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13073-35-3,MFCD00002626
Catalog No.:AA000UTK

13073-35-3 | L-Ethionine

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100mg
>98.0%(T)
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$82.00   $57.00
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250mg
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1g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000UTK
Chemical Name:
L-Ethionine
CAS Number:
13073-35-3
Molecular Formula:
C6H13NO2S
Molecular Weight:
163.2379
MDL Number:
MFCD00002626
SMILES:
CCSCC[C@@H](C(=O)O)N
Properties
Properties
 
BP:
310.391 °C at 760 mmHg  
Form:
Solid  
MP:
280 °C  
Refractive Index:
22 ° (C=1, 1mol/L HCl)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
108  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
-1.5  

Literature

Title: Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.

Journal: Toxicology and applied pharmacology 20170301

Title: Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.

Journal: PloS one 20140101

Title: Bmi1 is required for regeneration of the exocrine pancreas in mice.

Journal: Gastroenterology 20120901

Title: Small-molecule inhibitors of the protein methyltransferase SET7/9 identified in a high-throughput screen.

Journal: Journal of biomolecular screening 20120901

Title: The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.

Journal: Experimental and molecular pathology 20120801

Title: Prevention effects of ND-07, a novel drug candidate with a potent antioxidative action and anti-inflammatory action, in animal models of severe acute pancreatitis.

Journal: European journal of pharmacology 20120715

Title: Identification and characterization of genes related to the production of organic acids in yeast.

Journal: Journal of bioscience and bioengineering 20120501

Title: Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet.

Journal: Biochemical and biophysical research communications 20120420

Title: Automated annotation and quantification of metabolites in 1H NMR data of biological origin.

Journal: Analytical and bioanalytical chemistry 20120401

Title: Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

Journal: Nature medicine 20120304

Title: Importance of methionine metabolism in morula-to-blastocyst transition in bovine preimplantation embryos.

Journal: The Journal of reproduction and development 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.

Journal: The American journal of pathology 20111001

Title: Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice.

Journal: Laboratory investigation; a journal of technical methods and pathology 20110701

Title: Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20110601

Title: Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response.

Journal: Gut 20110401

Title: New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.

Journal: Cancer informatics 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet.

Journal: Hepatology (Baltimore, Md.) 20101101

Title: Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase.

Journal: Antioxidants & redox signaling 20100701

Title: Effects of acute ethionine injection on plasma ghrelin and obestatin levels in trained male rats.

Journal: Metabolism: clinical and experimental 20100701

Title: Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells.

Journal: Hepatology (Baltimore, Md.) 20100701

Title: Imprinting: RNA expression for homocysteine recycling in the human oocyte.

Journal: Fertility and sterility 20100315

Title: Time-resolved biomarker discovery in 1H-NMR data using generalized fuzzy Hough transform alignment and parallel factor analysis.

Journal: Analytical and bioanalytical chemistry 20100301

Title: A medium-term, rapid rat bioassay model for the detection of carcinogenic potential of chemicals.

Journal: Toxicologic pathology 20100101

Title: Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet.

Journal: Experimental animals 20100101

Title: An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20091201

Title: Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

Journal: Toxicology 20091109

Title: Superoxide dismutase activity as a measure of hepatic oxidative stress in cattle following ethionine administration.

Journal: Veterinary journal (London, England : 1997) 20091101

Title: Ethionine-induced ATP depletion represses mTOR signaling in the absence of increases in AMP-activated protein kinase activity in the rat liver.

Journal: Bioscience, biotechnology, and biochemistry 20090901

Title: Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.

Journal: The Journal of toxicological sciences 20090601

Title: Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction.

Journal: Journal of mass spectrometry : JMS 20090501

Title: Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury.

Journal: Hepatology (Baltimore, Md.) 20090501

Title: Expression of extracellular matrix genes in cultured hepatic oval cells: an origin of hepatic stellate cells through transforming growth factor beta?

Journal: Liver international : official journal of the International Association for the Study of the Liver 20090401

Title: Risperidone attenuates local and systemic inflammatory responses to ameliorate diet-induced severe necrotic pancreatitis in mice: it may provide a new therapy for acute pancreatitis.

Journal: The Journal of pharmacology and experimental therapeutics 20090101

Title: Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury.

Journal: Hepatology (Baltimore, Md.) 20090101

Title: Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats.

Journal: Clinics (Sao Paulo, Brazil) 20081201

Title: C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice.

Journal: Gastroenterology 20080901

Title: Bone marrow cells play only a very minor role in chronic liver regeneration induced by a choline-deficient, ethionine-supplemented diet.

