+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 1269440-17-6
1269440-17-6,MFCD25976758
Catalog No.:AA000WCF

1269440-17-6 | Lgx818

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$100.00   $70.00
- +
5mg
98%
in stock  
$132.00   $93.00
- +
25mg
98%
in stock  
$339.00   $237.00
- +
100mg
98%
in stock  
$902.00   $632.00
- +
250mg
95%
in stock  
$1,635.00   $1,144.00
- +
1g
98%
in stock  
$3,124.00   $2,187.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000WCF
Chemical Name:
Lgx818
CAS Number:
1269440-17-6
Molecular Formula:
C22H27ClFN7O4S
Molecular Weight:
540.0107
MDL Number:
MFCD25976758
SMILES:
COC(=O)N[C@H](CNc1nccc(n1)c1cn(nc1c1cc(Cl)cc(c1F)NS(=O)(=O)C)C(C)C)C
Properties
Computed Properties
 
Complexity:
836  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
2.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1Locationinpatent:Page/Pagecolumn58-59

[1]Patent:WO2011/25927,2011,A1

[2]Patent:WO2011/25927,2011,A1

[1]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1

[2]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1

[3]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1

[4]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1

[1]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1

[1]CurrentPatentAssignee:PFIZERINC-WO2011/25927,2011,A1

Literature

Title: Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.

Journal: The Lancet. Oncology 20180501

Title: Compounds and compositions as protein kinase inhibitors . Patent WO 2011025927 A1

Title: Li Z, et al. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370(2):332-44.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1269440-17-6
Building Blocks
More >
Tags:1269440-17-6 Molecular Formula|1269440-17-6 MDL|1269440-17-6 SMILES|1269440-17-6 Lgx818