126-19-2,MFCD00270414
Catalog No.:AA000QLD

126-19-2 | Sarsasapogenin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
in stock  
$104.00   $73.00
- +
100mg
in stock  
$197.00   $138.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000QLD
Chemical Name:
Sarsasapogenin
CAS Number:
126-19-2
Molecular Formula:
C27H44O3
Molecular Weight:
416.6365
MDL Number:
MFCD00270414
SMILES:
C[C@H]1CC[C@@]2(OC1)O[C@@H]1[C@H]([C@@H]2C)[C@@]2([C@@H](C1)[C@@H]1CC[C@H]3[C@]([C@H]1CC2)(C)CC[C@@H](C3)O)C
Properties
Computed Properties
 
Complexity:
694  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
6.5  

Downstream Synthesis Route
108-24-7    126-19-2   
sarsasapogeninacetate 

[1]Kaufmann;Fuchs[ChemischeBerichte,1923,vol.56,p.2527,2531]Courtneyetal.[AustralianJournalofChemistry,1954,vol.7,p.124]

[2]Askewetal.[JournaloftheChemicalSociety,1936,p.1399,1400]Marker;Rohrmann[JournaloftheAmericanChemicalSociety,1939,vol.61,p.846,851]vanderHaar[RecueildesTravauxChimiquesdesPays-Bas,1929,vol.48,p.726,732,738]FontanCandela;VillarPalasi[AnalesdelaRealSociedadEspanoladeFisicayQuimica,SerieB:Quimica,1951,vol.47,p.309,311]Power;Salway[JournaloftheChemicalSociety,1914,vol.105,p.201,216]

[3]Madaewa[ZhurnalObshcheiKhimii,1958,vol.28,p.551,552;engl.Ausg.S.541,542]Wall;Walens[JournaloftheAmericanChemicalSociety,1955,vol.77,p.5661][JournaloftheAmericanChemicalSociety,1958,vol.80,p.1984]Parisetal.[AnnalesPharmaceutiquesFrancaises,1952,vol.10,p.328,332]Scheeretal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.641,646]Stabursvik[NorgesTekniskeVitenskapsakademi,[Meddelelse],1959,vol.<2>,#6,p.56][ActaChemicaScandinavica(1947-1973),1953,vol.7,p.1220]

[4]Skhirtladze;Benidze;Sulakvelidze[ChemistryofNaturalCompounds,2005,vol.41,#3,p.357-358]

126-19-2   
Dihydrosarsasapogenin 

[1]Doukas;Fontaine[JournaloftheAmericanChemicalSociety,1953,vol.75,p.5355]

[2]Walletal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.1230,1236]Scheeretal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.641,646]

[1]Walletal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.3086,3088]Sannie;Lapin[BulletindelaSocieteChimiquedeFrance,1952,p.1080,1083]Callow;James[JournaloftheChemicalSociety,1955,p.1671,1672]Marker;Rohrmann[JournaloftheAmericanChemicalSociety,1939,vol.61,p.846,851]

[1]Loader,JaredI.;Wilkins,AlistairL.;Flaoyen,Arne;Ryste,Evrind;Hove,Knut[JournalofAgriculturalandFoodChemistry,2003,vol.51,#9,p.2641-2645]

[2]CurrentPatentAssignee:GOLDPORPPHARMA-WO2013/149580,2013,A1Locationinpatent:Paragraph00251

[3]Wall;Serota[JournaloftheAmericanChemicalSociety,1956,vol.78,p.1747,1749]Jacobs;Fleck[JournalofBiologicalChemistry,1930,vol.88,p.545,548]Courtneyetal.[AustralianJournalofChemistry,1954,vol.7,p.124]Simpson;Jacobs[JournalofBiologicalChemistry,1935,vol.109,p.573,580][JournalofBiologicalChemistry,1935,vol.110,p.565,573]

[4]Thompsonetal.[JournaloftheAmericanChemicalSociety,1959,vol.81,p.5225,5228]

[5]CurrentPatentAssignee:PHYTOVENTBIOPHARMA-CN109053854,2018,ALocationinpatent:Paragraph0073;0076-0078

[6]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;ShanghaiInstituteofMateriaMedica(in:CAS)-EP3564253,2019,A1Locationinpatent:Paragraph0082-0083

