[1]Patent:US2014/308235,2014,A1.Locationinpatent:Paragraph0362;0363
[2]Patent:US9320805,2016,B2.Locationinpatent:Page/Pagecolumn63-64
[3]Patent:US2017/258925,2017,A1.Locationinpatent:Paragraph0226;0227
Title: Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
Journal: Journal of medicinal chemistry 20130523
Title: The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice.
Journal: Obesity (Silver Spring, Md.) 20121001
Title: Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.
Journal: Chemistry & biology 20111028
Title: Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors.
Journal: Bioorganic & medicinal chemistry 20111015
Title: Temporal changes in microvessel leakiness during wound healing discriminated by in vivo fluorescence recovery after photobleaching.
Journal: The Journal of physiology 20111001
Title: Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts.
Journal: Cancer science 20110801
Title: Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances.
Journal: Biomaterials 20110701
Title: Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.
Journal: European journal of medicinal chemistry 20110401
Title: Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis.
Journal: The American journal of pathology 20110401
Title: Effect of nitroxoline on angiogenesis and growth of human bladder cancer.
Journal: Journal of the National Cancer Institute 20101215
Title: Inhibitory effects of TNP-470 in combination with BCNU on tumor growth of human glioblastoma xenografts.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20101201
Title: Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides.
Journal: The Journal of pharmacology and experimental therapeutics 20100901
Title: Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells.
Journal: European journal of medicinal chemistry 20100601
Title: An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.
Journal: Biochemical and biophysical research communications 20100108
Title: Broad spectrum antiangiogenic treatment for ocular neovascular diseases.
Journal: PloS one 20100101
Title: Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470.
Journal: Molecular and biochemical parasitology 20091201
Title: Antiparasitic activities of novel, orally available fumagillin analogs.
Journal: Bioorganic & medicinal chemistry letters 20090901
Title: Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin4.5, induces fetal microphthalmia.
Journal: Molecular vision 20090101
Title: TX-2152: a conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity.
Journal: Bioorganic & medicinal chemistry 20080815
Title: An orally delivered small-molecule formulation with antiangiogenic and anticancer activity.
Journal: Nature biotechnology 20080701
Title: Anti-tumor effect of angiogenesis inhibitor TNP-470 and 5-FU combined therapy on human gastric cancer xenograft.
Journal: Hepato-gastroenterology 20080101
Title: The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumor angiogenesis.
Journal: Anticancer research 20080101
Title: Judah Folkman's contribution to the inhibition of angiogenesis.
Journal: Lymphatic research and biology 20080101
Title: Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.
Journal: Cancer research 20071001
Title: Changes in the antioxidant system by TNP-470 in an in vivo model of hepatocarcinoma.
Journal: Translational research : the journal of laboratory and clinical medicine 20070901
Title: Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Journal: Journal of medicinal chemistry 20070809
Title: Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters.
Journal: Archivum immunologiae et therapiae experimentalis 20070801
Title: Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis.
Journal: Nature clinical practice. Rheumatology 20070801
Title: Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors.
Journal: Expert review of anti-infective therapy 20070801
Title: Antitumor effect of TNP-470, an angiogenesis inhibitor, combined with ultrasound irradiation for human uterine sarcoma xenografts evaluated using contrast color Doppler ultrasound.
Journal: Cancer science 20070601
Title: Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer.
Journal: Molecular cancer therapeutics 20070401
Title: Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732.
Journal: Journal of molecular endocrinology 20070401
Title: Genetic analysis of high-metastatic clone of RCT sarcoma in mice, and its growth regression in vivo in response to angiogenesis inhibitor TNP-470.
Journal: Journal of experimental & clinical cancer research : CR 20070301
Title: Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism.
Journal: Translational research : the journal of laboratory and clinical medicine 20070101
Title: Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in combination with gemcitabine.
Journal: Journal of Zhejiang University. Science. B 20061001
Title: Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo.
Journal: Journal of medicinal chemistry 20060921
Title: A noncanonical path to mechanism of action.
Journal: Chemistry & biology 20060901
Title: A chemical and genetic approach to the mode of action of fumagillin.
Journal: Chemistry & biology 20060901
Title: Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.
Journal: FEBS letters 20060515
Title: TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells.
Journal: Biochemical and biophysical research communications 20060303
Title: Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470.
Journal: Asian Pacific journal of cancer prevention : APJCP 20060101
Title: The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470.
Journal: Cellular & molecular biology letters 20060101
Title: Combination therapy with tumor-lysate pulsed dendritic cells and antiangiogenic drug TNP-470 for mouse pancreatic cancer.
Journal: International journal of cancer 20051110
Title: Antiangiogenic drugs for chemotherapy of bladder tumours.
Journal: Chemotherapy 20051001
Title: A novel mechanism of action of the fumagillin analog, TNP-470, in the B16F10 murine melanoma cell line.
