Title: An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170401
Title: Plasticizer DBP Activates NLRP3 Inflammasome through the P2X7 Receptor in HepG2 and L02 Cells.
Journal: Journal of biochemical and molecular toxicology 20160401
Title: Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Journal: Toxicology and applied pharmacology 20150915
Title: Involvement of CaM-CaMKII-ERK in bisphenol A-induced Sertoli cell apoptosis.
Journal: Toxicology 20141003
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Neuroprotective effect of resveratrol on ischemia/reperfusion injury in rats through TRPC6/CREB pathways.
Journal: Journal of molecular neuroscience : MN 20130701
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: a distinct target in the calcium dependent pathway.
Journal: Molecular immunology 20120901
Title: NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.
Journal: American journal of physiology. Cell physiology 20120801
Title: Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells.
Journal: Neurochemical research 20120601
Title: Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X(7) receptor antagonists.
Journal: Journal of medicinal chemistry 20120426
Title: Purinergic P2X7 receptors participate in disturbed intracellular calcium homeostasis in peripheral blood mononuclear cells of patients with chronic kidney disease.
Journal: Kidney & blood pressure research 20120101
Title: The affinity of histamine for Gq protein-coupled histamine H(1)-receptors is predominantly regulated by their internalization in human astrocytoma cells.
Journal: Journal of pharmacological sciences 20120101
Title: Exocrine pancreatic carcinogenesis and autotaxin expression.
Journal: PloS one 20120101
Title: Adipocyte P2X7 receptors expression: a role in modulating inflammatory response in subjects with metabolic syndrome?
Journal: Atherosclerosis 20111201
Title: CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116
Title: Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Journal: British journal of pharmacology 20110901
Title: Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes.
Journal: Neuropharmacology 20110601
Title: NMDA preconditioning protects against quinolinic acid-induced seizures via PKA, PI3K and MAPK/ERK signaling pathways.
Journal: Behavioural brain research 20110516
Title: TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.
Journal: Biochemical and biophysical research communications 20110506
Title: Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists.
Journal: Toxicology and applied pharmacology 20110415
Title: Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.
Journal: Biochemical and biophysical research communications 20110408
Title: LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.
Journal: Journal of neurochemistry 20110201
Title: Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
Journal: The Journal of endocrinology 20110101
Title: 4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca2+]i through P2X7 receptor pathway.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Title: Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes.
Journal: Cell biology international 20101201
Title: Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow.
Journal: American journal of physiology. Cell physiology 20101201
Title: TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes.
Journal: Biochimica et biophysica acta 20101101
Title: Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.
Journal: Bulletin of experimental biology and medicine 20100801
Title: Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
Journal: Synapse (New York, N.Y.) 20100501
Title: Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.
Journal: American journal of physiology. Cell physiology 20100301
Title: Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100106
Title: Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice.
Journal: Physiological research 20100101
Title: Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.
Journal: PloS one 20100101
Title: Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.
Journal: BMC systems biology 20100101
Title: Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20091101
Title: Acetylcholine rescues two-cell block through activation of IP3 receptors and Ca2+/calmodulin-dependent kinase II in an ICR mouse strain.
Journal: Pflugers Archiv : European journal of physiology 20091001
Title: Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.
Journal: Acta pharmacologica Sinica 20091001
Title: Role of calcineurin-mediated dephosphorylation in modulation of an inwardly rectifying K+ channel in human proximal tubule cells.
Journal: The Journal of membrane biology 20091001
Title: A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.
Journal: American journal of physiology. Endocrinology and metabolism 20090901
Title: A role for calcium-calmodulin-dependent protein kinase II in the consolidation of visual object recognition memory.
Journal: The European journal of neuroscience 20090901
Title: P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.
Journal: The Journal of biological chemistry 20090821
Title: Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
Journal: Bioorganic & medicinal chemistry 20090715
Title: Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P.
Journal: FEBS letters 20090618
Title: Expression of the dominant-negative tail of myosin Va enhances exocytosis of large dense core vesicles in neurons.
Journal: Cellular and molecular neurobiology 20090601
Title: Antagonists of the P2X(7) receptor. From lead identification to drug development.
Journal: Journal of medicinal chemistry 20090528
Title: Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells.
Journal: Toxicology and applied pharmacology 20090515
Title: The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent.
Journal: Acta biochimica et biophysica Sinica 20090501
Title: Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.
