Title: Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.
Journal: Journal of medicinal chemistry 20160922
Title: Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic.
Journal: Biopolymers 20160501
Title: Involvement of multiple µ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission.
Journal: Peptides 20140101
Title: Highly efficient synthesis of endomorphin-2 under thermodynamic control catalyzed by organic solvent stable proteases with in situ product removal.
Journal: Bioresource technology 20130201
Title: The effect of Pro(2) modifications on the structural and pharmacological properties of endomorphin-2.
Journal: Journal of medicinal chemistry 20121011
Title: cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2.
Journal: Journal of medicinal chemistry 20121011
Title: Characterization of antinociceptive potency of endomorphin-2 derivatives with unnatural amino acids in rats.
Journal: Acta physiologica Hungarica 20120901
Title: Endomorphin-2: a biased agonist at the μ-opioid receptor.
Journal: Molecular pharmacology 20120801
Title: Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs.
Journal: Medicinal research reviews 20120501
Title: The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues.
Journal: Journal of medicinal chemistry 20120412
Title: Pleiotropic opioid regulation of spinal endomorphin 2 release and its adaptations to opioid withdrawal are sexually dimorphic.
Journal: The Journal of pharmacology and experimental therapeutics 20120101
Title: Endogenous endomorphin-2 contributes to spinal ĸ-opioid antinociception.
Journal: Pharmacology 20120101
Title: Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Journal: Bioorganic & medicinal chemistry 20111201
Title: Structural basis for inhibiting β-amyloid oligomerization by a non-coded β-breaker-substituted endomorphin analogue.
Journal: ACS chemical biology 20111118
Title: Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111109
Title: Origins of endomorphin-2 immunopositive fibers and terminals in the rat medullary dorsal horn.
Journal: Brain research 20110902
Title: Pharmacology of a new tritiated endomorphin-2 analog containing the proline mimetic cis-2-aminocyclohexanecarboxylic acid.
Journal: Peptides 20110401
Title: Antinociception by endogenous ligands at peripheral level.
Journal: Ideggyogyaszati szemle 20110330
Title: Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.
Journal: Journal of medicinal chemistry 20110310
Title: The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord.
Journal: European journal of pharmacology 20110110
Title: Effects of endomorphins on human umbilical vein endothelial cells under high glucose.
Journal: Peptides 20110101
Title: Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.
Journal: European journal of medicinal chemistry 20101001
Title: Origins of endomorphin-2 immunopositive fibers and terminals in the spinal dorsal horn of the rat.
Journal: Neuroscience 20100811
Title: Recent advances in endomorphin engineering.
Journal: ChemMedChem 20100802
Title: A protective effect of endomorphins on the oxidative injury of islet.
Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20100801
Title: micro-Opioid receptor stimulation in the medial subnucleus of the tractus solitarius inhibits gastric tone and motility by reducing local GABA activity.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100801
Title: The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro.
Journal: Chemical biology & drug design 20100701
Title: Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.
Journal: Journal of medicinal chemistry 20100610
Title: Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.
Journal: Journal of medicinal chemistry 20100325
Title: Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2.
Journal: Basic & clinical pharmacology & toxicology 20100201
Title: Neurochemical phenotypes of endomorphin-2-containing neurons in vagal nodose neurons of the adult rat.
Journal: Neurochemistry international 20091201
Title: Analysis of the effect of neuropeptides and cannabinoids in gastric mucosal defense initiated centrally in the rat.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20091201
Title: The effect of opioids and their antagonists on the nocifensive response of Caenorhabditis elegans to noxious thermal stimuli.
Journal: Invertebrate neuroscience : IN 20091201
Title: Immunoneutralization of agmatine sensitizes mice to micro-opioid receptor tolerance.
Journal: The Journal of pharmacology and experimental therapeutics 20091101
Title: Intrathecally injected Ile-Pro-Ile, an inhibitor of membrane ectoenzyme dipeptidyl peptidase IV, is antihyperalgesic in rats by switching the enzyme from hydrolase to synthase functional mode to generate endomorphin 2.
