125-84-8,MFCD00010122
Catalog No.:AA000MWE

125-84-8 | 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%(HPLC)
in stock  
$24.00   $17.00
- +
5g
98%
in stock  
$62.00   $44.00
- +
25g
98%
in stock  
$145.00   $102.00
- +
100g
98%
in stock  
$311.00 $218.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000MWE
Chemical Name:
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
CAS Number:
125-84-8
Molecular Formula:
C13H16N2O2
Molecular Weight:
232.2783
MDL Number:
MFCD00010122
SMILES:
CCC1(CCC(=O)NC1=O)c1ccc(cc1)N
Properties
Computed Properties
 
Complexity:
321  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.2  

Literature

Title: Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals.

Journal: Chemico-biological interactions 20150905

Title: Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies.

Journal: Journal of applied toxicology : JAT 20131001

Title: Medical management of Cushing's disease: what is the future?

Journal: Pituitary 20120901

Title: Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.

Journal: Chemical research in toxicology 20120820

Title: Adsorption and detection of sport doping drugs on metallic plasmonic nanoparticles of different morphology.

Journal: Langmuir : the ACS journal of surfaces and colloids 20120619

Title: Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20120601

Title: Continuous de novo synthesis of neurosteroids is required for normal synaptic transmission and plasticity in the dentate gyrus of the rat hippocampus.

Journal: Neuropharmacology 20120601

Title: Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3β-hydroxysteroid dehydrogenase (3β-honestly significant difference (HSD)) activity and protein expression.

Journal: Theriogenology 20120501

Title: Evidence that LPS-reactive arthritis in rats depends on the glial activity and the fractalkine-TNF-α signaling in the spinal cord.

Journal: Neuropharmacology 20120201

Title: Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain.

Journal: Pain 20120101

Title: Treatment Options in Cushing's Disease.

Journal: Clinical Medicine Insights. Oncology 20120101

Title: Antioxidant-induced stress.

Journal: International journal of molecular sciences 20120101

Title: Combination drug delivery approaches in metastatic breast cancer.

Journal: Journal of drug delivery 20120101

Title: Management Strategies for Aggressive Cushing's Syndrome: From Macroadenomas to Ectopics.

Journal: Journal of oncology 20120101

Title: Development of a fritless packed column for capillary electrochromatography-mass spectrometry.

Journal: Journal of chromatography. A 20111202

Title: [Role of medical treatment for symptomatic leiomyoma management in premenopausal women].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Comparison of ketoconazole and estramustine for treating patients with castration-resistant prostate cancer.

Journal: Korean journal of urology 20111101

Title: Cushing's surgery: Role of the anesthesiologist.

Journal: Indian journal of endocrinology and metabolism 20111001

Title: Regulation of prolactin secretion during the estrus in rats: possible role of glucocorticoids.

Journal: Reproduction (Cambridge, England) 20110901

Title: Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.

Journal: Endocrinology 20110901

Title: Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites.

Journal: Chemical research in toxicology 20110718

Title: Lead optimization of 4-imidazolylflavans: new promising aromatase inhibitors.

Journal: European journal of medicinal chemistry 20110601

Title: A qualitative systematic review of the evidence base for non-cross-resistance between steroidal and non-steroidal aromatase inhibitors in metastatic breast cancer.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20110401

Title: Synthesis of some novel androstanes as potential aromatase inhibitors.

Journal: Steroids 20110401

Title: Differences between the non-steroidal aromatase inhibitors anastrozole and letrozole--of clinical importance?

Journal: British journal of cancer 20110329

Title: The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110301

Title: Pharmacological evidence that Ca²+ channels and, to a lesser extent, K+ channels mediate the relaxation of testosterone in the canine basilar artery.

Journal: Steroids 20110301

Title: Hormone treatment of depression.

Journal: Dialogues in clinical neuroscience 20110301

Title: Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201

Title: Facile synthesis of chrysin-derivatives with promising activities as aromatase inhibitors.

Journal: Natural product communications 20110101

Title: Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound.

Journal: BMC chemical biology 20110101

Title: Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis.

Journal: Reproductive biology and endocrinology : RB&E 20110101

Title: Aromatase inhibitors in men: effects and therapeutic options.

Journal: Reproductive biology and endocrinology : RB&E 20110101

Title: Predicting selective drug targets in cancer through metabolic networks.

Journal: Molecular systems biology 20110101

Title: Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation.

Journal: Reproductive biology and endocrinology : RB&E 20110101

Title: Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.

Journal: BMC cancer 20110101

Title: Exemestane in the adjuvant treatment of breast cancer in postmenopausal women.

Journal: Breast cancer : basic and clinical research 20110101

Title: Membrane-initiated estradiol signaling regulating sexual receptivity.

Journal: Frontiers in endocrinology 20110101

Title: The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge.

Journal: Frontiers in endocrinology 20110101

Title: Minimizing early relapse and maximizing treatment outcomes in hormone-sensitive postmenopausal breast cancer: efficacy review of AI trials.

Journal: Cancer metastasis reviews 20101201

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish.

Journal: Toxicology and applied pharmacology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.

Journal: Protoplasma 20101001

Title: Steroidal and gonadal effects on neural cell proliferation in vitro in an adult songbird.

Journal: Brain research 20100910

Title: Short-term dynamic culture of rat testicular fragments as a model to assess effects on steroidogenesis--potential use and limitations.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: Assessment of chemical effects on aromatase activity using the H295R cell line.

Journal: Environmental science and pollution research international 20100601

Title: Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis.

Journal: Chemical research in toxicology 20100517

Title: Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.

Journal: Bioorganic & medicinal chemistry 20100401

Title: Achiral and chiral separations using MEKC, polyelectrolyte multilayer coatings, and mixed mode separation techniques with molecular micelles.

Journal: Electrophoresis 20100301

Title: Evaluation of plasma and tissue estrogen suppression with third-generation aromatase inhibitors: of relevance to clinical understanding?

Journal: The Journal of steroid biochemistry and molecular biology 20100227

Title: On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Age-dependent role of steroids in the regulation of growth of the hen follicular wall.

Journal: Reproductive biology and endocrinology : RB&E 20100101

Title: Treatment of Cushing disease: overview and recent findings.

Journal: Therapeutics and clinical risk management 20100101

Title: FACE: the barefaced facts of AI potency.

Journal: Cancer management and research 20100101

Title: Applicability of Generic Assays Based on Liquid Chromatography-Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds.

Journal: Frontiers in pharmacology 20100101

Title: Oocyte hydration in the Japanese eel (Anguilla japonica) during meiosis resumption and ovulation.

Journal: Journal of experimental zoology. Part A, Ecological genetics and physiology 20091201

Title: Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response.

Journal: Journal of cellular physiology 20091201

Title: [Feminizing adrenal tumours in Spain: report of a case and review of the five previously published patients].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20091101

Title: Regulation of inhibin/activin expression in rat early antral follicles.

Journal: Molecular and cellular endocrinology 20091015

Title: Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women.

Journal: The Cochrane database of systematic reviews 20091007

Title: Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress.

Journal: Brain, behavior, and immunity 20091001

Title: An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.

Journal: European journal of medicinal chemistry 20091001

Title: An approach to the management of patients with residual Cushing's disease.

Journal: Journal of neuro-oncology 20090901

Title: Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells.

Journal: Biology of reproduction 20090801

Title: In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors.

Journal: The Journal of clinical endocrinology and metabolism 20090801

Title: An updated review on the efficacy of adjuvant endocrine therapies in hormone receptor-positive early breast cancer.

Journal: Current oncology (Toronto, Ont.) 20090701

Title: History of aromatase: saga of an important biological mediator and therapeutic target.

Journal: Endocrine reviews 20090601

Title: Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.

Journal: Journal of medicinal chemistry 20090409

Title: [The medical management of Cushing's syndrome].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20090401

Title: Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles.

Journal: Toxicology letters 20090328

Title: Dehydroepiandrosterone and neurotrophins favor axonal growth in a sensory neuron-keratinocyte coculture model.

Journal: Neuroscience 20090317

Title: Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome.

Journal: The Journal of pediatrics 20090301

Title: Determination of aminoglutethimide enantiomers in pharmaceutical formulations by capillary electrophoresis using methylated-beta-cyclodextrin as a chiral selector and computational calculation for their respective inclusion complexes.

Journal: Talanta 20090215

Title: Sulfated and sulfonated polysaccharide as chiral stationary phases for capillary electrochromatography and capillary electrochromatography-mass spectrometry.

Journal: Journal of chromatography. A 20090130

Title: Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?

Journal: Depression and anxiety 20090101

Title: Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.

Journal: PloS one 20090101

Title: Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine.

Journal: BMC emergency medicine 20090101

Title: Antiproliferative effect of exemestane in lung cancer cells.

Journal: Molecular cancer 20090101

Title: Enhanced Interaction between Warfarin and High-Dose Ketoconazole: A Case Report.

Journal: Case reports in medicine 20090101

Title: Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials.

Journal: International journal of general medicine 20090101

Title: Male breast cancer: a review.

Journal: Ecancermedicalscience 20090101

Title: The evolution of treatment for early breast cancer: what's next?

Journal: Ecancermedicalscience 20090101

Title: Predisposing factors for fibroids and outcome of laparoscopic myomectomy in infertility.

Journal: Journal of gynecological endoscopy and surgery 20090101

Title: Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer.

Journal: Clinical interventions in aging 20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption - screening of 30 selected chemicals in the human H295R cell model.

Journal: Journal of applied toxicology : JAT 20081101

Title: Screening of herbal constituents for aromatase inhibitory activity.

Journal: Bioorganic & medicinal chemistry 20080915

Title: Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080815

Title: Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080701

Title: Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.

Journal: Journal of natural products 20080701

Title: Synthesis and hypnotic activities of N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives.

Journal: Archives of pharmacal research 20080701

Title: Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells.

Journal: Molecular and cellular biochemistry 20080601

Title: Prolonged remission of severe Cushing syndrome without adrenalectomy in an infant with McCune-Albright syndrome.