Journal: Glia 20090415
Title: Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20090201
Title: Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.
Journal: Journal of medicinal chemistry 20081225
Title: Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity.
Journal: Neuron 20081210
Title: Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.
Journal: British journal of pharmacology 20081101
Title: CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes.
Journal: Cell metabolism 20081101
Title: P2X7 receptor-Pannexin1 complex: pharmacology and signaling.
Journal: American journal of physiology. Cell physiology 20080901
Title: Silencing-induced metaplasticity in hippocampal cultured neurons.
Journal: Journal of neurophysiology 20080801
Title: Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]i is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells.
Journal: The journal of physiological sciences : JPS 20080601
Title: [Effects of chronic hypoxia on the expression of calmodulin and calcicum/calmodulin-dependent protein kinase II and the calcium activity in myocardial cells in young rats].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20080601
Title: Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501
Title: Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs.
Journal: Current neurovascular research 20080501
Title: Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway.
Journal: Journal of neurochemistry 20080301
Title: A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis.
Journal: The Journal of biological chemistry 20080208
Title: Role for calcium in the development of ovarial patency in Heliothis virescens.
Journal: Journal of insect physiology 20080201
Title: Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.
Journal: British journal of pharmacology 20080201
Title: Negative and positive allosteric modulators of the P2X(7) receptor.
Journal: British journal of pharmacology 20080201
Title: Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor.
Journal: Bioorganic & medicinal chemistry letters 20080115
Title: Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors.
Journal: The Journal of biological chemistry 20071228
Title: Functional expression of ionotropic purinergic receptors on mouse taste bud cells.
Journal: The Journal of physiology 20071015
Title: Behavioral modulation of neuronal calcium/calmodulin-dependent protein kinase II activity: differential effects on nicotine-induced spinal and supraspinal antinociception in mice.
Journal: Biochemical pharmacology 20071015
Title: Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells.
Journal: Cellular signalling 20071001
Title: Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).
Journal: Journal of cellular physiology 20070901
Title: A quantitative method for routine measurement of cell surface P2X7 receptor function in leucocyte subsets by two-colour time-resolved flow cytometry.
Journal: Journal of immunological methods 20070831
Title: Hepatocyte growth factor-induced enhancement of dendritic branching is blocked by inhibitors of N-methyl-D-aspartate receptors and calcium/calmodulin-dependent kinases.
Journal: Journal of neuroscience research 20070815
Title: From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.
Journal: Journal of medicinal chemistry 20070726
Title: KN-62 analogues as potent differentiating agents of HL-60 cells.
Journal: Leukemia research 20070501
Title: Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.
Journal: American journal of physiology. Renal physiology 20070501
Title: CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.
Journal: The Journal of clinical investigation 20070501
Title: Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter.
Journal: The Journal of endocrinology 20070501
Title: Calcium signalling in the regulation of PGC-1alpha, PDK4 and HKII mRNA expression.
Journal: Biological chemistry 20070501
Title: Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.
Journal: Journal of neurophysiology 20070301
Title: The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function.
Journal: Neuroscience 20070209
Title: Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070201
Title: Microarray-based kinase inhibition assay by gold nanoparticle probes.
Journal: Analytical chemistry 20070115
Title: Stimulation of fibroblast proliferation by neokyotorphin requires Ca influx and activation of PKA, CaMK II and MAPK/ERK.
Journal: The FEBS journal 20070101
Title: Life and death in bovine monocytes: the fate of Mycobacterium avium subsp. paratuberculosis.
Journal: Microbial pathogenesis 20070101
Title: The retinoic acid receptor/CaMKII interaction: pharmacologic inhibition of CaMKII enhances the differentiation of myeloid leukemia cells.
Journal: Blood cells, molecules & diseases 20070101
Title: Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy.
Journal: Journal of cardiovascular pharmacology 20060701
Title: Modulation by LL-37 of the responses of salivary glands to purinergic agonists.
Journal: Molecular pharmacology 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Activation of P2Y1 receptor triggers two calcium signaling pathways in bone marrow erythroblasts.
Journal: European journal of pharmacology 20060318
Title: Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells.
Journal: The Journal of physiology 20060315
Title: Internalization and desensitization of a green fluorescent protein-tagged P2Y nucleotide receptor are differently controlled by inhibition of calmodulin-dependent protein kinase II.