Journal: European journal of pharmacology 20091012
Title: Immunoreactive endomorphin 2 is generated extracellularly in rat isolated L4,5 dorsal root ganglia by DPP-IV.
Journal: Regulatory peptides 20091009
Title: In vitro and in vivo characterization of opioid activities of C-terminal esterified endomorphin-2 analogs.
Journal: Peptides 20090901
Title: Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.
Journal: Bioorganic & medicinal chemistry letters 20090801
Title: Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.
Journal: Bioorganic & medicinal chemistry 20090601
Title: The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats.
Journal: Neurochemical research 20090501
Title: Effects of transgene-mediated endomorphin-2 in inflammatory pain.
Journal: European journal of pain (London, England) 20090401
Title: Endomorphin 1- and endomorphin 2-containing neurons in nucleus tractus solitarii send axons to the parabrachial nuclei in the rat.
Journal: Anatomical record (Hoboken, N.J. : 2007) 20090401
Title: Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS.
Journal: Analytical chemistry 20090315
Title: Cloning of opioid receptors in common carp (Cyprinus carpio L.) and their involvement in regulation of stress and immune response.
Journal: Brain, behavior, and immunity 20090201
Title: The novel micro-opioid receptor antagonist, [N-allyl-Dmt(1)]endomorphin-2, attenuates the enhancement of GABAergic neurotransmission by ethanol.
Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20090101
Title: [Endomorphins--endogenous ligands of the mu-opioid receptor].
Journal: Postepy biochemii 20090101
Title: Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells.
Journal: Neuroreport 20081203
Title: Enzymatic degradation of endomorphins.
Journal: Peptides 20081101
Title: Structure-activity relationships of modified C-terminal endomorphin-2 analogues by molecular dynamics simulations.
Journal: Journal of molecular graphics & modelling 20081101
Title: Endomorphins interact with the substance P (SP) aminoterminal SP(1-7) binding in the ventral tegmental area of the rat brain.
Journal: Peptides 20081001
Title: Possible involvement of dynorphin A release via mu1-opioid receptor on supraspinal antinociception of endomorphin-2.
Journal: Peptides 20080901
Title: Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 2.
Journal: Chemical biology & drug design 20080701
Title: Detection of a novel immunoreactive endomorphin 2-like peptide in rat brain extracts.
Journal: Regulatory peptides 20080605
Title: The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
Journal: Anesthesia and analgesia 20080601
Title: Opioid-induced regulation of mu-opioid receptor gene expression in the MCF-7 breast cancer cell line.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20080601
Title: [Analysis of central mechanisms involved in gastric mucosal integrity].
Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20080601
Title: Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors.
Journal: Neuropharmacology 20080501
Title: Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse.
Journal: Life sciences 20080326
Title: Role of GABA B receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.
Journal: European journal of pharmacology 20080310
Title: Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.
Journal: Bioorganic & medicinal chemistry letters 20080215
Title: Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats.
Journal: European journal of pharmacology 20080202
Title: Interactions of galanin with endomorphin-2, vasopressin and oxytocin in nociceptive modulation of the trigemino-hypoglossal reflex in rats.
Journal: Physiological research 20080101
Title: Search of the human proteome for endomorphin-1 and endomorphin-2 precursor proteins.
Journal: Life sciences 20071201
Title: From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides.
Journal: Peptides 20071201
Title: A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.
Journal: Bioorganic & medicinal chemistry 20071115
Title: [N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.
Journal: The Journal of pharmacology and experimental therapeutics 20071001
Title: Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibition.
Journal: Neuropharmacology 20071001
Title: Inhibition of opioid release in the rat spinal cord by serotonin 5-HT(1A) receptors.
Journal: Brain research 20070716
Title: Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor.
Journal: The Journal of comparative neurology 20070710
Title: Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.