3-O-<<α-L-rhamnopyranosyl(1->4)><β-D-glucopyranosyl(1->2)>-β-D-glucopyranosyl>-(25S)-5β-spirostan-3β-ol 
  126-19-2 

[1]Pant,G.;Panwar,M.S.;Negi,D.S.;Rawat,M.S.M.;Morris,G.A.[Phytochemistry,1988,vol.27,#10,p.3324-3325]

[2]Pant,G.;Panwar,M.S.;Negi,D.S.;Rawat,M.S.M.;Morris,G.A.[Phytochemistry,1988,vol.27,#10,p.3324-3325]

[3]Pant,G.;Panwar,M.S.;Negi,D.S.;Rawat,M.S.M.;Morris,G.A.[Phytochemistry,1988,vol.27,#10,p.3324-3325]

[4]Sharma,S.C.;Chand,R.;Sati,O.P.[Phytochemistry,1982,vol.21,#8,p.2075-2078]

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor.

Journal: Neuroscience 20120517

Title: Regioselective cleavage of 22-oxo-23-spiroketals. Novel cholestanic frameworks with pyranone and cyclopentenone E rings on the side chain.

Journal: Steroids 20120401

Title: Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells.

Journal: Journal of pharmacology & pharmacotherapeutics 20120101

Title: Concise synthesis and antitumor activities of trisaccharide steroidal saponins.

Journal: Carbohydrate research 20111108

Title: Hydroxylation of steroids by Fusarium oxysporum, Exophiala jeanselmei and Ceratocystis paradoxa.

Journal: Steroids 20111101

Title: A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia.

Journal: Neuroscience bulletin 20110801

Title: A novel sarsasapogenin glycoside from Asparagus racemosus elicits protective immune responses against HBsAg.

Journal: Immunology letters 20110330

Title: Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography.

Journal: Phytochemical analysis : PCA 20110101

Title: High-performance liquid chromatography analysis of plant saponins: An update 2005-2010.

Journal: Pharmacognosy reviews 20110101

Title: Inhibitory effects of steroidal timosaponins isolated from the rhizomes of Anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus.

Journal: Immunopharmacology and immunotoxicology 20100901

Title: A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma.

Journal: Acta pharmacologica Sinica 20100801

Title: One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity.

Journal: Bioorganic & medicinal chemistry letters 20100715

Title: Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.

Journal: Neurobiology of aging 20100601

Title: Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging.

Journal: FEBS letters 20100416

Title: Deacylation reactions of 20-acetyl dinorcholanic lactones and 20,23-diacetyl furost-22-enes.

Journal: Steroids 20100301

Title: Chemical constituents of Asparagus.

Journal: Pharmacognosy reviews 20100101

Title: An improved facile method for extraction and determination of steroidal saponins in Tribulus terrestris by focused microwave-assisted extraction coupled with GC-MS.

Journal: Journal of separation science 20091201

Title: (20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5β-preg-nan-3β,16β-diol.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice.

Journal: Pharmacology, biochemistry, and behavior 20090801

Title: The protective potential of Yucca schidigera (Sarsaponin 30) against nitrite-induced oxidative stress in rats.

Journal: Journal of natural medicines 20090701

Title: Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats.

Journal: Evidence-based complementary and alternative medicine : eCAM 20090601

Title: Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: a comparative study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090515

Title: Synthesis of 'glycospirostanes' via ring-closing metathesis.

Journal: Steroids 20090101

Title: Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress.

Journal: PloS one 20090101

Title: Antiviral activity of Solanum paniculatum extract and constituents.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells.

Journal: Cancer research 20081215

Title: Rat growth-hormone release stimulators from fenugreek seeds.

Journal: Chemistry & biodiversity 20080901

Title: PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080701

Title: Steroids from the roots of Asparagus officinalis and their cytotoxic activity.

Journal: Journal of integrative plant biology 20080601

Title: Role of glial cell derived neurotrophic factor in the protective effect of smilagenin on rat mesencephalic dopaminergic neurons damaged by MPP+.

Journal: FEBS letters 20080319

Title: Mitochondrial ROS burst as an early sign in sarsasapogenin-induced apoptosis in HepG2 cells.