Journal: The Journal of pediatrics 20080601

Title: Nitric oxide stimulates the production of atrial natriuretic peptide and progesterone by human granulosa luteinized cells with an antiapoptotic effect.

Journal: Endocrine regulations 20080601

Title: CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501

Title: Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes.

Journal: Reproduction (Cambridge, England) 20080501

Title: New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.

Journal: Journal of medicinal chemistry 20080410

Title: Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system.

Journal: Journal of pharmacological sciences 20080401

Title: Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080315

Title: Neuroprogesterone: key to estrogen positive feedback?

Journal: Brain research reviews 20080301

Title: Intrathecally injected morphine inhibits inflammatory paw edema: the involvement of nitric oxide and cyclic-guanosine monophosphate.

Journal: Anesthesia and analgesia 20080301

Title: Aromatase inhibitors: assessment of biochemical efficacy measured by total body aromatase inhibition and tissue estrogen suppression.

Journal: The Journal of steroid biochemistry and molecular biology 20080201

Title: Long-term safety of aromatase inhibitors in the treatment of breast cancer.

Journal: Therapeutics and clinical risk management 20080201

Title: Aromatase inhibitors: past, present and future in breast cancer therapy.

Journal: Medical oncology (Northwood, London, England) 20080101

Title: [Medical treatment for Cushing's syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20080101

Title: The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias.

Journal: BMC medical research methodology 20080101

Title: Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy.

Journal: BMC cancer 20080101

Title: Use of letrozole in assisted reproduction: a systematic review and meta-analysis.

Journal: Human reproduction update 20080101

Title: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature.

Journal: Journal of hematology & oncology 20080101

Title: Steroid biosynthesis inhibitors in the therapy of hypercortisolism: theory and practice.

Journal: Current medicinal chemistry 20080101

Title: Strength and weakness of phase I to IV trials, with an emphasis on translational aspects.

Journal: Breast cancer research : BCR 20080101

Title: Antioxidant systems and oxidative stress in the testes.

Journal: Oxidative medicine and cellular longevity 20080101

Title: Extended adjuvant therapy for breast cancer--how much is enough?

Journal: Journal of the National Cancer Institute 20071219

Title: Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a.

Journal: Journal of the National Cancer Institute 20071219

Title: The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer.

Journal: International journal of clinical practice 20071201

Title: Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols.

Journal: ChemMedChem 20071201

Title: Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.

Journal: Tennessee medicine : journal of the Tennessee Medical Association 20071201

Title: Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML.

Journal: Leukemia & lymphoma 20071101

Title: Letrozole in advanced breast cancer: the PO25 trial.

Journal: Breast cancer research and treatment 20071001

Title: The early days of letrozole.

Journal: Breast cancer research and treatment 20071001

Title: The discovery and mechanism of action of letrozole.

Journal: Breast cancer research and treatment 20071001

Title: A decade of letrozole: FACE.

Journal: Breast cancer research and treatment 20071001

Title: The patient experience.

Journal: Breast cancer research and treatment 20071001

Title: The effects of aromatase inhibitors and selective estrogen receptor modulators on eye development in the zebrafish (Danio rerio).

Journal: Current eye research 20071001

Title: Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells.

Journal: British journal of cancer 20070911

Title: PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells.

Journal: The Journal of endocrinology 20070901

Title: The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats.

Journal: The Journal of endocrinology 20070901

Title: Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.

Journal: Brain research 20070824

Title: An alpha-fetoprotein-derived peptide reduces the uterine hyperplasia and increases the antitumour effect of tamoxifen.

Journal: British journal of cancer 20070806

Title: Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.

Journal: Endocrinology 20070701

Title: Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.

Journal: Chemical research in toxicology 20070701

Title: Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.

Journal: Journal of medicinal chemistry 20070614

Title: Pharmacological therapy of Cushing's syndrome: drugs and indications.

Journal: Mini reviews in medicinal chemistry 20070501

Title: Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis.

Journal: Endocrinology 20070401

Title: Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane.

Journal: Bone 20070401

Title: Physiological testosterone stimulates tissue plasminogen activator and tissue factor pathway inhibitor and inhibits plasminogen activator inhibitor type 1 release in endothelial cells.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20070401

Title: Switching to an aromatase inhibitor provides mortality benefit in early breast carcinoma: pooled analysis of 2 consecutive trials.

Journal: Cancer 20070315

Title: Glucocorticoid feedback control of corticotropin in the hypoxic neonatal rat.

Journal: The Journal of endocrinology 20070201

Title: Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women.

Journal: The Cochrane database of systematic reviews 20070124

Title: Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20070122

Title: Validation and application of a screening method for beta2-agonists, anti-estrogenic substances and mesocarb in human urine using liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Adrenal toxicology: a strategy for assessment of functional toxicity to the adrenal cortex and steroidogenesis.

Journal: Journal of applied toxicology : JAT 20070101

Title: Is pseudo-Cushing's syndrome in a critically ill patient 'pseudo'? Hypothesis and supportive case report.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101

Title: Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome.

Journal: International seminars in surgical oncology : ISSO 20070101

Title: Medical management of Cushing disease.

Journal: Neurosurgical focus 20070101

Title: Treatment algorithm in hormone-resistant prostate cancer: Practical guidelines.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20070101

Title: Role of corticosterone in immunosuppressive effects of acute ethanol exposure on Toll-like receptor mediated cytokine production.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20061201

Title: Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.

Journal: Toxicology and applied pharmacology 20061115

Title: The H295R system for evaluation of endocrine-disrupting effects.

Journal: Ecotoxicology and environmental safety 20061101

Title: Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061101

Title: Hypothermic preconditioning reduces Purkinje cell death possibly by preventing the over-expression of inducible nitric oxide synthase in rat cerebellar slices after an in vitro simulated ischemia.

Journal: Neuroscience 20061013

Title: Effects of aromatase inhibitors on in vitro steroidogenesis by Atlantic salmon (Salmo salar) gonadal and brain tissue.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20061001

Title: Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.

Journal: Journal of the National Cancer Institute 20060920

Title: Relationship between steroidogenesis and spermiation in Rana catesbeiana and Leptodactylus ocellatus.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060801

Title: Progesterone regulation of the expression and function of multidrug resistance type I in porcine granulosa cells.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20060701

Title: An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

Journal: The FEBS journal 20060701

Title: Second- and third-generation aromatase inhibitors as first-line endocrine therapy in postmenopausal metastatic breast cancer patients: a pooled analysis of the randomised trials.

Journal: British journal of cancer 20060619

Title: The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine.

Journal: Psychoneuroendocrinology 20060601

Title: Future prospects in depression research.

Journal: Dialogues in clinical neuroscience 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons.

Journal: British journal of pharmacology 20060401

Title: Implication of glucocorticoid in anti-inflammatory effects of Ro5-4864 in mouse pleurisy induced by carrageenan.

Journal: Life sciences 20060313

Title: Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: [Effects of drugs on the adrenal cortex and its tumors].

Journal: Der Pathologe 20060201

Title: Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity.

Journal: International journal of cancer 20060115

Title: Secondary hormonal therapy for advanced prostate cancer.

Journal: The Journal of urology 20060101

Title: Studies of the role of steroid hormone in the regulation of oocyte maturation in cattle.

Journal: Reproductive biology and endocrinology : RB&E 20060101

Title: [Testosterone inhibits the contractile responses to phenylephrine associated with the release of intracellular calcium in rat aorta].

Journal: Gaceta medica de Mexico 20060101

Title: A proposed mechanism for progesterone regulation of trophoblast MMP2 transcription independent of classical progesterone response elements on its promoter.

Journal: Journal of experimental & clinical assisted reproduction 20060101

Title: The role of steroids in follicular growth.

Journal: Reproductive biology and endocrinology : RB&E 20060101

Title: Non-hormonal systemic therapy in men with hormone-refractory prostate cancer and metastases: a systematic review from the Cancer Care Ontario Program in Evidence-based Care's Genitourinary Cancer Disease Site Group.

Journal: BMC cancer 20060101

Title: Simple tandem repeat (TTTA)n polymorphism in CYP19 (aromatase) gene and breast cancer risk in Nigerian women.

Journal: Journal of carcinogenesis 20060101

Title: Efficacy and tolerability of high dose 'ethinylestradiol' in post-menopausal advanced breast cancer patients heavily pre-treated with endocrine agents.

Journal: World journal of surgical oncology 20060101

Title: Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.

Journal: Endocrinology 20051201

Title: Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells.

Journal: Breast cancer research and treatment 20051201

Title: Effect of progesterone on the expression of bax and bcl-2 and on caspase activity in bovine luteal cells.

Journal: Prostaglandins & other lipid mediators 20051201

Title: Role of adrenalectomy in ectopic ACTH syndrome.

Journal: Endocrine journal 20051201

Title: Neuroendocrine predictors of the evolution of depression.

Journal: Dialogues in clinical neuroscience 20050901

Title: Bone loss and the aromatase inhibitors.

Journal: British journal of cancer 20050801

Title: Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20050701

Title: Letrozole in the treatment of breast cancer.

Journal: Expert opinion on pharmacotherapy 20050701

Title: Polymer therapeutics designed for a combination therapy of hormone-dependent cancer.

Journal: Angewandte Chemie (International ed. in English) 20050627

Title: Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats.

Journal: European journal of pharmacology 20050615

Title: Synthesis and characterization of azole isoflavone inhibitors of aromatase.

Journal: Bioorganic & medicinal chemistry 20050602

Title: Secondary hormonal manipulations in the management of advanced prostate cancer.

Journal: The Canadian journal of urology 20050601

Title: Changes in peripheral benzodiazepine receptors in patients with bipolar disorder.

Journal: Neuropsychiatric disease and treatment 20050601

Title: Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats.

Journal: Psychopharmacology 20050501

Title: Evidence for a spinal serotonergic control of the peripheral inflammation in the rat.

Journal: Life sciences 20050401

Title: Synthesis and study of some new N-substituted imide derivatives as potential anticancer agents.