Journal: Anti-cancer drugs 20050901
Title: Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol.
Journal: Bioorganic & medicinal chemistry letters 20050801
Title: Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050801
Title: Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model.
Journal: International journal of cancer 20050310
Title: Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and docetaxel in a human prostate cancer PC-3 model.
Journal: International journal of oncology 20050301
Title: Antiangiogenic strategies in neuroblastoma.
Journal: Cancer treatment reviews 20050201
Title: Inhibition of tumor angiogenesis during cisplatin chemotherapy for bladder cancer improves treatment outcome.
Journal: Urology 20050201
Title: Acceleration of follicular development by administration of vascular endothelial growth factor in cycling female rats.
Journal: The Journal of reproduction and development 20050201
Title: Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice.
Journal: World journal of gastroenterology 20050121
Title: Roxithromycin inhibits angiogenesis of human hepatoma cells in vivo by suppressing VEGF production.
Journal: Anticancer research 20050101
Title: Pharmacokinetic model-predicted anticancer drug concentrations in human tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041201
Title: TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy.
Journal: Transplantation 20041027
Title: Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KoTCC-1 model.
Journal: The Journal of urology 20041001
Title: TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model.
Journal: Kidney international 20041001
Title: Participation of cyclin D1 deregulation in TNP-470-mediated cytostatic effect: involvement of senescence.
Journal: Biochemical pharmacology 20040815
Title: Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.
Journal: Circulation research 20040625
Title: A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells.
Journal: Oncology reports 20040501
Title: A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases.
Journal: The Journal of biological chemistry 20040305
Title: Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.
Journal: Nature medicine 20040301
Title: TNP-470 promotes initial vascular sprouting in xenograft tumors.
Journal: Molecular cancer therapeutics 20040301
Title: cis-Diamminedichloroplatinum-resistant cell lines derived from human epithelial ovarian carcinoma express increased susceptibility to angiogenesis inhibitor TNP-470.
Journal: Gynecologic oncology 20040201
Title: Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs.
Journal: Archives of pharmacal research 20040201
Title: Carcinosarcoma-induced endothelial cells tube formation through KDR/Flk-1 is blocked by TNP-470.
Journal: Cancer letters 20040108
Title: Investigation of novel fumagillin analogues as angiogenesis inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20040105
Title: Angiogenesis inhibition by angiostatin, endostatin and TNP-470 prevents cyclophosphamide induced cystitis.
Journal: Angiogenesis 20040101
Title: Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).
Journal: Angiogenesis 20040101
Title: The combination of antiangiogenic and cytotoxic agents in the treatment of prostate cancer.
Journal: Clinical prostate cancer 20031201
Title: Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.
Journal: Cancer research 20031115
Title: [Systemic treatment for hepatocellular carcinoma].
Journal: Zentralblatt fur Chirurgie 20031101
Title: Changes in tumor vascularization after irradiation, anthracyclin, or antiangiogenic treatment in nitrosomethyl ureas-induced rat mammary tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
Title: Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin.
Journal: Cancer research 20031001
Title: Effects of angiogenesis inhibitor TNP-470 on the development of uterine adenomyosis in mice.
Journal: Fertility and sterility 20030901
Title: Homology modeling and calculation of the cobalt cluster charges of the Encephazlitozoon cuniculi methionine aminopeptidase, a potential target for drug design.
Journal: Biophysical chemistry 20030801
Title: TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma.
Journal: Free radical research 20030801
Title: Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth.
Journal: The Journal of clinical investigation 20030701
Title: TNP-470 inhibits 7,12-dimethylbenz[a]anthracene-induced mammary tumor formation when administered before the formation of carcinoma in situ but is not additive with tamoxifen.
Journal: Laboratory investigation; a journal of technical methods and pathology 20030701
Title: Angiogenesis inhibitor TNP-470 (AGM-1470) suppresses vascular smooth muscle cell proliferation after balloon injury in rats.
Journal: The Journal of surgical research 20030615
Title: 'Vasocrine' formation of tumor cell-lined vascular spaces: implications for rational design of antiangiogenic therapies.
Journal: Cancer research 20030601
Title: Effect of angiogenesis inhibitor TNP-470 on the growth, blood flow, and microvessel density in xenografts of human uterine carcinosarcoma in nude mice.
Journal: Gynecologic oncology 20030401
Title: Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma.
Journal: Pancreas 20030301
Title: Preparation of poly-lactic acid microspheres containing the angiogenesis inhibitor TNP-470 with medium-chain triglyceride and the in vitro evaluation of release profiles.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030301
Title: Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470.
Journal: Chirality 20030201
Title: In vivo chamber angiogenesis assay: an optimized Matrigel plug assay for fast assessment of anti-angiogenic activity.
