Home Amines 1218942-37-0
1218942-37-0,MFCD27923122
Catalog No.:AA001697

1218942-37-0 | 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$7.00   $5.00
- +
5mg
97%
in stock  
$12.00   $8.00
- +
10mg
97%
in stock  
$16.00   $11.00
- +
100mg
97%
in stock  
$75.00   $53.00
- +
250mg
97%
in stock  
$126.00   $89.00
- +
1g
97%
in stock  
$341.00   $239.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001697
Chemical Name:
2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dione
CAS Number:
1218942-37-0
Molecular Formula:
C21H19ClN4O2
Molecular Weight:
394.8542
MDL Number:
MFCD27923122
SMILES:
Clc1ccccc1n1[nH]c2c(c1=O)c(c1cccc(c1)N(C)C)n(c(=O)c2)C
Properties
Computed Properties
 
Complexity:
732  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CALLIDITASTHERAPEUTICSAB-WO2016/189501,2016,A1Locationinpatent:Page/Pagecolumn19

Literature

Title: Dual oxidase: a novel therapeutic target in allergic disease.

Journal: British journal of pharmacology 20180501

Title: Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.

Journal: The Journal of pharmacology and experimental therapeutics 20150401

Title: Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.

Journal: Journal of neuroinflammation 20150101

Title: Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.

Journal: Hepatology (Baltimore, Md.) 20121201

Title: The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation.

Journal: American journal of respiratory cell and molecular biology 20121101

Title: Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

Journal: Free radical biology & medicine 20120715

Title: Aoyama T, et al. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec;56(6):2316-27.

Title: Green DE, et al. The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Am J Respir Cell Mol Biol. 2012 Nov;47(5):718-26.

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SDS
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Tags:1218942-37-0 Molecular Formula|1218942-37-0 MDL|1218942-37-0 SMILES|1218942-37-0 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1h-pyrazolo[4,3-c]pyridine-3,6(2h,5h)-dione