Journal: Farmaco (Societa chimica italiana : 1989) 20050401

Title: Benzofuran- and furan-2-yl-(phenyl)-3-pyridylmethanols: synthesis and inhibition of P450 aromatase.

Journal: Journal of enzyme inhibition and medicinal chemistry 20050401

Title: Synthesis and anti-aromatase activity of some new steroidal D-lactones.

Journal: Steroids 20050101

Title: The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment.

Journal: Reproductive biology and endocrinology : RB&E 20050101

Title: HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines.

Journal: Journal of drug targeting 20050101

Title: 2- and 3-[(aryl)(azolyl)methyl]indoles as potential non-steroidal aromatase inhibitors.

Journal: Journal of enzyme inhibition and medicinal chemistry 20041201

Title: Toward the development of a cephalosporin-based dual-release prodrug for use in ADEPT.

Journal: The Journal of organic chemistry 20041112

Title: Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells.

Journal: British journal of cancer 20041101

Title: Randomised phase III study of intravenous vinorelbine plus hormone therapy versus hormone therapy alone in hormone-refractory prostate cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20041101

Title: Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy.

Journal: Anti-cancer drugs 20041001

Title: Use of aromatase inhibitors in children with short stature.

Journal: Pediatric endocrinology reviews : PER 20040901

Title: Inhibition of ossification in vivo and differentiation of osteoblasts in vitro by tributyltin.

Journal: Biochemical pharmacology 20040815

Title: Methadone metabolism by human placenta.

Journal: Biochemical pharmacology 20040801

Title: Chiral resolution of some piperidine 2, 6-dione drugs by high performance liquid chromatography on Kromasil CHI-DMB column.

Journal: Archiv der Pharmazie 20040801

Title: Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.

Journal: Journal of medicinal chemistry 20040729

Title: Acute effects of testosterone on intracellular Ca2+ kinetics in rat coronary endothelial cells are exerted via aromatization to estrogens.

Journal: American journal of physiology. Heart and circulatory physiology 20040701

Title: Synthesis and evaluation of a dimer of 2-(4-pyridylmethyl)-1-indanone as a novel nonsteroidal aromatase inhibitor.

Journal: Archiv der Pharmazie 20040701

Title: Aminoglutethimide included in nanocapsules suspension: comparison of GC-MS and HPLC methods for control.

Journal: Journal of pharmaceutical and biomedical analysis 20040629

Title: Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

Journal: British journal of cancer 20040614

Title: Aromatase inhibition in the treatment of advanced breast cancer: is there a relationship between potency and clinical efficacy?

Journal: British journal of cancer 20040504

Title: Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium.

Journal: Biology of reproduction 20040501

Title: The estrogen suppression after sequential treatment with formestane in advanced breast cancer patients.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20040501

Title: Antinociceptive effects of peripheral benzodiazepine receptors.

Journal: Pharmacology 20040401

Title: Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.

Journal: Mediators of inflammation 20040401

Title: Prostate cancer metastasis to supraclavicular lymph node.

Journal: Clinical advances in hematology & oncology : H&O 20040401

Title: Oestrogen suppression--lessons from clinical studies.

Journal: Best practice & research. Clinical endocrinology & metabolism 20040301

Title: Aromatase inhibitors: new endocrine treatment of breast cancer.

Journal: Seminars in reproductive medicine 20040201

Title: Involvement of steroids in anti-inflammatory effects of peripheral benzodiazepine receptor ligands.

Journal: Life sciences 20040130

Title: The glucocorticoid receptor mediates the thymic epithelial cell-induced apoptosis of CD4+8+ thymic lymphoma cells.

Journal: Cellular immunology 20040101

Title: Cancer of the endometrium: current aspects of diagnostics and treatment.

Journal: World journal of surgical oncology 20040101

Title: Immature rats show ovulatory defects similar to those in adult rats lacking prostaglandin and progesterone actions.

Journal: Reproductive biology and endocrinology : RB&E 20040101

Title: Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens.

Journal: Breast cancer research : BCR 20040101

Title: Role of secondary hormonal therapy in the management of recurrent prostate cancer.

Journal: Urology 20031229

Title: Aminoglutethimide-induced leucopenia in a mouse model: effects of metabolic and structural determinates.

Journal: Environmental toxicology and pharmacology 20031201

Title: Aromatase inhibitors in breast cancer.

Journal: The New England journal of medicine 20030911

Title: Aromatase is the major enzyme metabolizing buprenorphine in human placenta.

Journal: The Journal of pharmacology and experimental therapeutics 20030901

Title: Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

Journal: British journal of cancer 20030804

Title: Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice.

Journal: Journal of cellular physiology 20030801

Title: Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells.

Journal: Endocrinology 20030801

Title: Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ.

Journal: Developmental biology 20030801

Title: A comparison of the efficacy of aromatase inhibitors in second-line treatment of metastatic breast cancer.

Journal: American journal of clinical oncology 20030801

Title: Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy.

Journal: American journal of clinical oncology 20030801

Title: The role of aromatase inhibitors in the treatment of metastatic breast cancer.

Journal: Seminars in oncology 20030801

Title: Expression of 11beta-hydroxysteroid dehydrogenase (11betaHSD) proteins in luteinizing human granulosa-lutein cells.

Journal: The Journal of endocrinology 20030701

Title: Antidepressant-like effect of Ro5-4864, a peripheral-type benzodiazepine receptor ligand, in forced swimming test.

Journal: European journal of pharmacology 20030613

Title: Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20030505

Title: Could exemestane affect insulin-like growth factors, interleukin 6 and bone metabolism in postmenopausal advanced breast cancer patients after failure on aminoglutethimide, anastrozole or letrozole?

Journal: International journal of oncology 20030501

Title: Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones.

Journal: Psychopharmacology 20030401

Title: Update on the current use of hormonals as therapy in advanced breast cancer.

Journal: Anti-cancer drugs 20030401

Title: Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection.

Journal: Journal of pharmaceutical and biomedical analysis 20030401

Title: Randomized trial of tamoxifen versus tamoxifen plus aminoglutethimide as adjuvant treatment in postmenopausal breast cancer patients with hormone receptor-positive disease: Austrian breast and colorectal cancer study group trial 6.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030315

Title: Acute ethanol administration profoundly alters poly I:C-induced cytokine expression in mice by a mechanism that is not dependent on corticosterone.

Journal: Life sciences 20030307

Title: Stimulatory effect of progesterone on the expression of steroidogenic acute regulatory protein in MA-10 Leydig cells.

Journal: Biology of reproduction 20030301

Title: The therapeutic potential of aromatase inhibitors.

Journal: Expert opinion on investigational drugs 20030301

Title: Aromatase inhibitors as adjuvant therapy in breast cancer.

Journal: Oncology (Williston Park, N.Y.) 20030301

Title: A spinal mechanism for the peripheral anti-inflammatory action of indomethacin.

Journal: Brain research 20030207

Title: Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells.

Journal: Endocrinology 20030101

Title: Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma.

Journal: Medical oncology (Northwood, London, England) 20030101

Title: The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?

Journal: Journal of applied toxicology : JAT 20030101

Title: [Maturation of the follicle-enclosed common frog oocytes stimulated by low progesterone concentrations depends on transcription].

Journal: Ontogenez 20030101

Title: [Effects of cycloheximide, aminoglutethimide, indomethacin, cytochalasin B and colchicine on ovulation and the ultrastructure of the ovarian follicle wall in the stellate sturgeon Acipenser stellatus Pall].

Journal: Ontogenez 20030101

Title: Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments.

Journal: Breast cancer research : BCR 20030101

Title: Medical treatment of hyperadrenocorticism in the dog.

Journal: Australian veterinary journal 20030101

Title: Elevation of soluble tumor necrosis factor receptor II in non-febrile patients with acute myeloid leukemia.

Journal: European journal of medical research 20021125

Title: Exemestane: treatment of breast cancer with selective inactivation of aromatase.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021115

Title: A phase II study of cisplatin and vinorelbine in patients with metastatic breast cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20021101

Title: Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.

Journal: Bioorganic & medicinal chemistry letters 20021021

Title: The evolving role of aromatase inhibitors in breast cancer.

Journal: International journal of clinical oncology 20021001

Title: Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase.

Journal: Bioorganic chemistry 20021001

Title: Secondary hormonal therapies in the treatment of prostate cancer.

Journal: Urology 20020901

Title: Glucocorticoids enhance activation of the human type II 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase gene.

Journal: The Journal of steroid biochemistry and molecular biology 20020901

Title: Enantiomeric separations using poly(L-valine) and poly(L-leucine) surfactants. Investigation of steric factors near the chiral center.

Journal: Journal of chromatography. A 20020809

Title: Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3beta-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts.

Journal: Biology of reproduction 20020701

Title: FSH and LH induce progesterone production and progesterone receptor synthesis in cumulus cells: a requirement for meiotic resumption in porcine oocytes.

Journal: Molecular human reproduction 20020701

Title: 11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020701

Title: Aromatase inhibitors in breast cancer: current and evolving roles.

Journal: Cleveland Clinic journal of medicine 20020701

Title: Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds.

Journal: Biochemical and biophysical research communications 20020607

Title: Erratum to 'CNS drugs in Cushing's disease: pathophysiological and therapeutic implications for mood disorders' [Prog. Neuro-Psycol. Biol. Psychiatry, 26, 763 (2002)].

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020601

Title: LC determination of aminoglutethimide enantiomers as dansyl and fluorescamine derivatives in tablet formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20020515

Title: Residual symptoms in depression an emerging therapeutic concept.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives.

Journal: Bioorganic & medicinal chemistry letters 20020408

Title: Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020401

Title: [The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile].

Journal: Minerva ginecologica 20020401

Title: Aromatase inhibitors in breast cancer therapy.

Journal: Expert review of anticancer therapy 20020401

Title: Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301

Title: Use of aminoglutethimide in the treatment of pituitary-dependent hyperadrenocorticism in the dog.

Journal: The Journal of small animal practice 20020301

Title: Synthesis and aromatase inhibitory activity of flavanones.

