Home Amines 125697-92-9
125697-92-9,MFCD00153822
Catalog No.:AA000OFJ

125697-92-9 | Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-

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1mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA000OFJ
Chemical Name:
Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-
CAS Number:
125697-92-9
Molecular Formula:
C21H19NO6
Molecular Weight:
381.3787
MDL Number:
MFCD00153822
SMILES:
Oc1ccc(c(c1)CN(c1ccc(c(c1)C(=O)O)O)Cc1ccccc1O)O
NSC Number:
678027
Properties
Computed Properties
 
Complexity:
517  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
6  
XLogP3:
3.7  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Synthesis and anticancer activity of chromone-based analogs of lavendustin A.

Journal: European journal of medicinal chemistry 20100901

Title: A rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly.

Journal: Bioorganic & medicinal chemistry letters 20100701

Title: Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616

Title: Genistein directly inhibits native and recombinant NMDA receptors.

Journal: Neuropharmacology 20100601

Title: Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.

Journal: Neuroscience 20100310

Title: Protein tyrosine kinase involvement in learning-produced changes in Hermissenda type B photoreceptors.

Journal: Journal of neurophysiology 20091201

Title: Tyrosine kinase-independent inhibition by genistein on spermatogenic T-type calcium channels attenuates mouse sperm motility and acrosome reaction.

Journal: Cell calcium 20090201

Title: Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.

Journal: Bioorganic & medicinal chemistry 20080815

Title: Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation.

Journal: Journal of cellular biochemistry 20080301

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Effects of monocarboxylic acid-derived Cl- channel blockers on depolarization-activated potassium currents in rat ventricular myocytes.

Journal: Experimental physiology 20070501

Title: Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents.

Journal: European journal of medicinal chemistry 20060801

Title: Cytotoxicity of organic compounds against ovarian cancer cells: a quantitative structure-activity relationship study.

Journal: Molecular pharmaceutics 20060101

Title: Phytoestrogen action in Leydig cells of Biłgoraj ganders (Anser anser).

Journal: Reproductive biology 20060101

Title: Tyrosine phosphorylation of the N-methyl-D-aspartate receptor is enhanced in synaptic membrane fractions of the adult rat hippocampus.

Journal: Brain research. Molecular brain research 20051207

Title: Regulatory and necrotic volume increase in boar spermatozoa.

Journal: Journal of cellular physiology 20050801

Title: Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1).

Journal: The Journal of toxicological sciences 20050801

Title: IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein.

Journal: Biological research 20050101

Title: 4-Anilinoquinazolines with Lavendustin A subunit as inhibitors of epidermal growth factor receptor tyrosine kinase: syntheses, chemical and pharmacological properties.

Journal: European journal of medicinal chemistry 20041201

Title: A unique mechanism for cyclic adenosine 3',5'-monophosphate-induced increase of 32-kDa tyrosine-phosphorylated protein in boar spermatozoa.

Journal: Molecular reproduction and development 20041001

Title: Activation of phospholipase D induced by hydrogen peroxide in suspension-cultured rice cells.

Journal: Plant & cell physiology 20040901

Title: Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040707

Title: Ceramide inhibits L-type calcium channel currents in GH3 cells.

Journal: Molecular and cellular endocrinology 20040415

Title: Evidence that activation of Src family kinase is not required for fertilization-associated [Ca2+]i oscillations in mouse eggs.

Journal: Reproduction (Cambridge, England) 20040401

Title: Lavendustin A enhances axon elongation in VHL gene-transfected neural stem cells.

Journal: Neuroreport 20040322

Title: Role of tyrosine kinase in desflurane-induced preconditioning.

Journal: Anesthesiology 20040301

Title: The efficacy of tyrosine kinase inhibitors on human pancreatic cancer cell lines.

Journal: The Journal of surgical research 20031201

Title: Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.

Journal: European journal of pharmacology 20030516

Title: Synthesis, anticancer activity, and inhibition of tubulin polymerization by conformationally restricted analogues of lavendustin A.

Journal: Journal of medicinal chemistry 20030424

Title: Evidence for a role of protein tyrosine kinases in cell death induced by gp120 in CHP100 neuroblastoma cells.

Journal: Toxicology letters 20030404

Title: Intracellular signaling involved in macrophage adhesion and FBGC formation as mediated by ligand-substrate interaction.

Journal: Journal of biomedical materials research 20021215

Title: Synthesis and investigation of conformationally restricted analogues of lavendustin A as cytotoxic inhibitors of tubulin polymerization.

Journal: Journal of medicinal chemistry 20021010

Title: Neonatal exposure to genistein induces estrogen receptor (ER)alpha expression and multioocyte follicles in the maturing mouse ovary: evidence for ERbeta-mediated and nonestrogenic actions.

Journal: Biology of reproduction 20021001

Title: Genistein inhibits cardiac L-type Ca(2+) channel activity by a tyrosine kinase-independent mechanism.

Journal: Molecular pharmacology 20020901

Title: Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction.

Journal: American journal of physiology. Heart and circulatory physiology 20020801

Title: Identification of myo-inositol 1,2-cyclic monophosphate by electrospray tandem mass spectrometry, a major constituent of EGF-stimulated phosphoinositide turnover in MDA 468 cells.

Journal: Experimental cell research 20020715

Title: Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor.

Journal: American journal of physiology. Cell physiology 20020601

Title: Regulation of an ERG K+ current by Src tyrosine kinase.

Journal: The Journal of biological chemistry 20020419

Title: Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.

Journal: American journal of physiology. Cell physiology 20020401

Title: Acute and chronic effects of genistein, tyrphostin and lavendustin A on steroid synthesis in luteinized human granulosa cells.

Journal: Human reproduction (Oxford, England) 20020301

Title: Trophic factor-induced excitatory synaptogenesis involves postsynaptic modulation of nicotinic acetylcholine receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020115

Title: Stimulation of cardiac glucose transport by inhibitors of oxidative phosphorylation.

Journal: Life sciences 20011005

Title: Stabilization of supersaturated solutions of a lipophilic drug for dermal delivery.

Journal: International journal of pharmaceutics 20010814

Title: Activation of the phosphatidylinositol 3-kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells: involvement of the ErbB receptor family.

Journal: The Journal of biological chemistry 20010720

Title: Modulation of excitability in Aplysia tail sensory neurons by tyrosine kinases.

Journal: Journal of neurophysiology 20010601

Title: Activation of store-operated Ca2+ entry in RBL cells without the contribution of protein kinases.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010601

Title: Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20010301

Title: PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth.

Journal: Journal of neurochemistry 20010301

Title: Thapsigargin inhibits angiogenesis in the rat isolated aorta: studies on the role of intracellular calcium pools.

Journal: Cardiovascular research 20010216

Title: Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization.

Journal: Journal of medicinal chemistry 20010201

Title: Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors.

Journal: Biochemistry 20010123

Title: Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20010101

Title: Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells.

Journal: The Journal of biological chemistry 19971212

Title: Identification of a second region upstream of the mouse heme oxygenase-1 gene that functions as a basal level and inducer-dependent transcription enhancer.

Journal: The Journal of biological chemistry 19950519

Title: Effect of various protein kinase inhibitors on the induction of milk protein gene expression by prolactin.

Journal: Molecular and cellular endocrinology 19930301

Title: Onoda T, et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7.

Title: Hu DE, et al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8.

Title: Gubellini P, et al. Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus. J Neurosci. 2005 Jun 15;25(24):5796-802.

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Tags:125697-92-9 Molecular Formula|125697-92-9 MDL|125697-92-9 SMILES|125697-92-9 Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-