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130018-87-0,MFCD07366507
Catalog No.:AA000TUB

130018-87-0 | 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride

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1mg
98%
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$6.00   $4.00
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5mg
98%
in stock  
$7.00   $5.00
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25mg
98%
in stock  
$9.00   $7.00
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5g
98%
in stock  
$21.00   $15.00
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25g
98%
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$62.00   $43.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000TUB
Chemical Name:
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
CAS Number:
130018-87-0
Molecular Formula:
C21H27Cl3N2O3
Molecular Weight:
461.8097
MDL Number:
MFCD07366507
SMILES:
OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1.Cl.Cl
Properties
Computed Properties
 
Complexity:
443  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  

Literature

Title: Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.

Journal: Gut 20141201

Title: Chitosan-based thermosensitive hydrogel as a promising ocular drug delivery system: preparation, characterization, and in vivo evaluation.

Journal: Journal of biomaterials applications 20121101

Title: H(1)-antihistamines and urticaria: how can we predict the best drug for our patient?

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20121001

Title: A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7-12 years.

Journal: International journal of pediatric otorhinolaryngology 20120701

Title: Bilastine: in allergic rhinitis and urticaria.

Journal: Drugs 20120618

Title: Development of a validated capillary electrophoresis method for enantiomeric purity control and quality control of levocetirizine in a pharmaceutical formulation.

Journal: Chirality 20120401

Title: Levocetirizine inhibits rhinovirus-induced bacterial adhesion to nasal epithelial cells through down-regulation of cell adhesion molecules.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20120101

Title: The loss of smell in persistent allergic rhinitis is improved by levocetirizine due to reduction of nasal inflammation but not nasal congestion (the CIRANO study).

Journal: International archives of allergy and immunology 20120101

Title: Simultaneous determination of levocetirizine and pseudoephedrine in dog plasma by liquid chromatography-mass spectrometry in the presence of dextrocetirizine.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

Title: The effectiveness of levocetirizine in comparison with loratadine in treatment of allergic rhinitis--a meta-analysis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20111201

Title: Examining the utilization and tolerability of the non-sedating antihistamine levocetirizine in England using prescription-event monitoring data.

Journal: Drug safety 20111201

Title: Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20111201

Title: Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety.

Journal: Journal of drugs in dermatology : JDD 20111201

Title: Levocetrizine has anti-inflammatory effects against Toll-like receptor (TLR)3 through the inhibition of Toll-IL-1 receptor (TIR)-domain-containing adapter inducing IFN-beta (TRIF) and receptor-interacting protein (RIP).

Journal: Auris, nasus, larynx 20110801

Title: Pharmacokinetic evaluation of levocetirizine.

Journal: Expert opinion on drug metabolism & toxicology 20110801

Title: Downmodulatory effects of cetirizine and levocetirizine on cytokine/chemokine production and CD54 expression in keratinocytes.

Journal: The Journal of dermatology 20110701

Title: Photodermatitis caused by oral ketoprofen: two case reports.

Journal: Contact dermatitis 20110301

Title: Chronic idiopathic urticaria in Taiwan: a clinical study of demographics, aggravating factors, laboratory findings, serum autoreactivity and treatment response.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20110301

Title: Anti-inflammatory activity and clinical efficacy of a 3-month levocetirizine therapy in mite-allergic children.

Journal: Inflammation & allergy drug targets 20110201

Title: Improving SAR symptoms with levocetirizine: evaluating active and placebo effects in pollen challenge vs. natural exposure studies.

Journal: Current medical research and opinion 20110101

Title: Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease.

Journal: International archives of allergy and immunology 20110101

Title: The basophil activation test as a promising diagnostic tool in hypersensitivity to chironomid larvae.

Journal: Journal of investigational allergology & clinical immunology 20110101

Title: Levocetirizine induced hepatotoxicity in a patient with chronic urticaria.

Journal: Annals of hepatology 20110101

Title: Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis.

Journal: American journal of rhinology & allergy 20110101

Title: Allergic contact dermatitis due to carteolol, with good tolerance to betaxolol.