Journal: Cell biology international 20080301

Title: (E)-(25S)-23-Acetyl-5β-furost-22-ene-3β,26-diol.

Journal: Acta crystallographica. Section E, Structure reports online 20080301

Title: Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines.

Journal: Chemico-biological interactions 20080110

Title: Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.

Journal: International journal of molecular medicine 20071001

Title: The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells.

Journal: Cell biology international 20070901

Title: [Studies on accumulation of active ingredients, N, P and K in Anemarrhena asphodeloides].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

Title: Identification of cytotoxic constituents of Narthecium ossifragum using bioassay-guided fractionation.

Journal: Journal of agricultural and food chemistry 20070725

Title: Treating senile dementia with traditional Chinese medicine.

Journal: Clinical interventions in aging 20070601

Title: Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells.

Journal: Molecular and cellular endocrinology 20070530

Title: [Investigation on the technology of processing Anemarrhena asphodeloides Bge. without hair by water].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070301

Title: Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae).

Journal: Die Pharmazie 20070101

Title: Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level.

Journal: Annals of general psychiatry 20070101

Title: Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay.

Journal: Analytical and bioanalytical chemistry 20061101

Title: Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae).

Journal: Biological & pharmaceutical bulletin 20061101

Title: Steroidal saponins from roots of Asparagus officinalis.

Journal: Steroids 20060201

Title: New bisfuran derivative from sarsasapogenin. An X-ray and NMR analysis.

Journal: Steroids 20060101

Title: A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models.

Journal: Brain research 20051026

Title: Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.

Journal: Bioorganic & medicinal chemistry 20050215

Title: Investigation of spectrophotometrically determined substances in Yucca extract by GC/MS, TLC and on-column injection GC.

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20040601

Title: [Synthesis from tigogenin and antituberculosis activity of some of the derivatives of 5alpha-ketosteroid hydrazones].

Journal: Bioorganicheskaia khimiia 20040101

Title: Effect of sarsaponin on ruminal fermentation with particular reference to methane production in vitro.

Journal: Journal of dairy science 20031001

Title: Ovine metabolism of lithogenic sapogenins. Synthesis of [2,2,4,4-(2)h(4)]sarsasapogenone, [2,2,4,4-(2)h(4)]sarsasapogenin, and [2,2,4,4-(2)h(4)]episarsasapogenin and evaluation of deuterium retention in a sheep-dosing trial.

Journal: Journal of agricultural and food chemistry 20030423

Title: Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells.

Journal: International journal of oncology 20030401

Title: Regioselective cleavage of rings E and F in sarsasapogenin.

Journal: Steroids 20030201

Title: Evidence for essential histidine and dicarboxylic amino-acid residues in the active site of UDP-glucose : solasodine glucosyltransferase from eggplant leaves.

Journal: Acta biochimica Polonica 20030101

Title: Ruminal metabolism in sheep of saponins from Yucca schidigera.

Journal: Veterinary research communications 20020201

Title: Effect of sarsasapogenin and its derivatives on the stimulus coupled responses of human neutrophils.

Journal: Clinica chimica acta; international journal of clinical chemistry 20011201

Title: Phospholipids modulate the substrate specificity of soluble UDP-glucose:steroid glucosyltransferase from eggplant leaves.

Journal: Phytochemistry 20011101

Title: [Screening of steroidal saponins from the bulbs of Lilium brownii var. colchesteri by combination of high performance liquid chromatography-electrospray ionization mass spectrometry and electron impact mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20010901

Title: [Determination of sarsasapogenin in 'tian dong' by TLCS].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010801

Title: Ovine metabolism of saponins: evaluation of a method for estimating the ovine uptake of steroidal saponins from Narthecium ossifragum.

Journal: Veterinary research communications 20010401

Title: Shen S, et al. Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells. Biochem Biophys Res Commun. 2013 Oct 26.

Title: Feng B, et al. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neurosci Lett. 2017 Feb 3;639:173-178.

Title: Lim SM, et al. Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. Int Immunopharmacol. 2015 Apr;25(2):493-503.