Journal: Pharmaceutical research 20020301

Title: Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels.

Journal: British journal of pharmacology 20020201

Title: Tamoxifen resistant and refractory breast cancer: the value of aromatase inhibitors.

Journal: Drugs 20020101

Title: Endocrine and clinical endpoints of exemestane as neoadjuvant therapy.

Journal: Cancer control : journal of the Moffitt Cancer Center 20020101

Title: Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells.

Journal: Journal of andrology 20020101

Title: Ectopic ACTH-syndrome due to a thymic carcinoid tumor.

Journal: Acta clinica Belgica 20020101

Title: Estrogen as therapy for breast cancer.

Journal: Breast cancer research : BCR 20020101

Title: Identification of the aromatase inhibitor aminoglutethimide in urine by gas chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20020101

Title: Aromatase inhibitors in breast cancer: an update.

Journal: Cancer control : journal of the Moffitt Cancer Center 20020101

Title: Interactions of antioestrogens and aromatase inhibitors.

Journal: Forum (Genoa, Italy) 20020101

Title: Medical therapy of Cushing's disease.

Journal: Pituitary 20020101

Title: Classic and recent etiologies of Cushing's syndrome: diagnosis and therapy.

Journal: Treatments in endocrinology 20020101

Title: Differential role of PR-A and -B isoforms in transcription regulation of human GnRH receptor gene.

Journal: Molecular endocrinology (Baltimore, Md.) 20011201

Title: Relationship between the production of prostaglandins and progesterone by luteinizing human granulosa cells.

Journal: The Journal of endocrinology 20011201

Title: High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy.

Journal: Surgery 20011201

Title: A summary of second-line randomized studies of aromatase inhibitors.

Journal: The Journal of steroid biochemistry and molecular biology 20011201

Title: Adjuvant trials of aromatase inhibitors: determining the future landscape of adjuvant endocrine therapy.

Journal: The Journal of steroid biochemistry and molecular biology 20011201

Title: Where do selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) now fit into breast cancer treatment algorithms?

Journal: The Journal of steroid biochemistry and molecular biology 20011201

Title: The role of tamoxifen and aromatase inhibitors/inactivators in postmenopausal patients.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

Title: Are differences in the available aromatase inhibitors and inactivators significant?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

Title: Sequential tamoxifen and aminoglutethimide versus tamoxifen alone in the adjuvant treatment of postmenopausal breast cancer patients: results of an Italian cooperative study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011115

Title: Aromatase inhibitors from Broussonetia papyrifera.

Journal: Journal of natural products 20011001

Title: Acute stress-induced facilitation of the hypothalamic-pituitary-adrenal axis: evidence for the roles of stressor duration and serotonin.

Journal: Neuroendocrinology 20010901

Title: Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis.

Journal: Toxicology 20010828

Title: New D-modified androstane derivatives as aromatase inhibitors.

Journal: Steroids 20010801

Title: Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes.

Journal: General and comparative endocrinology 20010801

Title: Nonsteroidal and steroidal aromatase inhibitors in breast cancer.

Journal: Oncology (Williston Park, N.Y.) 20010801

Title: Induction of atypical ductal hyperplasia in mouse mammary gland organ culture.

Journal: Journal of the National Cancer Institute 20010718

Title: Cytotoxic treatment of adrenocortical carcinoma.

Journal: World journal of surgery 20010701

Title: Aromatase inhibitors: past, present and future.

Journal: Molecular and cellular endocrinology 20010610

Title: Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Expression of messenger RNA for gonadotropin receptor in the granulosa layer during the ovulatory cycle of hens.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010601

Title: Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20010601

Title: Luteinization factor-stimulated steroidogenesis in porcine granulosa cells.

Journal: General physiology and biophysics 20010601

Title: Cold-induced increment in rat adrenal gland type II deiodinase is corticosterone dependent.

Journal: Endocrine 20010601

Title: Contribution of progesterone, follicle stimulating hormone and glucocorticoids in survival of serum-free cultured granulosa cell explants.

Journal: The Journal of endocrinology 20010501

Title: Enantioseparation of aminoglutethimide and thalidomide by high performance liquid chromatography or supercritical fluid chromatography on mono-2 and mono-6-O-pentenyl-beta-cyclodextrin-based chiral stationary phases.

Journal: Biomedical chromatography : BMC 20010501

Title: ACTH-receptor expression, regulation and role in adrenocortial tumor formation.

Journal: European journal of endocrinology 20010301

Title: A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.

Journal: Journal of medicinal chemistry 20010301

Title: Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor.

Journal: Biochemical and biophysical research communications 20010216

Title: Periovulatory changes in catfish ovarian oestradiol-17beta, oestrogen-2-hydroxylase and catechol-O-methyltransferase during GnRH analogue-induced ovulation and in vitro induction of oocyte maturation by catecholoestrogens.

Journal: The Journal of endocrinology 20010201

Title: Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type.

Journal: Anti-cancer drug design 20010201

Title: Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.

Journal: European journal of biochemistry 20010101

Title: [Modern approaches to hormone therapy of breast cancer as a reflection of pathogenesis of the disease].

Journal: Voprosy onkologii 20010101

Title: Psychiatric disorders associated with Cushing's syndrome. Epidemiology, pathophysiology and treatment.

Journal: CNS drugs 20010101

Title: Aromatase, aromatase inhibitors, and breast cancer.

Journal: American journal of therapeutics 20010101

Title: Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells.

Journal: The Journal of biological chemistry 20001124

Title: Antiandrogen withdrawal syndrome associated with prostate cancer therapies: incidence and clinical significance.

Journal: Drug safety 20001101

Title: PRAP, a prolactin receptor associated protein: its gene expression and regulation in the corpus luteum.

Journal: Endocrinology 19970801

Title: Exploration for drug therapy in endometrial carcinoma.

Journal: Chinese medical journal 19960501

Title: [Comparison between the roles of aminoglutethimide and hydroxyprogesterone caproates in the treatment of endometrial cancer].

Journal: Zhonghua fu chan ke za zhi 19950801

Title: Methotrexate induced brain necrosis and severe leukoencephalopathy due to disconnection of an Ommaya device.

Journal: Journal of neuro-oncology 19930301

Title: The effect of the aromatase inhibitor, rogletimide (pyridoglutethimide), on guinea pig adrenal cell steroidogenesis and placental microsomal aromatase activity: comparison with aminoglutethimide and CGS 16949A.

Journal: The Journal of steroid biochemistry and molecular biology 19911101

Title: Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.

Journal: Journal of medicinal chemistry 19910201

Title: Androgen depletion and repletion as a means of potentiating the effect of cytotoxic chemotherapy in advanced prostate cancer.

Journal: Journal of steroid biochemistry 19870101

Title: Inappropriate secretion of antidiuretic hormone following aminoglutethimide therapy.

Journal: British journal of urology 19861201

Title: Hormone stimulation and chemotherapy in advanced prostate cancer: interim analysis of an ongoing randomized trial.

Journal: Anticancer research 19860101

Title: Hormone stimulation and chemotherapy in advanced prostate cancer: preliminary results of a prospective controlled clinical trial.

Journal: Anticancer research 19850101

Title: Aminoglutethimide and cholestasis.

Journal: Annals of internal medicine 19840101

Title: Treatment of advanced breast cancer with aminoglutethimide after therapy with tamoxifen.

Journal: Cancer 19821101

Title: Phase II study of aminoglutethimide and medroxyprogesterone acetate in the treatment of patients with advanced breast cancer.

Journal: Cancer research 19820801

Title: Cholestatic jaundice and aminoglutethimide.

Journal: Annals of internal medicine 19820701

Title: [Treatment of metastasizing breast cancer with aminoglutethimide].

Journal: Acta medica Austriaca 19820101

Title: [Aminoglutethimide in metastasizing carcinoma of the breast resistant to hormonal and cytostatic treatment (author's transl)].

Journal: Deutsche medizinische Wochenschrift (1946) 19811002

Title: Medical adrenalectomy with aminoglutethimide-cortisol in the treatment of metastatic breast carcinoma.

Journal: European journal of cancer 19800101

Title: Mineralocorticoid hypertension in childhood.

Journal: Mayo Clinic proceedings 19770501

Title: Evidence for an unidentified ACTH-induced steroid hormone causing hypertension.

Journal: The Journal of clinical endocrinology and metabolism 19761201

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:125-84-8 Molecular Formula|125-84-8 MDL|125-84-8 SMILES|125-84-8 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
Catalog No.: AA000MWE
125-84-8,MFCD00010122
125-84-8 | 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
Pack Size: 1g
Purity: 98%(HPLC)
in stock
$24.00 $17.00
Pack Size: 5g
Purity: 98%
in stock
$62.00 $44.00
Pack Size: 25g
Purity: 98%
in stock
$145.00 $102.00
Pack Size: 100g
Purity: 98%
in stock
$311.00 $218.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000MWE
Chemical Name: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
CAS Number: 125-84-8
Molecular Formula: C13H16N2O2
Molecular Weight: 232.2783
MDL Number: MFCD00010122
SMILES: CCC1(CCC(=O)NC1=O)c1ccc(cc1)N
Properties
Complexity: 321  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 1  
XLogP3: 1.2  
Literature fold

Title: Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals.

Journal: Chemico-biological interactions20150905

Title: Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies.

Journal: Journal of applied toxicology : JAT20131001

Title: Medical management of Cushing's disease: what is the future?

Journal: Pituitary20120901

Title: Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.

Journal: Chemical research in toxicology20120820

Title: Adsorption and detection of sport doping drugs on metallic plasmonic nanoparticles of different morphology.

Journal: Langmuir : the ACS journal of surfaces and colloids20120619

Title: Endogenous acetaldehyde toxicity during antral follicular development in the mouse ovary.

Journal: Reproductive toxicology (Elmsford, N.Y.)20120601

Title: Continuous de novo synthesis of neurosteroids is required for normal synaptic transmission and plasticity in the dentate gyrus of the rat hippocampus.

