implications for their involvement in disease.
Journal: Current drug targets 20070101
Title: New immunosuppresor strategies in the treatment of murine lupus nephritis.
Journal: Lupus 20070101
Title: A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine.
Journal: Archives of pharmacal research 20070101
Title: Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
Journal: Neurochemical research 20070101
Title: FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
Journal: Anticancer research 20070101
Title: Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes.
Journal: BMC musculoskeletal disorders 20070101
Title: N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation.
Journal: Bioconjugate chemistry 20070101
Title: Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice.
Journal: Microsurgery 20070101
Title: Sphingosylphosphorylcholine stimulates expression of fibronectin through TGF-beta1-Smad-dependent mechanism in human mesenchymal stem cells.
Journal: The international journal of biochemistry & cell biology 20070101
Title: Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation.
Journal: Drug and chemical toxicology 20070101
Title: Analysis of sphingosine 1-phosphate by capillary electrophoresis coupled to laser-induced fluorescence detection: use of a transparent fused-silica capillary.
Journal: Journal of capillary electrophoresis and microchip technology 20070101
Title: Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries.
Journal: Journal of combinatorial chemistry 20070101
Title: A Novel sulfatide, GlcCer-I6 sulfate, from the ascidian Ciona intestinalis.
Journal: Journal of oleo science 20070101
Title: Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.
Journal: Journal of biochemical and molecular toxicology 20070101
Title: Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo.
Journal: Methods in enzymology 20070101
Title: A rapid and sensitive method to measure secretion of sphingosine-1-phosphate.
Journal: Methods in enzymology 20070101
Title: Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing.
Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20070101
Title: Sphingosine-1-phosphate signaling and the skin.
Journal: American journal of clinical dermatology 20070101
Title: Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells.
Journal: Pharmacological reports : PR 20070101
Title: Randomized controlled trial of FTY720 versus MMF in de novo renal transplantation.
Journal: Transplantation 20061227
Title: FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs.
Journal: International immunopharmacology 20061220
Title: FTY720 in combination with cyclosporine--an analysis of skin allograft survival and renal function.
Journal: International immunopharmacology 20061220
Title: Tacrolimus in combination with FTY720--an analysis of renal and blood parameters.
Journal: International immunopharmacology 20061220
Title: Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling.
Journal: The EMBO journal 20061213
Title: Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response.
Journal: Biochimica et biophysica acta 20061201
Title: S1P regulation of ovarian carcinoma invasiveness.
Journal: Gynecologic oncology 20061201
Title: Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes.
Journal: Endocrinology 20061201
Title: New developments in the biological functions of lysophospholipids.
Journal: Cellular and molecular life sciences : CMLS 20061201
Title: Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.
Journal: Journal of lipid research 20061201
Title: Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
Journal: Biochimica et biophysica acta 20061201
Title: Distribution and dynamic changes of sphingolipids in blood in response to platelet activation.
Journal: Journal of thrombosis and haemostasis : JTH 20061201
Title: Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11).
Journal: The Journal of biological chemistry 20061201
Title: Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?
Journal: Clinical immunology (Orlando, Fla.) 20061201
Title: Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice.
Journal: Journal of toxicology and environmental health. Part A 20061201
Title: FTY720 versus MMF with cyclosporine in de novo renal transplantation: a 1-year, randomized controlled trial in Europe and Australasia.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20061201
Title: Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids.
Journal: Biochimica et biophysica acta 20061201
Title: LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples.
Journal: Prostaglandins & other lipid mediators 20061201
Title: Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.
Journal: Journal of cell science 20061201
Title: A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death.
Journal: Biochimica et biophysica acta 20061201
Title: Regulation of donor T cells in the tolerant rats to graft-versus-host disease by FTY720 following small bowel transplantation.
Journal: Transplantation proceedings 20061201
Title: Exposure-efficacy relationships of a fingolimod-everolimus regimen in kidney transplant patients at risk for delayed graft function.
Journal: Transplantation proceedings 20061201
Title: [Phosphodiesterases that extracellularly produces a lysolipid mediator].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20061201
Title: Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate.
Journal: Stem cells and development 20061201
Title: Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.
Journal: Cellular & molecular immunology 20061201
Title: Stereoselective synthesis of jaspine B from D-xylose.
Journal: Carbohydrate research 20061127
Title: Versatile synthetic method for sphingolipids and functionalized sphingosine derivatives via olefin cross metathesis.
Journal: Organic letters 20061123
Title: Cytotoxic effect induced by retinoic acid loaded into galactosyl-sphingosine containing liposomes on human hepatoma cell lines.
Journal: International journal of pharmaceutics 20061115
Title: Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061115
Title: Measurement and stability of FTY720 in human whole blood by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061107
Title: Targeting sphingosine-1-phosphate for cancer therapy.
Journal: British journal of cancer 20061106
Title: Functions and metabolism of sphingolipids in Saccharomyces cerevisiae.
Journal: Progress in lipid research 20061101
Title: Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.
Journal: Journal of cellular biochemistry 20061101
Title: Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1.
Journal: Endocrinology 20061101
Title: Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells.
Journal: Stem cells (Dayton, Ohio) 20061101
Title: PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression.
Journal: Journal of neurochemistry 20061101
Title: Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway.
Journal: Apoptosis : an international journal on programmed cell death 20061101
Title: Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide.
Journal: Hepatology (Baltimore, Md.) 20061101
Title: Evaluation of sphinganine and sphingosine as human breast cancer chemotherapeutic and chemopreventive agents.
Journal: Experimental biology and medicine (Maywood, N.J.) 20061101
Title: Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases.
Journal: Investigative ophthalmology & visual science 20061101
Title: Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells.
Journal: Journal of pharmacological sciences 20061101
Title: Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
Journal: The Journal of clinical investigation 20061101
Title: Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent.
Journal: The Journal of endocrinology 20061101
Title: The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.
Journal: PLoS biology 20061101
Title: Effect of FTY720 in rat small bowel transplantation: apoptosis of crypt cells and lymphocytes in gut-associated lymphoid tissues.
Journal: Transplantation proceedings 20061101
Title: The curtain is drawn for both natalizumab and fingolimod (FTY720): a new era of multiple sclerosis therapy has arrived.
Journal: Expert review of neurotherapeutics 20061101
Title: Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.
Journal: Archives of pharmacal research 20061101
Title: Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
Title: Efficient synthesis of D-erythro-sphingosine and D-erythro-azidosphingosine from D-ribo-phytosphingosine via a cyclic sulfate intermediate.
Journal: The Journal of organic chemistry 20061027
Title: Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.
Journal: The Journal of biological chemistry 20061020
Title: Caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry.
Journal: The Journal of biological chemistry 20061013
Title: Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C.
Journal: Cellular signalling 20061001
Title: De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells.
Journal: Cellular signalling 20061001
Title: Bioactive sphingolipids in the modulation of the inflammatory response.
Journal: Pharmacology & therapeutics 20061001
Title: Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells.
Journal: Endocrinology 20061001
Title: Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-versus-host disease in small bowel transplantation.
Journal: Clinical and experimental immunology 20061001
Title: The S1P receptor modulator FTY720 prevents the development of experimental colitis in mice.
Journal: Oncology reports 20061001
Title: Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis.
Journal: Acta pharmacologica Sinica 20061001
Title: Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity.
Journal: The Journal of biological chemistry 20060929
Title: Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes.
Journal: Biochemical and biophysical research communications 20060929
Title: Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.
Journal: Circulation research 20060929
Title: Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel.
Journal: Circulation research 20060929
Title: High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor.
Journal: Circulation 20060926
Title: Interleukin-1beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons.
Journal: Neuroscience 20060915
Title: Highly sensitive determination of N-acyl dihydrosphingosine using liquid chromatography-electrospray ionization mass spectrometry. Application to human hair lipids.
Journal: Journal of chromatography. A 20060915
Title: Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration.
Journal: The New England journal of medicine 20060914
Title: Oral fingolimod (FTY720) for relapsing multiple sclerosis.
Journal: The New England journal of medicine 20060914
Title: Sphingosine kinase regulates voltage operated calcium channels in GH4C1 rat pituitary cells.
Journal: Cellular signalling 20060901
Title: Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells.
Journal: Histochemistry and cell biology 20060901
Title: Molecular requirements for doxorubicin-mediated death in murine oocytes.
Journal: Cell death and differentiation 20060901
Title: Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.
Journal: Blood 20060901
Title: Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons.
Journal: Journal of neurophysiology 20060901
Title: Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901
Title: Dietary sphingolipids suppress a subset of preneoplastic rat liver lesions exhibiting high PTEN, low phospho-Akt and high levels of ceramide species.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901
Title: C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts.
Journal: Endocrinology 20060901
Title: Sphingosine, a product of ceramide hydrolysis, influences the formation of ceramide channels.
Journal: Biophysical journal 20060901
Title: Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.
Journal: Cardiovascular research 20060901
Title: Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060901
Title: Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
Journal: American journal of physiology. Heart and circulatory physiology 20060901
Title: Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060901
Title: [Effect of ceramide on apoptosis of human colon cancer HT-29 cells].
Journal: Wei sheng yan jiu = Journal of hygiene research 20060901
Title: Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
Journal: The Journal of biological chemistry 20060825
Title: Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons.
Journal: The Journal of physiology 20060815
Title: Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.
Journal: Circulation research 20060804
Title: Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Journal: Journal of cellular biochemistry 20060801
Title: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20060801
Title: Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.
Journal: The Biochemical journal 20060801
Title: Antitumor activity of sphingosine kinase inhibitors.
Journal: The Journal of pharmacology and experimental therapeutics 20060801
Title: Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS.
Journal: Glycobiology 20060801
Title: Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach.
Journal: Journal of lipid research 20060801
Title: IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids.
Journal: Journal of leukocyte biology 20060801
Title: FTY720/cyclosporine regimens in de novo renal transplantation: a 1-year dose-finding study.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060801
Title: Membrane guanylyl cyclase receptors: an update.
Journal: Trends in endocrinology and metabolism: TEM 20060801
Title: The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes.
Journal: European journal of immunology 20060801
Title: Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Journal: Nature chemical biology 20060801
Title: Lipid-induced phenotypes.
Journal: Nature chemical biology 20060801
Title: FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects.
Journal: Journal of clinical pharmacology 20060801
Title: Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast.
Journal: FEMS yeast research 20060801
Title: Sphingosine and ceramide signalling in apoptosis.
Journal: IUBMB life 20060801
Title: Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.
Journal: IUBMB life 20060801
Title: [Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors].
Journal: Zhongguo shi yan xue ye xue za zhi 20060801
Title: Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line.
Journal: Archives of pharmacal research 20060801
Title: [Multifunctional sphingolipid, sphingosine (long-chain base) 1-phosphate: physiological role, metabolism, and intracellular dynamics].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20060801
Title: An efficient high-yield synthesis of D-ribo-phytosphingosine.
Journal: Organic letters 20060720
Title: Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.
Journal: The Biochemical journal 20060715
Title: Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles.
Journal: Journal of cell science 20060715
Title: Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation.
Journal: The Journal of biological chemistry 20060707
Title: 9-O-acetyl GD3 protects tumor cells from apoptosis.
Journal: International journal of cancer 20060701
Title: Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Journal: Molecular pharmacology 20060701
Title: Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes.
Journal: Journal of cellular physiology 20060701
Title: Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells.
Journal: Neuropharmacology 20060701
Title: 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Journal: Bioorganic & medicinal chemistry letters 20060701
Title: Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway.
Journal: Neurobiology of disease 20060701
Title: Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell.
Journal: Prostaglandins & other lipid mediators 20060701
Title: The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor.
Journal: Prostaglandins & other lipid mediators 20060701
Title: A ceramide and cerebroside from the starfish asterias amurensis Lütken and their plant-growth promotion activities.
Journal: Journal of natural products 20060701
Title: [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine].
Journal: Rinsho byori. The Japanese journal of clinical pathology 20060701
Title: Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice.
Journal: Biochemical and biophysical research communications 20060623
Title: Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation.
Journal: Biochemical and biophysical research communications 20060623
Title: Preparation of antibodies against a novel immunosuppressant, FTY720, and development of an enzyme immunoassay for FTY720.
Journal: Bioorganic & medicinal chemistry 20060615
Title: Apoptosis of human colon carcinoma HT-29 cells induced by ceramide.
Journal: World journal of gastroenterology 20060614
Title: Changes in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells.
Journal: Biochemical and biophysical research communications 20060609
Title: A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility.
Journal: Circulation research 20060609
Title: Enantiodivergent synthesis of D- and L-erythro-sphingosines through Mannich-type reactions of N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone.
Journal: The Journal of organic chemistry 20060609
Title: Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
Journal: American journal of physiology. Renal physiology 20060601
Title: Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells.
Journal: Journal of cellular physiology 20060601
Title: The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function.
Journal: Journal of lipid research 20060601
Title: Sphingosine increases the permeability of model and cell membranes.
Journal: Biophysical journal 20060601
Title: Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion.
Journal: Journal of lipid research 20060601
Title: Pulmonary and vascular pharmacology of sphingosine 1-phosphate.
Journal: Current opinion in pharmacology 20060601
Title: Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.
Journal: European journal of immunology 20060601
Title: Sphingosine impairs mitochondrial function by opening permeability transition pore.
Journal: Mitochondrion 20060601
Title: Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells.
Journal: Molecular cancer therapeutics 20060601
Title: Mice lacking both TNFalpha receptors show increased constitutive expression of IFNgamma: a possible reason for lack of protection from fumonisin B1 hepatotoxicity.
Journal: Cytokine 20060601
Title: Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system.
Journal: Biochemical and biophysical research communications 20060526
Title: Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle.
Journal: Biochemical and biophysical research communications 20060519
Title: Glycosynthase-mediated synthesis of glycosphingolipids.
Journal: Journal of the American Chemical Society 20060517
Title: The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver.
Journal: Toxicology 20060515
Title: Cytotoxicity of sphingoid marine compound analogs in mono- and multilayered solid tumor cell cultures.
Journal: Investigational new drugs 20060501
Title: Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes.
Journal: Journal of neurochemistry 20060501
Title: Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Valpha19 NKT cell with alpha-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit.
Journal: European journal of medicinal chemistry 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells.
Journal: Prostaglandins & other lipid mediators 20060501
Title: Efflux of sphingolipids metabolically labeled with [1-3H]sphingosine, L-[3- 3H]serine and [9,10- 3H]palmitic acid from normal cells in culture.
Journal: Glycoconjugate journal 20060501
Title: The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.
Journal: The Journal of biological chemistry 20060428
Title: [Inhibition of alphastatin on angiogenesis in human endothelial cells and the mechanism thereof: an experimental study].
Journal: Zhonghua yi xue za zhi 20060418
Title: Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors.
Journal: Glia 20060415
Title: Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.
Journal: Experimental cell research 20060415
Title: Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha.
Journal: Cell death and differentiation 20060401
Title: Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells.
Journal: American journal of physiology. Cell physiology 20060401
Title: Cardiac glycoside inhibits IL-8-induced biological responses by downregulating IL-8 receptors through altering membrane fluidity.
Journal: Journal of cellular physiology 20060401
Title: Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060401
Title: Semisynthetic sphingoglycolipid LIGA20 is neuroprotective against human immunodeficiency virus-gp120-mediated apoptosis.
Journal: Journal of neuroscience research 20060401
Title: Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060401
Title: Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060401
Title: Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes.
Journal: Pigment cell research 20060401
Title: Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies?
Journal: Cardiovascular research 20060401
Title: Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction?
Journal: Cardiovascular research 20060401
Title: Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents.
Journal: Cardiovascular research 20060401
Title: Ceramide is a mediator of apoptosis in retina photoreceptors.
Journal: Investigative ophthalmology & visual science 20060401
Title: Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060401
Title: Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes.
Journal: Journal of pharmacological sciences 20060401
Title: In vitro evaluation of the effect of a novel immunosuppressive agent, FTY720, on the function of feline neutrophils.
Journal: American journal of veterinary research 20060401
Title: Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels.
Journal: Biomacromolecules 20060401
Title: Evidence that FTY720 induces rat thymocyte apoptosis.
Journal: Transplant immunology 20060401
Title: FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells.
Journal: Transplant immunology 20060401
Title: FTY720 for treatment of ischemia-reperfusion injury following complete renal ischemia in C57/BL6 mice.
Journal: Transplantation proceedings 20060401
Title: TNF-alpha-induced impairment of mitochondrial integrity and apoptosis mediated by caspase-8 in adult ventricular myocytes.
Journal: Cytokine 20060401
Title: Sphingosine kinase: biochemical and cellular regulation and role in disease.
Journal: Journal of biochemistry and molecular biology 20060331
Title: A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs.
Journal: Organic & biomolecular chemistry 20060321
Title: Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
Journal: The Journal of biological chemistry 20060317
Title: Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development.
Journal: Developmental biology 20060315
Title: Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria.
Journal: The Journal of biological chemistry 20060310
Title: Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks.
Journal: Chemico-biological interactions 20060310
Title: Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks.
Journal: Chemico-biological interactions 20060310
Title: Ceramide-induced preconditioning involves reactive oxygen species.