Journal: Journal of neurochemistry 20060201
Title: Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
Title: Cocaine inhibition of GABA(A) current: role of dephosphorylation.
Journal: Critical reviews in neurobiology 20060101
Title: Modulation of intracellular Ca2+ release and capacitative Ca2+ entry by CaMKII inhibitors in bovine vascular endothelial cells.
Journal: American journal of physiology. Cell physiology 20051201
Title: N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts.
Journal: Journal of biomedical science 20051201
Title: Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20051101
Title: Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus.
Journal: Brain research. Molecular brain research 20051031
Title: Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin.
Journal: Molecular endocrinology (Baltimore, Md.) 20050901
Title: Human melanomas express functional P2 X(7) receptors.
Journal: Cell and tissue research 20050901
Title: Human epidermal and monocyte-derived langerhans cells express functional P2X receptors.
Journal: The Journal of investigative dermatology 20050901
Title: Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713
Title: Effects of 17beta-estradiol on chemically induced long-term depression.
Journal: Neuropharmacology 20050701
Title: Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.
Journal: The Journal of biological chemistry 20050610
Title: The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
Journal: British journal of pharmacology 20050601
Title: Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition.
Journal: Hepatology (Baltimore, Md.) 20050601
Title: Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.
Journal: Neuron 20050519
Title: Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.
Journal: Journal of neurochemistry 20050401
Title: Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216
Title: Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.
Journal: The European journal of neuroscience 20050201
Title: Heterologous desensitization of insulin secretion by GIP (glucose-dependent insulinotropic peptide) in INS-1 cells: the significance of Galphai2 and investigations on the mechanism involved.
Journal: Cell biochemistry and function 20050101
Title: Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor.
Journal: The Journal of biological chemistry 20041210
Title: AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.
Journal: Diabetes 20041201
Title: Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4.
Journal: Journal of medical microbiology 20041201
Title: Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor.
Journal: The Journal of biological chemistry 20041022
Title: Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones.
Journal: British journal of pharmacology 20041001
Title: Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040701
Title: Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.
Journal: British journal of pharmacology 20040701
Title: Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus.
Journal: Peptides 20040701
Title: KN-62, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase II, inhibits the lysozyme pre-mRNA splicing in myelomonocytic HD11 cells.
Journal: Biochemical and biophysical research communications 20040625
Title: Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei.
Journal: Neurochemistry international 20040601
Title: Brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus.
Journal: Acta pharmacologica Sinica 20040501
Title: A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040415
Title: Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Journal: Journal of cellular biochemistry 20040401
Title: Pavlovian fear conditioning regulates Thr286 autophosphorylation of Ca2+/calmodulin-dependent protein kinase II at lateral amygdala synapses.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331
Title: Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions.
Journal: Diabetes 20040201
Title: Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells.
Journal: Journal of molecular endocrinology 20040201
Title: Competitive binding of postsynaptic density 95 and Ca2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain.
Journal: Acta pharmacologica Sinica 20040201
Title: A role for calcium/calmodulin kinase in insulin stimulated glucose transport.
Journal: Life sciences 20040102
Title: NMDA receptor-mediated immediate Ser831 phosphorylation of GluR1 through CaMKIIalpha in rat hippocampus during early global ischemia.
Journal: Neuroscience research 20040101
Title: Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy.
Journal: Oncology research 20040101
Title: Agonists and antagonists acting at P2X7 receptor.
Journal: Current topics in medicinal chemistry 20040101
Title: Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors.
Journal: Current topics in medicinal chemistry 20040101
Title: Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide.
Journal: European journal of pharmacology 20031215
Title: Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20031117
Title: Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
Journal: Journal of neurochemistry 20031101
Title: Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.
Journal: Neuroscience letters 20031009
Title: Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor.
Journal: The Journal of physiology 20030901
Title: Beta-adrenergic stimulation induces cardiac ankyrin repeat protein expression: involvement of protein kinase A and calmodulin-dependent kinase.
Journal: Cardiovascular research 20030901
Title: Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Journal: Brain research. Molecular brain research 20030723
Title: Regulation of ERK phosphorylation by ethanol in fetal cortical neurons.
Journal: Neurochemical research 20030501
Title: Ca2+/calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons.
Journal: Journal of neuroscience research 20030415
Title: Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.
Journal: Journal of medicinal chemistry 20030410
Title: Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II.