Journal: Neuropharmacology20120601

Title: Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3β-hydroxysteroid dehydrogenase (3β-honestly significant difference (HSD)) activity and protein expression.

Journal: Theriogenology20120501

Title: Evidence that LPS-reactive arthritis in rats depends on the glial activity and the fractalkine-TNF-α signaling in the spinal cord.

Journal: Neuropharmacology20120201

Title: Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain.

Journal: Pain20120101

Title: Treatment Options in Cushing's Disease.

Journal: Clinical Medicine Insights. Oncology20120101

Title: Antioxidant-induced stress.

Journal: International journal of molecular sciences20120101

Title: Combination drug delivery approaches in metastatic breast cancer.

Journal: Journal of drug delivery20120101

Title: Management Strategies for Aggressive Cushing's Syndrome: From Macroadenomas to Ectopics.

Journal: Journal of oncology20120101

Title: Development of a fritless packed column for capillary electrochromatography-mass spectrometry.

Journal: Journal of chromatography. A20111202

Title: [Role of medical treatment for symptomatic leiomyoma management in premenopausal women].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Comparison of ketoconazole and estramustine for treating patients with castration-resistant prostate cancer.

Journal: Korean journal of urology20111101

Title: Cushing's surgery: Role of the anesthesiologist.

Journal: Indian journal of endocrinology and metabolism20111001

Title: Regulation of prolactin secretion during the estrus in rats: possible role of glucocorticoids.

Journal: Reproduction (Cambridge, England)20110901

Title: Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.

Journal: Endocrinology20110901

Title: Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites.

Journal: Chemical research in toxicology20110718

Title: Lead optimization of 4-imidazolylflavans: new promising aromatase inhibitors.

Journal: European journal of medicinal chemistry20110601

Title: A qualitative systematic review of the evidence base for non-cross-resistance between steroidal and non-steroidal aromatase inhibitors in metastatic breast cancer.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain))20110401

Title: Synthesis of some novel androstanes as potential aromatase inhibitors.

Journal: Steroids20110401

Title: Differences between the non-steroidal aromatase inhibitors anastrozole and letrozole--of clinical importance?

Journal: British journal of cancer20110329

Title: The potency and clinical efficacy of aromatase inhibitors across the breast cancer continuum.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology20110301

Title: Pharmacological evidence that Ca²+ channels and, to a lesser extent, K+ channels mediate the relaxation of testosterone in the canine basilar artery.

Journal: Steroids20110301

Title: Hormone treatment of depression.

Journal: Dialogues in clinical neuroscience20110301

Title: Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening.

Journal: Drug metabolism and disposition: the biological fate of chemicals20110201

Title: Facile synthesis of chrysin-derivatives with promising activities as aromatase inhibitors.

Journal: Natural product communications20110101

Title: Chemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compound.

Journal: BMC chemical biology20110101

Title: Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis.

Journal: Reproductive biology and endocrinology : RB&E20110101

Title: Aromatase inhibitors in men: effects and therapeutic options.

Journal: Reproductive biology and endocrinology : RB&E20110101

Title: Predicting selective drug targets in cancer through metabolic networks.

Journal: Molecular systems biology20110101

Title: Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation.

Journal: Reproductive biology and endocrinology : RB&E20110101

Title: Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.

Journal: BMC cancer20110101

Title: Exemestane in the adjuvant treatment of breast cancer in postmenopausal women.

Journal: Breast cancer : basic and clinical research20110101

Title: Membrane-initiated estradiol signaling regulating sexual receptivity.

Journal: Frontiers in endocrinology20110101

Title: The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge.

Journal: Frontiers in endocrinology20110101

Title: Minimizing early relapse and maximizing treatment outcomes in hormone-sensitive postmenopausal breast cancer: efficacy review of AI trials.

Journal: Cancer metastasis reviews20101201

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals20101201

Title: In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish.

Journal: Toxicology and applied pharmacology20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.

Journal: Protoplasma20101001

Title: Steroidal and gonadal effects on neural cell proliferation in vitro in an adult songbird.

Journal: Brain research20100910

Title: Short-term dynamic culture of rat testicular fragments as a model to assess effects on steroidogenesis--potential use and limitations.

Journal: Reproductive toxicology (Elmsford, N.Y.)20100801

Title: Assessment of chemical effects on aromatase activity using the H295R cell line.

Journal: Environmental science and pollution research international20100601

Title: Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis.

Journal: Chemical research in toxicology20100517

Title: Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

Journal: Bioorganic & medicinal chemistry letters20100515

Title: Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.

Journal: Bioorganic & medicinal chemistry20100401

Title: Achiral and chiral separations using MEKC, polyelectrolyte multilayer coatings, and mixed mode separation techniques with molecular micelles.

Journal: Electrophoresis20100301

Title: Evaluation of plasma and tissue estrogen suppression with third-generation aromatase inhibitors: of relevance to clinical understanding?

Journal: The Journal of steroid biochemistry and molecular biology20100227

Title: On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase.

Journal: Journal of pharmaceutical and biomedical analysis20100105

Title: Age-dependent role of steroids in the regulation of growth of the hen follicular wall.

Journal: Reproductive biology and endocrinology : RB&E20100101

Title: Treatment of Cushing disease: overview and recent findings.

Journal: Therapeutics and clinical risk management20100101

Title: FACE: the barefaced facts of AI potency.

Journal: Cancer management and research20100101

Title: Applicability of Generic Assays Based on Liquid Chromatography-Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds.

Journal: Frontiers in pharmacology20100101

Title: Oocyte hydration in the Japanese eel (Anguilla japonica) during meiosis resumption and ovulation.

Journal: Journal of experimental zoology. Part A, Ecological genetics and physiology20091201

Title: Human cytomegalovirus productively infects adrenocortical cells and induces an early cortisol response.

Journal: Journal of cellular physiology20091201

Title: [Feminizing adrenal tumours in Spain: report of a case and review of the five previously published patients].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion20091101

Title: Regulation of inhibin/activin expression in rat early antral follicles.

Journal: Molecular and cellular endocrinology20091015

Title: Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women.

Journal: The Cochrane database of systematic reviews20091007

Title: Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress.

Journal: Brain, behavior, and immunity20091001

Title: An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.

Journal: European journal of medicinal chemistry20091001

Title: An approach to the management of patients with residual Cushing's disease.

Journal: Journal of neuro-oncology20090901

Title: Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells.

Journal: Biology of reproduction20090801

Title: In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors.

Journal: The Journal of clinical endocrinology and metabolism20090801

Title: An updated review on the efficacy of adjuvant endocrine therapies in hormone receptor-positive early breast cancer.

Journal: Current oncology (Toronto, Ont.)20090701

Title: History of aromatase: saga of an important biological mediator and therapeutic target.

Journal: Endocrine reviews20090601

Title: Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities.

Journal: Journal of medicinal chemistry20090409

Title: [The medical management of Cushing's syndrome].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion20090401

Title: Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles.

Journal: Toxicology letters20090328

Title: Dehydroepiandrosterone and neurotrophins favor axonal growth in a sensory neuron-keratinocyte coculture model.

Journal: Neuroscience20090317

Title: Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome.

Journal: The Journal of pediatrics20090301

Title: Determination of aminoglutethimide enantiomers in pharmaceutical formulations by capillary electrophoresis using methylated-beta-cyclodextrin as a chiral selector and computational calculation for their respective inclusion complexes.

Journal: Talanta20090215

Title: Sulfated and sulfonated polysaccharide as chiral stationary phases for capillary electrochromatography and capillary electrochromatography-mass spectrometry.

Journal: Journal of chromatography. A20090130

Title: Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?

Journal: Depression and anxiety20090101

Title: Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.

Journal: PloS one20090101

Title: Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine.

Journal: BMC emergency medicine20090101

Title: Antiproliferative effect of exemestane in lung cancer cells.

Journal: Molecular cancer20090101

Title: Enhanced Interaction between Warfarin and High-Dose Ketoconazole: A Case Report.

Journal: Case reports in medicine20090101

Title: Role of neo-adjuvant hormonal therapy in the treatment of breast cancer: a review of clinical trials.

Journal: International journal of general medicine20090101

Title: Male breast cancer: a review.

Journal: Ecancermedicalscience20090101

Title: The evolution of treatment for early breast cancer: what's next?

Journal: Ecancermedicalscience20090101

Title: Predisposing factors for fibroids and outcome of laparoscopic myomectomy in infertility.

Journal: Journal of gynecological endoscopy and surgery20090101

Title: Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer.

Journal: Clinical interventions in aging20081201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption - screening of 30 selected chemicals in the human H295R cell model.

Journal: Journal of applied toxicology : JAT20081101

Title: Screening of herbal constituents for aromatase inhibitory activity.

Journal: Bioorganic & medicinal chemistry20080915

Title: Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20080815

Title: Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms.

Journal: American journal of physiology. Gastrointestinal and liver physiology20080701

Title: Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.

Journal: Journal of natural products20080701

Title: Synthesis and hypnotic activities of N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives.

Journal: Archives of pharmacal research20080701

Title: Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells.

Journal: Molecular and cellular biochemistry20080601

Title: Prolonged remission of severe Cushing syndrome without adrenalectomy in an infant with McCune-Albright syndrome.

Journal: The Journal of pediatrics20080601

Title: Nitric oxide stimulates the production of atrial natriuretic peptide and progesterone by human granulosa luteinized cells with an antiapoptotic effect.

Journal: Endocrine regulations20080601

Title: CYP1B1 is not a major determinant of the disposition of aromatase inhibitors in epithelial cells of invasive ductal carcinoma.

Journal: Drug metabolism and disposition: the biological fate of chemicals20080501

Title: Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes.

Journal: Reproduction (Cambridge, England)20080501

Title: New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.

Journal: Journal of medicinal chemistry20080410

Title: Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system.

Journal: Journal of pharmacological sciences20080401

Title: Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080315

Title: Neuroprogesterone: key to estrogen positive feedback?

Journal: Brain research reviews20080301

Title: Intrathecally injected morphine inhibits inflammatory paw edema: the involvement of nitric oxide and cyclic-guanosine monophosphate.