Journal: Life sciences 20060306
Title: Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis.
Journal: The Journal of biological chemistry 20060303
Title: A photoreactive analogue of the immunosuppressant FTY720.
Journal: The Journal of organic chemistry 20060303
Title: Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration.
Journal: Cellular signalling 20060301
Title: Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1.
Journal: Endocrinology 20060301
Title: Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK.
Journal: Journal of lipid research 20060301
Title: Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways.
Journal: Molecular pharmacology 20060301
Title: Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins.
Journal: Molecular pharmacology 20060301
Title: Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner.
Journal: Journal of lipid research 20060301
Title: Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060301
Title: Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20060301
Title: Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry.
Journal: Journal of mass spectrometry : JMS 20060301
Title: Phenoxodiol: isoflavone analog with antineoplastic activity.
Journal: Current oncology reports 20060301
Title: Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.
Journal: Arthritis and rheumatism 20060301
Title: Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics.
Journal: Cancer cell 20060301
Title: Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages.
Journal: Cancer cell 20060301
Title: S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK.
Journal: The European journal of neuroscience 20060301
Title: The role of the phospholipid sphingomyelin in heart disease.
Journal: Current opinion in investigational drugs (London, England : 2000) 20060301
Title: Meeting report: Barossa 2005--Signaling Networks.
Journal: Science's STKE : signal transduction knowledge environment 20060227
Title: Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells.
Journal: Molecules and cells 20060227
Title: Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner.
Journal: Biochemical and biophysical research communications 20060224
Title: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase.
Journal: Cancer letters 20060220
Title: Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient with Fabry disease.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060217
Title: Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups.
Journal: Organic letters 20060216
Title: Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
Journal: Blood 20060215
Title: Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis.
Journal: The Biochemical journal 20060215
Title: Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis.
Journal: Free radical biology & medicine 20060215
Title: A direct organocatalytic entry to sphingoids: asymmetric synthesis of D-arabino- and L-ribo-phytosphingosine.
Journal: Chemical communications (Cambridge, England) 20060214
Title: Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells.
Journal: The Journal of biological chemistry 20060210
Title: IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Journal: The Journal of biological chemistry 20060203
Title: Stereoselective synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B) from D-xylose.
Journal: The Journal of organic chemistry 20060203
Title: Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity.
Journal: American journal of physiology. Lung cellular and molecular physiology 20060201
Title: Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia.
Journal: American journal of respiratory cell and molecular biology 20060201
Title: Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum.
Journal: The Journal of pharmacology and experimental therapeutics 20060201
Title: Influence of chain length and unsaturation on sphingomyelin bilayers.
Journal: Biophysical journal 20060201
Title: Sphingosine kinase 1 is up-regulated in colon carcinogenesis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201
Title: Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201
Title: Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts.
Journal: Journal of molecular and cellular cardiology 20060201
Title: Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind?
Journal: British journal of pharmacology 20060201
Title: Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation.
Journal: British journal of pharmacology 20060201
Title: Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases.
Journal: European journal of cancer (Oxford, England : 1990) 20060201
Title: Emerging medicinal roles for lysophospholipid signaling.
Journal: Trends in molecular medicine 20060201
Title: Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060201
Title: Fingolimod (FTY720) in severe hepatic impairment: pharmacokinetics and relationship to markers of liver function.
Journal: Journal of clinical pharmacology 20060201
Title: Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes.
Journal: Journal of biochemistry 20060201
Title: CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.
Journal: Immunity 20060201
Title: [Disturbances of antimicrobial lipids in atopic dermatitis].
Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060201
Title: [Molecular action mechanisms of the therapeutic agents for kidney diseases: Immunosuppressants].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060201
Title: Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus.
Journal: Cellular & molecular immunology 20060201
Title: An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine.
Journal: The Journal of organic chemistry 20060120
Title: Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
Journal: The Biochemical journal 20060115
Title: Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060115
Title: Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study.
Journal: International journal of pharmaceutics 20060113
Title: Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone.
Journal: Biology of reproduction 20060101
Title: Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.
Journal: The Journal of surgical research 20060101
Title: Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060101
Title: NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.
Journal: Bioorganic & medicinal chemistry letters 20060101
Title: Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Title: Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response.
Journal: Archives of biochemistry and biophysics 20060101
Title: The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells.
Journal: British journal of pharmacology 20060101
Title: ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria.
Journal: Biochimica et biophysica acta 20060101
Title: Novel insights into the mechanism of action of FTY720 in a transgenic model of allograft rejection: implications for therapy of chronic rejection.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060101
Title: Induction of endonuclease G-mediated apopotosis in human oral squamous cell carcinoma cells by protein kinase C inhibitor safingol.
Journal: Apoptosis : an international journal on programmed cell death 20060101
Title: Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization.
Journal: Cancer research 20060101
Title: Gene transfer mediated by sphingosine/ dioleoylphosphatidylethanolamine liposomes in the presence of poloxamer 188.
Journal: Drug delivery 20060101
Title: Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases.
Journal: Current pharmaceutical design 20060101
Title: Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells.
Journal: Anticancer research 20060101
Title: Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts.
Journal: Biochimica et biophysica acta 20060101
Title: Sphingosine kinase and sphingosine-1-phosphate regulate migration, endocytosis and apoptosis of dendritic cells.
Journal: Immunological investigations 20060101
Title: [New ceramides from sea sponge Oceanapia sp].
Journal: Bioorganicheskaia khimiia 20060101
Title: The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology.
Journal: Archivum immunologiae et therapiae experimentalis 20060101
Title: Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin.
Journal: Molecular medicine (Cambridge, Mass.) 20060101
Title: Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line.
Journal: BMC bioinformatics 20060101
Title: Signal transduction of sphingosine-1-phosphate G protein-coupled receptors.
Journal: TheScientificWorldJournal 20060101
Title: Quantification of the wound healing using polarization-sensitive optical coherence tomography.
Journal: Journal of biomedical optics 20060101
Title: Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway.
Journal: The international journal of biochemistry & cell biology 20060101
Title: Transport across the endothelium: regulation of endothelial permeability.
Journal: Handbook of experimental pharmacology 20060101
Title: S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver.
Journal: Journal of applied toxicology : JAT 20060101
Title: FTY720 (fingolimod) in renal transplantation.
Journal: Clinical transplantation 20060101
Title: Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.
Journal: Clinical transplantation 20060101
Title: Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling.
Journal: Molecular cancer 20060101
Title: Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
Journal: Current pharmaceutical design 20060101
Title: Protective effect of the hexapeptide TGENHR on the TNF-induced death of HL-60 cells.
Journal: Doklady. Biochemistry and biophysics 20060101
Title: The mechanism of membrane targeting of human sphingosine kinase 1.
Journal: The Journal of biological chemistry 20051230
Title: Sphingosine releases Ca2+ from intracellular stores via the ryanodine receptor in sea urchin egg homogenates.
Journal: Biochemical and biophysical research communications 20051223
Title: An efficient synthesis of D-erythro- and D-threo-sphingosine from D-glucose: olefin cross-metathesis approach.
Journal: Organic letters 20051222
Title: FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.
Journal: International journal of cancer 20051220
Title: The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20051215
Title: Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
Journal: Cancer research 20051215
Title: Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.
Journal: The Journal of organic chemistry 20051209
Title: FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors.
Journal: Pharmacology & therapeutics 20051201
Title: Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine.
Journal: Toxicology 20051201
Title: Influence of phytosphingosine-type ceramides on the structure of DMPC membrane.
Journal: Chemistry and physics of lipids 20051201
Title: Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production.
Journal: Cell calcium 20051201
Title: Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
Journal: Nature immunology 20051201
Title: Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.
Journal: European journal of immunology 20051201
Title: Two ligands for a GPCR, proton vs lysolipid.
Journal: Acta pharmacologica Sinica 20051201
Title: Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20051201
Title: Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.
Journal: Journal of neurochemistry 20051201
Title: FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051201
Title: Multiple sclerosis poses tough drug development challenges.
Journal: Drug discovery today 20051201
Title: Use of FTY 720 and ICAM-1 antisense oligonucleotides for attenuating chronic renal damage secondary to ischemia-reperfusion injury.
Journal: Transplantation proceedings 20051201
Title: Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1.
Journal: Transplantation proceedings 20051201
Title: FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.
Journal: Cellular & molecular immunology 20051201
Title: Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051123
Title: Characterization of the bactericidal effect of dietary sphingosine and its activity under intestinal conditions.
Journal: International journal of food microbiology 20051115
Title: Effect of FTY720 on chronic cyclosporine nephropathy in rats.
Journal: Transplantation 20051115
Title: Chirality transfer from guanidinium ylides to 3-alkenyl (or 3-alkynyl) aziridine-2-carboxylates and application to the syntheses of (2R,3S)-3-hydroxyleucinate and D-erythro-sphingosine.
Journal: The Journal of organic chemistry 20051111
Title: Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
Journal: The Journal of biological chemistry 20051104
Title: Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.
Journal: The Journal of biological chemistry 20051104
Title: Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.
Journal: The Journal of biological chemistry 20051104
Title: Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.
Journal: Journal of lipid research 20051101
Title: beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells.
Journal: The Journal of nutritional biochemistry 20051101
Title: Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.
Journal: Journal of lipid research 20051101
Title: Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101
Title: C2-ceramide exhibits antiproliferative activity and potently induces apoptosis in endometrial carcinoma.
Journal: Oncology reports 20051101
Title: The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051101
Title: C2-ceramide induces vasodilation in phenylephrine-induced pre-contracted rat thoracic aorta: role of RhoA/Rho-kinase and intracellular Ca2+ concentration.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20051101
Title: FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship.
Journal: Journal of clinical pharmacology 20051101
Title: Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae.
Journal: Biochemical Society transactions 20051101
Title: Candida albicans serotype B strains synthesize a serotype-specific phospholipomannan overexpressing a beta-1,2-linked mannotriose.
Journal: Molecular microbiology 20051101
Title: Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1.
Journal: Progress in lipid research 20051101
Title: FTY720 inhibits TH1-mediated allogeneic humoral immune response.
Journal: Transplantation proceedings 20051101
Title: [Establishment of a method for determining the sphingosine kinase activity and its initial application].
Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101
Title: APP1 transcription is regulated by inositol-phosphorylceramide synthase 1-diacylglycerol pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans.
Journal: The Journal of biological chemistry 20051028
Title: One-step labelling of sphingolipids via a scrambling cross-metathesis reaction.
Journal: Chemical communications (Cambridge, England) 20051028
Title: Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.
Journal: Journal of cell science 20051015
Title: The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.
Journal: The Journal of biological chemistry 20051007
Title: Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.
Journal: Oncogene 20051006
Title: Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
Journal: Cardiovascular research 20051001
Title: Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.
Journal: The Biochemical journal 20051001
Title: Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
Journal: Cellular signalling 20051001
Title: Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.
Journal: Cardiovascular research 20051001
Title: Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation.
Journal: Journal of pharmacological sciences 20051001
Title: Inflammation and perturbation of the l-carnitine system in heart failure.
Journal: European journal of heart failure 20051001
Title: [Multiple sclerosis. A new oral immunomodulator].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20051001
Title: A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925
Title: Endothelial/pericyte interactions.
Journal: Circulation research 20050916
Title: Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates.
Journal: Toxicology 20050915
Title: Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice.
Journal: Toxicon : official journal of the International Society on Toxinology 20050915
Title: Immunology. Dietary factors and immunological consequences.
Journal: Science (New York, N.Y.) 20050909
Title: Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
Journal: Science (New York, N.Y.) 20050909
Title: Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050901
Title: Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response.
Journal: Journal of lipid research 20050901
Title: Differential regulation of NPR-B/GC-B by protein kinase c and calcium.
Journal: Biochemical pharmacology 20050901
Title: Regulation of vascular reactivity by established and emerging GPCRs.
Journal: Trends in pharmacological sciences 20050901
Title: Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor.
Journal: European journal of immunology 20050901
Title: Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics.
Journal: Prostaglandins & other lipid mediators 20050901
Title: Lysophospholipids in the nervous system.
Journal: Prostaglandins & other lipid mediators 20050901
Title: Chemical approaches to the lysophospholipid receptors.
Journal: Prostaglandins & other lipid mediators 20050901
Title: Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050901
Title: Sphingosine-1-phosphate mediates migration of mature dendritic cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050901
Title: Protein kinases influence bovine oocyte competence during short-term treatment with recombinant human follicle stimulating hormone.
Journal: Reproduction (Cambridge, England) 20050901
Title: [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20050901
Title: Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma.
Journal: Molecular cancer therapeutics 20050901
Title: Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt.
Journal: Thrombosis and haemostasis 20050901
Title: A new turning point in glycosphingolipid research.
Journal: Human cell 20050901
Title: The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
Journal: Blood 20050815
Title: Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.
Journal: Journal of neuroscience research 20050815
Title: FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Journal: Cancer research 20050815
Title: Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Journal: Journal of medicinal chemistry 20050811
Title: Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive.
Journal: American journal of physiology. Heart and circulatory physiology 20050801
Title: HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.
Journal: American journal of physiology. Cell physiology 20050801
Title: Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells.
Journal: Endocrinology 20050801
Title: Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.
Journal: Journal of leukocyte biology 20050801
Title: The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.
Journal: Molecular pharmacology 20050801
Title: Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20050801
Title: The crystal structure of human CD1d with and without alpha-galactosylceramide.
Journal: Nature immunology 20050801
Title: Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: physicochemical and molecular modeling studies.
Journal: Archives of biochemistry and biophysics 20050801
Title: [Effects of sphingosine 1-phosphate on functions of T cell - review].
Journal: Zhongguo shi yan xue ye xue za zhi 20050801
Title: Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor.
Journal: Annals of biomedical engineering 20050801
Title: Sphingosine forms channels in membranes that differ greatly from those formed by ceramide.
Journal: Journal of bioenergetics and biomembranes 20050801
Title: Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC).
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050801
Title: Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Journal: The Journal of biological chemistry 20050729
Title: Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells.
Journal: FEBS letters 20050718
Title: Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism.
Journal: The Journal of biological chemistry 20050715
Title: Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells.
Journal: Biochemical pharmacology 20050715
Title: Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.
Journal: The Biochemical journal 20050701
Title: Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate.
Journal: Blood 20050701
Title: Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response.
Journal: Cellular signalling 20050701
Title: TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx.
Journal: Journal of leukocyte biology 20050701
Title: Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050701
Title: Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts.
Journal: Experimental dermatology 20050701
Title: Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model.
Journal: Birth defects research. Part A, Clinical and molecular teratology 20050701
Title: Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network.
Journal: Nature reviews. Immunology 20050701
Title: Ceramides, sphinganine, sphingosine and acid sphingomyelinases in the human umbilical cord blood.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050701
Title: Sphingosine 1-phosphate-related metabolism in the blood vessel.
Journal: Journal of biochemistry 20050701
Title: Protection of mouse small bowel allografts by FTY720 and costimulation blockade.
Journal: Transplantation 20050627
Title: Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
Journal: The Journal of biological chemistry 20050617
Title: The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.
Journal: The Journal of biological chemistry 20050617
Title: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Journal: Transplantation 20050615
Title: 2n-fatty acids from phosphatidylcholine label sphingolipids--a novel role of phospholipase A2?
Journal: Biochimica et biophysica acta 20050615
Title: Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue.
Journal: The Journal of organic chemistry 20050610
Title: Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Journal: The Journal of biological chemistry 20050603
Title: Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells.
Journal: Biochemical and biophysical research communications 20050603
Title: Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue.
Journal: American journal of physiology. Cell physiology 20050601
Title: Chloride channel activity in human lung fibroblasts and myofibroblasts.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050601
Title: Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways.
Journal: Cellular signalling 20050601
Title: Myriocin prevents fumonisin B1-induced sphingoid base accumulation in mice liver without ameliorating hepatotoxicity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050601
Title: Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry.
Journal: Methods (San Diego, Calif.) 20050601
Title: Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides.
Journal: Biochimica et biophysica acta 20050601
Title: Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in experimental autoimmune encephalitis.
Journal: Journal of magnetic resonance imaging : JMRI 20050601
Title: LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance.
Journal: Investigative ophthalmology & visual science 20050601
Title: Survival role of protein kinase C (PKC) in chronic lymphocytic leukemia and determination of isoform expression pattern and genes altered by PKC inhibition.
Journal: American journal of hematology 20050601
Title: Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20050601
Title: Off the shelf but not mass produced.
Journal: Chemistry & biology 20050601
Title: S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
Journal: Chemistry & biology 20050601
Title: A comparison of the roles of protein kinase C in long-term potentiation in rat hippocampal areas CA1 and CA3.
Journal: Cellular and molecular neurobiology 20050601
Title: Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.
Journal: The Journal of biological chemistry 20050520
Title: Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases.
Journal: Bioorganic & medicinal chemistry 20050516
Title: Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720.
Journal: Transplantation 20050515
Title: Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells.
Journal: FEBS letters 20050509
Title: Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor.
Journal: Journal of lipid research 20050501
Title: A central role for ceramide in the age-related acceleration of apoptosis in the female germline.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501
Title: Ceramide alters endothelial cell permeability by a nonapoptotic mechanism.
