130-86-9,MFCD00022322
Catalog No.:AA000TS9

130-86-9 | Protopine

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Purity
Availability
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5mg
>98.0%(GC)
in stock  
$52.00   $36.00
- +
25mg
>98.0%(GC)
in stock  
$149.00   $104.00
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100mg
>98.0%(GC)
in stock  
$406.00   $284.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000TS9
Chemical Name:
Protopine
CAS Number:
130-86-9
Molecular Formula:
C20H19NO5
Molecular Weight:
353.3686
MDL Number:
MFCD00022322
SMILES:
CN1CCc2cc3OCOc3cc2C(=O)Cc2c(C1)c1OCOc1cc2
Properties
Computed Properties
 
Complexity:
542  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.8  

Literature

Title: A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Journal: Journal of ethnopharmacology 20131212

Title: Genetic and chemical components analysis of Papaver setigerum naturalized in Korea.

Journal: Forensic science international 20121010

Title: Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts.

Journal: Drug development and industrial pharmacy 20121001

Title: Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.

Journal: Journal of ethnopharmacology 20120830

Title: [Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

Title: Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.

Journal: Natural product communications 20120501

Title: Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells.

Journal: Fitoterapia 20120301

Title: Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20120205

Title: Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines.

Journal: Cancer letters 20120201

Title: Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages.

Journal: BMB reports 20120201

Title: Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats.

Journal: Molecules (Basel, Switzerland) 20120118

Title: Alkaloids and flavonoids of Argemone mexicana.

Journal: Natural product research 20120101

Title: Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora.

Journal: BMC complementary and alternative medicine 20120101

Title: Inhibitory Effect of Ginsenoside Rg1 on Vascular Smooth Muscle Cell Proliferation Induced by PDGF-BB Is Involved in Nitric Oxide Formation.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/m cell cycle arrest and apoptosis.

Journal: PloS one 20120101

Title: [Chemical constituents from Corydalis yanhusuo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

Title: CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20111201

Title: Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells.

Journal: Bioorganic & medicinal chemistry letters 20111201

Title: Preparative isolation of alkaloids from Dactylicapnos scandens using pH-zone-refining counter-current chromatography by changing the length of the separation column.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111201

Title: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20111101

Title: Alkaloids from Papaver coreanum.

Journal: Natural product communications 20111101

Title: Acetylcholinesterase inhibitors from Corydalis yanhusuo.

Journal: Natural product research 20110901

Title: Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.

Journal: The Journal of organic chemistry 20110819

Title: Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.

Journal: Journal of chromatography. A 20110805

Title: Identification of a novel bacterial K(+) channel.

Journal: The Journal of membrane biology 20110801

Title: [Determination of four alkaloids in Corydalis decumbens by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR.

Journal: Toxicology letters 20110610

Title: Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae.

Journal: The Journal of pharmacy and pharmacology 20110601

Title: Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution.

Journal: Journal of separation science 20110501

Title: Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde.

Journal: Molecules (Basel, Switzerland) 20110420

Title: [Simultaneous determination of four alkaloids in Corydalis decumbens (Thunb.) Pers. by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20110201

Title: A 'reverse pharmacology' approach for developing an anti-malarial phytomedicine.

Journal: Malaria journal 20110101

Title: Phytochemical and antimicrobial characterization of Macleaya cordata herb.

Journal: Fitoterapia 20101201

Title: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae).

Journal: Natural product communications 20101101

Title: Extractions of isoquinoline alkaloids with butanol and octanol.

Journal: Fitoterapia 20100901

Title: [Determination of protopine in Corydalis racemose by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

Title: In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus.

Journal: Veterinary parasitology 20100804

Title: A study on separation and extraction of four main alkaloids in Macleaya cordata (Willd) R. Br. with strip dispersion hybrid liquid membrane.

Journal: Journal of separation science 20100701

Title: Optimization of microwave-assisted extraction of protopine and allocryptopine from stems of Macleaya cordata (Willd) R. Br. using response surface methodology.

