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Home Other Building Blocks 1375465-91-0
1375465-91-0,MFCD28347706
Catalog No.:AA0013G5

1375465-91-0 | Acy-738

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
2mg
98%
in stock  
$21.00   $15.00
- +
1000mg
98% by HPLC
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0013G5
Chemical Name:
Acy-738
CAS Number:
1375465-91-0
Molecular Formula:
C14H14N4O2
Molecular Weight:
270.2866
MDL Number:
MFCD28347706
SMILES:
ONC(=O)c1cnc(nc1)NC1(CC1)c1ccccc1
Properties
Computed Properties
 
Complexity:
345  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
1.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2015/99744,2015,A1Locationinpatent:Paragraph0253

[2]CurrentPatentAssignee:DANA-FARBERCANCERINSTITUTE;BRISTOL-MYERSSQUIBBCO-US2015/105358,2015,A1Locationinpatent:Paragraph0413

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2015/105409,2015,A1Locationinpatent:Paragraph0221

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2015/105383,2015,A1Locationinpatent:Paragraph0233

[5]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2015/150871,2015,A1Locationinpatent:Paragraph0271

[6]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2016/7423,2016,A1Locationinpatent:Page/Pagecolumn42

[7]CurrentPatentAssignee:REGENACYPHARMACEUTICALSLLC-WO2016/90230,2016,A1Locationinpatent:Page/Pagecolumn20

[8]CurrentPatentAssignee:UNIVERSITYOFMODENAANDREGGIOEMILIA-WO2016/87950,2016,A1Locationinpatent:Page/Pagecolumn30

[9]CurrentPatentAssignee:REGENACYPHARMACEUTICALSLLC;BRISTOL-MYERSSQUIBBCO-US2017/114023,2017,A1Locationinpatent:Paragraph0117;0120

[10]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2017/143237,2017,A1Locationinpatent:Paragraph53;54

[11]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO;H.LEEMOFFITTCANCERCENTER&RESEARCHINSTITUTE-WO2017/184774,2017,A1Locationinpatent:Page/Pagecolumn48;49

[12]CurrentPatentAssignee:DANA-FARBERCANCERINSTITUTE-WO2017/214565,2017,A1Locationinpatent:Page/Pagecolumn38;39

Literature

Title: Jochems J, et al. Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability. Neuropsychopharmacology. 2014 Jan;39(2):389-400.

Title: Regna NL, et al. Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice. Clin Immunol. 2016 Jan;162:58-73.

Title: Mithraprabhu S, et al. Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC. Br J Haematol. 2013 Aug;162(4):559-62.

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SDS
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Tags:1375465-91-0 Molecular Formula|1375465-91-0 MDL|1375465-91-0 SMILES|1375465-91-0 Acy-738