1190307-88-0,MFCD18782704
Catalog No.:AA000P0P

1190307-88-0 | Sofosbuvir

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98%
in stock  
$69.00   $48.00
- +
100mg
98%
in stock  
$108.00   $76.00
- +
1g
95%
in stock  
$143.00   $100.00
- +
5g
98%
in stock  
$284.00   $199.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000P0P
Chemical Name:
Sofosbuvir
CAS Number:
1190307-88-0
Molecular Formula:
C22H29FN3O9P
Molecular Weight:
529.4525
MDL Number:
MFCD18782704
SMILES:
CC(OC(=O)[C@@H](N[P@@](=O)(Oc1ccccc1)OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)F)n1ccc(=O)[nH]c1=O)C)C
Properties
Computed Properties
 
Complexity:
913  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
11  
XLogP3:
1  

Downstream Synthesis Route

[1]Patent:WO2010/135569,2010,A1.Locationinpatent:Page/Pagecolumn47-48

(S)-2-(1R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yI)-4-(R)-fluoro-3-(4-oxopentanoyl)-4-methyl-tetrahydrofuran-2-ylmethoxy-phenoxy-phosphorylamino}-propionicacid(S)-isopropylester 
  1190307-88-0 

[1]Patent:WO2010/135569,2010,A1.Locationinpatent:Page/Pagecolumn56;59

[1]JournalofOrganicChemistry,2011,vol.76,p.8311-8319

[1]Patent:CN106565805,2017,A.Locationinpatent:Paragraph0027;0035;0036;0044

[2]JournalofOrganicChemistry,2011,vol.76,p.8311-8319

[3]Patent:WO2012/12465,2012,A1.Locationinpatent:Page/Pagecolumn83

[1]Patent:WO2016/160646,2016,A1.Locationinpatent:Page/Pagecolumn32

[2]Patent:CN107253971,2017,A.Locationinpatent:Paragraph0017;0036-0039;0044

[3]JournalofOrganicChemistry,2011,vol.76,p.8311-8319

[4]Patent:CN104558079,2017,B.Locationinpatent:Paragraph0046;0047

[5]Patent:WO2016/151542,2016,A1.Locationinpatent:Page/Pagecolumn24;25

[6]Patent:CN103848876,2016,B.Locationinpatent:Paragraph0113-0118

[7]Patent:WO2018/25195,2018,A1.Locationinpatent:Page/Pagecolumn14

Literature

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs 20170701

Title: Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.

Journal: The New England journal of medicine 20170601

Title: In vitro selection of resistance to sofosbuvir in HCV replicons of genotype-1 to -6.

Journal: Antiviral therapy 20170101

Title: Daclatasvir: A NS5A Replication Complex Inhibitor for Hepatitis C Infection.

Journal: The Annals of pharmacotherapy 20160101

Title: Rapid reductions in prices for generic sofosbuvir and daclatasvir to treat hepatitis C.

Journal: Journal of virus eradication 20160101

Title: Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance.

Journal: Viruses 20151001

Title: Interferon-free therapy for hepatitis C: The hurdles amid a golden era.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20150901

Title: Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1.

Journal: The New England journal of medicine 20150820

Title: Hepatitis C virus: Virology, diagnosis and treatment.

Journal: World journal of hepatology 20150608

Title: Finding Truth in a World Full of Spin: Myth-Busting in the Case of Sovaldi.

Journal: Clinical therapeutics 20150501

Title: Fixed-dose combination of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C genotype 1.

Journal: Expert opinion on pharmacotherapy 20150401

Title: Ledipasvir/Sofosbuvir: a review of its use in chronic hepatitis C.

Journal: Drugs 20150401

Title: Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study.

Journal: Lancet (London, England) 20150321

Title: Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection.

Journal: JAMA 20150301

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology 20150101

Title: Changing the face of hepatitis C management - the design and development of sofosbuvir.

Journal: Drug design, development and therapy 20150101

Title: Cost-effectiveness of sofosbuvir-based treatments for chronic hepatitis C in the US.

Journal: BMC gastroenterology 20150101

Title: Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase.

Journal: Antimicrobial agents and chemotherapy 20140701

Title: The combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti-hepatitis C virus activity without detectable cross-resistance.

Journal: Antimicrobial agents and chemotherapy 20140601

Title: Intracellular effects of the Hepatitis C virus nucleoside polymerase inhibitor RO5855 (Mericitabine Parent) and Ribavirin in combination.