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SDS
Tags:126-19-2 Molecular Formula|126-19-2 MDL|126-19-2 SMILES|126-19-2 Sarsasapogenin
Catalog No.: AA000QLD
126-19-2,MFCD00270414
126-19-2 | Sarsasapogenin
Pack Size: 25mg
Purity:
in stock
$104.00 $73.00
Pack Size: 100mg
Purity:
in stock
$197.00 $138.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA000QLD
Chemical Name: Sarsasapogenin
CAS Number: 126-19-2
Molecular Formula: C27H44O3
Molecular Weight: 416.6365
MDL Number: MFCD00270414
SMILES: C[C@H]1CC[C@@]2(OC1)O[C@@H]1[C@H]([C@@H]2C)[C@@]2([C@@H](C1)[C@@H]1CC[C@H]3[C@]([C@H]1CC2)(C)CC[C@@H](C3)O)C
Properties
Complexity: 694  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 12  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 6.5  
Downstream Synthesis Route
108-24-7    126-19-2   
sarsasapogeninacetate 

[1]Kaufmann;Fuchs[ChemischeBerichte,1923,vol.56,p.2527,2531]Courtneyetal.[AustralianJournalofChemistry,1954,vol.7,p.124]

[2]Askewetal.[JournaloftheChemicalSociety,1936,p.1399,1400]Marker;Rohrmann[JournaloftheAmericanChemicalSociety,1939,vol.61,p.846,851]vanderHaar[RecueildesTravauxChimiquesdesPays-Bas,1929,vol.48,p.726,732,738]FontanCandela;VillarPalasi[AnalesdelaRealSociedadEspanoladeFisicayQuimica,SerieB:Quimica,1951,vol.47,p.309,311]Power;Salway[JournaloftheChemicalSociety,1914,vol.105,p.201,216]

[3]Madaewa[ZhurnalObshcheiKhimii,1958,vol.28,p.551,552;engl.Ausg.S.541,542]Wall;Walens[JournaloftheAmericanChemicalSociety,1955,vol.77,p.5661][JournaloftheAmericanChemicalSociety,1958,vol.80,p.1984]Parisetal.[AnnalesPharmaceutiquesFrancaises,1952,vol.10,p.328,332]Scheeretal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.641,646]Stabursvik[NorgesTekniskeVitenskapsakademi,[Meddelelse],1959,vol.&lt;2&gt;,#6,p.56][ActaChemicaScandinavica(1947-1973),1953,vol.7,p.1220]

[4]Skhirtladze;Benidze;Sulakvelidze[ChemistryofNaturalCompounds,2005,vol.41,#3,p.357-358]

126-19-2   
Dihydrosarsasapogenin 

[1]Doukas;Fontaine[JournaloftheAmericanChemicalSociety,1953,vol.75,p.5355]

[2]Walletal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.1230,1236]Scheeretal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.641,646]

126-19-2    126-18-1 

[1]Walletal.[JournaloftheAmericanChemicalSociety,1955,vol.77,p.3086,3088]Sannie;Lapin[BulletindelaSocieteChimiquedeFrance,1952,p.1080,1083]Callow;James[JournaloftheChemicalSociety,1955,p.1671,1672]Marker;Rohrmann[JournaloftheAmericanChemicalSociety,1939,vol.61,p.846,851]

126-19-2    639-96-3 

[1]Loader,JaredI.;Wilkins,AlistairL.;Flaoyen,Arne;Ryste,Evrind;Hove,Knut[JournalofAgriculturalandFoodChemistry,2003,vol.51,#9,p.2641-2645]

[2]CurrentPatentAssignee:GOLDPORPPHARMA-WO2013/149580,2013,A1Locationinpatent:Paragraph00251

[3]Wall;Serota[JournaloftheAmericanChemicalSociety,1956,vol.78,p.1747,1749]Jacobs;Fleck[JournalofBiologicalChemistry,1930,vol.88,p.545,548]Courtneyetal.[AustralianJournalofChemistry,1954,vol.7,p.124]Simpson;Jacobs[JournalofBiologicalChemistry,1935,vol.109,p.573,580][JournalofBiologicalChemistry,1935,vol.110,p.565,573]

[4]Thompsonetal.[JournaloftheAmericanChemicalSociety,1959,vol.81,p.5225,5228]

[5]CurrentPatentAssignee:PHYTOVENTBIOPHARMA-CN109053854,2018,ALocationinpatent:Paragraph0073;0076-0078