Journal: Anesthesia and analgesia20080301

Title: Aromatase inhibitors: assessment of biochemical efficacy measured by total body aromatase inhibition and tissue estrogen suppression.

Journal: The Journal of steroid biochemistry and molecular biology20080201

Title: Long-term safety of aromatase inhibitors in the treatment of breast cancer.

Journal: Therapeutics and clinical risk management20080201

Title: Aromatase inhibitors: past, present and future in breast cancer therapy.

Journal: Medical oncology (Northwood, London, England)20080101

Title: [Medical treatment for Cushing's syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine20080101

Title: The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias.

Journal: BMC medical research methodology20080101

Title: Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy.

Journal: BMC cancer20080101

Title: Use of letrozole in assisted reproduction: a systematic review and meta-analysis.

Journal: Human reproduction update20080101

Title: A dramatic, objective antiandrogen withdrawal response: case report and review of the literature.

Journal: Journal of hematology & oncology20080101

Title: Steroid biosynthesis inhibitors in the therapy of hypercortisolism: theory and practice.

Journal: Current medicinal chemistry20080101

Title: Strength and weakness of phase I to IV trials, with an emphasis on translational aspects.

Journal: Breast cancer research : BCR20080101

Title: Antioxidant systems and oxidative stress in the testes.

Journal: Oxidative medicine and cellular longevity20080101

Title: Extended adjuvant therapy for breast cancer--how much is enough?

Journal: Journal of the National Cancer Institute20071219

Title: Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group Trial 6a.

Journal: Journal of the National Cancer Institute20071219

Title: The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer.

Journal: International journal of clinical practice20071201

Title: Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols.

Journal: ChemMedChem20071201

Title: Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.

Journal: Tennessee medicine : journal of the Tennessee Medical Association20071201

Title: Advanced age and high initial WBC influence the outcome of inv(3) (q21q26)/t(3;3) (q21;q26) positive AML.

Journal: Leukemia & lymphoma20071101

Title: Letrozole in advanced breast cancer: the PO25 trial.

Journal: Breast cancer research and treatment20071001

Title: The early days of letrozole.

Journal: Breast cancer research and treatment20071001

Title: The discovery and mechanism of action of letrozole.

Journal: Breast cancer research and treatment20071001

Title: A decade of letrozole: FACE.

Journal: Breast cancer research and treatment20071001

Title: The patient experience.

Journal: Breast cancer research and treatment20071001

Title: The effects of aromatase inhibitors and selective estrogen receptor modulators on eye development in the zebrafish (Danio rerio).

Journal: Current eye research20071001

Title: Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells.

Journal: British journal of cancer20070911

Title: PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11beta-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa lutein cells.

Journal: The Journal of endocrinology20070901

Title: The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats.

Journal: The Journal of endocrinology20070901

Title: Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.

Journal: Brain research20070824

Title: An alpha-fetoprotein-derived peptide reduces the uterine hyperplasia and increases the antitumour effect of tamoxifen.

Journal: British journal of cancer20070806

Title: Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.

Journal: Endocrinology20070701

Title: Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.

Journal: Chemical research in toxicology20070701

Title: Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.

Journal: Journal of medicinal chemistry20070614

Title: Pharmacological therapy of Cushing's syndrome: drugs and indications.

Journal: Mini reviews in medicinal chemistry20070501

Title: Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis.

Journal: Endocrinology20070401

Title: Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane.

Journal: Bone20070401

Title: Physiological testosterone stimulates tissue plasminogen activator and tissue factor pathway inhibitor and inhibits plasminogen activator inhibitor type 1 release in endothelial cells.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire20070401

Title: Switching to an aromatase inhibitor provides mortality benefit in early breast carcinoma: pooled analysis of 2 consecutive trials.

Journal: Cancer20070315

Title: Glucocorticoid feedback control of corticotropin in the hypoxic neonatal rat.

Journal: The Journal of endocrinology20070201

Title: Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women.

Journal: The Cochrane database of systematic reviews20070124

Title: Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.

Journal: Journal of controlled release : official journal of the Controlled Release Society20070122

Title: Validation and application of a screening method for beta2-agonists, anti-estrogenic substances and mesocarb in human urine using liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20070101

Title: Adrenal toxicology: a strategy for assessment of functional toxicity to the adrenal cortex and steroidogenesis.

Journal: Journal of applied toxicology : JAT20070101

Title: Is pseudo-Cushing's syndrome in a critically ill patient 'pseudo'? Hypothesis and supportive case report.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists20070101

Title: Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome.

Journal: International seminars in surgical oncology : ISSO20070101

Title: Medical management of Cushing disease.

Journal: Neurosurgical focus20070101

Title: Treatment algorithm in hormone-resistant prostate cancer: Practical guidelines.

Journal: Indian journal of urology : IJU : journal of the Urological Society of India20070101

Title: Role of corticosterone in immunosuppressive effects of acute ethanol exposure on Toll-like receptor mediated cytokine production.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology20061201

Title: Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.

Journal: Toxicology and applied pharmacology20061115

Title: The H295R system for evaluation of endocrine-disrupting effects.

Journal: Ecotoxicology and environmental safety20061101

Title: Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP20061101

Title: Hypothermic preconditioning reduces Purkinje cell death possibly by preventing the over-expression of inducible nitric oxide synthase in rat cerebellar slices after an in vitro simulated ischemia.

Journal: Neuroscience20061013

Title: Effects of aromatase inhibitors on in vitro steroidogenesis by Atlantic salmon (Salmo salar) gonadal and brain tissue.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology20061001

Title: Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.

Journal: Journal of the National Cancer Institute20060920

Title: Relationship between steroidogenesis and spermiation in Rana catesbeiana and Leptodactylus ocellatus.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology20060801

Title: Progesterone regulation of the expression and function of multidrug resistance type I in porcine granulosa cells.

Journal: Reproductive toxicology (Elmsford, N.Y.)20060701

Title: An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

Journal: The FEBS journal20060701

Title: Second- and third-generation aromatase inhibitors as first-line endocrine therapy in postmenopausal metastatic breast cancer patients: a pooled analysis of the randomised trials.

Journal: British journal of cancer20060619

Title: The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine.

Journal: Psychoneuroendocrinology20060601

Title: Future prospects in depression research.

Journal: Dialogues in clinical neuroscience20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons.

Journal: British journal of pharmacology20060401

Title: Implication of glucocorticoid in anti-inflammatory effects of Ro5-4864 in mouse pleurisy induced by carrageenan.

Journal: Life sciences20060313

Title: Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20060301

Title: [Effects of drugs on the adrenal cortex and its tumors].

Journal: Der Pathologe20060201

Title: Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity.

Journal: International journal of cancer20060115

Title: Secondary hormonal therapy for advanced prostate cancer.

Journal: The Journal of urology20060101

Title: Studies of the role of steroid hormone in the regulation of oocyte maturation in cattle.

Journal: Reproductive biology and endocrinology : RB&E20060101

Title: [Testosterone inhibits the contractile responses to phenylephrine associated with the release of intracellular calcium in rat aorta].

Journal: Gaceta medica de Mexico20060101

Title: A proposed mechanism for progesterone regulation of trophoblast MMP2 transcription independent of classical progesterone response elements on its promoter.

Journal: Journal of experimental & clinical assisted reproduction20060101

Title: The role of steroids in follicular growth.

Journal: Reproductive biology and endocrinology : RB&E20060101

Title: Non-hormonal systemic therapy in men with hormone-refractory prostate cancer and metastases: a systematic review from the Cancer Care Ontario Program in Evidence-based Care's Genitourinary Cancer Disease Site Group.

Journal: BMC cancer20060101

Title: Simple tandem repeat (TTTA)n polymorphism in CYP19 (aromatase) gene and breast cancer risk in Nigerian women.

Journal: Journal of carcinogenesis20060101

Title: Efficacy and tolerability of high dose 'ethinylestradiol' in post-menopausal advanced breast cancer patients heavily pre-treated with endocrine agents.

Journal: World journal of surgical oncology20060101

Title: Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.

Journal: Endocrinology20051201

Title: Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells.

Journal: Breast cancer research and treatment20051201

Title: Effect of progesterone on the expression of bax and bcl-2 and on caspase activity in bovine luteal cells.

Journal: Prostaglandins & other lipid mediators20051201

Title: Role of adrenalectomy in ectopic ACTH syndrome.

Journal: Endocrine journal20051201

Title: Neuroendocrine predictors of the evolution of depression.

Journal: Dialogues in clinical neuroscience20050901

Title: Bone loss and the aromatase inhibitors.

Journal: British journal of cancer20050801

Title: Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20050701

Title: Letrozole in the treatment of breast cancer.

Journal: Expert opinion on pharmacotherapy20050701

Title: Polymer therapeutics designed for a combination therapy of hormone-dependent cancer.

Journal: Angewandte Chemie (International ed. in English)20050627

Title: Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats.

Journal: European journal of pharmacology20050615

Title: Synthesis and characterization of azole isoflavone inhibitors of aromatase.

Journal: Bioorganic & medicinal chemistry20050602

Title: Secondary hormonal manipulations in the management of advanced prostate cancer.

Journal: The Canadian journal of urology20050601

Title: Changes in peripheral benzodiazepine receptors in patients with bipolar disorder.

Journal: Neuropsychiatric disease and treatment20050601

Title: Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats.

Journal: Psychopharmacology20050501

Title: Evidence for a spinal serotonergic control of the peripheral inflammation in the rat.

Journal: Life sciences20050401

Title: Synthesis and study of some new N-substituted imide derivatives as potential anticancer agents.

Journal: Farmaco (Societa chimica italiana : 1989)20050401

Title: Benzofuran- and furan-2-yl-(phenyl)-3-pyridylmethanols: synthesis and inhibition of P450 aromatase.

Journal: Journal of enzyme inhibition and medicinal chemistry20050401

Title: Synthesis and anti-aromatase activity of some new steroidal D-lactones.

