Home Amines 139667-74-6
139667-74-6,MFCD09878290
Catalog No.:AA001BEA

139667-74-6 | Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-

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1mg
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$15.00   $11.00
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5mg
97%
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$35.00   $25.00
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10mg
97%
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$53.00   $37.00
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25mg
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$90.00   $63.00
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50mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001BEA
Chemical Name:
Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-
CAS Number:
139667-74-6
Molecular Formula:
C15H24Cl2NO4P
Molecular Weight:
384.2351
MDL Number:
MFCD09878290
SMILES:
CCOC(P(=O)(CCCNCc1ccc(c(c1)Cl)Cl)O)OCC
Properties
Computed Properties
 
Complexity:
369  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
11  

Downstream Synthesis Route
Literature

Title: Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120718

Title: [The role of GABAA and GABAB receptors in formation of evoked potentials in the barrel cortex of rats].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20120101

Title: Blockade of GABA(B) receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse.

Journal: Neuroscience 20111013

Title: GABA(B) restrains release from singly-evoked GABA terminals.

Journal: Neuroscience 20111013

Title: GABA(B)-mediated inhibition of multiple modes of glutamate release in the nucleus of the solitary tract.

Journal: Journal of neurophysiology 20111001

Title: Mechanisms underlying the renoprotective effect of GABA against ischemia/reperfusion-induced renal injury in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727

Title: Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.

Journal: Journal of neurochemistry 20101201

Title: Histamine: from flop to flip-flop.

Journal: The Journal of physiology 20101101

Title: Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation.

Journal: Journal of neuroscience methods 20100930

Title: Activation of GABA-B receptors induced by systemic amphetamine abolishes dopamine release in the rat lateral septum.

Journal: Journal of neurochemistry 20100901

Title: GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep.

Journal: Advances in experimental medicine and biology 20100101

Title: Renoprotective effects of gamma-aminobutyric acid on ischemia/reperfusion-induced renal injury in rats.

Journal: European journal of pharmacology 20091125

Title: Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.

Journal: Molecular psychiatry 20090701

Title: Gamma-aminobutyric acid B receptor mediated inhibition of gonadotropin-releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling.

Journal: Endocrinology 20090501

Title: Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor.

Journal: Neuron 20090326

Title: GABA(B) presynaptic receptors modulate glycine exocytosis from mouse spinal cord and hippocampus glycinergic nerve endings.

Journal: Pharmacological research 20090301

Title: Source, topography and excitatory effects of GABAergic innervation in cockroach salivary glands.

Journal: The Journal of experimental biology 20090101

Title: The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons.

Journal: Journal of neurophysiology 20081201

Title: Functional mapping of GABA(B)-receptor subtypes in the thalamus.

Journal: Journal of neurophysiology 20071201

Title: Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070801

Title: Differential expression of intrinsic membrane currents in defined cell types of the anterolateral bed nucleus of the stria terminalis.

Journal: Journal of neurophysiology 20070801

Title: Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors.

Journal: Neuroscience 20061013

Title: Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons.

Journal: The Journal of physiology 20060815

Title: Enhancement of the synchronized firing of CA1 pyramidal cells by medial septum preconditioning: time-dependent involvement of muscarinic cholinoceptors and GABAB receptors.

Journal: Neuroscience letters 20060123

Title: HPLC conditions are critical for the detection of GABA by microdialysis.

Journal: Journal of neurochemistry 20050801

Title: Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: GABA(B) receptor activation modulates GABA(A) receptor-mediated inhibition in chicken nucleus magnocellularis neurons.

Journal: Journal of neurophysiology 20050301

Title: Differential GABAB Receptor Modulation of Ethanol Effects on GABA(A) synaptic activity in hippocampal CA1 neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Modulation of glutamate mobility reveals the mechanism underlying slow-rising AMPAR EPSCs and the diffusion coefficient in the synaptic cleft.

Journal: Neuron 20040610

Title: Effects of applying gamma-aminobutyric acid(B) drugs into the medial basal hypothalamus on basal luteinizing hormone concentrations and on luteinizing hormone surges in the female sheep.

Journal: Biology of reproduction 20040201

Title: Blockade of GABA(B) receptors alters the tangential migration of cortical neurons.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20030901

Title: The ATP-mediated fast current of rat dorsal root ganglion neurons is a novel effector for GABA(B) receptor activation.

Journal: Neuroscience letters 20030306

Title: Evidence for a GABA(B) receptor component in the spinal action of Substance P (SP) on arterial blood pressure in the awake rat.

Journal: British journal of pharmacology 20020801

Title: The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep.

Journal: Experimental biology and medicine (Maywood, N.J.) 20020501

Title: GABA(B) receptor inhibition causes locomotor stimulation in mice.

Journal: European journal of pharmacology 20011214

Title: A GABA(B) mystery: the search for pharmacologically distinct GABA(B) receptors.

Journal: Molecular interventions 20011001

Title: Lanza M, et al. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex. Eur J Pharmacol. 1993 Jun 24;237(2-3):191-5.

Title: Sweeney FF, et al. Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice. Neuropharmacology. 2014 Jun;81:303-10.

Title: Kobuchi S, et al. Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion-induced renal injury in rats. Clin Exp Pharmacol Physiol. 2015 Mar;42(3):278-86.

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Tags:139667-74-6 Molecular Formula|139667-74-6 MDL|139667-74-6 SMILES|139667-74-6 Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)-