Journal: British journal of pharmacology 20050501
Title: Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20050501
Title: Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase.
Journal: Analytical biochemistry 20050501
Title: Signal transduction in human endothelial cells induced by their interaction with group B Streptococci.
Journal: International journal of molecular medicine 20050501
Title: Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050501
Title: Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice.
Journal: Nature medicine 20050501
Title: Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis.
Journal: Experimental dermatology 20050501
Title: Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines.
Journal: Diabetes 20050501
Title: GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501
Title: Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells.
Journal: Biochimica et biophysica acta 20050501
Title: Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20050501
Title: [Skin barrier dysfunction in atopic dermatitis].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20050501
Title: Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells.
Journal: Prostaglandins & other lipid mediators 20050501
Title: Induction of apoptosis in chicken oviduct cells by C2-ceramide.
Journal: Molecules and cells 20050430
Title: Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells.
Journal: The Journal of biological chemistry 20050429
Title: Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.
Journal: Circulation research 20050429
Title: A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis.
Journal: Regulatory peptides 20050415
Title: Ceramide increase cytoplasmic Ca2+ concentration in Jurkat T cells by liberation of calcium from intracellular stores and activation of a store-operated calcium channel.
Journal: Archives of biochemistry and biophysics 20050415
Title: Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme.
Journal: Biochemical and biophysical research communications 20050408
Title: Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
Journal: American journal of physiology. Cell physiology 20050401
Title: Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells.
Journal: Molecular pharmacology 20050401
Title: Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
Journal: Histology and histopathology 20050401
Title: Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry.
Journal: Analytical biochemistry 20050401
Title: FTY720 pharmacokinetics in mild to moderate hepatic impairment.
Journal: Journal of clinical pharmacology 20050401
Title: FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.
Journal: Pancreas 20050401
Title: A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice.
Journal: Biological & pharmaceutical bulletin 20050401
Title: Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050401
Title: Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat.
Journal: Die Pharmazie 20050401
Title: Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice.
Journal: The Journal of biological chemistry 20050318
Title: Sphingosine 1-phosphate analogs as receptor antagonists.
Journal: The Journal of biological chemistry 20050318
Title: [Study of the effects of immunosuppressive agents on human islet cells in vitro].
Journal: Zhonghua yi xue za zhi 20050316
Title: Sphingosine 1-phosphate induces cytoskeletal reorganization in C2C12 myoblasts: physiological relevance for stress fibres in the modulation of ion current through stretch-activated channels.
Journal: Journal of cell science 20050315
Title: Total synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B).
Journal: Organic letters 20050303
Title: Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected].
Journal: Molecular pharmacology 20050301
Title: The role of sphingosine-1-phosphate in smooth muscle contraction.
Journal: Cellular signalling 20050301
Title: Significance of the Rac signaling pathway in HCC cell motility: implications for a new therapeutic target.
Journal: Carcinogenesis 20050301
Title: Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301
Title: Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme.
Journal: Development (Cambridge, England) 20050301
Title: The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050301
Title: Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes.
Journal: Journal of neurochemistry 20050301
Title: Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050301
Title: On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approach.
Journal: Basic & clinical pharmacology & toxicology 20050301
Title: Sphingosine kinase signalling in immune cells.
Journal: Clinical and experimental pharmacology & physiology 20050301
Title: Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors.
Journal: The American journal of pathology 20050301
Title: FTIR spectroscopic studies of lipid dynamics in phytosphingosine ceramide models of the stratum corneum lipid matrix.
Journal: Chemistry and physics of lipids 20050301
Title: Study on action mode of sphingosine 1-phosphate in rat hepatocytes.
Journal: Journal of pharmacological sciences 20050301
Title: Fingolimod. Mitsubishi Pharma/Novartis.
Journal: IDrugs : the investigational drugs journal 20050301
Title: Preoperative administration of FTY720 prolonged renal allograft survival.
Journal: Transplant immunology 20050301
Title: Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells.
Journal: Journal of oral science 20050301
Title: Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells.
Journal: Molecular and cellular endocrinology 20050227
Title: Novel mediators of FTY720 in human lymphocytes.
Journal: Transplantation 20050227
Title: Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells.
Journal: Biochemical and biophysical research communications 20050218
Title: Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells.
Journal: Brain research. Molecular brain research 20050218
Title: Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release.
Journal: Blood 20050215
Title: Synthesis and biological properties of novel sphingosine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20050215
Title: FTY720 in corneal concordant xenotransplantation.
Journal: Transplantation 20050215
Title: Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels.
Journal: FEBS letters 20050214
Title: Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209
Title: Synthesis of alpha-series ganglioside GM1alpha containing C20-sphingosine.
Journal: Carbohydrate research 20050207
Title: In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights.
Journal: Cellular signalling 20050201
Title: c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells.
Journal: Cellular signalling 20050201
Title: Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils.
Journal: Journal of leukocyte biology 20050201
Title: A rapid radioassay for sphingosine kinase.
Journal: Analytical biochemistry 20050201
Title: The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells.
Journal: European journal of immunology 20050201
Title: Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20050201
Title: Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture.
Journal: Plant physiology 20050201
Title: Disruption of nuclear maturation and rearrangement of cytoskeletal elements in bovine oocytes exposed to heat shock during maturation.
Journal: Reproduction (Cambridge, England) 20050201
Title: Phytosphingosine induced mitochondria-involved apoptosis.
Journal: Cancer science 20050201
Title: Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner.
Journal: Biological chemistry 20050201
Title: An increase of MMP-1 is stimulated by sphingosine in keloid fibroblasts.
Journal: The Journal of dermatology 20050201
Title: The role of sphingosine and ceramide kinases in inflammatory responses.
Journal: Immunology letters 20050131
Title: Sphingolipid uptake by cultured cells: complex aggregates of cell sphingolipids with serum proteins and lipoproteins are rapidly catabolized.
Journal: The Journal of biological chemistry 20050128
Title: Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice.
Journal: World journal of gastroenterology 20050128
Title: KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.
Journal: Circulation 20050118
Title: Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate.
Journal: Bioorganic & medicinal chemistry 20050117
Title: Sphingomyelinase causes endothelium-dependent vasorelaxation through endothelial nitric oxide production without cytosolic Ca(2+) elevation.
Journal: FEBS letters 20050117
Title: Fungal metabolite sulfamisterin suppresses sphingolipid synthesis through inhibition of serine palmitoyltransferase.
Journal: Biochemistry 20050111
Title: Interaction of cholesterol with sphingosine: physicochemical characterization and impact on intestinal absorption.
Journal: Journal of lipid research 20050101
Title: High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.
Journal: Atherosclerosis 20050101
Title: Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins.
Journal: Atherosclerosis 20050101
Title: Polymorphism of ceramide 6: a vibrational spectroscopic and X-ray powder diffraction investigation of the diastereomers of N-(alpha-hydroxyoctadecanoyl)-phytosphingosine.
Journal: Chemistry and physics of lipids 20050101
Title: Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20050101
Title: A convenient synthesis of immunosuppressive agent FTY720 using the petasis reaction.
Journal: Chemical & pharmaceutical bulletin 20050101
Title: FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050101
Title: Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin.
Journal: Eukaryotic cell 20050101
Title: Chronic effects of fumonisin B1 on ducks.
Journal: Poultry science 20050101
Title: Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin.
Journal: Journal of vascular surgery 20050101
Title: Similarities of cow mammary gland cytosolic 21-kDa protein, the substrate for protein kinase C, to the 20-kDa myosin light chain from smooth muscle.
Journal: The Journal of veterinary medical science 20050101
Title: The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets.
Journal: Thrombosis research 20050101
Title: Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
Journal: Annual review of immunology 20050101
Title: [New immunodepressant drugs for the prevention and control of kidney transplant rejection].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101
Title: Anticancer compounds and sphingolipid metabolism in the colon.
Journal: In vivo (Athens, Greece) 20050101
Title: Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: I. Prevention of allograft rejection in rats and dogs by FTY720 and FTY720-phosphate.
Journal: Transplantation proceedings 20050101
Title: Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice.
Journal: Transplantation proceedings 20050101
Title: FTY720 inhibits tumor growth and angiogenesis.
Journal: Transplantation proceedings 20050101
Title: Prolonged administration of FTY720 does not cause renal toxicity in mice.
Journal: Transplantation proceedings 20050101
Title: Control of intestinal allograft rejection by FTY720 and costimulation blockade.
Journal: Transplantation proceedings 20050101
Title: FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury.
Journal: Transplantation proceedings 20050101
Title: Total synthesis and biological activities of (+)-sulfamisterin (AB5366) and its analogues.
Journal: The Journal of antibiotics 20050101
Title: Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways.
Journal: Respiratory research 20050101
Title: Inhibition of gene expression in vivo using multiplex siRNA.
Journal: Methods in molecular biology (Clifton, N.J.) 20050101
Title: The effect of a novel immunosuppressant, FTY720, in mice without secondary lymphoid organs.
Journal: Surgery today 20050101
Title: Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD.
Journal: Journal of molecular neuroscience : MN 20050101
Title: Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells.
Journal: Stem cells (Dayton, Ohio) 20050101
Title: [Effects of PACAP and C2-ceramide on motility of cerebellar granule neurons: the fastest is not the farthest].
Journal: Medecine sciences : M/S 20050101
Title: Effect of sphingosine on Ca2+ entry and mitochondrial potential of Jurkat T cells--interaction with Bcl2.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101
Title: Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models.
Journal: Arzneimittel-Forschung 20050101
Title: A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate.
Journal: Journal of inherited metabolic disease 20050101
Title: Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase.
Journal: The Kobe journal of medical sciences 20050101
Title: Involvement of the ubiquitin-mediated proteolytic system in the signaling pathway induced by ceramide in primary astrocyte cultures.
Journal: Developmental neuroscience 20050101
Title: Modulation of ERK1/2 activity is crucial for sphingosine-induced death of glioma C6 cells.
Journal: Acta biochimica Polonica 20050101
Title: Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells.
Journal: Endothelium : journal of endothelial cell research 20050101
Title: Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.
Journal: Acta biomaterialia 20050101
Title: NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis.
Journal: BioFactors (Oxford, England) 20050101
Title: FTY720: mechanism of action and potential benefit in organ transplantation.
Journal: Yonsei medical journal 20041231
Title: Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
Journal: The Journal of biological chemistry 20041224
Title: The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis.
Journal: The Journal of biological chemistry 20041217
Title: FTY720 suppresses humoral immunity by inhibiting germinal center reaction.
Journal: Blood 20041215
Title: Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
Journal: The Journal of biological chemistry 20041210
Title: Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
Journal: The Journal of biological chemistry 20041203
Title: Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition.
Journal: FEBS letters 20041203
Title: Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism.
Journal: American journal of physiology. Cell physiology 20041201
Title: FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.
Journal: Carcinogenesis 20041201
Title: Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation.
Journal: Cell death and differentiation 20041201
Title: Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation.
Journal: Biology of reproduction 20041201
Title: Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells.
Journal: Journal of cancer research and clinical oncology 20041201
Title: Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis.
Journal: Cell motility and the cytoskeleton 20041201
Title: Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death.
Journal: Biochemical pharmacology 20041201
Title: Differential regulation of ERK1/2 and p38(MAPK) by components of the Rho signaling pathway during sphingosine-1-phosphate-induced smooth muscle cell migration.
Journal: The Journal of surgical research 20041201
Title: Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells.
Journal: Journal of neurochemistry 20041201
Title: Overview of FTY720 clinical pharmacokinetics and pharmacology.
Journal: Therapeutic drug monitoring 20041201
Title: Novel immunosuppressants.
Journal: Pediatric transplantation 20041201
Title: Production profile of the major allergen Alt a 1 in Alternaria alternata cultures.
Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20041201
Title: Efflux of sphingoid bases by P-glycoprotein in human intestinal Caco-2 cells.
Journal: Bioscience, biotechnology, and biochemistry 20041201
Title: Cerebroside analogues from marine-derived fungus Aspergillus flavipes.
Journal: Journal of Asian natural products research 20041201
Title: Ceramide enhances acrosomal exocytosis triggered by calcium and the calcium ionophore A23187 in boar spermatozoa.
Journal: The Journal of reproduction and development 20041201
Title: The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20041201
Title: Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.
Journal: Circulation 20041130
Title: Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis.
Journal: The Journal of biological chemistry 20041126
Title: High-density lipoprotein stimulates myocardial perfusion in vivo.
Journal: Circulation 20041123
Title: Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells.
Journal: FEBS letters 20041119
Title: The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.
Journal: Biochemical pharmacology 20041115
Title: Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury.
Journal: American journal of respiratory and critical care medicine 20041101
Title: Rejection following donor or recipient preoperative treatment with FTY720 in rat small bowel transplantation.
Journal: Transplant immunology 20041101
Title: Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells.
Journal: British journal of pharmacology 20041101
Title: Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures.
Journal: The Journal of investigative dermatology 20041101
Title: Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity.
Journal: Kidney international 20041101
Title: The mitochondrion--an organelle commonly involved in programmed cell death in Arabidopsis thaliana.
Journal: The Plant journal : for cell and molecular biology 20041101
Title: Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites.
Journal: British journal of pharmacology 20041101
Title: Lung injury: sphingosine-1-phosphate to the rescue.
Journal: American journal of respiratory and critical care medicine 20041101
Title: [Challenge to a riddle of brain: neuroglycobiology in retrospect and anticipation].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20041101
Title: Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century.
Journal: Current opinion in investigational drugs (London, England : 2000) 20041101
Title: Forward chemical genetics: library scaffold design.
Journal: Combinatorial chemistry & high throughput screening 20041101
Title: Attenuation of shock-induced acute lung injury by sphingosine kinase inhibition.
Journal: The Journal of trauma 20041101
Title: A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20041101
Title: ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism.
Journal: Endocrine research 20041101
Title: Synthesis of 7-oxasphingosine and -ceramide analogues and their evaluation in a model for apoptosis.
Journal: Chemistry & biodiversity 20041101
Title: Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells.
Journal: Experimental & molecular medicine 20041031
Title: Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells.
Journal: Experimental & molecular medicine 20041031
Title: Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.
Journal: Circulation research 20041029
Title: An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters.
Journal: The Journal of organic chemistry 20041029
Title: Efficient synthesis of alpha-C-galactosyl ceramide immunostimulants: use of ethylene-promoted olefin cross-metathesis.
Journal: Organic letters 20041028
Title: Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase.
Journal: The Journal of biological chemistry 20041022
Title: G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.
Journal: The Journal of biological chemistry 20041008
Title: Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.
Journal: The Journal of biological chemistry 20041008
Title: Sphingosine kinase activation mediates ischemic preconditioning in murine heart.
Journal: Circulation 20041005
Title: Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20041004
Title: The influence of zinc on the modulatory effect of sphingosylphosphorylcholine on Kv1.3 channels in human T lymphocytes.
Journal: European biophysics journal : EBJ 20041001
Title: A novel approach for preventing esophageal stricture formation: sphingosylphosphorylcholine-enhanced tissue remodeling.
Journal: Pediatric surgery international 20041001
Title: Rat intestinal ceramidase: purification, properties, and physiological relevance.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20041001
Title: Cell surface receptors in lysophospholipid signaling.
Journal: Seminars in cell & developmental biology 20041001
Title: Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
Journal: Seminars in cell & developmental biology 20041001
Title: Physiological and pathological actions of sphingosine 1-phosphate.
Journal: Seminars in cell & developmental biology 20041001
Title: Modulation of adaptive immune responses by sphingosine-1-phosphate.
Journal: Seminars in cell & developmental biology 20041001
Title: Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate.
Journal: Seminars in cell & developmental biology 20041001
Title: Selective lymphocyte inhibition by FTY720 slows the progressive course of chronic anti-thy 1 glomerulosclerosis.
Journal: Kidney international 20041001
Title: Synergistic effect of interleukin (IL)-1alpha and ceramide analogue on the production of IL-6, IL-8, and macrophage colony-stimulating factor by endometrial stromal cells.
Journal: Fertility and sterility 20041001
Title: Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes.
Journal: Fundamental & clinical pharmacology 20041001
Title: mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate.
Journal: Zhongguo shi yan xue ye xue za zhi 20041001
Title: High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.
Journal: The Journal of veterinary medical science 20041001
Title: Modulation by sphingosine of phosphorylation of substrate proteins by protein kinase C in nuclei from cow mammary gland.
Journal: The Journal of veterinary medical science 20041001
Title: Effects of FTY720 on rat lymphoid organs.
Journal: Transplantation proceedings 20041001
Title: Cytoskeletal rearrangement and caspase activation in sphingosine 1-phosphate-induced lung capillary tube formation.
Journal: Stem cells and development 20041001
Title: Sphingosine 1-phosphate breakdown in platelets.
Journal: Journal of biochemistry 20041001
Title: [Immunossupresive drugs in renal transplantation].
Journal: Polskie Archiwum Medycyny Wewnetrznej 20041001
Title: Skin lipid synthesis inhibition: a possible means for enhancing percutaneous delivery of levodopa.
Journal: Current drug delivery 20041001
Title: Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells.