Journal: Journal of separation science 20100701

Title: Validated liquid chromatography-tandem mass spectrometry method for quantitative determination of dauricine in human plasma and its application to pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100501

Title: Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.

Journal: Phytotherapy research : PTR 20100401

Title: Simultaneous determination of seven main alkaloids of Chelidonium majus L. by ultra-performance LC with photodiode-array detection.

Journal: Journal of separation science 20100401

Title: Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20100301

Title: BIAdb: a curated database of benzylisoquinoline alkaloids.

Journal: BMC pharmacology 20100101

Title: Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures.

Journal: BMC plant biology 20100101

Title: Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogens.

Journal: Natural product communications 20091101

Title: Electron ionisation mass spectral study of 2-(2-carboxy-4, 5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt.

Journal: Die Pharmazie 20091101

Title: [Alkaloids from Dactylicapnos scandens Hutch].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Title: [Alkaloids from Macleaya cordata].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.

Journal: Journal of chromatography. A 20090313

Title: Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20090220

Title: Alkaloids from Mongolian species Hypecoum lactiflorum Kar. et Kir. Pazij.

Journal: Natural product research 20090101

Title: Identification and characterization of a dual-acting antinematodal agent against the pinewood nematode, Bursaphelenchus xylophilus.

Journal: PloS one 20090101

Title: Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca(2+) antagonism and antioxidant mechanisms.

Journal: European journal of pharmacology 20080904

Title: Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080601

Title: Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures.

Journal: BMC plant biology 20080101

Title: Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts.

Journal: Phytochemical analysis : PCA 20080101

Title: On the synthesis of protopine alkaloids.

Journal: The Journal of organic chemistry 20070914

Title: Conventional sample enrichment strategies combined with high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance analysis allows analyte identification from a single minuscule Corydalis solida plant tuber.

Journal: Journal of chromatography. A 20070907

Title: Protective effect of protopine on the focal cerebral ischaemic injury in rats.

Journal: Basic & clinical pharmacology & toxicology 20070801

Title: Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy.

Journal: The Journal of biological chemistry 20070518

Title: Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism.

Journal: Planta 20070401

Title: Poppy alkaloid profiling by electrospray tandem mass spectrometry and electrospray FT-ICR mass spectrometry after [ring-13C6]-tyramine feeding.

Journal: Phytochemistry 20070101

Title: Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

Title: Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro.

Journal: Planta medica 20061001

Title: Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.

Journal: Neuropharmacology 20060601

Title: Large-scale separation of alkaloids from Corydalis decumbens by pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. A 20060519

Title: Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.

Journal: Journal of natural products 20060301

Title: Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway.

Journal: BMC cancer 20060101

Title: Intestinal spasmolytic effects of STW 5 (Iberogast) and its components.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060101

Title: Rapid determination of protopine, allocryptopine, sanguinarine and chelerythrine in fruits of Macleaya cordata by microwave-assisted solvent extraction and HPLC-ESI/MS.

Journal: Phytochemical analysis : PCA 20060101

Title: Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata.

Journal: Experimental & molecular medicine 20050831

Title: Theoretical and experimental NMR study of protopine hydrochloride isomers.

Journal: Magnetic resonance in chemistry : MRC 20050701

Title: Effects of protopine on intracellular calcium and the PKC activity of rat aorta smooth muscle.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20050425

Title: Effect of binary combination of some plant-derived molluscicides with MGK-264 or piperonyl butoxide on the reproduction of the snail Lymnaea acuminata.

Journal: Pest management science 20050201

Title: [Studies on the alkaloids from the herb of Corydalis adunca].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

Title: Identification and quantification of isoquinoline alkaloids in the genus Sarcocapnos by GC-MS.

Journal: Phytochemical analysis : PCA 20050101

Title: Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.

Journal: European journal of pharmacology 20041215

Title: Protopine alkaloids in horse urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105

Title: Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.

Journal: Archives of pharmacal research 20041101

Title: 1H and 13C NMR signal assignment of benzylisoquinoline alkaloids from Fumaria officinalis L. (Papaveraceae).

