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Home Other Building Blocks 1254473-64-7
1254473-64-7,MFCD22124884
Catalog No.:AA000NLZ

1254473-64-7 | Ponatinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$36.00   $25.00
- +
10mg
98%
in stock  
$60.00   $42.00
- +
25mg
98%
in stock  
$119.00   $83.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000NLZ
Chemical Name:
Ponatinib
CAS Number:
1254473-64-7
Molecular Formula:
C21H19Cl2N5O2
Molecular Weight:
444.3139
MDL Number:
MFCD22124884
SMILES:
OCCn1ncc(c1)/C=C/c1n[nH]c2c1cc(cc2)O[C@@H](c1c(Cl)cncc1Cl)C
Properties
Computed Properties
 
Complexity:
576  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
3.5  

Upstream Synthesis Route

[1]Patent:WO2010/129509,2010,A1,.Locationinpatent:Page/Pagecolumn8

[2]Patent:US2012/83511,2012,A1,.Locationinpatent:Page/Pagecolumn3

[1]Patent:US2012/83511,2012,A1,

[1]Patent:US2012/83511,2012,A1,

[1]Patent:US2012/83511,2012,A1,

[1]Patent:US2012/83511,2012,A1,

Downstream Synthesis Route

[1]Patent:WO2010/129509,2010,A1.Locationinpatent:Page/Pagecolumn8

[2]Patent:US2012/83511,2012,A1.Locationinpatent:Page/Pagecolumn3

[1]Patent:US2012/83511,2012,A1

[1]Patent:US2012/83511,2012,A1

[1]Patent:US2012/83511,2012,A1

[1]Patent:US2012/83511,2012,A1

Literature

Title: A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models.

Journal: Molecular cancer therapeutics 20111101

Title: Zhao G, et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models. Molecular Cancer Therapeutics (2011), 10(11), 2200-2210.

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SDS
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