Journal: Steroids20050101

Title: The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment.

Journal: Reproductive biology and endocrinology : RB&E20050101

Title: HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines.

Journal: Journal of drug targeting20050101

Title: 2- and 3-[(aryl)(azolyl)methyl]indoles as potential non-steroidal aromatase inhibitors.

Journal: Journal of enzyme inhibition and medicinal chemistry20041201

Title: Toward the development of a cephalosporin-based dual-release prodrug for use in ADEPT.

Journal: The Journal of organic chemistry20041112

Title: Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells.

Journal: British journal of cancer20041101

Title: Randomised phase III study of intravenous vinorelbine plus hormone therapy versus hormone therapy alone in hormone-refractory prostate cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology20041101

Title: Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy.

Journal: Anti-cancer drugs20041001

Title: Use of aromatase inhibitors in children with short stature.

Journal: Pediatric endocrinology reviews : PER20040901

Title: Inhibition of ossification in vivo and differentiation of osteoblasts in vitro by tributyltin.

Journal: Biochemical pharmacology20040815

Title: Methadone metabolism by human placenta.

Journal: Biochemical pharmacology20040801

Title: Chiral resolution of some piperidine 2, 6-dione drugs by high performance liquid chromatography on Kromasil CHI-DMB column.

Journal: Archiv der Pharmazie20040801

Title: Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.

Journal: Journal of medicinal chemistry20040729

Title: Acute effects of testosterone on intracellular Ca2+ kinetics in rat coronary endothelial cells are exerted via aromatization to estrogens.

Journal: American journal of physiology. Heart and circulatory physiology20040701

Title: Synthesis and evaluation of a dimer of 2-(4-pyridylmethyl)-1-indanone as a novel nonsteroidal aromatase inhibitor.

Journal: Archiv der Pharmazie20040701

Title: Aminoglutethimide included in nanocapsules suspension: comparison of GC-MS and HPLC methods for control.

Journal: Journal of pharmaceutical and biomedical analysis20040629

Title: Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

Journal: British journal of cancer20040614

Title: Aromatase inhibition in the treatment of advanced breast cancer: is there a relationship between potency and clinical efficacy?

Journal: British journal of cancer20040504

Title: Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium.

Journal: Biology of reproduction20040501

Title: The estrogen suppression after sequential treatment with formestane in advanced breast cancer patients.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie20040501

Title: Antinociceptive effects of peripheral benzodiazepine receptors.

Journal: Pharmacology20040401

Title: Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.

Journal: Mediators of inflammation20040401

Title: Prostate cancer metastasis to supraclavicular lymph node.

Journal: Clinical advances in hematology & oncology : H&O20040401

Title: Oestrogen suppression--lessons from clinical studies.

Journal: Best practice & research. Clinical endocrinology & metabolism20040301

Title: Aromatase inhibitors: new endocrine treatment of breast cancer.

Journal: Seminars in reproductive medicine20040201

Title: Involvement of steroids in anti-inflammatory effects of peripheral benzodiazepine receptor ligands.

Journal: Life sciences20040130

Title: The glucocorticoid receptor mediates the thymic epithelial cell-induced apoptosis of CD4+8+ thymic lymphoma cells.

Journal: Cellular immunology20040101

Title: Cancer of the endometrium: current aspects of diagnostics and treatment.

Journal: World journal of surgical oncology20040101

Title: Immature rats show ovulatory defects similar to those in adult rats lacking prostaglandin and progesterone actions.

Journal: Reproductive biology and endocrinology : RB&E20040101

Title: Endocrinology and hormone therapy in breast cancer: aromatase inhibitors versus antioestrogens.

Journal: Breast cancer research : BCR20040101

Title: Role of secondary hormonal therapy in the management of recurrent prostate cancer.

Journal: Urology20031229

Title: Aminoglutethimide-induced leucopenia in a mouse model: effects of metabolic and structural determinates.

Journal: Environmental toxicology and pharmacology20031201

Title: Aromatase inhibitors in breast cancer.

Journal: The New England journal of medicine20030911

Title: Aromatase is the major enzyme metabolizing buprenorphine in human placenta.

Journal: The Journal of pharmacology and experimental therapeutics20030901

Title: Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

Journal: British journal of cancer20030804

Title: Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice.

Journal: Journal of cellular physiology20030801

Title: Corticosterone enhances adrenocorticotropin-induced calcium signals in bovine adrenocortical cells.

Journal: Endocrinology20030801

Title: Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ.

Journal: Developmental biology20030801

Title: A comparison of the efficacy of aromatase inhibitors in second-line treatment of metastatic breast cancer.

Journal: American journal of clinical oncology20030801

Title: Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy.

Journal: American journal of clinical oncology20030801

Title: The role of aromatase inhibitors in the treatment of metastatic breast cancer.

Journal: Seminars in oncology20030801

Title: Expression of 11beta-hydroxysteroid dehydrogenase (11betaHSD) proteins in luteinizing human granulosa-lutein cells.

Journal: The Journal of endocrinology20030701

Title: Antidepressant-like effect of Ro5-4864, a peripheral-type benzodiazepine receptor ligand, in forced swimming test.

Journal: European journal of pharmacology20030613

Title: Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20030505

Title: Could exemestane affect insulin-like growth factors, interleukin 6 and bone metabolism in postmenopausal advanced breast cancer patients after failure on aminoglutethimide, anastrozole or letrozole?

Journal: International journal of oncology20030501

Title: Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones.

Journal: Psychopharmacology20030401

Title: Update on the current use of hormonals as therapy in advanced breast cancer.

Journal: Anti-cancer drugs20030401

Title: Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection.

Journal: Journal of pharmaceutical and biomedical analysis20030401

Title: Randomized trial of tamoxifen versus tamoxifen plus aminoglutethimide as adjuvant treatment in postmenopausal breast cancer patients with hormone receptor-positive disease: Austrian breast and colorectal cancer study group trial 6.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20030315

Title: Acute ethanol administration profoundly alters poly I:C-induced cytokine expression in mice by a mechanism that is not dependent on corticosterone.

Journal: Life sciences20030307

Title: Stimulatory effect of progesterone on the expression of steroidogenic acute regulatory protein in MA-10 Leydig cells.

Journal: Biology of reproduction20030301

Title: The therapeutic potential of aromatase inhibitors.

Journal: Expert opinion on investigational drugs20030301

Title: Aromatase inhibitors as adjuvant therapy in breast cancer.

Journal: Oncology (Williston Park, N.Y.)20030301

Title: A spinal mechanism for the peripheral anti-inflammatory action of indomethacin.

Journal: Brain research20030207

Title: Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells.

Journal: Endocrinology20030101

Title: Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma.

Journal: Medical oncology (Northwood, London, England)20030101

Title: The adrenal cortex and steroidogenesis as cellular and molecular targets for toxicity: critical omissions from regulatory endocrine disrupter screening strategies for human health?

Journal: Journal of applied toxicology : JAT20030101

Title: [Maturation of the follicle-enclosed common frog oocytes stimulated by low progesterone concentrations depends on transcription].

Journal: Ontogenez20030101

Title: [Effects of cycloheximide, aminoglutethimide, indomethacin, cytochalasin B and colchicine on ovulation and the ultrastructure of the ovarian follicle wall in the stellate sturgeon Acipenser stellatus Pall].

Journal: Ontogenez20030101

Title: Breast cancer patients with bone metastases are characterised by increased levels of nonisomerised type I collagen fragments.

Journal: Breast cancer research : BCR20030101

Title: Medical treatment of hyperadrenocorticism in the dog.

Journal: Australian veterinary journal20030101

Title: Elevation of soluble tumor necrosis factor receptor II in non-febrile patients with acute myeloid leukemia.

Journal: European journal of medical research20021125

Title: Exemestane: treatment of breast cancer with selective inactivation of aromatase.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20021115

Title: A phase II study of cisplatin and vinorelbine in patients with metastatic breast cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology20021101

Title: Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.

Journal: Bioorganic & medicinal chemistry letters20021021

Title: The evolving role of aromatase inhibitors in breast cancer.

Journal: International journal of clinical oncology20021001

Title: Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase.

Journal: Bioorganic chemistry20021001

Title: Secondary hormonal therapies in the treatment of prostate cancer.

Journal: Urology20020901

Title: Glucocorticoids enhance activation of the human type II 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase gene.

Journal: The Journal of steroid biochemistry and molecular biology20020901

Title: Enantiomeric separations using poly(L-valine) and poly(L-leucine) surfactants. Investigation of steric factors near the chiral center.

Journal: Journal of chromatography. A20020809

Title: Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3beta-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts.

Journal: Biology of reproduction20020701

Title: FSH and LH induce progesterone production and progesterone receptor synthesis in cumulus cells: a requirement for meiotic resumption in porcine oocytes.

Journal: Molecular human reproduction20020701

Title: 11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research20020701

Title: Aromatase inhibitors in breast cancer: current and evolving roles.

Journal: Cleveland Clinic journal of medicine20020701

Title: Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds.

Journal: Biochemical and biophysical research communications20020607

Title: Erratum to 'CNS drugs in Cushing's disease: pathophysiological and therapeutic implications for mood disorders' [Prog. Neuro-Psycol. Biol. Psychiatry, 26, 763 (2002)].

Journal: Progress in neuro-psychopharmacology & biological psychiatry20020601

Title: LC determination of aminoglutethimide enantiomers as dansyl and fluorescamine derivatives in tablet formulations.

Journal: Journal of pharmaceutical and biomedical analysis20020515

Title: Residual symptoms in depression an emerging therapeutic concept.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives.

Journal: Bioorganic & medicinal chemistry letters20020408

Title: Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20020401

Title: [The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile].

Journal: Minerva ginecologica20020401

Title: Aromatase inhibitors in breast cancer therapy.

Journal: Expert review of anticancer therapy20020401

Title: Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20020301

Title: Use of aminoglutethimide in the treatment of pituitary-dependent hyperadrenocorticism in the dog.

Journal: The Journal of small animal practice20020301

Title: Synthesis and aromatase inhibitory activity of flavanones.