Journal: Magnetic resonance in chemistry : MRC 20041001

Title: [Determination of protopine and isocorydine in root of Dactylicapnos scandens by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001

Title: How to treat tremor.

Journal: Journal of neurology 20040501

Title: Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine.

Journal: European journal of pharmacology 20040206

Title: Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.

Journal: Toxicology letters 20031215

Title: Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum.

Journal: Fitoterapia 20030701

Title: Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030605

Title: In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.

Journal: Phytotherapy research : PTR 20030301

Title: Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.

Journal: Planta medica 20030201

Title: In vitro anti-influenza virus activity of isoquinoline alkaloids from thalictrum species.

Journal: Planta medica 20030201

Title: Cytotoxic activity and quality control determinations on Chelidonium majus.

Journal: Fitoterapia 20030201

Title: Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis.

Journal: Veterinary parasitology 20020301

Title: Direct determination of alkaloid contents in Fumaria species by GC-MS.

Journal: Phytochemical analysis : PCA 20020101

Title: [RP-HPLC method for determination of protopine in plasma and pharmacokinetics in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20011001

Title: Elevational trends in defense chemistry, vegetation, and reproduction in Sanguinaria canadensis.

Journal: Journal of chemical ecology 20010901

Title: A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi.

Journal: Planta medica 20010701

Title: Protopine hydrochloride.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010501

Title: Bae DS, et al. Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages. BMB Rep. 2012 Feb;45(2):108-13.

Title: Chen CH, et al. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 2012 Feb 1;315(1):1-11.

Title: Vrba J, et al. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011 Jun 10;203(2):135-41.

Title: He K, et al. Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors. Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):415-24.

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Tags:130-86-9 Molecular Formula|130-86-9 MDL|130-86-9 SMILES|130-86-9 Protopine
Catalog No.: AA000TS9
130-86-9,MFCD00022322
130-86-9 | Protopine
Pack Size: 5mg
Purity: >98.0%(GC)
in stock
$52.00 $36.00
Pack Size: 25mg
Purity: >98.0%(GC)
in stock
$149.00 $104.00
Pack Size: 100mg
Purity: >98.0%(GC)
in stock
$406.00 $284.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA000TS9
Chemical Name: Protopine
CAS Number: 130-86-9
Molecular Formula: C20H19NO5
Molecular Weight: 353.3686
MDL Number: MFCD00022322
SMILES: CN1CCc2cc3OCOc3cc2C(=O)Cc2c(C1)c1OCOc1cc2
Properties
Complexity: 542  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.8  
Literature fold

Title: A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Journal: Journal of ethnopharmacology20131212

Title: Genetic and chemical components analysis of Papaver setigerum naturalized in Korea.

Journal: Forensic science international20121010

Title: Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts.

Journal: Drug development and industrial pharmacy20121001

Title: Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.

Journal: Journal of ethnopharmacology20120830

Title: [Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20120701

Title: Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.

Journal: Natural product communications20120501

Title: Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells.

Journal: Fitoterapia20120301

Title: Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis20120205

Title: Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines.

Journal: Cancer letters20120201

Title: Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages.

Journal: BMB reports20120201

Title: Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats.

Journal: Molecules (Basel, Switzerland)20120118

Title: Alkaloids and flavonoids of Argemone mexicana.

Journal: Natural product research20120101

Title: Species and tissue-specificity of prokinetic, laxative and spasmodic effects of Fumaria parviflora.

Journal: BMC complementary and alternative medicine20120101

Title: Inhibitory Effect of Ginsenoside Rg1 on Vascular Smooth Muscle Cell Proliferation Induced by PDGF-BB Is Involved in Nitric Oxide Formation.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/m cell cycle arrest and apoptosis.

Journal: PloS one20120101

Title: [Chemical constituents from Corydalis yanhusuo].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20120101

Title: CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds.

Journal: Drug metabolism and disposition: the biological fate of chemicals20111201

Title: Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells.