Journal: The Journal of biological chemistry 20040924
Title: Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.
Journal: Bioorganic & medicinal chemistry 20040915
Title: Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040915
Title: Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes.
Journal: The Journal of biological chemistry 20040910
Title: MuLK, a eukaryotic multi-substrate lipid kinase.
Journal: The Journal of biological chemistry 20040910
Title: Transcriptional repression of the CTP:phosphocholine cytidylyltransferase gene by sphingosine.
Journal: The Biochemical journal 20040901
Title: Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1.
Journal: The Biochemical journal 20040901
Title: The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040901
Title: Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901
Title: Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats.
Journal: British journal of pharmacology 20040901
Title: Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration.
Journal: Kidney international 20040901
Title: Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid.
Journal: Journal of thrombosis and haemostasis : JTH 20040901
Title: A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice.
Journal: Biological & pharmaceutical bulletin 20040901
Title: The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior.
Journal: Biophysical journal 20040901
Title: Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis.
Journal: The Journal of laboratory and clinical medicine 20040901
Title: Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine.
Journal: The Journal of biological chemistry 20040827
Title: Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses.
Journal: The Journal of biological chemistry 20040820
Title: In vivo influence of ceramide accumulation induced by treatment with a glucosylceramide synthase inhibitor on ischemic neuronal cell death.
Journal: Brain research 20040820
Title: Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine.
Journal: The Journal of organic chemistry 20040820
Title: Endothelial cell barrier regulation by sphingosine 1-phosphate.
Journal: Journal of cellular biochemistry 20040815
Title: Mechanisms of cardioprotection by lysophospholipids.
Journal: Journal of cellular biochemistry 20040815
Title: Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system.
Journal: Journal of cellular biochemistry 20040815
Title: Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells.
Journal: Experimental cell research 20040815
Title: Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids.
Journal: The Journal of biological chemistry 20040813
Title: Synthesis of l-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon.
Journal: The Journal of organic chemistry 20040806
Title: PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
Journal: The EMBO journal 20040804
Title: Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.
Journal: Circulation 20040803
Title: Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040801
Title: Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts.
Journal: The Biochemical journal 20040801
Title: Inhibition of phospholipase C-epsilon by Gi-coupled receptors.
Journal: Cellular signalling 20040801
Title: The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801
Title: Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801
Title: Prosaposin: a new player in cell death prevention of U937 monocytic cells.
Journal: Experimental cell research 20040801
Title: Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling.
Journal: Experimental cell research 20040801
Title: An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes.
Journal: Analytical biochemistry 20040801
Title: Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators.
Journal: Journal of cellular biochemistry 20040801
Title: Generation and metabolism of bioactive sphingosine-1-phosphate.
Journal: Journal of cellular biochemistry 20040801
Title: Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for 'old' ligands.
Journal: Journal of cellular biochemistry 20040801
Title: Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets.
Journal: Atherosclerosis 20040801
Title: Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.
Journal: Journal of neuroimmunology 20040801
Title: Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040801
Title: Biologically active sphingolipids in cancer pathogenesis and treatment.
Journal: Nature reviews. Cancer 20040801
Title: Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators.
Journal: Cancer research 20040801
Title: New sphingosines from a gorgonian, Pseudopterogorgia australiensis Ridley, of the Indian Ocean.
Journal: Journal of natural products 20040801
Title: Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks.
Journal: Poultry science 20040801
Title: Separation and characterisation of sphingoceramides by high-performance liquid chromatography-electrospray ionisation mass spectrometry.
Journal: Journal of separation science 20040801
Title: Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: Identification of a novel family of Gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences.
Journal: The Journal of biological chemistry 20040730
Title: Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.
Journal: Biochemical and biophysical research communications 20040730
Title: D-galactosyl-beta1-1'-sphingosine and D-glucosyl-beta1-1'-sphingosine induce human natural killer cell apoptosis.
Journal: Biochemical and biophysical research communications 20040730
Title: Prolactin acts as a potent survival factor for human breast cancer cell lines.
Journal: British journal of cancer 20040719
Title: Disruption of sphingolipid biosynthesis in hepatocyte nodules: selective proliferative stimulus induced by fumonisin B1.
Journal: Toxicology 20040715
Title: FTY720-enhanced T cell homing is dependent on CCR2, CCR5, CCR7, and CXCR4: evidence for distinct chemokine compartments.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040715
Title: Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20040705
Title: Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes.
Journal: Journal of leukocyte biology 20040701
Title: The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine.
Journal: Chemistry and physics of lipids 20040701
Title: Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
Journal: Nature immunology 20040701
Title: Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin.
Journal: Apoptosis : an international journal on programmed cell death 20040701
Title: FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040701
Title: Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate.
Journal: British journal of pharmacology 20040701
Title: FTY720--the first compound of a new promising class of immunosuppressive drugs.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040701
Title: FTY720 prolongs clear corneal allograft survival with a differential effect on different lymphocyte populations.
Journal: The British journal of ophthalmology 20040701
Title: Sphingosine signaling and atherogenesis.
Journal: Acta pharmacologica Sinica 20040701
Title: Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040701
Title: Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging.
Journal: Journal of magnetic resonance imaging : JMRI 20040701
Title: Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.
Journal: Investigative ophthalmology & visual science 20040701
Title: Should we B-leavin' now?
Journal: Nature immunology 20040701
Title: Lysophospholipids are potential biomarkers of ovarian cancer.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040701
Title: Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells.
Journal: Journal of neurosurgery 20040701
Title: Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries.
Journal: Autonomic & autacoid pharmacology 20040701
Title: FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation.
Journal: Transplantation 20040627
Title: Effect of FTY720 on rat small bowel transplantation.
Journal: Transplantation 20040627
Title: Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.
Journal: Bioorganic & medicinal chemistry letters 20040621
Title: The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells.
Journal: Blood 20040615
Title: Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity.
Journal: The Biochemical journal 20040615
Title: Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.
Journal: Cancer research 20040615
Title: A practical synthesis of D-erythro-sphingosine using a cross-metathesis approach.
Journal: Organic & biomolecular chemistry 20040607
Title: Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase.
Journal: The Journal of biological chemistry 20040604
Title: Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.
Journal: American journal of respiratory cell and molecular biology 20040601
Title: Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.
Journal: American journal of respiratory and critical care medicine 20040601
Title: Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601
Title: Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization.
Journal: Journal of cellular physiology 20040601
Title: Independence of tumor necrosis factor-alpha-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells.
Journal: Journal of thrombosis and haemostasis : JTH 20040601
Title: Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo.
Journal: The Journal of infectious diseases 20040601
Title: FTY720 prevents anti-CD4 mAb-induced tolerance but cannot reverse established tolerance in a rat kidney transplantation model.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040601
Title: The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling.
Journal: The Plant cell 20040601
Title: Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy.
Journal: Biochimica et biophysica acta 20040601
Title: Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages.
Journal: Biochimica et biophysica acta 20040601
Title: Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts.
Journal: The Journal of investigative dermatology 20040601
Title: Ceramide influences neurite outgrowth and neuroblastoma cell apoptosis regulated by novel protein kinase C isoforms.
Journal: Journal of neurochemistry 20040601
Title: Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
Journal: Journal of neurochemistry 20040601
Title: Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs.
Journal: Eukaryotic cell 20040601
Title: Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells.
Journal: Journal of biochemistry 20040601
Title: Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes.
Journal: Journal of pharmacological sciences 20040601
Title: S1P and LPA trigger Schwann cell actin changes and migration.
Journal: The European journal of neuroscience 20040601
Title: ['Vegetable wasps and plant worms' and G-protein-coupled receptors].
Journal: Journal of UOEH 20040601
Title: Future immunosuppressive agents in solid-organ transplantation.
Journal: Progress in transplantation (Aliso Viejo, Calif.) 20040601
Title: Osteoblastic cells express phospholipid receptors and phosphatases and proliferate in response to sphingosine-1-phosphate.
Journal: Calcified tissue international 20040601
Title: Sphingolipids in inflammation: roles and implications.
Journal: Current molecular medicine 20040601
Title: Iron-catalyzed cross-coupling reactions. A scalable synthesis of the immunosuppressive agent FTY720.
Journal: The Journal of organic chemistry 20040528
Title: Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors.
Journal: Bioorganic & medicinal chemistry letters 20040517
Title: FTY: not just a homely drug.
Journal: Transplantation 20040515
Title: FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes.
Journal: Transplantation 20040515
Title: Expression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells.
Journal: Biochemical and biophysical research communications 20040507
Title: Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine.
Journal: The Biochemical journal 20040501
Title: Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B).
Journal: Hypertension (Dallas, Tex. : 1979) 20040501
Title: Immunoregulatory lysophospholipids: new stars in the mast cell constellation.
Journal: Current allergy and asthma reports 20040501
Title: Distinctive G protein-dependent signaling in smooth muscle by sphingosine 1-phosphate receptors S1P1 and S1P2.
Journal: American journal of physiology. Cell physiology 20040501
Title: Assembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contacts.
Journal: American journal of physiology. Cell physiology 20040501
Title: Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects.
Journal: British journal of clinical pharmacology 20040501
Title: Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects.
Journal: Journal of clinical pharmacology 20040501
Title: Role of ceramide in ischemic preconditioning.
Journal: Journal of the American College of Surgeons 20040501
Title: Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501
Title: An extensive microarray analysis of AAL-toxin-induced cell death in Arabidopsis thaliana brings new insights into the complexity of programmed cell death in plants.
Journal: Cellular and molecular life sciences : CMLS 20040501
Title: FTY720 impairs necrosis development after ischemia-reperfusion injury.
Journal: Transplantation proceedings 20040501
Title: FTY720 treatment prolongs skin graft survival in a completely incompatible strain combination.
Journal: Transplantation proceedings 20040501
Title: Therapeutic effects of a new lymphocyte homing reagent FTY720 in interleukin-10 gene-deficient mice with colitis.
Journal: Inflammatory bowel diseases 20040501
Title: Phospholipid mediators and MgATPase modulation causes changes in the cardiovascular effects of vasopressin in lithium carbonate-induced polyuric rats.
Journal: Methods and findings in experimental and clinical pharmacology 20040501
Title: Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.
Journal: Circulation research 20040430
Title: Straightforward synthesis of sphinganines via a serine-derived Weinreb amide.
Journal: The Journal of organic chemistry 20040430
Title: The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions.
Journal: The Journal of biological chemistry 20040423
Title: Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.
Journal: Blood 20040415
Title: Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii.
Journal: Yeast (Chichester, England) 20040415
Title: Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.
Journal: European journal of pharmacology 20040405
Title: Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.
Journal: The Journal of biological chemistry 20040402
Title: Point-counterpoint of sphingosine 1-phosphate metabolism.
Journal: Circulation research 20040402
Title: Cerebrosides of Candida lipolytica yeast.
Journal: Applied microbiology and biotechnology 20040401
Title: Novel protein kinase C and matrix metalloproteinase inhibitors of vegetable origin as potential modulators of Langerhans cell migration following hapten-induced sensitization.
Journal: International archives of allergy and immunology 20040401
Title: Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Journal: Journal of cellular biochemistry 20040401
Title: Studies on sulfatides by quadrupole ion-trap mass spectrometry with electrospray ionization: structural characterization and the fragmentation processes that include an unusual internal galactose residue loss and the classical charge-remote fragmentation.
Journal: Journal of the American Society for Mass Spectrometry 20040401
Title: A lipid transfer protein gene BG-14 is differentially regulated by abiotic stress, ABA, anisomycin, and sphingosine in bromegrass (Bromus inermis).
Journal: Journal of plant physiology 20040401
Title: Inhibition of serine palmitoyltransferase by myriocin, a natural mycotoxin, causes induction of c-myc in mouse liver.
Journal: Mycopathologia 20040401
Title: Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720.
Journal: Transplantation 20040327
Title: Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes.
Journal: The Journal of biological chemistry 20040326
Title: Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5.
Journal: The Journal of biological chemistry 20040326
Title: Sphingolipids as bioactive regulators of thrombin generation.
Journal: The Journal of biological chemistry 20040326
Title: Ceramide-1-phosphate: a novel regulator of cell activation.
Journal: FEBS letters 20040326
Title: SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I.
Journal: Neurology 20040323
Title: Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2.
Journal: Bioorganic & medicinal chemistry letters 20040322
Title: Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.
Journal: Blood 20040315
Title: Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate.
Journal: Biology of reproduction 20040301
Title: Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level.
Journal: Cellular signalling 20040301
Title: The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301
Title: FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040301
Title: Fluorescence-based assay of sphingosine kinases.
Journal: Analytical biochemistry 20040301
Title: FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury.
Journal: Kidney international 20040301
Title: Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation.
Journal: Journal of cellular biochemistry 20040301
Title: FTY720: from bench to bedside.
Journal: Transplantation proceedings 20040301
Title: FTY720: early clinical experience.
Journal: Transplantation proceedings 20040301
Title: FTY720 immunomodulation: optimism for improved transplant regimens.
Journal: Transplantation proceedings 20040301
Title: The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat.
Journal: Pediatric diabetes 20040301
Title: Inhibition of skin sphingosine synthesis: enhanced percutaneous permeation of 5-fluorouracil.
Journal: Die Pharmazie 20040301
Title: Myriocin, a serine palmitoyltransferase inhibitor, alters regional brain neurotransmitter levels without concurrent inhibition of the brain sphingolipid biosynthesis in mice.
Journal: Toxicology letters 20040227
Title: Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation.
Journal: Biochimica et biophysica acta 20040227
Title: Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Journal: European journal of pharmacology 20040220
Title: Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.
Journal: The Biochemical journal 20040215
Title: Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040215
Title: Characterization of the ceramide moieties of sphingoglycolipids from mouse brain by ESI-MS/MS: identification of ceramides containing sphingadienine.
Journal: Journal of lipid research 20040201
Title: S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201
Title: Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells.
Journal: International journal of molecular medicine 20040201
Title: Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells.
Journal: Journal of neurochemistry 20040201
Title: Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production.
Journal: Critical care medicine 20040201
Title: Ceramide lances the lungs.
Journal: Nature medicine 20040201
Title: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Journal: Nature 20040122
Title: Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine.
Journal: European journal of pharmacology 20040119
Title: Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.
Journal: FEBS letters 20040116
Title: Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration.
Journal: Biochemistry 20040113
Title: Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
Journal: The Journal of biological chemistry 20040109
Title: (3Z)-2-Acetylamino-3-octadecen-1-ol as a potent apoptotic agent against HL-60 cells.
Journal: Bioorganic & medicinal chemistry 20040102
Title: Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure.
Journal: American journal of physiology. Cell physiology 20040101
Title: Sphingosine 1-phosphate induces cell contraction via calcium-independent/Rho-dependent pathways in undifferentiated skeletal muscle cells.
Journal: Journal of cellular physiology 20040101
Title: Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation.
Journal: Cellular signalling 20040101
Title: Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes.
Journal: Glia 20040101
Title: CD4+ CD25+ CD62+ T-regulatory cell subset has optimal suppressive and proliferative potential.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040101
Title: Platelet-derived sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.
Journal: Journal of thrombosis and haemostasis : JTH 20040101
Title: Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide.
Journal: Arthritis and rheumatism 20040101
Title: Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells.
Journal: The Journal of surgical research 20040101
Title: Sphingosine may have cytotoxic effects via apoptosis on the growth of keloid fibroblasts.
Journal: The Journal of dermatology 20040101
Title: Pharmacologic immunosuppression.
Journal: Frontiers in bioscience : a journal and virtual library 20040101
Title: A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity.
Journal: Glycoconjugate journal 20040101
Title: FTY720 and cyclosporine: evaluation for a pharmacokinetic interaction.
Journal: The Annals of pharmacotherapy 20040101
Title: Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
Journal: Prostaglandins & other lipid mediators 20040101
Title: Constitutive expression of the S1P1 receptor in adult tissues.
Journal: Prostaglandins & other lipid mediators 20040101
Title: Role of extracelluar regulated protein kinases in FTY720-induced apoptosis of leukemia cell lines HL-60 and U937.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101
Title: Down-regulation of Bcl-2 in the fetal brain of the Gaucher disease mouse model: a possible role in the neuronal loss.
Journal: Journal of human genetics 20040101
Title: A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.
Journal: BMC biochemistry 20040101
Title: Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors.
Journal: Drug news & perspectives 20040101
Title: [Bioeffector sphingolipids as stimulators of cell growth and survival].
Journal: Bioorganicheskaia khimiia 20040101
Title: Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20.
Journal: Glycoconjugate journal 20040101
Title: Differential regulation of apoptotic cell death in senescent human cells.
Journal: Experimental gerontology 20040101
Title: Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms.
Journal: Cells, tissues, organs 20040101
Title: Treatment of focal cerebral ischemia with liposomal nerve growth factor.
Journal: Drug delivery 20040101
Title: Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells.
Journal: Glycoconjugate journal 20040101
Title: Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells.
Journal: Molecules and cells 20031231
Title: Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices.