[6]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;ShanghaiInstituteofMateriaMedica(in:CAS)-EP3564253,2019,A1Locationinpatent:Paragraph0082-0083

3-O-<<α-L-rhamnopyranosyl(1->4)><β-D-glucopyranosyl(1->2)>-β-D-glucopyranosyl>-(25S)-5β-spirostan-3β-ol 
  126-19-2 

[1]Pant,G.;Panwar,M.S.;Negi,D.S.;Rawat,M.S.M.;Morris,G.A.[Phytochemistry,1988,vol.27,#10,p.3324-3325]

[2]Pant,G.;Panwar,M.S.;Negi,D.S.;Rawat,M.S.M.;Morris,G.A.[Phytochemistry,1988,vol.27,#10,p.3324-3325]

[3]Pant,G.;Panwar,M.S.;Negi,D.S.;Rawat,M.S.M.;Morris,G.A.[Phytochemistry,1988,vol.27,#10,p.3324-3325]

[4]Sharma,S.C.;Chand,R.;Sati,O.P.[Phytochemistry,1982,vol.21,#8,p.2075-2078]

Literature fold

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor.

Journal: Neuroscience20120517

Title: Regioselective cleavage of 22-oxo-23-spiroketals. Novel cholestanic frameworks with pyranone and cyclopentenone E rings on the side chain.

Journal: Steroids20120401

Title: Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells.

Journal: Journal of pharmacology & pharmacotherapeutics20120101

Title: Concise synthesis and antitumor activities of trisaccharide steroidal saponins.

Journal: Carbohydrate research20111108

Title: Hydroxylation of steroids by Fusarium oxysporum, Exophiala jeanselmei and Ceratocystis paradoxa.

Journal: Steroids20111101

Title: A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia.

Journal: Neuroscience bulletin20110801

Title: A novel sarsasapogenin glycoside from Asparagus racemosus elicits protective immune responses against HBsAg.

Journal: Immunology letters20110330

Title: Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography.

Journal: Phytochemical analysis : PCA20110101

Title: High-performance liquid chromatography analysis of plant saponins: An update 2005-2010.

Journal: Pharmacognosy reviews20110101

Title: Inhibitory effects of steroidal timosaponins isolated from the rhizomes of Anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus.

Journal: Immunopharmacology and immunotoxicology20100901

Title: A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma.

Journal: Acta pharmacologica Sinica20100801

Title: One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity.

Journal: Bioorganic & medicinal chemistry letters20100715

Title: Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats.

Journal: Neurobiology of aging20100601

Title: Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging.

Journal: FEBS letters20100416

Title: Deacylation reactions of 20-acetyl dinorcholanic lactones and 20,23-diacetyl furost-22-enes.

Journal: Steroids20100301

Title: Chemical constituents of Asparagus.

Journal: Pharmacognosy reviews20100101

Title: An improved facile method for extraction and determination of steroidal saponins in Tribulus terrestris by focused microwave-assisted extraction coupled with GC-MS.

Journal: Journal of separation science20091201

Title: (20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5β-preg-nan-3β,16β-diol.

Journal: Acta crystallographica. Section E, Structure reports online20091201

Title: Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice.

Journal: Pharmacology, biochemistry, and behavior20090801

Title: The protective potential of Yucca schidigera (Sarsaponin 30) against nitrite-induced oxidative stress in rats.

Journal: Journal of natural medicines20090701

Title: Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats.

Journal: Evidence-based complementary and alternative medicine : eCAM20090601

Title: Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: a comparative study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20090515

Title: Synthesis of 'glycospirostanes' via ring-closing metathesis.

Journal: Steroids20090101

Title: Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress.

Journal: PloS one20090101

Title: Antiviral activity of Solanum paniculatum extract and constituents.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20090101

Title: Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells.

Journal: Cancer research20081215

Title: Rat growth-hormone release stimulators from fenugreek seeds.

Journal: Chemistry & biodiversity20080901

Title: PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20080701

Title: Steroids from the roots of Asparagus officinalis and their cytotoxic activity.

Journal: Journal of integrative plant biology20080601

Title: Role of glial cell derived neurotrophic factor in the protective effect of smilagenin on rat mesencephalic dopaminergic neurons damaged by MPP+.