Journal: Dermatitis : contact, atopic, occupational, drug 20110101

Title: Nasal nitric oxide and nasal eosinophils decrease with levocetirizine in subjects with perennial allergic rhinitis.

Journal: American journal of rhinology & allergy 20110101

Title: Levocetirizine inhibits rhinovirus-induced up-regulation of fibrogenic and angiogenic factors in nasal polyp fibroblasts.

Journal: American journal of rhinology & allergy 20110101

Title: [The approaches to diagnostics and therapy of allergic rhinitis].

Journal: Vestnik otorinolaringologii 20110101

Title: [Off-season manifestations of pollen hypersensitization].

Journal: Vestnik otorinolaringologii 20110101

Title: Enantioselective determination of cetirizine in human plasma by normal-phase liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101215

Title: A randomized, double-blind, active-controlled, parallel-group pilot study to compare the efficacy and sedative effects of desloratadine 5 mg with levocetirizine 5 mg in the treatment of chronic idiopathic urticaria.

Journal: Journal of the American Academy of Dermatology 20101101

Title: An open-label, multicentre study of levocetirizine for the treatment of allergic rhinitis and urticaria in Taiwanese patients.

Journal: The Chinese journal of physiology 20100831

Title: Rupatadine and levocetirizine for seasonal allergic rhinitis: a comparative study of efficacy and safety.

Journal: Archives of otolaryngology--head & neck surgery 20100801

Title: Study of levocetirizine in seasonal allergic rhinitis.

Journal: Current medical research and opinion 20100601

Title: Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence.

Journal: Journal of the Indian Medical Association 20100601

Title: Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study.

Journal: Allergy 20100401

Title: The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria.

Journal: The Journal of allergy and clinical immunology 20100301

Title: Efficacy and safety of levocetirizine in improving symptoms and health-related quality of life in US adults with seasonal allergic rhinitis: a randomized, placebo-controlled study.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20100301

Title: Clinical assessment of levocetirizine and budesonide in treatment of persistent allergic rhinitis regarding to symptom severity.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100201

Title: Development of taste masked fast disintegrating films of levocetirizine dihydrochloride for oral use.

Journal: Current drug delivery 20100101

Title: Levocetirizine-induced iridocyclitis in a patient with allergic rhinitis.

Journal: Journal of investigational allergology & clinical immunology 20100101

Title: Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC.

Journal: Journal of chromatographic science 20100101

Title: Safety and tolerability of levocetirizine dihydrochloride in infants and children with allergic rhinitis or chronic urticaria.

Journal: Allergy and asthma proceedings 20100101

Title: [Levocetirizine in therapy for allergic rhinitis].

Journal: Vestnik otorinolaringologii 20100101

Title: Study on the interaction of levocetirizine dihydrochloride with human serum albumin by molecular spectroscopy.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091201

Title: Levocetirizine in the treatment of allergic diseases.

Journal: Expert opinion on pharmacotherapy 20091001

Title: Stereoselective renal tubular secretion of cetirizine enantiomers--initial plasma and urine data analysis may hold the key.

Journal: Fundamental & clinical pharmacology 20091001

Title: Sleep actigraphy evidence of improved sleep after treatment of allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20091001

Title: The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20090801

Title: Levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children.

Journal: Clinical therapeutics 20090801

Title: FDC of montelukast with levocetirizine: focus on bilayer technology.

Journal: Journal of the Indian Medical Association 20090801

Title: Enantiomeric purity control of levocetirizine in pharmaceuticals using anionic cyclodextrin mediated capillary electrophoresis separation and fiber-based diode array detection.

Journal: Die Pharmazie 20090701

Title: A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.

Journal: Clinical therapeutics 20090501

Title: Comparison of the efficacy of levocetirizine 5 mg and desloratadine 5 mg in chronic idiopathic urticaria patients.

Journal: Allergy 20090401

Title: Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells.

Journal: Antiviral research 20090301

Title: Effect of levocetirizine on nasal provocation testing with adenosine monophosphate compared with allergen challenge in allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090301

Title: Levocetirizine for chronic idiopathic urticaria: a review.

