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Home Amines 1310746-10-1
1310746-10-1,MFCD26960938
Catalog No.:AA000VEV

1310746-10-1 | Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, phosphate (1:1)

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Purity
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Price(USD)
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5mg
99%
in stock  
$234.00   $164.00
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25mg
99%
in stock  
$647.00   $453.00
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  • Technical Information
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Technical Information
Catalog Number:
AA000VEV
Chemical Name:
Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, phosphate (1:1)
CAS Number:
1310746-10-1
Molecular Formula:
C26H34Cl2N7O7P
Molecular Weight:
658.4706
MDL Number:
MFCD26960938
SMILES:
OP(=O)(O)O.CCN1CCN(CC1)c1ccc(cc1)Nc1ncnc(c1)N(C(=O)Nc1c(Cl)c(OC)cc(c1Cl)OC)C
Properties
Computed Properties
 
Complexity:
773  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
8  

Literature

Title: Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Journal: Journal of medicinal chemistry 20111027

Title: Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6--(4-ethyl-piperazin-1-yl)-phenylamino-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T

Title: Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42.

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Tags:1310746-10-1 Molecular Formula|1310746-10-1 MDL|1310746-10-1 SMILES|1310746-10-1 Urea, N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-, phosphate (1:1)