Journal: Bioorganic & medicinal chemistry letters20111201

Title: Preparative isolation of alkaloids from Dactylicapnos scandens using pH-zone-refining counter-current chromatography by changing the length of the separation column.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20111201

Title: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20111101

Title: Alkaloids from Papaver coreanum.

Journal: Natural product communications20111101

Title: Acetylcholinesterase inhibitors from Corydalis yanhusuo.

Journal: Natural product research20110901

Title: Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids.

Journal: The Journal of organic chemistry20110819

Title: Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.

Journal: Journal of chromatography. A20110805

Title: Identification of a novel bacterial K(+) channel.

Journal: The Journal of membrane biology20110801

Title: [Determination of four alkaloids in Corydalis decumbens by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20110801

Title: Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR.

Journal: Toxicology letters20110610

Title: Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae.

Journal: The Journal of pharmacy and pharmacology20110601

Title: Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution.

Journal: Journal of separation science20110501

Title: Seasonal variation of bioactive alkaloid contents in Macleaya microcarpa (Maxim.) Fedde.

Journal: Molecules (Basel, Switzerland)20110420

Title: [Simultaneous determination of four alkaloids in Corydalis decumbens (Thunb.) Pers. by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography20110201

Title: A 'reverse pharmacology' approach for developing an anti-malarial phytomedicine.

Journal: Malaria journal20110101

Title: Phytochemical and antimicrobial characterization of Macleaya cordata herb.

Journal: Fitoterapia20101201

Title: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae).

Journal: Natural product communications20101101

Title: Extractions of isoquinoline alkaloids with butanol and octanol.

Journal: Fitoterapia20100901

Title: [Determination of protopine in Corydalis racemose by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20100901

Title: In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus.

Journal: Veterinary parasitology20100804

Title: A study on separation and extraction of four main alkaloids in Macleaya cordata (Willd) R. Br. with strip dispersion hybrid liquid membrane.

Journal: Journal of separation science20100701

Title: Optimization of microwave-assisted extraction of protopine and allocryptopine from stems of Macleaya cordata (Willd) R. Br. using response surface methodology.

Journal: Journal of separation science20100701

Title: Validated liquid chromatography-tandem mass spectrometry method for quantitative determination of dauricine in human plasma and its application to pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20100501

Title: Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.

Journal: Phytotherapy research : PTR20100401

Title: Simultaneous determination of seven main alkaloids of Chelidonium majus L. by ultra-performance LC with photodiode-array detection.

Journal: Journal of separation science20100401

Title: Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry20100301

Title: BIAdb: a curated database of benzylisoquinoline alkaloids.

Journal: BMC pharmacology20100101

Title: Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures.

Journal: BMC plant biology20100101

Title: Isoquinoline alkaloids from Macleaya cordata active against plant microbial pathogens.

Journal: Natural product communications20091101

Title: Electron ionisation mass spectral study of 2-(2-carboxy-4, 5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt.

Journal: Die Pharmazie20091101

Title: [Alkaloids from Dactylicapnos scandens Hutch].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090801

Title: [Alkaloids from Macleaya cordata].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090701

Title: Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.

Journal: Journal of chromatography. A20090313

Title: Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis20090220

Title: Alkaloids from Mongolian species Hypecoum lactiflorum Kar. et Kir. Pazij.

Journal: Natural product research20090101

Title: Identification and characterization of a dual-acting antinematodal agent against the pinewood nematode, Bursaphelenchus xylophilus.

Journal: PloS one20090101

Title: Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca(2+) antagonism and antioxidant mechanisms.

Journal: European journal of pharmacology20080904

Title: Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20080601

Title: Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures.

Journal: BMC plant biology20080101

Title: Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts.

Journal: Phytochemical analysis : PCA20080101

Title: On the synthesis of protopine alkaloids.

Journal: The Journal of organic chemistry20070914

Title: Conventional sample enrichment strategies combined with high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance analysis allows analyte identification from a single minuscule Corydalis solida plant tuber.

Journal: Journal of chromatography. A20070907

Title: Protective effect of protopine on the focal cerebral ischaemic injury in rats.