Journal: Antimicrobial agents and chemotherapy 20140501

Title: Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

Journal: Journal of medicinal chemistry 20140313

Title: Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors.

Journal: Hepatology (Baltimore, Md.) 20140201

Title: Sofosbuvir for the treatment of hepatitis C virus.

Journal: Expert opinion on pharmacotherapy 20140101

Title: Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects.

Journal: Antimicrobial agents and chemotherapy 20130301

Title: Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.

Journal: Antimicrobial agents and chemotherapy 20120601

Title: Interferon free hepatitis C treatment regimens: the beginning of another era.

Journal: Current gastroenterology reports 20120201

Title: Treatment of chronic hepatitis C--are interferons really necessary?

Journal: Liver international : official journal of the International Association for the Study of the Liver 20120201

Title: What's new in HCV genotype 2 treatment.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20120201

Title: Trial watch: an all-oral and interferon-free future for HCV therapy?

Journal: Nature reviews. Drug discovery 20111201

Title: Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

Journal: Nucleosides, nucleotides & nucleic acids 20111101

Title: Synthesis of diastereomerically pure nucleotide phosphoramidates.

Journal: The Journal of organic chemistry 20111021

Title: The HCV NS5B nucleoside and non-nucleoside inhibitors.

Journal: Clinics in liver disease 20110801

Title: Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Journal: The Journal of biological chemistry 20101105

Title: Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Journal: Journal of medicinal chemistry 20101014

Title: Genetic diversity and evolution of hepatitis C virus--15 years on.

Journal: The Journal of general virology 20041101

Title: Side effects of alpha interferon in chronic hepatitis C.

Journal: Hepatology (Baltimore, Md.) 19970901

Title: Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.

Title: Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.

Title: Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18.

Title: Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.

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SDS
Tags:1190307-88-0 Molecular Formula|1190307-88-0 MDL|1190307-88-0 SMILES|1190307-88-0 Sofosbuvir
Catalog No.: AA000P0P
1190307-88-0,MFCD18782704
1190307-88-0 | Sofosbuvir
Pack Size: 25mg
Purity: 98%
in stock
$69.00 $48.00
Pack Size: 100mg
Purity: 98%
in stock
$108.00 $76.00
Pack Size: 1g
Purity: 95%
in stock
$143.00 $100.00
Pack Size: 5g
Purity: 98%
in stock
$284.00 $199.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000P0P
Chemical Name: Sofosbuvir
CAS Number: 1190307-88-0
Molecular Formula: C22H29FN3O9P
Molecular Weight: 529.4525
MDL Number: MFCD18782704
SMILES: CC(OC(=O)[C@@H](N[P@@](=O)(Oc1ccccc1)OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)F)n1ccc(=O)[nH]c1=O)C)C
Properties
Complexity: 913  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 6  
Heavy Atom Count: 36  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 11  
XLogP3: 1  
Downstream Synthesis Route
863329-66-2    1256490-49-9    1256490-31-9    1190307-88-0    1190308-01-0 

[1]Patent:WO2010/135569,2010,A1.Locationinpatent:Page/Pagecolumn47-48

(S)-2-(1R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yI)-4-(R)-fluoro-3-(4-oxopentanoyl)-4-methyl-tetrahydrofuran-2-ylmethoxy-phenoxy-phosphorylamino}-propionicacid(S)-isopropylester 
  1190307-88-0 

[1]Patent:WO2010/135569,2010,A1.Locationinpatent:Page/Pagecolumn56;59

863329-66-2    1256490-48-8    1190307-88-0    1190308-01-0 

[1]JournalofOrganicChemistry,2011,vol.76,p.8311-8319

863329-66-2    1256490-31-9    1190307-88-0 

[1]Patent:CN106565805,2017,A.Locationinpatent:Paragraph0027;0035;0036;0044

[2]JournalofOrganicChemistry,2011,vol.76,p.8311-8319

[3]Patent:WO2012/12465,2012,A1.Locationinpatent:Page/Pagecolumn83

863329-66-2    1334513-02-8    1190307-88-0 

[1]Patent:WO2016/160646,2016,A1.Locationinpatent:Page/Pagecolumn32

[2]Patent:CN107253971,2017,A.Locationinpatent:Paragraph0017;0036-0039;0044

[3]JournalofOrganicChemistry,2011,vol.76,p.8311-8319

[4]Patent:CN104558079,2017,B.Locationinpatent:Paragraph0046;0047

[5]Patent:WO2016/151542,2016,A1.Locationinpatent:Page/Pagecolumn24;25

[6]Patent:CN103848876,2016,B.Locationinpatent:Paragraph0113-0118

[7]Patent:WO2018/25195,2018,A1.Locationinpatent:Page/Pagecolumn14

Literature fold

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs20170701

Title: Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection.

Journal: The New England journal of medicine20170601

Title: In vitro selection of resistance to sofosbuvir in HCV replicons of genotype-1 to -6.

Journal: Antiviral therapy20170101

Title: Daclatasvir: A NS5A Replication Complex Inhibitor for Hepatitis C Infection.

Journal: The Annals of pharmacotherapy20160101

Title: Rapid reductions in prices for generic sofosbuvir and daclatasvir to treat hepatitis C.

Journal: Journal of virus eradication20160101

Title: Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance.

Journal: Viruses20151001

Title: Interferon-free therapy for hepatitis C: The hurdles amid a golden era.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver20150901

Title: Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1.

Journal: The New England journal of medicine20150820

Title: Hepatitis C virus: Virology, diagnosis and treatment.

Journal: World journal of hepatology20150608

Title: Finding Truth in a World Full of Spin: Myth-Busting in the Case of Sovaldi.

Journal: Clinical therapeutics20150501

Title: Fixed-dose combination of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C genotype 1.

Journal: Expert opinion on pharmacotherapy20150401

Title: Ledipasvir/Sofosbuvir: a review of its use in chronic hepatitis C.

Journal: Drugs20150401

Title: Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study.

Journal: Lancet (London, England)20150321

Title: Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection.

Journal: JAMA20150301

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology20150101

Title: Changing the face of hepatitis C management - the design and development of sofosbuvir.

Journal: Drug design, development and therapy20150101

Title: Cost-effectiveness of sofosbuvir-based treatments for chronic hepatitis C in the US.

Journal: BMC gastroenterology20150101

Title: Efficiency of incorporation and chain termination determines the inhibition potency of 2'-modified nucleotide analogs against hepatitis C virus polymerase.

Journal: Antimicrobial agents and chemotherapy20140701

Title: The combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti-hepatitis C virus activity without detectable cross-resistance.

Journal: Antimicrobial agents and chemotherapy20140601

Title: Intracellular effects of the Hepatitis C virus nucleoside polymerase inhibitor RO5855 (Mericitabine Parent) and Ribavirin in combination.

Journal: Antimicrobial agents and chemotherapy20140501

Title: Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

Journal: Journal of medicinal chemistry20140313

Title: Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors.

Journal: Hepatology (Baltimore, Md.)20140201

Title: Sofosbuvir for the treatment of hepatitis C virus.

Journal: Expert opinion on pharmacotherapy20140101

Title: Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects.

Journal: Antimicrobial agents and chemotherapy20130301

Title: Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.

Journal: Antimicrobial agents and chemotherapy20120601

Title: Interferon free hepatitis C treatment regimens: the beginning of another era.

Journal: Current gastroenterology reports20120201

Title: Treatment of chronic hepatitis C--are interferons really necessary?

Journal: Liver international : official journal of the International Association for the Study of the Liver20120201

Title: What's new in HCV genotype 2 treatment.

Journal: Liver international : official journal of the International Association for the Study of the Liver20120201

Title: Trial watch: an all-oral and interferon-free future for HCV therapy?

Journal: Nature reviews. Drug discovery20111201

Title: Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

Journal: Nucleosides, nucleotides & nucleic acids20111101

Title: Synthesis of diastereomerically pure nucleotide phosphoramidates.

Journal: The Journal of organic chemistry20111021

Title: The HCV NS5B nucleoside and non-nucleoside inhibitors.

Journal: Clinics in liver disease20110801

Title: Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Journal: The Journal of biological chemistry20101105

Title: Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Journal: Journal of medicinal chemistry20101014

Title: Genetic diversity and evolution of hepatitis C virus--15 years on.

Journal: The Journal of general virology20041101

Title: Side effects of alpha interferon in chronic hepatitis C.

Journal: Hepatology (Baltimore, Md.)19970901

Title: Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.

Title: Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.

Title: Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18.

Title: Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.

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