Journal: Circulation 20030325
Title: Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.
Journal: Neuropharmacology 20030301
Title: Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.
Journal: Brain research 20030207
Title: The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.
Journal: Archives of biochemistry and biophysics 20030101
Title: Formation of AP-1 transcription factors during learning in Helix.
Journal: Neuroscience and behavioral physiology 20030101
Title: A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Journal: Neuroscience 20030101
Title: c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis.
Journal: Anticancer research 20030101
Title: Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.
Journal: The Journal of biological chemistry 20021122
Title: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.
Journal: European journal of biochemistry 20021001
Title: Postsynaptic kinase signaling underlies inhibitory synaptic plasticity in the lateral superior olive.
Journal: Journal of neurobiology 20021001
Title: KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection.
Journal: FEMS microbiology letters 20020924
Title: Purine and pyrimidine (P2) receptors as drug targets.
Journal: Journal of medicinal chemistry 20020912
Title: Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Journal: The Journal of endocrinology 20020801
Title: Ca(2+)/calmodulin-dependent protein kinase (CaM-kinase) inhibitor KN-62 suppresses the activity of mitogen-activated protein kinase (MAPK), c-myc activation and human keratinocyte proliferation.
Journal: Archives of dermatological research 20020701
Title: CaMKII regulates amphetamine-induced ERK1/2 phosphorylation in striatal neurons.
Journal: Neuroreport 20020612
Title: CaMKII is activated and translocated to the secretory apical membrane during cholinergically conveyed gastric acid secretion.
Journal: Cellular signalling 20020201
Title: Pharmacological characterization of the P2X(7) receptor on human macrophages using the patch-clamp technique.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020201
Title: Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells.
Journal: Journal of andrology 20020101
Title: Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety.
Journal: Arzneimittel-Forschung 20020101
Title: Effects of calcium, calmodulin, protein kinase C and protein tyrosine kinases on volume-activated taurine efflux in human erythroleukemia cells.
Journal: Journal of cellular physiology 20011201
Title: Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons.
Journal: Endocrine 20011101
Title: Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.
Journal: European journal of pharmacology 20010907
Title: Functional characterization of P2Y and P2X receptors in human eosinophils.
Journal: Journal of cellular physiology 20010901
Title: P2Y(11) receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors.
Journal: European journal of pharmacology 20010831
Title: Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons).
Journal: Molecular pharmacology 20010701
Title: Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling.
Journal: Journal of neurochemistry 20010701
Title: Histamine production by cultured microglial cells of the mouse.
Journal: Neuroscience letters 20010615
Title: Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Journal: Brain research 20010608
Title: CAMKII inhibition in the parabrachial nuclei elicits conditioned taste aversion in rats.
Journal: Neurobiology of learning and memory 20010501
Title: Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (rapamycin and FK506) and calcium/calmodulin-dependent kinase inhibitors.
Journal: Experimental hematology 20010501
Title: Complexities of measuring antagonist potency at P2X(7) receptor orthologs.
Journal: The Journal of pharmacology and experimental therapeutics 20010301
Title: Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Journal: Journal of neurochemistry 20010301
Title: The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
Journal: Molecular and cellular endocrinology 20010227
Title: Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
Journal: FEBS letters 20010209
Title: The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Journal: Oncogene 20010111
Title: Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Journal: Neurochemistry international 20010101
Title: Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells.
Journal: American journal of physiology. Cell physiology 20010101
Title: A proposed mechanism for the potentiation of cAMP-mediated acid secretion by carbachol.
Journal: American journal of physiology. Cell physiology 20010101
Title: Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin-dependent enzymes.
Journal: Biochemical pharmacology 20010101
Title: Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats.
Journal: Circulation research 20001110
Title: Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.
Journal: Molecular endocrinology (Baltimore, Md.) 20001101
Title: Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Journal: The Biochemical journal 20001001
Title: Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20000411
Title: MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells.
Journal: Biochemical and biophysical research communications 19990624
Title: Effects of antagonists at the human recombinant P2X7 receptor.
Journal: British journal of pharmacology 19980701
Title: Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse.
Journal: The Journal of pharmacology and experimental therapeutics 19970801
Title: The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes.
Journal: British journal of pharmacology 19970401
Title: Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.
Journal: Research in virology 19970101
Title: KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Journal: The Journal of biological chemistry 19900315
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