Journal: Pharmaceutical research20020301

Title: Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels.

Journal: British journal of pharmacology20020201

Title: Tamoxifen resistant and refractory breast cancer: the value of aromatase inhibitors.

Journal: Drugs20020101

Title: Endocrine and clinical endpoints of exemestane as neoadjuvant therapy.

Journal: Cancer control : journal of the Moffitt Cancer Center20020101

Title: Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells.

Journal: Journal of andrology20020101

Title: Ectopic ACTH-syndrome due to a thymic carcinoid tumor.

Journal: Acta clinica Belgica20020101

Title: Estrogen as therapy for breast cancer.

Journal: Breast cancer research : BCR20020101

Title: Identification of the aromatase inhibitor aminoglutethimide in urine by gas chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20020101

Title: Aromatase inhibitors in breast cancer: an update.

Journal: Cancer control : journal of the Moffitt Cancer Center20020101

Title: Interactions of antioestrogens and aromatase inhibitors.

Journal: Forum (Genoa, Italy)20020101

Title: Medical therapy of Cushing's disease.

Journal: Pituitary20020101

Title: Classic and recent etiologies of Cushing's syndrome: diagnosis and therapy.

Journal: Treatments in endocrinology20020101

Title: Differential role of PR-A and -B isoforms in transcription regulation of human GnRH receptor gene.

Journal: Molecular endocrinology (Baltimore, Md.)20011201

Title: Relationship between the production of prostaglandins and progesterone by luteinizing human granulosa cells.

Journal: The Journal of endocrinology20011201

Title: High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: a renewed role for adrenalectomy.

Journal: Surgery20011201

Title: A summary of second-line randomized studies of aromatase inhibitors.

Journal: The Journal of steroid biochemistry and molecular biology20011201

Title: Adjuvant trials of aromatase inhibitors: determining the future landscape of adjuvant endocrine therapy.

Journal: The Journal of steroid biochemistry and molecular biology20011201

Title: Where do selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) now fit into breast cancer treatment algorithms?

Journal: The Journal of steroid biochemistry and molecular biology20011201

Title: The role of tamoxifen and aromatase inhibitors/inactivators in postmenopausal patients.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20011201

Title: Are differences in the available aromatase inhibitors and inactivators significant?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20011201

Title: Sequential tamoxifen and aminoglutethimide versus tamoxifen alone in the adjuvant treatment of postmenopausal breast cancer patients: results of an Italian cooperative study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20011115

Title: Aromatase inhibitors from Broussonetia papyrifera.

Journal: Journal of natural products20011001

Title: Acute stress-induced facilitation of the hypothalamic-pituitary-adrenal axis: evidence for the roles of stressor duration and serotonin.

Journal: Neuroendocrinology20010901

Title: Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis.

Journal: Toxicology20010828

Title: New D-modified androstane derivatives as aromatase inhibitors.

Journal: Steroids20010801

Title: Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes.

Journal: General and comparative endocrinology20010801

Title: Nonsteroidal and steroidal aromatase inhibitors in breast cancer.

Journal: Oncology (Williston Park, N.Y.)20010801

Title: Induction of atypical ductal hyperplasia in mouse mammary gland organ culture.

Journal: Journal of the National Cancer Institute20010718

Title: Cytotoxic treatment of adrenocortical carcinoma.

Journal: World journal of surgery20010701

Title: Aromatase inhibitors: past, present and future.

Journal: Molecular and cellular endocrinology20010610

Title: Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone.

Journal: The Journal of pharmacology and experimental therapeutics20010601

Title: Expression of messenger RNA for gonadotropin receptor in the granulosa layer during the ovulatory cycle of hens.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology20010601

Title: Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society20010601

Title: Luteinization factor-stimulated steroidogenesis in porcine granulosa cells.

Journal: General physiology and biophysics20010601

Title: Cold-induced increment in rat adrenal gland type II deiodinase is corticosterone dependent.

Journal: Endocrine20010601

Title: Contribution of progesterone, follicle stimulating hormone and glucocorticoids in survival of serum-free cultured granulosa cell explants.

Journal: The Journal of endocrinology20010501

Title: Enantioseparation of aminoglutethimide and thalidomide by high performance liquid chromatography or supercritical fluid chromatography on mono-2 and mono-6-O-pentenyl-beta-cyclodextrin-based chiral stationary phases.

Journal: Biomedical chromatography : BMC20010501

Title: ACTH-receptor expression, regulation and role in adrenocortial tumor formation.

Journal: European journal of endocrinology20010301

Title: A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.

Journal: Journal of medicinal chemistry20010301

Title: Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor.

Journal: Biochemical and biophysical research communications20010216

Title: Periovulatory changes in catfish ovarian oestradiol-17beta, oestrogen-2-hydroxylase and catechol-O-methyltransferase during GnRH analogue-induced ovulation and in vitro induction of oocyte maturation by catecholoestrogens.

Journal: The Journal of endocrinology20010201

Title: Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type.

Journal: Anti-cancer drug design20010201

Title: Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.

Journal: European journal of biochemistry20010101

Title: [Modern approaches to hormone therapy of breast cancer as a reflection of pathogenesis of the disease].

Journal: Voprosy onkologii20010101

Title: Psychiatric disorders associated with Cushing's syndrome. Epidemiology, pathophysiology and treatment.

Journal: CNS drugs20010101

Title: Aromatase, aromatase inhibitors, and breast cancer.

Journal: American journal of therapeutics20010101

Title: Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells.

Journal: The Journal of biological chemistry20001124

Title: Antiandrogen withdrawal syndrome associated with prostate cancer therapies: incidence and clinical significance.

Journal: Drug safety20001101

Title: PRAP, a prolactin receptor associated protein: its gene expression and regulation in the corpus luteum.

Journal: Endocrinology19970801

Title: Exploration for drug therapy in endometrial carcinoma.

Journal: Chinese medical journal19960501

Title: [Comparison between the roles of aminoglutethimide and hydroxyprogesterone caproates in the treatment of endometrial cancer].

Journal: Zhonghua fu chan ke za zhi19950801

Title: Methotrexate induced brain necrosis and severe leukoencephalopathy due to disconnection of an Ommaya device.

Journal: Journal of neuro-oncology19930301

Title: The effect of the aromatase inhibitor, rogletimide (pyridoglutethimide), on guinea pig adrenal cell steroidogenesis and placental microsomal aromatase activity: comparison with aminoglutethimide and CGS 16949A.

Journal: The Journal of steroid biochemistry and molecular biology19911101

Title: Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.

Journal: Journal of medicinal chemistry19910201

Title: Androgen depletion and repletion as a means of potentiating the effect of cytotoxic chemotherapy in advanced prostate cancer.

Journal: Journal of steroid biochemistry19870101

Title: Inappropriate secretion of antidiuretic hormone following aminoglutethimide therapy.

Journal: British journal of urology19861201

Title: Hormone stimulation and chemotherapy in advanced prostate cancer: interim analysis of an ongoing randomized trial.

Journal: Anticancer research19860101

Title: Hormone stimulation and chemotherapy in advanced prostate cancer: preliminary results of a prospective controlled clinical trial.

Journal: Anticancer research19850101

Title: Aminoglutethimide and cholestasis.

Journal: Annals of internal medicine19840101

Title: Treatment of advanced breast cancer with aminoglutethimide after therapy with tamoxifen.

Journal: Cancer19821101

Title: Phase II study of aminoglutethimide and medroxyprogesterone acetate in the treatment of patients with advanced breast cancer.

Journal: Cancer research19820801

Title: Cholestatic jaundice and aminoglutethimide.

Journal: Annals of internal medicine19820701

Title: [Treatment of metastasizing breast cancer with aminoglutethimide].

Journal: Acta medica Austriaca19820101

Title: [Aminoglutethimide in metastasizing carcinoma of the breast resistant to hormonal and cytostatic treatment (author's transl)].

Journal: Deutsche medizinische Wochenschrift (1946)19811002

Title: Medical adrenalectomy with aminoglutethimide-cortisol in the treatment of metastatic breast carcinoma.

Journal: European journal of cancer19800101

Title: Mineralocorticoid hypertension in childhood.

Journal: Mayo Clinic proceedings19770501

Title: Evidence for an unidentified ACTH-induced steroid hormone causing hypertension.

Journal: The Journal of clinical endocrinology and metabolism19761201

Building Blocks More >
125175-64-6
125175-64-6
Butanoic acid, 2,2-dimethyl-, 6-[2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-3,4,5,5a,6,7-hexahydro-7-methyl-2H-3,9a-methano-1-benzoxepin-5-yl ester, [3R-[3α,5β,5aα,6α(2R*,4R*),7α,9aS*]]- (9CI)
AA000N7Z | MFCD18252366
1254163-81-9
1254163-81-9
Methyl 6-chloro-5-cyanopicolinate
AA000NKM | MFCD18632617
125562-30-3
125562-30-3
M-Peg9-bromide
AA000NTF | MFCD28950767
1256354-96-7
1256354-96-7
2,4-Dichloro-5-(trifluoromethoxy)phenylboronic acid
AA000O06 | MFCD17214246
1256359-27-9
1256359-27-9
2-Amino-4-trifluoromethoxyphenylboronic acid pinacol ester
AA000O4E | MFCD16618968
1256802-03-5
1256802-03-5
1H-Pyrazolo[4,3-c]pyridine-6-carboxylic acid
AA000OBF | MFCD18260541
1257554-02-1
1257554-02-1
3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3h-imidazo[4,5-b]pyridine
AA000OJW | MFCD00223579
1259065-07-0
1259065-07-0
1-tert-Butyl 4-methyl azepane-1,4-dicarboxylate
AA000OVJ | MFCD18088888
1195-45-5
1195-45-5
4-Fluorophenyl isocyanate
AA000P53 | MFCD00002023
1197-22-4
1197-22-4
N-Phenylmethanesulfonamide
AA000PE4 | MFCD00043782
Submit
© 2017 AA BLOCKS, INC. All rights reserved.