Journal: Journal of drugs in dermatology : JDD 20090301

Title: Levocetirizine: from scientific evidence to a potent modern-day treatment of today's allergic patients.

Journal: Drugs of today (Barcelona, Spain : 1998) 20090301

Title: Pharmacotherapy of allergic rhinitis: a pharmaco-economic approach.

Journal: Allergy 20090101

Title: Evaluation by (99m)Tc-pertechnetate scintigraphy of the effect of levocetirizine on salivary glands function, in allergic rhinitis patients.

Journal: Hellenic journal of nuclear medicine 20090101

Title: Treatment of chronic idiopathic urticaria with levamisole: a multicentre, randomized, double-blind, controlled trial.

Journal: The Journal of international medical research 20090101

Title: Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Journal: Drugs 20090101

Title: Formulation and evaluation of taste-masked levocetirizine dihydrochloride orally disintegrating tablets.

Journal: PDA journal of pharmaceutical science and technology 20090101

Title: Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venom immunotherapy.

Journal: The Journal of allergy and clinical immunology 20081101

Title: Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study.

Journal: Current medical research and opinion 20081001

Title: Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis.

Journal: Journal of pharmacological sciences 20081001

Title: Efficacy comparison of levocetirizine vs montelukast in ragweed sensitized patients.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20080901

Title: Antihistamine effects on experimental middle ear inflammatory model.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20080801

Title: Allergic rhinitis in family practice: the role of levocetirizine in clinical care.

Journal: Postgraduate medicine 20080701

Title: A review of the role of levocetirizine as an effective therapy for allergic disease.

Journal: Expert opinion on pharmacotherapy 20080401

Title: [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20080401

Title: Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine.

Journal: British journal of clinical pharmacology 20080201

Title: Stereoselective renal tubular secretion of levocetirizine and dextrocetirizine, the two enantiomers of the H1-antihistamine cetirizine.

Journal: Fundamental & clinical pharmacology 20080201

Title: Determination of levocetirizine in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

Title: Anaphylaxis induced by Anisakis.

Journal: Allergologia et immunopathologia 20080101

Title: Xyzal (levocetirizine dihydrochloride).

Journal: Skinmed 20080101

Title: Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.

Journal: Clinical pharmacokinetics 20080101

Title: Non-interventional study comparing treatment satisfaction in patients treated with antihistamines.

Journal: Clinical drug investigation 20080101

Title: Efficacy of levocetirizine compared with montelukast in subjects with ragweed-induced seasonal allergic rhinitis in the Environmental Exposure Unit.

Journal: Allergy and asthma proceedings 20080101

Title: Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial.

Journal: Acta dermato-venereologica 20080101

Title: Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine.

Journal: Current medicinal chemistry 20080101

Title: [Hypocalcaemia in a patient presenting severe solar urticaria].

Journal: Annales de dermatologie et de venereologie 20080101

Title: Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test.

Journal: Indian journal of dermatology, venereology and leprology 20080101

Title: Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells.

Journal: Allergy and asthma proceedings 20080101

Title: Quality of life in patients with persistent allergic rhinitis treated with montelukast alone or in combination with levocetirizine or desloratadine.

Journal: Journal of investigational allergology & clinical immunology 20080101

Title: Histamine 2 blocker potentiates the effects of histamine 1 blocker in suppressing histamine-induced wheal.

Journal: Indian journal of dermatology, venereology and leprology 20080101

Title: Levocetirizine (Xyzal) for allergic rhinitis and urticaria.

Journal: The Medical letter on drugs and therapeutics 20071203

Title: Levocetirizine does not prolong the QT/QTc interval in healthy subjects: results from a thorough QT study.

Journal: European journal of clinical pharmacology 20071101

Title: Safety of levocetirizine treatment in young atopic children: An 18-month study.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20070901

Title: H1-antihistamine treatment in young atopic children: effect on urticaria.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20070901

Title: Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig.

