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Home Other Building Blocks 1393477-72-9
1393477-72-9,MFCD27987944
Catalog No.:AA001APV

1393477-72-9 | Kpt-330

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$21.00   $15.00
- +
5mg
98%
in stock  
$47.00   $33.00
- +
100mg
95%
in stock  
$363.00   $254.00
- +
250mg
98%
in stock  
$428.00   $300.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001APV
Chemical Name:
Kpt-330
CAS Number:
1393477-72-9
Molecular Formula:
C17H11F6N7O
Molecular Weight:
443.3060
MDL Number:
MFCD27987944
SMILES:
O=C(/C=C\n1cnc(n1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)NNc1cnccn1
Properties
Computed Properties
 
Complexity:
621  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3  

Upstream Synthesis Route

[1]Patent:WO2018/129227,2018,A1,.Locationinpatent:Paragraph00196;00197;00215;00216;00218

[2]Patent:WO2013/19548,2013,A1,.Locationinpatent:Page/Pagecolumn56-57

[3]DrugsoftheFuture,2014,vol.39,#10,p.685-692

[4]Patent:WO2017/118940,2017,A1,.Locationinpatent:Page/Pagecolumn61

[1]Patent:CN106831731,2017,A,.Locationinpatent:Paragraph0018;0019;0029;0030;0037;0038;0045;0046

[1]Patent:WO2013/19548,2013,A1,

[2]Patent:WO2013/19548,2013,A1,

[3]DrugsoftheFuture,2014,vol.39,#10,p.685-692

[4]Patent:WO2017/118940,2017,A1,

[5]Patent:WO2018/129227,2018,A1,

[1]Patent:WO2016/25904,2016,A1,.Locationinpatent:Paragraph00326

[1]Patent:WO2013/19548,2013,A1,

[2]Patent:WO2013/19548,2013,A1,

[3]DrugsoftheFuture,2014,vol.39,#10,p.685-692

Downstream Synthesis Route

[1]Patent:WO2013/19548,2013,A1

[2]Patent:WO2013/19548,2013,A1

[3]DrugsoftheFuture,2014,vol.39,p.685-692

[4]Patent:WO2017/118940,2017,A1

[5]Patent:WO2018/129227,2018,A1

[1]Patent:WO2013/19548,2013,A1

[1]Patent:WO2018/129227,2018,A1.Locationinpatent:Paragraph00196;00197;00215;00216;00218

[2]Patent:WO2013/19548,2013,A1.Locationinpatent:Page/Pagecolumn56-57

[3]DrugsoftheFuture,2014,vol.39,p.685-692

[4]Patent:WO2017/118940,2017,A1.Locationinpatent:Page/Pagecolumn61

[1]Patent:WO2013/19548,2013,A1

[2]Patent:WO2013/19548,2013,A1

[3]DrugsoftheFuture,2014,vol.39,p.685-692

[1]Patent:WO2013/19548,2013,A1

[2]Patent:WO2013/19548,2013,A1

[3]DrugsoftheFuture,2014,vol.39,p.685-692

Literature

Title: KPT-330, a potent and selective CRM1 inhibitor, exhibits anti-inflammation effects and protection against sepsis.

Journal: Biochemical and biophysical research communications 20180910

Title: KPT-330 inhibition of chromosome region maintenance 1 is cytotoxic and sensitizes chronic myeloid leukemia to Imatinib.

Journal: Cell death discovery 20180101

Title: Pharmacological treatment with inhibitors of nuclear export enhances the antitumor activity of docetaxel in human prostate cancer.

Journal: Oncotarget 20171219

Title: KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells.

Journal: Leukemia 20170101

Title: Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin.

Journal: Scientific reports 20170101

Title: SINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agents.

Journal: Journal of hematology & oncology 20140101

Title: Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.

Journal: Journal of hematology & oncology 20140101

Title: Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.

Journal: The Journal of biological chemistry 19971121

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SDS
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