Home Amines 138470-70-9
138470-70-9,MFCD11111965
Catalog No.:AA00194Z

138470-70-9 | Benzamide, N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-, hydrochloride (1:1)

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00194Z
Chemical Name:
Benzamide, N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-, hydrochloride (1:1)
CAS Number:
138470-70-9
Molecular Formula:
C27H30ClN3O2
Molecular Weight:
463.9990
MDL Number:
MFCD11111965
SMILES:
O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C.Cl
Properties
Computed Properties
 
Complexity:
643  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  

Literature

Title: V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists.

Journal: The Journal of biological chemistry 20120113

Title: [Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20120101

Title: Vasotocin- and mesotocin-induced increases in short-circuit current across tree frog skin.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20110201

Title: Clinical implication of the antidiuretic hormone (ADH) receptor antagonist mozavaptan hydrochloride in patients with ectopic ADH syndrome.

Journal: Japanese journal of clinical oncology 20110101

Title: [Vasopressin receptor antagonists: the vaptans].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100501

Title: Effects of arginine vasotocin and mesotocin on the activation and development of amiloride-blockable short-circuit current across larval, adult, and cultured larval bullfrog skins.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100301

Title: Bumetanide-induced enlargement of the rat intrastrial space and effects of a vasopressin type 2 antagonist.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20100101

Title: Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist.

Journal: Acta oto-laryngologica 20090701

Title: Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090201

Title: Role of vasopressin antagonists.

Journal: Clinical journal of the American Society of Nephrology : CJASN 20080701

Title: Effects of hypertonic stimuli and arginine vasotocin (AVT) on water absorption response in Japanese treefrog, Hyla japonica.

Journal: General and comparative endocrinology 20080601

Title: Effects of arginine vasotocin and vasopressin receptor antagonists on Na+ and Cl- transport in the isolated skin of two frog species, Hyla japonica and Rana nigromaculata.

Journal: General and comparative endocrinology 20080515

Title: Inhibitory effect of vasopressin receptor antagonist OPC-31260 on experimental brain oedema induced by global cerebral ischaemia.

Journal: Acta neurochirurgica 20080301

Title: Prevention of hypoxic brain oedema by the administration of vasopressin receptor antagonist OPC-31260.

Journal: Progress in brain research 20080101

Title: Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway.

Journal: American journal of physiology. Renal physiology 20070801

Title: Biological half-life and organ distribution of [3H]8-arginine vasopressin following administration of vasopressin receptor antagonist OPC-31260.

Journal: Regulatory peptides 20070607

Title: Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070101

Title: Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells.

Journal: American journal of physiology. Cell physiology 20061001

Title: Hyponatremia in cirrhosis: clinical features and management.

Journal: Gastroenterologie clinique et biologique 20061001

Title: Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.

Journal: The American journal of medicine 20060701

Title: Molecular analysis of impaired urinary diluting capacity in glucocorticoid deficiency.

Journal: American journal of physiology. Renal physiology 20060501

Title: Effects of long-term oral treatment with selective vasopressin V2 receptor antagonist (OPC-31260) on adriamycin-induced heart failure in rats.

Journal: International journal of cardiology 20060404

Title: [Renal action of vasopressin].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060201

Title: BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats.

Journal: Kidney international 20050501

Title: Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

Journal: Journal of the American Society of Nephrology : JASN 20050401

Title: 2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20031117

Title: Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.

Journal: Clinical science (London, England : 1979) 20030701

Title: Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze.

Journal: Neuropharmacology 20030301

Title: Combined effects of vasopressin V2 receptor antagonist and loop diuretic in humans.

Journal: Clinical nephrology 20030301

Title: Vasopressin V(1) receptor-mediated activation of central sympatho-adrenomedullary outflow in rats.

Journal: European journal of pharmacology 20021213

Title: Adaptation to sustained high plasma vasopressin in water and electrolyte homeostasis in the rat transgenic for the metallothionein-vasopressin fusion gene.

Journal: The Journal of endocrinology 20020401

Title: Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure.

Journal: American journal of physiology. Renal physiology 20020201

Title: Role of sodium depletion in acute antidiuretic effect of bendroflumethiazide in rats with nephrogenic diabetes insipidus.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze.

Journal: European journal of pharmacology 20010907

Title: Vascular and renal effects of vasopressin and its antagonists in conscious rats with chronic myocardial infarction; evidence for receptor shift.

Journal: European journal of pharmacology 20010706

Title: Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells.

Journal: British journal of pharmacology 19981201

Title: Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist.

Journal: The Journal of clinical investigation 19961215

Title: Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist.

Journal: British journal of pharmacology 19920401

Title: Yamamura Y, et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. Br J Pharmacol. 1992 Apr;105(4):787-91.

Title: Yamaguchi K, et al. Clinical implication of the antidiuretic hormone (ADH) receptor antagonist mozavaptan hydrochloride in patients with ectopic ADH syndrome. Jpn J Clin Oncol. 2011 Jan;41(1):148-52.

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Tags:138470-70-9 Molecular Formula|138470-70-9 MDL|138470-70-9 SMILES|138470-70-9 Benzamide, N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-, hydrochloride (1:1)