Journal: British journal of pharmacology 20070801

Title: A case of urticaria induced by both hydroxyzine and cetirizine but not by levocetirizine.

Journal: Allergy 20070701

Title: New hay fever, hives treatment approved.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070701

Title: Relevance of H1-receptor occupancy to H1-antihistamine dosing in children.

Journal: The Journal of allergy and clinical immunology 20070601

Title: Evaluation of the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients by rhinoscintigraphy.

Journal: Nuclear medicine communications 20070201

Title: Contractile properties of various histaprodifen derivatives in guinea pig isolated ileum and trachea.

Journal: Pharmacology 20070101

Title: Comparative efficacy of cetirizine and levocetirizine in chronic idiopathic urticaria.

Journal: The Journal of dermatological treatment 20070101

Title: Levocetirizine and cytokine production and apoptosis of human eosinophils.

Journal: Allergy and asthma proceedings 20070101

Title: Levocetirizine: The latest treatment option for allergic rhinitis and chronic idiopathic urticaria.

Journal: Allergy and asthma proceedings 20070101

Title: [Visual evoked potentials in the in evaluation of the safety profile of levocetirizine].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101

Title: [Does new antihistamines characterize tachyphylaxis phenomenon?].

Journal: Otolaryngologia polska = The Polish otolaryngology 20070101

Title: Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment.

Journal: The British journal of dermatology 20061201

Title: Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.

Journal: European annals of allergy and clinical immunology 20061201

Title: New antihistamines: a critical view.

Journal: Jornal de pediatria 20061101

Title: Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061101

Title: [Inhibition of histamine-induced wheel after a recommended single dose administration of 10 mg cetirizine, 5 mg desloratadine, 120 i 180 mg fexofenadine, 5 mg levocetirizine and 10 mg loratadine--a randomized, double-blind, placebo controlled trial].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

Title: [The effect of 5-days of cetirizine, desloratadine, fexofenadine 120 and 180 mg, levocetirizine, loratadine treatment on the histamine-induced skin reaction and skin blood flow--a randomized, double-blind, placebo controlled trial].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061101

Title: Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis.

Journal: Respiratory medicine 20061001

Title: Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060901

Title: Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine.

Journal: British journal of clinical pharmacology 20060801

Title: Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060801

Title: Chiral separation of cetirizine by capillary electrophoresis.

Journal: Electrophoresis 20060601

Title: A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060601

Title: Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060501

Title: Levocetirizine in patients with chronic idiopathic urticaria: results of a multicenter clinical practice study.

Journal: International journal of clinical pharmacology and therapeutics 20060401

Title: Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study.

Journal: International journal of dermatology 20060401

Title: Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.

Journal: The British journal of dermatology 20060301

Title: Familial aquagenic urticaria and bernard-soulier syndrome.

Journal: Dermatology (Basel, Switzerland) 20060101

Title: A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

Journal: Clinical therapeutics 20060101

Title: Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies.

Journal: Drugs 20060101

Title: Levocetirizine for treatment of immediate and delayed mosquito bite reactions.

Journal: Acta dermato-venereologica 20060101

Title: Levocetirizine as treatment for symptoms of seasonal allergic rhinitis.

Journal: B-ENT 20060101

Title: Effect of levocetirizine on the contraction induced by histamine on isolated rabbit bronchioles from precision-cut lung slices.

Journal: Pharmacology 20060101

Title: Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England.

Journal: Drug safety 20060101

Title: Levocetirizine: an update.

Journal: Current medicinal chemistry 20060101

Title: The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is inhibited by levocetirizine.

Journal: American journal of rhinology 20060101

Title: Clinicopathologic features of systemic contact dermatitis from ethylenediamine in cetirizine and levocetirizine.

Journal: Dermatology (Basel, Switzerland) 20060101

Title: Cost effectiveness of levocetirizine in chronic idiopathic urticaria : a pooled analysis of two randomised controlled trials.

Journal: Clinical drug investigation 20060101

Title: Selecting the optimal oral antihistamine for patients with allergic rhinitis.

Journal: Drugs 20060101

Title: Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study.