Journal: Biochemical and biophysical research communications 20031226
Title: Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
Journal: The Journal of biological chemistry 20031212
Title: Cycloserine and threo-dihydrosphingosine inhibit TNF-alpha-induced cytotoxicity: evidence for the importance of de novo ceramide synthesis in TNF-alpha signaling.
Journal: Biochimica et biophysica acta 20031207
Title: Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes.
Journal: Pigment cell research 20031201
Title: Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20031201
Title: Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways.
Journal: Biochemical Society transactions 20031201
Title: Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.
Journal: Human reproduction (Oxford, England) 20031201
Title: Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201
Title: Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells.
Journal: Molecular and cellular biochemistry 20031201
Title: Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3.
Journal: Neurobiology of disease 20031201
Title: Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins.
Journal: Cellular and molecular life sciences : CMLS 20031201
Title: Current immunosuppressive agents: efficacy, side effects, and utilization.
Journal: Pediatric clinics of North America 20031201
Title: Ceramide pathways modulate ethanol-induced cell death in astrocytes.
Journal: Journal of neurochemistry 20031201
Title: Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.
Journal: Journal of enzyme inhibition and medicinal chemistry 20031201
Title: Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.
Journal: The Journal of biological chemistry 20031128
Title: Significant prolongation of orthotopic corneal-graft survival in FTY720-treated mice.
Journal: Transplantation 20031127
Title: Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
Journal: The Journal of biological chemistry 20031121
Title: Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors.
Journal: The Journal of biological chemistry 20031121
Title: Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.
Journal: FEBS letters 20031120
Title: The effects of protein kinase C activity on synaptic transmission in two areas of rat hippocampus.
Journal: Brain research 20031114
Title: Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.
Journal: Brain research 20031114
Title: Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway.
Journal: Biochemical and biophysical research communications 20031114
Title: The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
Journal: FEBS letters 20031106
Title: Quantification of sphingosine and sphinganine from crude lipid extracts by HPLC electrospray ionization tandem mass spectrometry.
Journal: Journal of lipid research 20031101
Title: Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms.
Journal: The Biochemical journal 20031101
Title: Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels.
Journal: Biochemical pharmacology 20031101
Title: Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected].
Journal: Journal of immunology (Baltimore, Md. : 1950) 20031101
Title: Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.
Journal: Molecular pharmacology 20031101
Title: Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration.
Journal: Journal of cellular biochemistry 20031101
Title: Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function.
Journal: The Journal of clinical investigation 20031101
Title: Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis.
Journal: The Journal of clinical endocrinology and metabolism 20031101
Title: Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor.
Journal: Journal of biochemistry 20031101
Title: Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts.
Journal: European journal of cell biology 20031101
Title: Differential regulation of cyclooxygenase-2 expression by phytosphingosine derivatives, NAPS and TAPS, and its role in the NAPS or TAPS-mediated apoptosis.
Journal: The Journal of investigative dermatology 20031101
Title: Tetraacetyl phytosphingosine-induced caspase activation and apoptosis occur through G2 arrest in human keratinocyte HaCaT cells.
Journal: The Journal of investigative dermatology 20031101
Title: FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model.
Journal: Transplantation 20031027
Title: Sphingosine 1-phosphate and cell migration: resistance to angiogenesis inhibitors.
Journal: Biochemical and biophysical research communications 20031024
Title: Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20031020
Title: Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites.
Journal: Toxicology and applied pharmacology 20031015
Title: Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study.
Journal: Transplantation 20031015
Title: Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.
Journal: The Journal of biological chemistry 20031010
Title: Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate.
Journal: The Journal of organic chemistry 20031003
Title: Sphingosine-1-phosphate promotes mouse melanocyte survival via ERK and Akt activation.
Journal: Cellular signalling 20031001
Title: Egress: a receptor-regulated step in lymphocyte trafficking.
Journal: Immunological reviews 20031001
Title: Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20031001
Title: Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031001
Title: Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors.
Journal: Journal of biomolecular screening 20031001
Title: Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids.
Journal: Journal of biochemistry 20031001
Title: Pharmacodynamics of FTY720, the first member of a new class of immune-modulating therapeutics in transplantation medicine.
Journal: International journal of clinical pharmacology and therapeutics 20031001
Title: [Study the mechanisms and inducing transplantation immune tolerance of FTY720].
Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20031001
Title: Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D.
Journal: Biochimica et biophysica acta 20030922
Title: Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells.
Journal: The Biochemical journal 20030915
Title: Agonist function of the neurokinin receptor antagonist, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, in monocytes.
Journal: Regulatory peptides 20030915
Title: Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.
Journal: Biochemical and biophysical research communications 20030912
Title: Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells.
Journal: Cancer letters 20030910
Title: Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.
Journal: The Journal of biological chemistry 20030905
Title: Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets.
Journal: The Journal of organic chemistry 20030905
Title: Novel, short, stereospecific synthesis of lyxo-(2R,3R,4R)-phytosphingosine and erythro-(2R,3S)-sphingosine.
Journal: The Journal of organic chemistry 20030905
Title: Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.
Journal: Blood 20030901
Title: Metabolism of the unnatural anticancer lipid safingol, L-threo-dihydrosphingosine, in cultured cells.
Journal: Journal of lipid research 20030901
Title: Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies.
Journal: Cell biochemistry and function 20030901
Title: Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.
Journal: Nature cell biology 20030901
Title: Enlargement and contracture of C2-ceramide channels.
Journal: Biophysical journal 20030901
Title: FTY720, a new immunosuppressant, as rescue therapy in mouse cardiac transplantation.
Journal: Acta pharmacologica Sinica 20030901
Title: Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Journal: Cancer research 20030901
Title: Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.
Journal: Archives of pharmacal research 20030901
Title: Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.
Journal: The Journal of biological chemistry 20030829
Title: Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells.
Journal: The Journal of biological chemistry 20030822
Title: Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.
Journal: The Journal of biological chemistry 20030815
Title: The reverse activity of human acid ceramidase.
Journal: The Journal of biological chemistry 20030808
Title: Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx.
Journal: American journal of physiology. Heart and circulatory physiology 20030801
Title: Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo.
Journal: EMBO reports 20030801
Title: Prevalence of necrosis in C2-ceramide-induced cytotoxicity in NB16 neuroblastoma cells.
Journal: Molecular pharmacology 20030801
Title: Sphingosine 1-phosphate promotes cell migration through the activation of Cdc42 in Edg-6/S1P4-expressing cells.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20030801
Title: Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells.
Journal: Diabetes 20030801
Title: Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes.
Journal: Melanoma research 20030801
Title: The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801
Title: Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801
Title: A sphingosine-dependent protein kinase that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain of PKCdelta: a preliminary note.
Journal: Biochemical and biophysical research communications 20030801
Title: Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm.
Journal: Current opinion in chemical biology 20030801
Title: Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukaemia cell line MOLT-4.
Journal: International journal of radiation biology 20030801
Title: Synthesis and potent antileukemic activities of N-lactylsphingosine and N-lactyldihydrosphingosine.
Journal: Journal of medicinal chemistry 20030731
Title: Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry.
Journal: The Journal of biological chemistry 20030725
Title: Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes.
Journal: The Journal of biological chemistry 20030725
Title: Sphinganine to sphingosine ratio and predictive biochemical markers of fumonisin B1 exposure in ducks.
Journal: Chemico-biological interactions 20030725
Title: Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism.
Journal: Organic & biomolecular chemistry 20030721
Title: Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae.
Journal: The Journal of biological chemistry 20030718
Title: Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP).
Journal: The Biochemical journal 20030715
Title: Synthesis of 4-hydroxysphinganine and characterization of sphinganine hydroxylase activity in corn.
Journal: Archives of biochemistry and biophysics 20030715
Title: Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells.
Journal: Journal of neuroscience research 20030715
Title: Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells.
Journal: Biochemical and biophysical research communications 20030711
Title: A facile synthesis of phytosphingosine from diisopropylidene-D-mannofuranose.
Journal: The Journal of organic chemistry 20030711
Title: Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells.
Journal: Bioorganic & medicinal chemistry 20030703
Title: Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products.
Journal: American journal of physiology. Lung cellular and molecular physiology 20030701
Title: Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride.
Journal: Journal of lipid research 20030701
Title: Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1).
Journal: Cellular signalling 20030701
Title: High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030701
Title: Pleiotropic actions of sphingosine-1-phosphate.
Journal: Progress in lipid research 20030701
Title: Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030701
Title: FTY720: A new kid on the block for transplant immunosuppression.
Journal: Expert opinion on biological therapy 20030701
Title: Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells.
Journal: Experimental hematology 20030701
Title: Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate.
Journal: American heart journal 20030701
Title: Sphingolipids, new players in plant signaling.
Journal: Trends in plant science 20030701
Title: A novel action of palmitoyl-L-carnitine in human vascular endothelial cells.
Journal: Journal of pharmacological sciences 20030701
Title: Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha(i)- and pi3-kinase-dependent p38(MAPK) activation.
Journal: The Journal of surgical research 20030701
Title: Possible modulators of IL-8 and GRO-alpha production by granulosa cells.
Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20030701
Title: Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach.
Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20030701
Title: Metabolomic profiling of sphingolipids in human glioma cell lines by liquid chromatography tandem mass spectrometry.
Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20030701
Title: Functional role of caspases in sphingosine-induced apoptosis in human hepatoma cells.
Journal: IUBMB life 20030701
Title: [Sphingolipid and apoptosis].
Journal: Sheng li ke xue jin zhan [Progress in physiology] 20030701
Title: Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms.
Journal: The Journal of biological chemistry 20030627
Title: Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway.
Journal: Circulation 20030624
Title: Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans.
Journal: The Journal of biological chemistry 20030620
Title: Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.
Journal: Blood 20030615
Title: Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance.
Journal: Experimental cell research 20030610
Title: Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins.
Journal: Nature 20030605
Title: Increased myocardial oxygen consumption by TNF-alpha is mediated by a sphingosine signaling pathway.
Journal: American journal of physiology. Heart and circulatory physiology 20030601
Title: Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathway.
Journal: Fungal genetics and biology : FG & B 20030601
Title: Sphingosine 1-phosphate and control of vascular tone.
Journal: American journal of physiology. Heart and circulatory physiology 20030601
Title: Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings.
Journal: Molecular pharmacology 20030601
Title: A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells.
Journal: Cell death and differentiation 20030601
Title: Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
Journal: The Journal of urology 20030601
Title: Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures.
Journal: Journal of neurovirology 20030601
Title: Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis.
Journal: British journal of haematology 20030601
Title: Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20030601
Title: Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C.
Journal: Atherosclerosis 20030601
Title: The presence of ceramidase activity in liver nuclear membrane.
Journal: Biological & pharmaceutical bulletin 20030601
Title: Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?
Journal: Molecular genetics and metabolism 20030601
Title: The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance.
Journal: Transplant international : official journal of the European Society for Organ Transplantation 20030601
Title: Prevention of renal ischemic reperfusion injury using FTY 720 and ICAM-1 antisense oligonucleotides.
Journal: Transplantation proceedings 20030601
Title: S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate.
Journal: European journal of pharmacology 20030523
Title: Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress.
Journal: Journal of cell science 20030515
Title: Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories.
Journal: Statistics in medicine 20030515
Title: Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria.
Journal: Bioorganic & medicinal chemistry 20030515
Title: Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity.
Journal: Biochemical pharmacology 20030515
Title: FTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells.
Journal: Transplantation 20030515
Title: Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity.
Journal: Toxicology 20030503
Title: The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling.
Journal: The Biochemical journal 20030501
Title: Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation.
Journal: Journal of cell science 20030501
Title: Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action.
Journal: Pharmacological research 20030501
Title: Signaling and biological actions of sphingosine 1-phosphate.
Journal: Pharmacological research 20030501
Title: The roles of ceramide and complex sphingolipids in neuronal cell function.
Journal: Pharmacological research 20030501
Title: Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer.
Journal: Pharmacological research 20030501
Title: Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones.
Journal: Journal of neuroendocrinology 20030501
Title: Sphingosine-1-phosphate: an enigmatic signalling lipid.
Journal: Nature reviews. Molecular cell biology 20030501
Title: Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve.
Journal: Journal of neuropathology and experimental neurology 20030501
Title: Leukocyte motility in response to neuropeptides is heparan sulfate proteoglycan dependent.
Journal: Peptides 20030501
Title: Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats.
Journal: Transplantation 20030427
Title: Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm.
Journal: The Journal of biological chemistry 20030418
Title: Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate.
Journal: Archives of biochemistry and biophysics 20030415
Title: FTY720, an immunosuppressant that alters lymphocyte trafficking, abrogates chronic rejection in combination with cyclosporine A.
Journal: Transplantation 20030415
Title: Antinutritional effects of fumonisin B1 and pathophysiological consequences.
Journal: Toxicology letters 20030411
Title: BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Journal: Science (New York, N.Y.) 20030404
Title: Total syntheses of symbioramide derivatives from l-serine and their antileukemic activities.
Journal: The Journal of organic chemistry 20030404
Title: EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway.
Journal: Journal of cell science 20030401
Title: Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.
Journal: Cellular signalling 20030401
Title: Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.
Journal: Cellular signalling 20030401
Title: Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030401
Title: New acylceramide in native and reconstructed epidermis.
Journal: The Journal of investigative dermatology 20030401
Title: Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.
Journal: The Journal of investigative dermatology 20030401
Title: Paradoxical effects of sphingosine-1-phosphate.
Journal: The Journal of investigative dermatology 20030401
Title: Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment.
Journal: The Journal of pharmacology and experimental therapeutics 20030401
Title: Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.
Journal: Cardiovascular research 20030401
Title: Sphingoid bases as possible diagnostic parameters.
Journal: Croatian medical journal 20030401
Title: A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells.
Journal: British journal of pharmacology 20030401
Title: The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice.
Journal: Clinical immunology (Orlando, Fla.) 20030401
Title: Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase.
Journal: Cellular and molecular life sciences : CMLS 20030401
Title: High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Journal: Molecular and cellular biochemistry 20030401
Title: Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages.
Journal: FEBS letters 20030327
Title: Divergent synthesis of D-erythro-sphingosine, L-threo-sphingosine, and their regioisomers.
Journal: The Journal of organic chemistry 20030321
Title: Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function.
Journal: The Biochemical journal 20030315
Title: Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20030315
Title: Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
Journal: The Journal of biological chemistry 20030314
Title: Ceramide increases oxidative damage due to inhibition of catalase by caspase-3-dependent proteolysis in HL-60 cell apoptosis.
Journal: The Journal of biological chemistry 20030314
Title: Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic.
Journal: The Journal of biological chemistry 20030314
Title: Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.
Journal: Science (New York, N.Y.) 20030314
Title: S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20030301
Title: Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030301
Title: Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate.
Journal: Journal of cellular biochemistry 20030301
Title: Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20030301
Title: Myoclonic epilepsy in Gaucher disease: genotype-phenotype insights from a rare patient subgroup.
Journal: Pediatric research 20030301
Title: Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.
Journal: Diabetes 20030301
Title: Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages.
Journal: Molecular pharmacology 20030301
Title: Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.
Journal: Epilepsia 20030301
Title: FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.
Journal: The Journal of clinical investigation 20030301
Title: Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.
Journal: The Journal of clinical investigation 20030301
Title: Ca2+ and voltage dependence of cardiac ryanodine receptor channel block by sphingosylphosphorylcholine.
Journal: Pflugers Archiv : European journal of physiology 20030301
Title: Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.
Journal: Laboratory investigation; a journal of technical methods and pathology 20030301
Title: [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030301
Title: Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway.
Journal: Molecular and cellular neurosciences 20030301
Title: Elimination of cell-cycle regulators during caspase-3-dependent apoptosis caused by an immunosuppressant, FTY720.
Journal: Bioscience, biotechnology, and biochemistry 20030301
Title: Ceramide mediates growth inhibition of the Plasmodium falciparum parasite.
Journal: Cellular and molecular life sciences : CMLS 20030301
Title: Sphingosine 1-phosphate signal transduction in muscle cells.
Journal: The Italian journal of biochemistry 20030301
Title: Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis.
Journal: Cancer letters 20030227
Title: Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells.
Journal: Bioorganic & medicinal chemistry letters 20030224
Title: Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior.
Journal: Bioorganic & medicinal chemistry letters 20030224
Title: Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells.
Journal: The Journal of biological chemistry 20030221
Title: Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells.
Journal: The Journal of biological chemistry 20030221
Title: Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate.
Journal: The Biochemical journal 20030215
Title: Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate.
Journal: Biochemical and biophysical research communications 20030207
Title: Structure-function relations in self-assembled C18- and C20-sphingosines monolayers at gas/water interfaces.
Journal: Journal of the American Chemical Society 20030205
Title: Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes.
Journal: Biochemical pharmacology 20030201
Title: Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis.
Journal: Molecular pharmacology 20030201
Title: Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.
Journal: Cell calcium 20030201
Title: Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.
Journal: Gastroenterology 20030201
Title: Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death.
Journal: Journal of neurochemistry 20030201
Title: Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function.
Journal: British journal of pharmacology 20030201
Title: Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201
Title: Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030201
Title: [Effects of three different immunosuppressive drugs on SD rat islet cell viability].
Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030201
Title: CTLA4Ig-gene transfection with FTY720 administration markedly inhibits the obliterative airway disease in heterotopically transplanted rat tracheas.