Journal: Stem cell research 20080901

Title: Total glutathione and glutathione reductase in bovine erythrocytes and liver biopsy.

Journal: The Journal of veterinary medical science 20080801

Title: X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima.

Journal: The Journal of biological chemistry 20080704

Title: Random mutagenesis and recombination of sam1 gene by integrating error-prone PCR with staggered extension process.

Journal: Biotechnology letters 20080701

Title: Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model.

Journal: Carcinogenesis 20080201

Title: Misincorporation of amino acid analogues into proteins by biosynthesis.

Journal: The international journal of biochemistry & cell biology 20080101

Title: Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice.

Journal: Laboratory investigation; a journal of technical methods and pathology 20071201

Title: Analysis of time-related metabolic fluctuations induced by ethionine in the rat.

Journal: Journal of proteome research 20071201

Title: The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

Journal: The Journal of biological chemistry 20070824

Title: Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury.

Journal: British journal of pharmacology 20070801

Title: 6His-Eco29kI methyltransferase methylation site and kinetic mechanism characterization.

Journal: Biochimica et biophysica acta 20070801

Title: Characteristics of methionine production by an engineered Corynebacterium glutamicum strain.

Journal: Metabolic engineering 20070701

Title: Silencing MAT2A gene by RNA interference inhibited cell growth and induced apoptosis in human hepatoma cells.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20070501

Title: Hepatotoxin-induced hypertyrosinemia and its toxicological significance.

Journal: Archives of toxicology 20070301

Title: Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal: Plant & cell physiology 20070201

Title: Different effects of sulfur amino acids on prolidase and prolinase activity in normal and prolidase-deficient human erythrocytes.

Journal: Clinica chimica acta; international journal of clinical chemistry 20070101

Title: Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice.

Journal: Journal of hepatology 20070101

Title: Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet.

Journal: The international journal of biochemistry & cell biology 20070101

Title: An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated.

Journal: BMC molecular biology 20070101

Title: Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis.

Journal: Pancreas 20061001

Title: Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor.

Journal: Carcinogenesis 20060801

Title: Integrity of the methylation cycle is essential for mammalian neural tube closure.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20060701

Title: Natural and directed biosynthesis of communesin alkaloids.

Journal: Phytochemistry 20060301

Title: Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: Effect of amino acids containing sulfur on dithiolopyrrolone antibiotic productions by Saccharothrix algeriensis NRRL B-24137.

Journal: Journal of applied microbiology 20060201

Title: S-adenosyl methionine: A connection between nutritional and genetic risk factors for neurodegeneration in Alzheimer's disease.

Journal: The journal of nutrition, health & aging 20060101

Title: Harnessing natural diversity to probe metabolic pathways.

Journal: PLoS genetics 20051201

Title: Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis.

Journal: European journal of pharmacology 20051003

Title: Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.

Journal: Carcinogenesis 20051001

Title: Regional differences in gastrointestinal motility disturbances during acute necrotising pancreatitis.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20051001

Title: Single-gene knockout of a novel regulatory element confers ethionine resistance and elevates methionine production in Corynebacterium glutamicum.

Journal: Applied microbiology and biotechnology 20050801

Title: Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury.

Journal: Immunology and cell biology 20050801

Title: Natural disruption of group 2 phospholipase A2 gene protects against choline-deficient ethionine-supplemented diet-induced acute pancreatitis and lung injury.

Journal: Pancreas 20050701

Title: Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture.

Journal: Experimental cell research 20050515

Title: Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury.

Journal: Hepatology (Baltimore, Md.) 20050201

Title: TNF/LTalpha double knockout mice display abnormal inflammatory and regenerative responses to acute and chronic liver injury.

Journal: Cell and tissue research 20050101

Title: In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid.

Journal: Journal of medicinal food 20050101

Title: Selection and characterization of L-ethionine resistant mutants of Trichosporon cutaneum.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101

Title: Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis.

Journal: The American journal of pathology 20041201

Title: [Animal experimental models for acute pancreatitis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041101

Title: Decreases in serum apolipoprotein C-III concentration in cows with ethionine-induced fatty liver.

Journal: The Journal of veterinary medical science 20040901

Title: Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis (2-oxopropyl)amine in hamsters by esculetin and esculin.

Journal: Free radical research 20040801

Title: Protective effect of soybean against hepatocarcinogenesis induced by DL-ethionine.

Journal: Journal of biochemistry and molecular biology 20040531

Title: Gene expression profiles in liver regeneration with oval cell induction.

Journal: Biochemical and biophysical research communications 20040430

Title: Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers.

Journal: Cell proliferation 20040401

Title: Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation.

Journal: Journal of cell science 20040401

Title: Direct effects of interleukin-6 on liver progenitor oval cells in culture.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101

Title: Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine.

Journal: Journal of agricultural and food chemistry 20030910

Title: Cellular proliferation in the canine pancreas after d,l-ethionine dosage as detected by double immunohistochemical labelling.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030901

Title: S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030601

Title: Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese.

Journal: Biochemistry 20030506

Title: An hypothesis for a mechanism underlying hepatotoxin-induced hypercreatinuria.

Journal: Archives of toxicology 20030401

Title: Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis.

Journal: Gastroenterology 20030301

Title: Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis.

Journal: Surgery 20030201

Title: Pancreatic concentrations of cefepime in experimental necrotizing pancreatitis.

Journal: Journal of chemotherapy (Florence, Italy) 20030201

Title: Role of S-adenosylmethionine in two experimental models of pancreatitis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030101

Title: Effect of IS-741 on ethionine-induced acute pancreatitis in rats: relation to pancreatic acinar cell regeneration.

Journal: Journal of gastroenterology 20030101

Title: Pancreatic regeneration after ethionine-induced acute pancreatitis in rats lacking pancreatic CCK-A receptor gene expression.

Journal: Journal of gastroenterology 20030101

Title: Translational initiation regulators are hypophosphorylated in rat liver during ethionine-mediated ATP depletion.

Journal: Biochemical and biophysical research communications 20021025

Title: Ethanol interactions with a choline-deficient, ethionine-supplemented feeding regime potentiate pre-neoplastic cellular alterations in rat liver.

Journal: Carcinogenesis 20021001

Title: Identification of a short highly conserved amino acid sequence as the functional region required for posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis.

Journal: The Journal of biological chemistry 20020927

Title: Isolation, cloning and expression of a multifunctional O-methyltransferase capable of forming 2,5-dimethyl-4-methoxy-3(2H)-furanone, one of the key aroma compounds in strawberry fruits.

Journal: The Plant journal : for cell and molecular biology 20020901

Title: Effect of d,l-ethionine administration on the histomorphology of canine pancreatic acinar and beta-cells.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20020801

Title: A single-nucleotide mutation in a gene encoding S-adenosylmethionine synthetase is associated with methionine over-accumulation phenotype in Arabidopsis thaliana.

Journal: Genes & genetic systems 20020401

Title: Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma.

Journal: Carcinogenesis 20020301

Title: Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides.

Journal: The Journal of biological chemistry 20020111

Title: Constitutive overexpression of cystathionine gamma-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine.

Journal: Plant physiology 20020101

Title: Evaluation of d,l-ethionine as a mechanism for pancreatic islet regeneration in dogs.

Journal: Australian veterinary journal 20020101

Title: Methionine depletion induces transcription of the mRNA (N6-adenosine)methyltransferase.

Journal: The international journal of biochemistry & cell biology 20011101

Title: Methylation is involved in the Ustilago maydis mating response.

Journal: Fungal genetics and biology : FG & B 20011001

Title: A modified choline-deficient, ethionine-supplemented diet protocol effectively induces oval cells in mouse liver.

Journal: Hepatology (Baltimore, Md.) 20010901

Title: Adenoviral delivery of human and viral IL-10 in murine sepsis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010715

Title: Biosynthesis of diaporthin and orthosporin by Aspergillus ochraceus.

Journal: Phytochemistry 20010501

Title: Evaluation of lysine and methionine production in some Lactobacilli and yeasts from ogi.

Journal: International journal of food microbiology 20010122

Title: Methionine deprivation and methionine analogs inhibit cell proliferation and growth of human xenografted gliomas.

Journal: Life sciences 19970101

Title: 13-cis-retinoic acid and hepatic steatosis in rats.

Journal: Biochemical pharmacology 19930720

Title: Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.

Journal: Pancreas 19910501

Title: Correlation between medium-term liver bioassay system data and results of long-term testing in rats.

Journal: Carcinogenesis 19900401

Title: Hepatic levels of cytosolic, microsomal and 'mitochondrial' epoxide hydrolases and other drug-metabolizing enzymes after treatment of mice with various xenobiotics and endogenous compounds.

Journal: Chemico-biological interactions 19870101

Title: Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.

Journal: Environmental health perspectives 19830401

Title: Increased alpha1-fetoprotein production in rat liver injuries induced by various hepatotoxins.

Journal: Gan 19760401

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Tags:13073-35-3 Molecular Formula|13073-35-3 MDL|13073-35-3 SMILES|13073-35-3 L-Ethionine