Journal: International immunopharmacology 20051201

Title: Fixed drug eruption: a novel side-effect of levocetirizine.

Journal: International journal of dermatology 20050901

Title: Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901

Title: Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years.

Journal: The Journal of allergy and clinical immunology 20050801

Title: A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20050801

Title: Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050801

Title: Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration.

Journal: British journal of clinical pharmacology 20050701

Title: A treatment for allergic rhinitis: a view on the role of levocetirizine.

Journal: Current medical research and opinion 20050701

Title: A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis.

Journal: Clinical therapeutics 20050701

Title: Costs associated with persistent allergic rhinitis are reduced by levocetirizine.

Journal: Allergy 20050601

Title: Potential of levocetirizine in the relief of nasal congestion.

Journal: International journal of clinical practice 20050601

Title: Bacillus clausii effects in children with allergic rhinitis.

Journal: Allergy 20050501

Title: Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050501

Title: Levocetirizine in 1-2 year old children: pharmacokinetic and pharmacodynamic profile.

Journal: International journal of clinical pharmacology and therapeutics 20050401

Title: Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.

Journal: Journal of medicinal chemistry 20050324

Title: Population pharmacokinetics of levocetirizine in very young children: the pediatricians' perspective.

Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20050301

Title: Retrospective population pharmacokinetics of levocetirizine in atopic children receiving cetirizine: the ETAC study.

Journal: British journal of clinical pharmacology 20050101

Title: Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: a pilot study.

Journal: European annals of allergy and clinical immunology 20050101

Title: Fixed drug eruption due to levocetirizine.

Journal: Indian journal of dermatology, venereology and leprology 20050101

Title: [Patient report: allergic rhinitis].

Journal: Krankenpflege Journal 20050101

Title: H1 histamine receptor mediates inflammatory responses in human keratinocytes.

Journal: The Journal of allergy and clinical immunology 20041101

Title: Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours.

Journal: International archives of allergy and immunology 20041001

Title: Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis.

Journal: The Journal of allergy and clinical immunology 20041001

Title: Modern histamine H1-receptor antagonists in the unified airway.

Journal: The Journal of allergy and clinical immunology 20040901

Title: Antihistamines: do they work? Further well-controlled trials involving larger samples are needed.

Journal: Allergy 20040801

Title: Interactions between eotaxin, histamine and mast cells in early microvascular events associated with eosinophil recruitment to the site of allergic skin reactions in humans.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

Title: Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.

Journal: Fundamental & clinical pharmacology 20040801

Title: Levocetirizine: the allergist's arsenal grows larger.

Journal: Expert opinion on pharmacotherapy 20040701

Title: Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040601

Title: A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC).

Journal: Current medical research and opinion 20040601

Title: Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders.

Journal: Drugs of today (Barcelona, Spain : 1998) 20040501

Title: Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040401

Title: Levocetirizine better protects than desloratadine in a nasal provocation with allergen.

Journal: The Journal of allergy and clinical immunology 20040401

Title: Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU).

Journal: International journal of clinical practice 20040201

Title: Chronic urticaria: clinical aspects and focus on a new antihistamine, levocetirizine.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists.

Journal: Biochemical pharmacology 20031001

Title: Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites.

Journal: Allergy 20030901

Title: Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial.

Journal: Psychopharmacology 20030801

Title: [Clinical aspects of anti-inflammatory action of antihistamines].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20030601

Title: [H1 histamine antagonists].

Journal: Revue medicale de Bruxelles 20030401

Title: Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood.

Journal: The Journal of allergy and clinical immunology 20030301

Title: Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.

Journal: The Journal of allergy and clinical immunology 20030201

Title: Blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans.

Journal: Fundamental & clinical pharmacology 20021201

Title: The new antihistamines--desloratadine and levocetirizine: a review.

Journal: Journal of drugs in dermatology : JDD 20021201

Title: Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020801

Title: Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672.

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Tags:130018-87-0 Molecular Formula|130018-87-0 MDL|130018-87-0 SMILES|130018-87-0 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride