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1201902-80-8,MFCD18251437
Catalog No.:AA000QH1

1201902-80-8 | 4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$8.00   $6.00
- +
5mg
99%
in stock  
$26.00   $18.00
- +
10mg
99%
in stock  
$44.00   $31.00
- +
25mg
95%
in stock  
$83.00   $58.00
- +
100mg
99%
in stock  
$130.00   $91.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000QH1
Chemical Name:
4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
CAS Number:
1201902-80-8
Molecular Formula:
C20H23BCl2N2O9
Molecular Weight:
517.1216
MDL Number:
MFCD18251437
SMILES:
CC(C[C@@H](B1OC(=O)CC(O1)(CC(=O)O)C(=O)O)NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)C
Properties
Computed Properties
 
Complexity:
815  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  

Literature

Title: The investigational proteasome inhibitor ixazomib for the treatment of multiple myeloma.

Journal: Future oncology (London, England) 20150101

Title: Ixazomib for the treatment of multiple myeloma.

Journal: Expert opinion on investigational drugs 20150101

Title: Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.

Journal: Molecular & cellular proteomics : MCP 20121201

Title: Next-generation proteasome blockers promise safer cancer therapy.

Journal: Nature medicine 20120106

Title: Drugs: More shots on target.

Journal: Nature 20111214

Title: Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20111201

Title: In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110815

Title: Chemical and biological evaluation of dipeptidyl boronic acid proteasome inhibitors for use in prodrugs and pro-soft drugs targeting solid tumors.

Journal: Journal of medicinal chemistry 20110714

Title: Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.

Journal: Cancer research 20100301

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Tags:1201902-80-8 Molecular Formula|1201902-80-8 MDL|1201902-80-8 SMILES|1201902-80-8 4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid