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147025-53-4,MFCD06407655
Catalog No.:AA001EGR

147025-53-4 | 1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-

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5mg
2 weeks  
$1,929.00   $1,350.00
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25mg
2 weeks  
$4,225.00   $2,958.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001EGR
Chemical Name:
1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-
CAS Number:
147025-53-4
Molecular Formula:
C10H15NO
Molecular Weight:
165.2322
MDL Number:
MFCD06407655
SMILES:
C#CCO[C@H]1CN2CCC1CC2
Properties
Computed Properties
 
Complexity:
197  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
0.8  

Literature

Title: Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20060201

Title: Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling.

Journal: Journal of neuroscience research 20040715

Title: Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.

Journal: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20030301

Title: M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.

Journal: Journal of molecular neuroscience : MN 20030101

Title: Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine.

Journal: Psychopharmacology 20020701

Title: Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man.

Journal: Life sciences 20010427

Title: Ensinger HA, et al. WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties. Life Sci. 1993;52(5-6):473-80.

Title: Wienrich M, et al. Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life Sci. 2001 Apr 27;68(22-23):2593-600.

Title: Walland A, et al. In vivo consequences of M1-receptor activation by talsaclidine. Life Sci. 1997;60(13-14):977-84.

Title: Walland A, et al. Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs. Eur J Pharmacol. 1997 Jul 9;330(2-3):213-9.

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Tags:147025-53-4 Molecular Formula|147025-53-4 MDL|147025-53-4 SMILES|147025-53-4 1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-