Journal: FEBS letters20080319

Title: Mitochondrial ROS burst as an early sign in sarsasapogenin-induced apoptosis in HepG2 cells.

Journal: Cell biology international20080301

Title: (E)-(25S)-23-Acetyl-5β-furost-22-ene-3β,26-diol.

Journal: Acta crystallographica. Section E, Structure reports online20080301

Title: Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines.

Journal: Chemico-biological interactions20080110

Title: Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.

Journal: International journal of molecular medicine20071001

Title: The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells.

Journal: Cell biology international20070901

Title: [Studies on accumulation of active ingredients, N, P and K in Anemarrhena asphodeloides].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20070801

Title: Identification of cytotoxic constituents of Narthecium ossifragum using bioassay-guided fractionation.

Journal: Journal of agricultural and food chemistry20070725

Title: Treating senile dementia with traditional Chinese medicine.

Journal: Clinical interventions in aging20070601

Title: Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells.

Journal: Molecular and cellular endocrinology20070530

Title: [Investigation on the technology of processing Anemarrhena asphodeloides Bge. without hair by water].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20070301

Title: Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae).

Journal: Die Pharmazie20070101

Title: Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level.

Journal: Annals of general psychiatry20070101

Title: Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay.

Journal: Analytical and bioanalytical chemistry20061101

Title: Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae).

Journal: Biological & pharmaceutical bulletin20061101

Title: Steroidal saponins from roots of Asparagus officinalis.

Journal: Steroids20060201

Title: New bisfuran derivative from sarsasapogenin. An X-ray and NMR analysis.

Journal: Steroids20060101

Title: A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models.

Journal: Brain research20051026

Title: Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.

Journal: Bioorganic & medicinal chemistry20050215

Title: Investigation of spectrophotometrically determined substances in Yucca extract by GC/MS, TLC and on-column injection GC.

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan20040601

Title: [Synthesis from tigogenin and antituberculosis activity of some of the derivatives of 5alpha-ketosteroid hydrazones].

Journal: Bioorganicheskaia khimiia20040101

Title: Effect of sarsaponin on ruminal fermentation with particular reference to methane production in vitro.

Journal: Journal of dairy science20031001

Title: Ovine metabolism of lithogenic sapogenins. Synthesis of [2,2,4,4-(2)h(4)]sarsasapogenone, [2,2,4,4-(2)h(4)]sarsasapogenin, and [2,2,4,4-(2)h(4)]episarsasapogenin and evaluation of deuterium retention in a sheep-dosing trial.

Journal: Journal of agricultural and food chemistry20030423

Title: Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells.

Journal: International journal of oncology20030401

Title: Regioselective cleavage of rings E and F in sarsasapogenin.

Journal: Steroids20030201

Title: Evidence for essential histidine and dicarboxylic amino-acid residues in the active site of UDP-glucose : solasodine glucosyltransferase from eggplant leaves.

Journal: Acta biochimica Polonica20030101

Title: Ruminal metabolism in sheep of saponins from Yucca schidigera.

Journal: Veterinary research communications20020201

Title: Effect of sarsasapogenin and its derivatives on the stimulus coupled responses of human neutrophils.

Journal: Clinica chimica acta; international journal of clinical chemistry20011201

Title: Phospholipids modulate the substrate specificity of soluble UDP-glucose:steroid glucosyltransferase from eggplant leaves.

Journal: Phytochemistry20011101

Title: [Screening of steroidal saponins from the bulbs of Lilium brownii var. colchesteri by combination of high performance liquid chromatography-electrospray ionization mass spectrometry and electron impact mass spectrometry].

Journal: Se pu = Chinese journal of chromatography20010901

Title: [Determination of sarsasapogenin in 'tian dong' by TLCS].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20010801

Title: Ovine metabolism of saponins: evaluation of a method for estimating the ovine uptake of steroidal saponins from Narthecium ossifragum.

Journal: Veterinary research communications20010401

Title: Shen S, et al. Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells. Biochem Biophys Res Commun. 2013 Oct 26.

Title: Feng B, et al. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neurosci Lett. 2017 Feb 3;639:173-178.

Title: Lim SM, et al. Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. Int Immunopharmacol. 2015 Apr;25(2):493-503.

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