Journal: Transplantation proceedings 20030201
Title: Pretreatment with FTY720 alone induced long-term survival of mouse heart allograft.
Journal: Transplantation proceedings 20030201
Title: A novel role for sphingolipid intermediates in activation-induced cell death in T cells.
Journal: Cell death and differentiation 20030201
Title: Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells.
Journal: Cell death and differentiation 20030201
Title: Sphingosine-1-phosphate stimulates cortisol secretion.
Journal: FEBS letters 20030130
Title: First asymmetric synthesis of 6-hydroxy-4-sphingenine-containing ceramides. Use of chiral propargylic alcohols to prepare a lipid found in human skin.
Journal: The Journal of organic chemistry 20030124
Title: Synthesis and growth inhibitory activity of chiral 5-hydroxy-2-N-acyl-(3E)-sphingenines: ceramides with an unusual sphingoid backbone.
Journal: The Journal of organic chemistry 20030124
Title: Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways.
Journal: Biochemistry 20030121
Title: Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.
Journal: Bioorganic & medicinal chemistry letters 20030120
Title: Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells.
Journal: The Biochemical journal 20030115
Title: Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes.
Journal: Glia 20030115
Title: Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation.
Journal: Biochemical and biophysical research communications 20030110
Title: Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells.
Journal: FEBS letters 20030102
Title: Analysis of ceramides in cosmetics by reversed-phase liquid chromatography/electrospray ionization mass spectrometry with collision-induced dissociation.
Journal: Rapid communications in mass spectrometry : RCM 20030101
Title: Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids.
Journal: Endocrinology 20030101
Title: Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide.
Journal: European journal of biochemistry 20030101
Title: Linking Chinese medicine and G-protein-coupled receptors.
Journal: Trends in pharmacological sciences 20030101
Title: Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis.
Journal: Journal of lipid research 20030101
Title: Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine.
Journal: British journal of pharmacology 20030101
Title: Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030101
Title: Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy.
Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20030101
Title: Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts.
Journal: Archives of dermatological research 20030101
Title: Ceramide and sphingosine 1-phosphate in anti-cancer therapies.
Journal: Cancer treatment and research 20030101
Title: Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20030101
Title: Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101
Title: [The changes in the sphingenine/sphinganine ratio in sphingolipids of transplantable rat tumors depends on a transplantation organ].
Journal: Bioorganicheskaia khimiia 20030101
Title: C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis.
Journal: Neuroscience 20030101
Title: [Progress in the study of physiological function of sphingosine 1-phosphate].
Journal: Sheng li ke xue jin zhan [Progress in physiology] 20030101
Title: C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt.
Journal: Journal of endotoxin research 20030101
Title: Highly effective non-viral gene transfer into vascular smooth muscle cells of cultured resistance arteries demonstrated by genetic inhibition of sphingosine-1-phosphate-induced vasoconstriction.
Journal: Journal of vascular research 20030101
Title: Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.
Journal: Anticancer research 20030101
Title: Differential branching of the sphingolipid metabolic pathways with the stage of development. Involvement of sphingosine kinase.
Journal: Biology of the neonate 20030101
Title: Sphingosine-1-phosphate signaling in endothelial activation.
Journal: Journal of atherosclerosis and thrombosis 20030101
Title: Renal transplantation: basic concepts and evolution of therapy.
Journal: Journal of clinical apheresis 20030101
Title: New paradigms in immunosuppression.
Journal: CANNT journal = Journal ACITN 20030101
Title: [Sphingolipid-mediated apoptotic signaling pathways].
Journal: Journal de la Societe de biologie 20030101
Title: Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle.
Journal: Journal of muscle research and cell motility 20030101
Title: Different mechanisms for membrane and nuclear damages in apoptosis induced by an immunosuppressant, FTY720.
Journal: Molecules and cells 20021231
Title: Sphingosine in apoptosis signaling.
Journal: Biochimica et biophysica acta 20021230
Title: Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.
Journal: Biochimica et biophysica acta 20021230
Title: Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.
Journal: Biochimica et biophysica acta 20021230
Title: Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice.
Journal: Transplantation 20021227
Title: Gangliosides activate Trk receptors by inducing the release of neurotrophins.
Journal: The Journal of biological chemistry 20021220
Title: Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice.
Journal: Toxicology and applied pharmacology 20021215
Title: Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.
Journal: Biochemical and biophysical research communications 20021206
Title: Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK.
Journal: Cellular signalling 20021201
Title: Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.
Journal: Cellular signalling 20021201
Title: Isolation and characterization of the genes encoding delta(8)-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis.
Journal: Current microbiology 20021201
Title: Host resistance to Trypanosoma cruzi infection is enhanced in mice fed Fusarium verticillioides (=F. moniliforme) culture material containing fumonisins.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021201
Title: T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2.
Journal: British journal of pharmacology 20021201
Title: Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20021201
Title: The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase.
Journal: Endocrinology 20021201
Title: Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201
Title: Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021201
Title: Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20021201
Title: Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation.
Journal: Genes to cells : devoted to molecular & cellular mechanisms 20021201
Title: Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation.
Journal: Archives of biochemistry and biophysics 20021201
Title: Cis-4-methylsphingosine phosphate induces apoptosis in neuroblastoma cells by opposite effects on p38 and ERK mitogen-activated protein kinases.
Journal: Biological chemistry 20021201
Title: Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila.
Journal: Gene expression patterns : GEP 20021201
Title: Sphingosine modulation of cAMP levels and beating rate in rat heart.
Journal: Fundamental & clinical pharmacology 20021201
Title: Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway.
Journal: Biochemical and biophysical research communications 20021129
Title: Efficacy of mycophenolate sodium as monotherapy and in combination with FTY720 in a DA-to-Lewis-rat heart-transplantation model.
Journal: Transplantation 20021127
Title: Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021115
Title: Slight impairment of Na+,K+-ATPase synergistically aggravates ceramide- and beta-amyloid-induced apoptosis in cortical neurons.
Journal: Brain research 20021115
Title: Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway.
Journal: Circulation research 20021115
Title: Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Journal: Experimental cell research 20021115
Title: Comparative study of naphthalene-2,3-dicarboxaldehyde and o-phthalaldehyde fluorogenic reagents for chromatographic detection of sphingoid bases.
Journal: Journal of chromatography. A 20021115
Title: Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS).
Journal: The Journal of biological chemistry 20021108
Title: Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.
Journal: The Biochemical journal 20021101
Title: C(2)-ceramide-induced circular smooth muscle cell contraction involves PKC-epsilon and p44/p42 MAPK activation in cat oesophagus. Mitogen-activated protein kinase.
Journal: Cellular signalling 20021101
Title: Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Journal: Cellular signalling 20021101
Title: Modulation of BK(Ca) channel activity by fatty acids: structural requirements and mechanism of action.
Journal: American journal of physiology. Cell physiology 20021101
Title: Inhibition of CTP:phosphocholine cytidylyltransferase by C(2)-ceramide and its relationship to apoptosis.
Journal: Molecular pharmacology 20021101
Title: Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status.
Journal: Archives of biochemistry and biophysics 20021101
Title: An experimental approach for direct observation of the interaction of polyanions with sphingosine-containing giant vesicles.
Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20021101
Title: Glucosylceramide modulates membrane traffic along the endocytic pathway.
Journal: Journal of lipid research 20021101
Title: Increased biosynthesis of glycosphingolipids in congenital disorder of glycosylation Ia (CDG-Ia) fibroblasts.
Journal: Pediatric research 20021101
Title: Role of protein kinase C alpha in primary human osteoblast proliferation.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20021101
Title: A new class of lipid desaturase central to sphingolipid biosynthesis and signalling.
Journal: Trends in plant science 20021101
Title: Sirolimus and FTY720: new approaches to transplant immunosuppression.
Journal: Transplantation proceedings 20021101
Title: Effects of mycophenolate sodium with or without FTY720 in a DA-to-Lewis rat heart transplantation model.
Journal: Transplantation proceedings 20021101
Title: Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration.
Journal: The Journal of surgical research 20021101
Title: New sphingosines from the marine sponge Grayella cyatophora.
Journal: Journal of natural products 20021101
Title: Prolactin signaling in porcine adrenocortical cells: involvement of protein kinases.
Journal: Domestic animal endocrinology 20021101
Title: Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis.
Journal: Annals of the New York Academy of Sciences 20021101
Title: [Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: [Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: Cellular regulation of sodium-calcium exchange.
Journal: Annals of the New York Academy of Sciences 20021101
Title: Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells.
Journal: Thrombosis research 20021101
Title: Sphingosine-1-phosphate: dual messenger functions.
Journal: FEBS letters 20021030
Title: Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.
Journal: Biochemical pharmacology 20021015
Title: Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20021015
Title: Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD.
Journal: Transplantation 20021015
Title: Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships.
Journal: Journal of medicinal chemistry 20021010
Title: Sphingosine 1-phosphate triggers both apoptotic and survival signals for human hepatic myofibroblasts.
Journal: The Journal of biological chemistry 20021004
Title: Transplantation.
Journal: Current opinion in immunology 20021001
Title: FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.
Journal: Current opinion in immunology 20021001
Title: D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.
Journal: Atherosclerosis 20021001
Title: Mitochondrial cytochrome c release precedes transmembrane depolarisation and caspase-3 activation during ceramide-induced apoptosis of Jurkat T cells.
Journal: Apoptosis : an international journal on programmed cell death 20021001
Title: Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20021001
Title: Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology.
Journal: Current opinion in lipidology 20021001
Title: Effects of C2-ceramide on the Malme-3M melanoma cell line.
Journal: Journal of dermatological science 20021001
Title: Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes.
Journal: Investigative ophthalmology & visual science 20021001
Title: FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20021001
Title: Pachastrissamine, a cytotoxic anhydrophytosphingosine from a marine sponge, Pachastrissa sp.
Journal: Journal of natural products 20021001
Title: Identification of platelet-activating factor acetylhydrolase II in human skin.
Journal: The Journal of investigative dermatology 20021001
Title: Apoptosis induction by wheat-flour sphingoid bases in DLD-1 human colon cancer cells.
Journal: Bioscience, biotechnology, and biochemistry 20021001
Title: Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway.
Journal: The Journal of biological chemistry 20020927
Title: Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.
Journal: The Journal of biological chemistry 20020927
Title: Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.
Journal: Biochemical and biophysical research communications 20020927
Title: PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA).
Journal: The Journal of biological chemistry 20020920
Title: Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine.
Journal: Neuroscience letters 20020920
Title: Glycosphingolipids from Magnaporthe grisea cells: expression of a ceramide dihexoside presenting phytosphingosine as the long-chain base.
Journal: Archives of biochemistry and biophysics 20020915
Title: Effects of immunosuppressant FTY720 on renal and hepatic hemodynamics in the rat.
Journal: Transplantation 20020915
Title: Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice.
Journal: Life sciences 20020913
Title: A role for the de novo sphingolipids in apoptosis of photosensitized cells.
Journal: Experimental cell research 20020910
Title: Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes.
Journal: Cellular signalling 20020901
Title: Phosphorylation of cardiac protein kinase B is regulated by palmitate.
Journal: American journal of physiology. Heart and circulatory physiology 20020901
Title: Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific.
Journal: Molecular pharmacology 20020901
Title: Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.
Journal: Hepatology (Baltimore, Md.) 20020901
Title: Sphingosine 1-phosphate as a therapeutic agent.
Journal: Leukemia 20020901
Title: Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring.
Journal: Nature medicine 20020901
Title: The roles of sphingosine-1-phosphate in asthma.
Journal: Molecular immunology 20020901
Title: FTY720 alters the composition of T-lymphocyte subpopulations in the peripheral blood compartment of renal transplant patients.
Journal: Transplantation proceedings 20020901
Title: Serum factors involved in human microvascular endothelial cell morphogenesis.
Journal: The Journal of laboratory and clinical medicine 20020901
Title: Effect of acute exercise on the content of free sphinganine and sphingosine in different skeletal muscle types of the rat.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020901
Title: Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway.
Journal: Cellular immunology 20020901
Title: Ceramide mediates age-associated increase in macrophage cyclooxygenase-2 expression.
Journal: The Journal of biological chemistry 20020823
Title: Antifungal activity of bifunctional sphingolipids. Intramolecular synergism within long-chain alpha,omega-bis-aminoalcohols.
Journal: Bioorganic & medicinal chemistry letters 20020819
Title: Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells.
Journal: The Journal of biological chemistry 20020816
Title: Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.
Journal: The Biochemical journal 20020815
Title: Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell.
Journal: World journal of gastroenterology 20020815
Title: Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells.
Journal: Molecular pharmacology 20020801
Title: Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.
Journal: Gastroenterology 20020801
Title: Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression.
Journal: Journal of neurochemistry 20020801
Title: Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction.
Journal: British journal of pharmacology 20020801
Title: Effect of thalidomide on the skeletal muscle in experimental heart failure.
Journal: European journal of heart failure 20020801
Title: Combined therapy of CTLA4Ig-gene transfection with FTY720 administration in rat lung allografts.
Journal: Transplantation proceedings 20020801
Title: FTY720: a novel approach to the treatment of hepatic ischemia-reperfusion injury.
Journal: Transplantation proceedings 20020801
Title: Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus.
Journal: The Journal of investigative dermatology 20020801
Title: Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype.
Journal: Molecular genetics and metabolism 20020801
Title: Sphingosine-based liposome as DNA vector for intramuscular gene delivery.
Journal: Pharmaceutical research 20020801
Title: The role of H2O2 in the platelet-derived growth factor-induced transcription of the gamma-glutamylcysteine synthetase heavy subunit.
Journal: Cellular and molecular life sciences : CMLS 20020801
Title: Sphingosine-induced c-jun expression: differences between sphingosine- and C2-ceramide-mediated signaling pathways.
Journal: FEBS letters 20020731
Title: Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins.
Journal: The Journal of biological chemistry 20020726
Title: New roads leading to Ca2+ sensitization.
Journal: Circulation research 20020726
Title: Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.
Journal: Circulation research 20020726
Title: Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction.
Journal: Circulation research 20020726
Title: A novel immunosuppressive drug, FTY720, prevents the cancer progression induced by cyclosporine.
Journal: Cancer letters 20020726
Title: Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta.
Journal: Cancer letters 20020726
Title: Sphingosine 1-phosphate, a key cell signaling molecule.
Journal: The Journal of biological chemistry 20020719
Title: Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells.
Journal: Cellular signalling 20020701
Title: Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide.
Journal: The Biochemical journal 20020701
Title: Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.
Journal: The Journal of laboratory and clinical medicine 20020701
Title: N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701
Title: Ethanol-induced increase of sphingosine recycling for ganglioside biosynthesis: a study performed on cerebellar granule cells in culture.
Journal: Journal of neuroscience research 20020701
Title: Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.
Journal: European journal of immunology 20020701
Title: Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1.
Journal: Structure (London, England : 1993) 20020701
Title: Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.
Journal: The Journal of biological chemistry 20020628
Title: A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells.
Journal: Biochemical and biophysical research communications 20020628
Title: Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.
Journal: Biochemical and biophysical research communications 20020628
Title: A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts.
Journal: FEBS letters 20020619
Title: Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells.
Journal: Journal of cell science 20020615
Title: Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood.
Journal: The Journal of biological chemistry 20020614
Title: The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Journal: The Journal of biological chemistry 20020614
Title: Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.
Journal: Cellular signalling 20020601
Title: Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells.
Journal: American journal of physiology. Cell physiology 20020601
Title: Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.
Journal: American journal of physiology. Heart and circulatory physiology 20020601
Title: Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020601
Title: Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase.
Journal: Cell death and differentiation 20020601
Title: The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.
Journal: Journal of biochemistry 20020601
Title: Structural studies on ceramides as lithiated adducts by low energy collisional-activated dissociation tandem mass spectrometry with electrospray ionization.
Journal: Journal of the American Society for Mass Spectrometry 20020601
Title: Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020601
Title: Cytotoxic sphingosine 4-sulfates from the sponge Spirastrella abata.
Journal: Journal of natural products 20020601
Title: Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells.
Journal: Journal of biosciences 20020601
Title: Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Journal: Biological chemistry 20020601
Title: Sphingosine-1-phosphate and lipid phosphohydrolases.
Journal: Biochimica et biophysica acta 20020523
Title: Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors.
Journal: Biochimica et biophysica acta 20020523
Title: Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction.
Journal: Biochimica et biophysica acta 20020523
Title: Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors.
Journal: Biochimica et biophysica acta 20020523
Title: Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors.
Journal: Biochimica et biophysica acta 20020523
Title: Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors.
Journal: Biochimica et biophysica acta 20020523
Title: Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
Journal: Biochimica et biophysica acta 20020523
Title: Sphingosylphosphorylcholine-biological functions and mechanisms of action.
Journal: Biochimica et biophysica acta 20020523
Title: Differential effects of sphingosine 1-phosphate and lysophosphatidic acid on endothelial cells.
Journal: Biochimica et biophysica acta 20020523
Title: Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate.
Journal: Biochimica et biophysica acta 20020523
Title: Lysophospholipids and the cardiovascular system.
Journal: Biochimica et biophysica acta 20020523
Title: Lipid mediators of angiogenesis and the signalling pathways they initiate.
Journal: Biochimica et biophysica acta 20020523
Title: Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation.
Journal: The Journal of biological chemistry 20020517
Title: Synthesis of D-erythro-dihydrosphingosine and D-xylo-phytosphingosine from a serine-derived 1,5-dioxaspiro[3.2]hexane template.
Journal: Organic letters 20020516
Title: Role of sphingosine synthesis inhibition in transcutaneous delivery of levodopa.
Journal: International journal of pharmaceutics 20020515
Title: Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.
Journal: Transplantation 20020515
Title: Stimulation of trehalose efflux from cockroach (Periplaneta americana) fat body by hypertrehalosemic hormone is dependent on protein kinase C and calmodulin.
Journal: Archives of insect biochemistry and physiology 20020501
Title: HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20020501
Title: Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses.
Journal: The Journal of pharmacology and experimental therapeutics 20020501
Title: Cell type-specific localization of human cardiac S1P receptors.
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020501
Title: 3-O-acetyl-sphingosine-series myelin glycolipids: characterization of novel 3-O-acetyl-sphingosine galactosylceramide.
Journal: Journal of lipid research 20020501
Title: Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.
Journal: Experimental biology and medicine (Maywood, N.J.) 20020501
Title: Characterization of ceramides by low energy collisional-activated dissociation tandem mass spectrometry with negative-ion electrospray ionization.
Journal: Journal of the American Society for Mass Spectrometry 20020501
Title: Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy.
Journal: Transplantation proceedings 20020501
Title: Donor pretreatment with FTY720 increases graft lymphocytes but does not affect graft survival following rat small bowel transplantation.
Journal: Transplantation proceedings 20020501
Title: Dihydroceramide desaturase activity in tumors.
Journal: Biochemistry. Biokhimiia 20020501
Title: Sphingosine 1-phosphate signaling: providing cells with a sense of direction.
Journal: Trends in cell biology 20020501
Title: Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo.
Journal: Pharmacology & toxicology 20020501
Title: Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis.
Journal: Journal of neuroscience research 20020501
Title: Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-alpha, and sphingosine.
Journal: Circulation research 20020419
Title: Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase.
Journal: Analytical biochemistry 20020415
Title: Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation.
Journal: Biochemical pharmacology 20020415
Title: Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density.
Journal: The Journal of biological chemistry 20020412
Title: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Journal: Science (New York, N.Y.) 20020412
Title: Membrane restructuring via ceramide results in enhanced solute efflux.
Journal: The Journal of biological chemistry 20020405
Title: Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells.
Journal: Neurochemistry international 20020401
Title: Sphingosine kinase inhibitors in the apoptosis of leukaemia cells.
Journal: Leukemia research 20020401
Title: Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway.
Journal: Cellular signalling 20020401
Title: Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.
Journal: Current opinion in cell biology 20020401
Title: Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response.
Journal: Experimental cell research 20020401
Title: First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients.
Journal: Journal of the American Society of Nephrology : JASN 20020401
Title: Conformational characterization of ceramides by nuclear magnetic resonance spectroscopy.
Journal: Biophysical journal 20020401
Title: Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20020401
Title: Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020401
Title: Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus.
Journal: The Journal of rheumatology 20020401
Title: Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism.
Journal: In vitro cellular & developmental biology. Animal 20020401
Title: Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase.
Journal: The Journal of biological chemistry 20020322
Title: Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells.
Journal: The Journal of biological chemistry 20020322
Title: Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C zeta induced by C2-ceramide in rat hepatocytes.
Journal: FEBS letters 20020313
Title: Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis.
Journal: International journal of cancer 20020310
Title: Synthesis of D-erythro-sphingosine and D-erythro-ceramide.
Journal: Chemical communications (Cambridge, England) 20020307
Title: Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine.
Journal: Leukemia research 20020301
Title: Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors.
Journal: The Biochemical journal 20020301
Title: Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells.
Journal: Molecular pharmacology 20020301
Title: Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis.
Journal: Molecular pharmacology 20020301
Title: Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells).
Journal: The Journal of pharmacology and experimental therapeutics 20020301
Title: A thematic series on lipid signaling: prologue.
Journal: Journal of biochemistry 20020301
Title: C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Journal: Diabetes 20020301
Title: Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies?
Journal: Teratology 20020301
Title: Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor.
Journal: Experimental hematology 20020301
Title: Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.
Journal: Cancer research 20020301
Title: [Sphingosine 1-phosphate in yeast].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Signal transduction of ceramide].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Molecular evolution of neutral ceramidase: signalling molecule and virulence factor].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Sphingosine 1-phosphate and vascular endothelial cells].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Molecular diversity of sphingosine kinase].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: [Chemical syntheses of sphingophospholipids and their analogues].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20020301
Title: Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation.
Journal: The Journal of biological chemistry 20020222
Title: Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells.
Journal: Circulation research 20020222
Title: L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20020215
Title: Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine.
Journal: The Biochemical journal 20020215
Title: Ceramide and sphingosine have an antagonistic effect on the plasma-membrane Ca2+-ATPase from human erythrocytes.
Journal: The Biochemical journal 20020215
Title: Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
Journal: Blood 20020215
Title: Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense.
Journal: Genes & development 20020215
Title: Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest.
Journal: The Journal of biological chemistry 20020201
Title: Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin-Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor.
Journal: The Biochemical journal 20020201
Title: Update on pharmacokinetic/pharmacodynamic studies with FTY720 and sirolimus.
Journal: Therapeutic drug monitoring 20020201
Title: Calyculin A sensitive protein phosphatase is required for Bacillus anthracis lethal toxin induced cytotoxicity.
Journal: Current microbiology 20020201
Title: mAChRs in the grasshopper brain mediate excitation by activation of the AC/PKA and the PLC second-messenger pathways.
Journal: Journal of neurophysiology 20020201
Title: Sphingolipids and the regulation of the immune response.
Journal: Seminars in immunology 20020201
Title: Factors controlling smooth muscle proliferation and airway remodelling.
Journal: Current opinion in allergy and clinical immunology 20020201
Title: Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
Journal: Oncogene 20020131
Title: 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase.
Journal: Biochimica et biophysica acta 20020130
Title: What role for FTY720, a novel immunosuppressive agent, in canine nonmyeloablative hematopoietic stem cell transplantation?
Journal: Transplantation 20020127
Title: Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis.
Journal: Oncogene 20020103
Title: Sphingosine modulates myocyte electrophysiology, induces negative inotropy, and decreases survival after myocardial ischemia.
Journal: Journal of cardiovascular pharmacology 20020101
Title: Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells.
Journal: Cellular signalling 20020101
Title: TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones.
Journal: Neuropharmacology 20020101
Title: Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation.
Journal: Endocrinology 20020101
Title: Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20020101
Title: Substrate specificity of rat brain ceramidase.
Journal: Journal of lipid research 20020101
Title: Transient relaxation of rat mesenteric microvessels by ceramides.
Journal: British journal of pharmacology 20020101
Title: Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival.
Journal: Journal of cellular biochemistry 20020101
Title: Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?
Journal: The oncologist 20020101
Title: [Biologically effective sphingolipids devoid of 4-trans-double bond in the sphingoid hydrocarbon chain].
Journal: Bioorganicheskaia khimiia 20020101
Title: Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines.
Journal: Anti-cancer drugs 20020101
Title: Dependence of the sphingoid bases concentration on growth phase and temperature in the yeast Yarrowia lipolytica.
Journal: Journal of basic microbiology 20020101
Title: Lysophospholipids induce membrane hyperpolarization in microglia by activation of IKCa1 Ca(2+)-dependent K(+) channels.
Journal: Neuroscience 20020101
Title: Heat shock and ceramide have different apoptotic pathways in radiation induced fibrosarcoma (RIF) cells.
Journal: Molecular and cellular biochemistry 20020101
Title: Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis.
Journal: Sub-cellular biochemistry 20020101
Title: Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides).
Journal: Cancer detection and prevention 20020101
Title: Sphingosine kinases: a novel family of lipid kinases.
Journal: Progress in nucleic acid research and molecular biology 20020101
Title: [Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling].
Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20020101
Title: High levels of exogenous C2-ceramide promote morphological and biochemical evidences of necrotic features in thyroid follicular cells.
Journal: Journal of cellular biochemistry 20020101
Title: Mitochondria and ceramide: intertwined roles in regulation of apoptosis.
Journal: Advances in enzyme regulation 20020101
Title: Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays.
Journal: Genome biology 20020101
Title: Two forms of membrane-bound sphingosine kinase in Tetrahymena and activity changes during growth and the cell cycle.
Journal: The Journal of eukaryotic microbiology 20020101
Title: In vitro activity of phytosphingosines against Malassezia furfur and Candida albicans.
Journal: Acta dermato-venereologica 20020101
Title: Deregulated activation of matriptase in breast cancer cells.
Journal: Clinical & experimental metastasis 20020101
Title: Sphingosine 1-phosphate: a Ca2+ release mediator in the balance.
Journal: Cell calcium 20020101
Title: Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes.
Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020101
Title: Phosphatidic acid is the prominent product of endogenous neuronal nuclear lipid phosphorylation, an activity enhanced by sphingosine, linked to phospholipase C and associated with the nuclear envelope.
Journal: Biochimica et biophysica acta 20011230
Title: A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.
Journal: The Journal of biological chemistry 20011228
Title: Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells.
Journal: The Journal of biological chemistry 20011228
Title: A point mutant of human sphingosine kinase 1 with increased catalytic activity.
Journal: FEBS letters 20011207
Title: Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate.
Journal: FEBS letters 20011207
Title: Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast.
Journal: The EMBO journal 20011203
Title: The IL-15R alpha chain signals through association with Syk in human B cells.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20011201
Title: Selective ligands for lysophosphatidic acid receptor subtypes: gaining control over the endothelial differentiation gene family.
Journal: Molecular pharmacology 20011201
Title: EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201
Title: A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells.
Journal: The Journal of physiology 20011201
Title: Adaptive concentrations of hydrogen peroxide suppress cell death by blocking the activation of SAPK/JNK pathway.
Journal: Journal of cell science 20011201
Title: Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm.
Journal: Stroke 20011201
Title: Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells.
Journal: American journal of reproductive immunology (New York, N.Y. : 1989) 20011201
Title: [Establishment of the method for the measurement of sphingosine-1-phosphate in biological samples and its application for S1P research].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20011201
Title: Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cells.
Journal: Current genetics 20011201
Title: Sphingolipids in mammalian cell signalling.
Journal: Cellular and molecular life sciences : CMLS 20011201
Title: Exogenous sphingosine enters Xenopus laevis embryos grown in petri dishes and it is metabolized.
Journal: Bioscience reports 20011201
Title: Lysophospholipids--receptor revelations.
Journal: Science (New York, N.Y.) 20011130
Title: Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.
Journal: Biochemistry 20011120
Title: High-performance liquid chromatography analysis of molecular species of sphingolipid-related long chain bases and long chain base phosphates in Saccharomyces cerevisiae after derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate.
Journal: Analytical biochemistry 20011115
Title: Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
Journal: The Journal of biological chemistry 20011102
Title: Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases.
Journal: Cellular signalling 20011101
Title: Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
Journal: Blood 20011101
Title: A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20011101
Title: The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility.
Journal: Biochemical Society transactions 20011101
Title: 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate.
Journal: The Journal of investigative dermatology 20011101
Title: Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china.
Journal: Cancer causes & control : CCC 20011101
Title: Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis.
Journal: Plant & cell physiology 20011101
Title: [Survey on the fumonisins intake and the urinary Sa/So ratio of people suffered from a high incidence of esophageal cancer].
Journal: Wei sheng yan jiu = Journal of hygiene research 20011101
Title: Cdc42-independent activation and translocation of the cytostatic p21-activated protein kinase gamma-PAK by sphingosine.
Journal: FEBS letters 20011026
Title: Human and rat alveolar macrophages express multiple EDG receptors.
Journal: European journal of pharmacology 20011019
Title: Sphingosine-induced apoptosis is dependent on lysosomal proteases.
Journal: The Biochemical journal 20011015
Title: TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation.
Journal: Experimental cell research 20011015
Title: Fumonisin B(1) induces apoptosis in LLC-PK(1) renal epithelial cells via a sphinganine- and calmodulin-dependent pathway.
Journal: Toxicology and applied pharmacology 20011015
Title: Nitric oxide production in living neurons is modulated by sphingosine: a fluorescence microscopy study.
Journal: FEBS letters 20011012
Title: Cytoskeleton elements mediate the inhibition of the (Na++K+)atpase activity by PKC in Rhodnius prolixus malpighian tubules during hyperosmotic shock.
Journal: Archives of insect biochemistry and physiology 20011001
Title: Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes.
Journal: Journal of lipid research 20011001
Title: Apoptosis in the skeletal muscle of rats with heart failure is associated with increased serum levels of TNF-alpha and sphingosine.
Journal: Journal of molecular and cellular cardiology 20011001
Title: Activation of caspases and mitochondria in FTY720-mediated apoptosis in human T cell line Jurkat.
Journal: International immunopharmacology 20011001
Title: Cellular location of (2R, 3R, 7Z)-2-aminotetradec-7-ene-1, 3-diol, a potent antimicrobial metabolite produced by the Caribbean sponge Haliclona vansoesti.
Journal: Cell and tissue research 20011001
Title: Neurobiology of the Edg2 lysophosphatidic acid receptor.
Journal: Japanese journal of pharmacology 20011001
Title: Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways.
Journal: The Journal of biological chemistry 20010928
Title: Sphingomyelinase but not ceramide induces nitric oxide synthase expression in rat brain microglia.
Journal: Neuroscience letters 20010928
Title: Structural requirements of sphingosine molecules for inhibition of DNA primase: biochemical and computational analyses.
Journal: Biochemistry 20010925
Title: Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate.
Journal: The Journal of biological chemistry 20010921
Title: Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae.
Journal: The Journal of biological chemistry 20010921
Title: Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3.
Journal: The Journal of biological chemistry 20010921
Title: Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate.
Journal: Biochemistry 20010918
Title: Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids.
Journal: Cancer research 20010915
Title: FTY720: altered lymphocyte traffic results in allograft protection.
Journal: Transplantation 20010915
Title: Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.
Journal: The Journal of biological chemistry 20010914
Title: Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells.
Journal: Circulation research 20010914
Title: Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration.
Journal: Circulation research 20010914
Title: Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3.
Journal: The Journal of biological chemistry 20010907
Title: Ceramide blocks PDGF-induced DNA synthesis in mesangial cells via inhibition of Akt kinase in the absence of apoptosis.
Journal: Biochemical and biophysical research communications 20010907
Title: Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.
Journal: The Journal of clinical investigation 20010901
Title: EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes.
Journal: Journal of molecular and cellular cardiology 20010901
Title: The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes.
Journal: Journal of molecular and cellular cardiology 20010901
Title: Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated?
Journal: Trends in biochemical sciences 20010901
Title: The induction and persistence of altered sphingolipid biosynthesis in rats treated with fumonisin B1.
Journal: Food additives and contaminants 20010901
Title: Immunoseparation of sphingolipid-enriched membrane domains enriched in Src family protein tyrosine kinases and in the neuronal adhesion molecule TAG-1 by anti-GD3 ganglioside monoclonal antibody.
Journal: Journal of neurochemistry 20010901
Title: Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum.
Journal: Development (Cambridge, England) 20010901
Title: [mTOR and FTY 720 inhibitors].
Journal: Presse medicale (Paris, France : 1983) 20010901
Title: [What is new on transplantation in 2001?].
Journal: Presse medicale (Paris, France : 1983) 20010901
Title: Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
Journal: Molecular cell 20010901
Title: Potential application of plant lipid transfer proteins for drug delivery.
Journal: Biochemical pharmacology 20010901
Title: Effect of bilirubin on lipid peroxidation, sphingomyelinase activity, and apoptosis induced by sphingosine and UV irradiation.
Journal: Biochemistry. Biokhimiia 20010901
Title: Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010901
Title: Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor.
Journal: Biochemical and biophysical research communications 20010831
Title: Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice.
Journal: Toxicology 20010828
Title: Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells.
Journal: The Journal of biological chemistry 20010824
Title: Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
Journal: FEBS letters 20010817
Title: Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase.
Journal: Biochemistry 20010814
Title: Nuclear translocation of extracellular signal-regulated kinases in neuronal excitotoxicity.
Journal: Neuroreport 20010808
Title: Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor.
Journal: The Journal of biological chemistry 20010803
Title: Coexpression of CD4 and CD8alpha on rat T-cells in whole blood: a sensitive marker for monitoring T-cell immunosuppressive drugs.
Journal: Journal of immunological methods 20010801
Title: Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells.
Journal: Journal of cellular physiology 20010801
Title: Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts.
Journal: Cellular signalling 20010801
Title: Propagation of the apoptotic signal by mitochondrial waves.
Journal: The EMBO journal 20010801
Title: Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations.