Journal: Basic & clinical pharmacology & toxicology20070801

Title: Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy.

Journal: The Journal of biological chemistry20070518

Title: Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism.

Journal: Planta20070401

Title: Poppy alkaloid profiling by electrospray tandem mass spectrometry and electrospray FT-ICR mass spectrometry after [ring-13C6]-tyramine feeding.

Journal: Phytochemistry20070101

Title: Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences20070101

Title: Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro.

Journal: Planta medica20061001

Title: Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.

Journal: Neuropharmacology20060601

Title: Large-scale separation of alkaloids from Corydalis decumbens by pH-zone-refining counter-current chromatography.

Journal: Journal of chromatography. A20060519

Title: Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.

Journal: Journal of natural products20060301

Title: Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway.

Journal: BMC cancer20060101

Title: Intestinal spasmolytic effects of STW 5 (Iberogast) and its components.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20060101

Title: Rapid determination of protopine, allocryptopine, sanguinarine and chelerythrine in fruits of Macleaya cordata by microwave-assisted solvent extraction and HPLC-ESI/MS.

Journal: Phytochemical analysis : PCA20060101

Title: Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata.

Journal: Experimental & molecular medicine20050831

Title: Theoretical and experimental NMR study of protopine hydrochloride isomers.

Journal: Magnetic resonance in chemistry : MRC20050701

Title: Effects of protopine on intracellular calcium and the PKC activity of rat aorta smooth muscle.

Journal: Sheng li xue bao : [Acta physiologica Sinica]20050425

Title: Effect of binary combination of some plant-derived molluscicides with MGK-264 or piperonyl butoxide on the reproduction of the snail Lymnaea acuminata.

Journal: Pest management science20050201

Title: [Studies on the alkaloids from the herb of Corydalis adunca].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050201

Title: Identification and quantification of isoquinoline alkaloids in the genus Sarcocapnos by GC-MS.

Journal: Phytochemical analysis : PCA20050101

Title: Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.

Journal: European journal of pharmacology20041215

Title: Protopine alkaloids in horse urine.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20041105

Title: Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa.

Journal: Archives of pharmacal research20041101

Title: 1H and 13C NMR signal assignment of benzylisoquinoline alkaloids from Fumaria officinalis L. (Papaveraceae).

Journal: Magnetic resonance in chemistry : MRC20041001

Title: [Determination of protopine and isocorydine in root of Dactylicapnos scandens by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20041001

Title: How to treat tremor.

Journal: Journal of neurology20040501

Title: Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine.

Journal: European journal of pharmacology20040206

Title: Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.

Journal: Toxicology letters20031215

Title: Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum.

Journal: Fitoterapia20030701

Title: Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20030605

Title: In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.

Journal: Phytotherapy research : PTR20030301

Title: Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.

Journal: Planta medica20030201

Title: In vitro anti-influenza virus activity of isoquinoline alkaloids from thalictrum species.

Journal: Planta medica20030201

Title: Cytotoxic activity and quality control determinations on Chelidonium majus.

Journal: Fitoterapia20030201

Title: Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis.

Journal: Veterinary parasitology20020301

Title: Direct determination of alkaloid contents in Fumaria species by GC-MS.

Journal: Phytochemical analysis : PCA20020101

Title: [RP-HPLC method for determination of protopine in plasma and pharmacokinetics in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20011001

Title: Elevational trends in defense chemistry, vegetation, and reproduction in Sanguinaria canadensis.

Journal: Journal of chemical ecology20010901

Title: A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi.

Journal: Planta medica20010701

Title: Protopine hydrochloride.

Journal: Acta crystallographica. Section C, Crystal structure communications20010501

Title: Bae DS, et al. Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages. BMB Rep. 2012 Feb;45(2):108-13.

Title: Chen CH, et al. Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett. 2012 Feb 1;315(1):1-11.

Title: Vrba J, et al. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011 Jun 10;203(2):135-41.

Title: He K, et al. Protopine inhibits heterotypic cell adhesion in MDA-MB-231 cells through down-regulation of multi-adhesive factors. Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):415-24.

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