Journal: International journal of oncology 20030201
Title: Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol] enhances its antitumor and antiangiogenic efficacies.
Journal: The Journal of pharmacology and experimental therapeutics 20030201
Title: Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030201
Title: [Inhibitory effects of TNP-470 in combination with 5-fluorouracil on growth of human colon cancer].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20021201
Title: [Experimental therapy with angiogenesis inhibitor TNP-470 on human ovarian cancer transplanted subcutaniously in nude mice].
Journal: Zhonghua fu chan ke za zhi 20020901
Title: Enhanced suppression of prostate tumor growth by combining C-CAM1 gene therapy and angiogenesis inhibitor TNP-470.
Journal: Anti-cancer drugs 20020801
Title: Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice.
Journal: Journal of cancer research and clinical oncology 20020801
Title: Angiogenesis inhibitors in lung cancer.
Journal: Current oncology reports 20020701
Title: Novel bicyclic oxazolone derivatives as anti-angiogenic agents.
Journal: Bioorganic & medicinal chemistry letters 20020603
Title: Angiogenesis in bladder cancer--prognostic marker and target for future therapy.
Journal: Surgical oncology 20020601
Title: Antitumor effect of TNP-470 is not associated to decrease of angiogenesis in an experimental malignant neuroectodermic tumor.
Journal: Journal of neuro-oncology 20020601
Title: CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogenic drugs.
Journal: Pediatric research 20020501
Title: Assay of TNP-470 and its two major metabolites in human plasma by high-performance liquid chromatography-mass spectrometry.
Journal: Journal of chromatographic science 20020401
Title: Injection of antiangiogenic agents into the macaque preovulatory follicle: disruption of corpus luteum development and function.
Journal: Endocrine 20020401
Title: Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.
Journal: Journal of biomedical science 20020101
Title: [Human microsporidiosis].
Journal: Klinische Padiatrie 20020101
Title: The role of growth factors, angiogenic enzymes and apoptosis in neovascularization and tumor growth-collected publications.
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20020101
Title: TNP-470 combined with nicardipine suppresses in vivo growth of PC-3, a human prostate cancer cell line.
Journal: Urologic oncology 20020101
Title: QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin analogues: another example of an allosteric interaction.
Journal: Bioorganic & medicinal chemistry 20011201
Title: TNP-470 reduces collagen and macrophage accumulation in expanded polytetrafluoroethylene tube implants.
Journal: The Journal of surgical research 20011101
Title: A potential use of a synthetic retinoid TAC-101 as an orally active agent that blocks angiogenesis in liver metastases of human stomach cancer cells.
Journal: Japanese journal of cancer research : Gann 20011101
Title: Drug targeting to choroidal neovascularization.
Journal: Advanced drug delivery reviews 20011031
Title: Inhibition of inflammatory corneal angiogenesis by TNP-470.
Journal: Investigative ophthalmology & visual science 20011001
Title: The inhibitory effects of TNP470 on tumour growth of head and neck carcinoma cell producing interleukin-8.
Journal: The Journal of laryngology and otology 20011001
Title: Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.
Journal: Cancer research 20010715
Title: Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010501
Title: General aspects of anti-angiogenesis and cancer therapy.
Journal: Expert opinion on biological therapy 20010301
Title: In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment.
Journal: International journal of radiation oncology, biology, physics 20010201
Title: Effect of TNP-470 (AGM-1470) on the growth of rat rhabdomyosarcoma tumors of different sizes.
Journal: Cancer investigation 20010101
Title: Regulation and action of angiogenic factors in the primate ovary.
Journal: Archives of medical research 20010101
Title: Treatment of tamoxifen-refractory breast cancer--approach by animal models.
Journal: Breast cancer (Tokyo, Japan) 20010101
Title: A re-evaluation of fumagillin selectivity towards endothelial cells.
Journal: Anticancer research 20010101
Title: Microsporidian methionine aminopeptidase type 2.
Journal: The Journal of eukaryotic microbiology 20010101
Title: In vitro and in vivo evaluation of aminopeptidase inhibitors as antimicrosporidial therapies.
Journal: The Journal of eukaryotic microbiology 20010101
Title: Antiangiogenic and antitumour effects in vivo of genistein applied alone or combined with cyclophosphamide.
Journal: Anticancer research 20010101
Title: Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
Journal: Cancer research 20000401
Title: TNP-470 is an effective antimicrosporidial agent.
Journal: The Journal of infectious diseases 19980201
Title: Screening of compounds for antimicrosporidial activity in vitro.
Journal: Folia parasitologica 19980101
Title: Effects of albendazole, fumagillin, and TNP-470 on microsporidial replication in vitro.
Journal: Antimicrobial agents and chemotherapy 19970701
Title: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.
Journal: Nature 19901206
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