Journal: Journal of lipid research 20010801
Title: Preparation of deacetyl-, lyso-, and deacetyl-lyso-GM(3) by selective alkaline hydrolysis of GM3 ganglioside.
Journal: Journal of lipid research 20010801
Title: Characterization of novel structures of mannosylinositolphosphorylceramides from the yeast forms of Sporothrix schenckii.
Journal: European journal of biochemistry 20010801
Title: Reaction of fumonisin with glucose prevents promotion of hepatocarcinogenesis in female F344/N rats while maintaining normal hepatic sphinganine/sphingosine ratios.
Journal: Journal of agricultural and food chemistry 20010801
Title: Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010801
Title: Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells.
Journal: The Journal of biological chemistry 20010727
Title: Immunology. The push-me pull-you of T cell activation.
Journal: Science (New York, N.Y.) 20010727
Title: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.
Journal: Science (New York, N.Y.) 20010727
Title: Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum.
Journal: The Journal of biological chemistry 20010720
Title: A method for quantitative extraction of sphingosine 1-phosphate into organic solvent.
Journal: Analytical biochemistry 20010715
Title: Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model.
Journal: Transplantation 20010715
Title: Intracellular signalling: sphingosine-1-phosphate branches out.
Journal: Current biology : CB 20010710
Title: The effect of repeated gavage doses of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys.
Journal: Toxicon : official journal of the International Society on Toxinology 20010701
Title: Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis.
Journal: Current microbiology 20010701
Title: Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists.
Journal: Blood 20010701
Title: TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010701
Title: N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.
Journal: Cancer research 20010701
Title: Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition.
Journal: Toxicology and applied pharmacology 20010701
Title: Occupational acute lung injury due to Alternaria alternata: early stage of organic dust toxic syndrome requires no corticosteroids.
Journal: Intensive care medicine 20010701
Title: Uncoupling protein-3 mRNA up-regulation in C2C12 myotubes after etomoxir treatment.
Journal: Biochimica et biophysica acta 20010629
Title: Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro.
Journal: The Journal of biological chemistry 20010615
Title: Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor.
Journal: FEBS letters 20010615
Title: Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Journal: Brain research 20010608
Title: Angiostatin effects on endothelial cells mediated by ceramide and RhoA.
Journal: EMBO reports 20010606
Title: Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells.
Journal: The Journal of biological chemistry 20010601
Title: A high-capacity quantitative mouse model of drug-mediated immunosuppression based on rejection of an allogeneic subcutaneous tumor.
Journal: The Journal of pharmacology and experimental therapeutics 20010601
Title: Caspase-resistant vimentin suppresses apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells.
Journal: Archives of biochemistry and biophysics 20010601
Title: C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p.
Journal: The EMBO journal 20010601
Title: The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.
Journal: The EMBO journal 20010601
Title: Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity.
Journal: American journal of respiratory cell and molecular biology 20010601
Title: Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation.
Journal: The European journal of neuroscience 20010601
Title: Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts.
Journal: The European journal of neuroscience 20010601
Title: Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720.
Journal: Japanese journal of cancer research : Gann 20010601
Title: The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog.
Journal: Chemistry and physics of lipids 20010601
Title: Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades.
Journal: The European journal of neuroscience 20010601
Title: Regulatory mechanisms of female germ cell apoptosis during embryonic development.
Journal: Endocrine journal 20010601
Title: C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis.
Journal: Cell death and differentiation 20010601
Title: Toxicity of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducks.
Journal: Toxicology 20010528
Title: Effects of ceramide on aggrecanase activity in rabbit articular cartilage.
Journal: Biochemical and biophysical research communications 20010525
Title: Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator.
Journal: Molecular and cellular endocrinology 20010525
Title: Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.
Journal: The Journal of biological chemistry 20010518
Title: Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells.
Journal: The EMBO journal 20010515
Title: YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells.
Journal: Cellular microbiology 20010501
Title: The effect of a single gavage dose of fumonisin B(2) on the sphinganine and sphingosine concentrations in vervet monkeys.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010501
Title: Ineffectiveness of activated carbon in reducing the alteration of sphingolipid metabolism in rats exposed to fumonisin-contaminated diets.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010501
Title: Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010501
Title: Lysophospholipids increase interleukin-8 expression in ovarian cancer cells.
Journal: Gynecologic oncology 20010501
Title: Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501
Title: Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis.
Journal: Journal of the American College of Cardiology 20010501
Title: Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
Journal: Environmental health perspectives 20010501
Title: Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis.
Journal: Environmental health perspectives 20010501
Title: Analysis of fumonisin B1-induced apoptosis.
Journal: Environmental health perspectives 20010501
Title: Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count.
Journal: Transplantation proceedings 20010501
Title: FTY-720 is efficacious in monkey kidney transplantation.
Journal: Transplantation proceedings 20010501
Title: Engagement of CD147 molecule-induced cell aggregation through the activation of protein kinases and reorganization of the cytoskeleton.
Journal: Immunobiology 20010501
Title: Sphinganine in sphingomyelins of tumors and mouse regenerating liver.
Journal: Biochemistry. Biokhimiia 20010501
Title: S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus.
Journal: The Journal of antibiotics 20010501
Title: Fluorescent staining of subcellular organelles: ER, Golgi complex, and mitochondria.
Journal: Current protocols in cell biology 20010501
Title: Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries.
Journal: Circulation research 20010427
Title: Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.
Journal: Life sciences 20010427
Title: High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from an endemic nephropathy area in Croatia.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010425
Title: Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase.
Journal: Biochemistry 20010424
Title: G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells.
Journal: The Journal of biological chemistry 20010420
Title: Basic fibroblast growth factor-induced proliferation of primary astrocytes. evidence for the involvement of sphingomyelin biosynthesis.
Journal: The Journal of biological chemistry 20010420
Title: Functional identification of a delta8-sphingolipid desaturase from Borago officinalis.
Journal: Archives of biochemistry and biophysics 20010415
Title: Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins.
Journal: The Journal of biological chemistry 20010413
Title: Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells.
Journal: The Journal of biological chemistry 20010413
Title: Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.
Journal: The Journal of biological chemistry 20010413
Title: Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production.
Journal: The Journal of biological chemistry 20010406
Title: Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana.
Journal: FEBS letters 20010406
Title: Fumonisin B(1) increases serum sphinganine concentration but does not alter serum sphingosine concentration or induce cardiovascular changes in milk-fed calves.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401
Title: Fumonisin B(1) is hepatotoxic and nephrotoxic in milk-fed calves.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401
Title: Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors.
Journal: The Biochemical journal 20010401
Title: Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout.
Journal: Toxicology and applied pharmacology 20010401
Title: Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells.
Journal: Cardiovascular research 20010401
Title: Involvement of sphingomyelinase in insulin-induced phosphatidylinositol 3-kinase activation.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010401
Title: Ceramide inhibits cell proliferation through Akt/PKB inactivation and decreases melanin synthesis in Mel-Ab cells.
Journal: Pigment cell research 20010401
Title: Sphingosine 1-phosphate: synthesis and release.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Sphingosine kinase: a mediator of vital cellular functions.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Sphingosine 1-phosphate receptors.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Sphingosine-1-phosphate phosphatases.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Structure activity relationships of lysophospholipid mediators.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate.
Journal: Prostaglandins & other lipid mediators 20010401
Title: Differential effects of fumonisin B1 on cell death in cultured cells: the significance of the elevated sphinganine.
Journal: Archives of pharmacal research 20010401
Title: Long-term graft acceptance in rat heart transplantation by CTLA4Ig gene transfection combined with FTY720 treatment.
Journal: World journal of surgery 20010401
Title: Drought-induced guard cell signal transduction involves sphingosine-1-phosphate.
Journal: Nature 20010329
Title: Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists.
Journal: Oncogene 20010326
Title: A short and practical route to 3-O-benzoyl azidosphingosine.
Journal: Carbohydrate research 20010309
Title: Targeting ceramide metabolism--a strategy for overcoming drug resistance.
Journal: Journal of the National Cancer Institute 20010307
Title: Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
Journal: Science (New York, N.Y.) 20010302
Title: Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors.
Journal: European journal of pharmacology 20010302
Title: Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation.
Journal: Cytometry 20010301
Title: Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation.
Journal: The Biochemical journal 20010301
Title: Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.
Journal: Molecular pharmacology 20010301
Title: NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide.
Journal: Free radical biology & medicine 20010301
Title: New immunosuppressive drugs: an update.
Journal: Current opinion in urology 20010301
Title: Glycoinositolphosphosphingolipids (basidiolipids) of higher mushrooms.
Journal: European journal of biochemistry 20010301
Title: Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.
Journal: Journal of neurochemistry 20010301
Title: Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010301
Title: An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010301
Title: Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010301
Title: A mechanistic approach to modelling the risk of liver tumours in mice exposed to fumonisin B1 in the diet.
Journal: Food additives and contaminants 20010301
Title: Tissue sphinganine as a biomarker of fumonisin-induced apoptosis.
Journal: Food additives and contaminants 20010301
Title: Determination of sphinganine, sphingosine and Sa/So ratio in urine of humans exposed to dietary fumonisin B1.
Journal: Food additives and contaminants 20010301
Title: Elevated expression of mitochondrial NADH dehydrogenase subunit 4/4L genes in vascular endothelial cells undergoing sphingosine-induced apoptosis.
Journal: Thrombosis and haemostasis 20010301
Title: Comparative investigation of human stratum corneum ceramides.
Journal: Lipids 20010301
Title: Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure.
Journal: Acta physiologica Scandinavica 20010301
Title: Treatment of transplant rejection: are the traditional immunosuppressants good enough?
Journal: Current opinion in investigational drugs (London, England : 2000) 20010301
Title: Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions.
Journal: Biochimica et biophysica acta 20010226
Title: Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.
Journal: The Journal of biological chemistry 20010223
Title: FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
Journal: Biochemical and biophysical research communications 20010223
Title: Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors.
Journal: International journal of cancer 20010220
Title: G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways.
Journal: The Journal of biological chemistry 20010216
Title: Platelet-released phospholipids link haemostasis and angiogenesis.
Journal: Cardiovascular research 20010216
Title: Inhibition of sodium-calcium exchange by ceramide and sphingosine.
Journal: The Journal of biological chemistry 20010209
Title: Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells.
Journal: Biochemical and biophysical research communications 20010209
Title: Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Journal: Biochemical and biophysical research communications 20010202
Title: t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast.
Journal: The EMBO journal 20010201
Title: Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20.
Journal: Journal of neurochemistry 20010201
Title: C2-ceramide and reactive oxygen species inhibit pituitary adenylate cyclase activating polypeptide (PACAP)-induced cyclic-AMP-dependent signalling pathway.
Journal: Journal of neurochemistry 20010201
Title: Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release.
Journal: Seminars in cell & developmental biology 20010201
Title: T-cell receptor downregulation by ceramide-induced caspase activation and cleavage of the zeta chain.
Journal: Scandinavian journal of immunology 20010201
Title: Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720.
Journal: Clinical and experimental immunology 20010201
Title: Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Journal: Cancer research 20010201
Title: Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.
Journal: Diabetologia 20010201
Title: Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.
Journal: Journal of hepatology 20010201
Title: Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.
Journal: Cell death and differentiation 20010201
Title: Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to lewis heart and skin transplantation models.
Journal: Transplant immunology 20010201
Title: Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.
Journal: Science's STKE : signal transduction knowledge environment 20010130
Title: Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria.
Journal: FEBS letters 20010119
Title: Regulation of phospholipase D (PLD) in growth plate chondrocytes by 24R,25-(OH)2D3 is dependent on cell maturation state (resting zone cells) and is specific to the PLD2 isoform.
Journal: Biochimica et biophysica acta 20010115
Title: The effect of a single gavage dose of fumonisin B(1) on the sphinganine and sphingosine levels in vervet monkeys.
Journal: Toxicon : official journal of the International Society on Toxinology 20010101
Title: Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells.
Journal: The Biochemical journal 20010101
Title: Differential regulation of protein tyrosine kinase on free radical production, granule enzyme release, and cytokine synthesis by activated murine peritoneal macrophages.
Journal: Biochemical pharmacology 20010101
Title: The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010101
Title: Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come?
Journal: European journal of biochemistry 20010101
Title: Distinct signals generate repeating striped pattern in the embryonic parasegment.
Journal: Molecular cell 20010101
Title: Immunosuppressive drugs in paediatric liver transplantation.
Journal: Paediatric drugs 20010101
Title: The role and clinical applications of bioactive lysolipids in ovarian cancer.
Journal: Journal of the Society for Gynecologic Investigation 20010101
Title: Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway.
Journal: Biological chemistry 20010101
Title: FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression.
Journal: Transplantation proceedings 20010101
Title: FTY720 prevents chronic rejection of rat heterotopic cardiac allografts.
Journal: Transplantation proceedings 20010101
Title: FTY720, a novel immunosuppressive agent with insulinotropic activity, prolongs graft survival in a mouse islet transplantation model.
Journal: Transplantation proceedings 20010101
Title: FTY 720 prevents ischemic reperfusion damage in rat kidneys.
Journal: Transplantation proceedings 20010101
Title: Lysosomal involvement in apoptosis.
Journal: Redox report : communications in free radical research 20010101
Title: The role of sphingosine and its derivatives in the regulation of Ca2+ homeostasis.
Journal: Membrane & cell biology 20010101
Title: Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes.
Journal: Acta neurobiologiae experimentalis 20010101
Title: Glial cell responses to lipids bound to albumin in serum and plasma.
Journal: Progress in brain research 20010101
Title: [Relationship between the induction of MDR1, a multidrug resistance gene in tumor cells, and apoptosis].
Journal: Ontogenez 20010101
Title: Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis.
Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20010101
Title: In vitro and in vivo studies to assess the effectiveness of cholestyramine as a binding agent for fumonisins.
Journal: Mycopathologia 20010101
Title: Involvement of wild-type p53 in radiation-induced c-Jun N-terminal kinase activation in human thyroid cells.
Journal: Anticancer research 20010101
Title: Comparative analysis of glycosylinositol phosphorylceramides from fungi by electrospray tandem mass spectrometry with low-energy collision-induced dissociation of Li(+) adduct ions.
Journal: Rapid communications in mass spectrometry : RCM 20010101
Title: FTY720, a novel transplantation drug, modulates lymphocyte migratory responses to chemokines.
Journal: Transplantation proceedings 20010101
Title: FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects.
Journal: Transplantation proceedings 20010101
Title: FTY720: a new dimension in transplantation.
Journal: Transplantation proceedings 20010101
Title: T-cell apoptosis triggered by FTY720 via mitochondrial pathway.
Journal: Transplantation proceedings 20010101
Title: Tumor necrosis factor-alpha, sphingomyelinase and ceramides activate tyrosine kinase, p21Ras and phosphatidylinositol 3-kinase: implications for glucose transport and insulin resistance.
Journal: Advances in experimental medicine and biology 20010101
Title: Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms.
Journal: Cell communication & adhesion 20010101
Title: Emerging technologies to control oocyte apoptosis are finally treading on fertile ground.
Journal: TheScientificWorldJournal 20010101
Title: Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide.
Journal: Journal of neuroscience research 20001215
Title: Regulation of phospholipase D activity and ceramide production in daunorubicin-induced apoptosis in A-431 cells.
Journal: Biochimica et biophysica acta 20001115
Title: Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells.
Journal: The Journal of biological chemistry 20000526
Title: Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20000509
Title: Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.
Journal: Nature cell biology 20000501
Title: Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.
Journal: Blood 20000415
Title: Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis?
Journal: Journal of neuroscience methods 20000315
Title: Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation.
Journal: Nature medicine 20000301
Title: Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
Journal: Journal of neurochemistry 19990801
Title: Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamide].
Journal: The Journal of biological chemistry 19990402
Title: Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.
Journal: The Journal of biological chemistry 19990219
Title: Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells.
Journal: The Biochemical journal 19990215
Title: EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition.
Journal: The Journal of biological chemistry 19981016
Title: Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.
Journal: Journal of neurochemistry 19980701
Title: Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
Journal: Biochemical and biophysical research communications 19971229
Title: Ursodeoxycholic acid enhances glucocorticoid-induced tyrosine aminotransferase-gene expression in cultured rat hepatocytes.
Journal: Biochemical and biophysical research communications 19971126
Title: Activation of protein kinase C does not participate in disruption of the blood-brain barrier to albumin during acute hypertension.
Journal: Brain research 19951023
Title: Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor.
Journal: Stem cells (Dayton, Ohio) 19950501
Title: PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.
Journal: The EMBO journal 19950501
Title: Opioids induce while nicotine suppresses apoptosis in human lung cancer cells.
Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 19941001
Title: Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.
Journal: Molecular and cellular endocrinology 19930301
Title: Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells.
Journal: The Journal of biological chemistry 19901005
Title: A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
Journal: The Journal of biological chemistry 19900205
Title: A further comparison of insulin- and phorbol ester-stimulated glucose transport in adipocytes.
Journal: Molecular and cellular endocrinology 19890801
Title: Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 ( Pt 3):699-703.
Title: Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172(2):683-91.
Title: Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30(1):22-7.
Title: Cheng P, et al. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359(1-2):48-56.