Journal: Journal of medicinal chemistry 20070614
Title: Endomorphin-2-immunoreactive fibers selectively appose serotonergic neuronal somata in the rostral ventral medial medulla.
Journal: The Journal of comparative neurology 20070610
Title: A Tyr-W-MIF-1 analog containing D-Pro2 discriminates among antinociception in mice mediated by different classes of mu-opioid receptors.
Journal: European journal of pharmacology 20070601
Title: Differential receptor binding characteristics of consecutive phenylalanines in micro-opioid specific peptide ligand endomorphin-2.
Journal: Bioorganic & medicinal chemistry 20070601
Title: Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling.
Journal: Bioorganic & medicinal chemistry 20070515
Title: Sex-/ovarian steroid-dependent release of endomorphin 2 from spinal cord.
Journal: The Journal of pharmacology and experimental therapeutics 20070501
Title: Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401
Title: Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide.
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus.
Journal: ChemMedChem 20070301
Title: Synthesis and analgesic activities of endomorphin-2 and its analogues.
Journal: Chemistry & biodiversity 20070301
Title: Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).
Journal: Journal of medicinal chemistry 20070208
Title: Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.
Journal: Bioorganic & medicinal chemistry 20070201
Title: Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.
Journal: European journal of pharmacology 20070112
Title: The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats.
Journal: Neurochemistry international 20061201
Title: Synthesis, radiolabeling and receptor binding of [3H][(1S,2R)ACPC2]endomorphin-2.
Journal: Peptides 20061201
Title: Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats.
Journal: Peptides 20061101
Title: Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.
Journal: Journal of medicinal chemistry 20060907
Title: Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3 or 4.
Journal: Bioorganic & medicinal chemistry letters 20060715
Title: Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus.
Journal: Peptides 20060701
Title: Involvement of spinal mu1-opioid receptors on the Tyr-d-Arg-Phe-sarcosine-induced antinociception.
Journal: European journal of pharmacology 20060701
Title: New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal: Journal of medicinal chemistry 20060629
Title: [(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs.
Journal: Biochemical and biophysical research communications 20060623
Title: 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.
Journal: Journal of medicinal chemistry 20060615
Title: Partial and full agonism in endomorphin derivatives: comparison by null and operational model.
Journal: Peptides 20060601
Title: Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay.
Journal: The Journal of pharmacology and experimental therapeutics 20060601
Title: Endomorphin-2, an endogenous tetrapeptide, protects against Abeta1-42 in vitro and in vivo.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060601
Title: Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060419
Title: Possible involvement of dynorphin A-(1-17) release via mu1-opioid receptors in spinal antinociception by endomorphin-2.
Journal: The Journal of pharmacology and experimental therapeutics 20060401
Title: Endomorphin synthesis in rat brain from intracerebroventricularly injected [3H]-Tyr-Pro: a possible biosynthetic route for endomorphins.
Journal: Regulatory peptides 20060315
Title: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation.
Journal: The FEBS journal 20060301
Title: Endomorphin-2 in the medial NTS attenuates the responses to baroreflex activation.
Journal: Brain research 20060216
Title: Endomorphin-2 and endomorphin-1 promote the extracellular amount of accumbal dopamine via nonopioid and mu-opioid receptors, respectively.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060201
Title: CD26 modulates nociception in mice via its dipeptidyl-peptidase IV activity.
Journal: Behavioural brain research 20060130
Title: A new electrochemical HPLC method for analysis of enkephalins and endomorphins.
Journal: Journal of neuroscience methods 20060115
Title: Enzymatic degradation studies of endomorphin-2 and its analogs containing N-methylated amino acids.
Journal: Peptides 20060101
Title: C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.
Journal: Peptides 20060101
Title: The reciprocal connections of endomorphin 1- and endomorphin 2-containing neurons between the hypothalamus and nucleus tractus solitarii in the rat.
Journal: Neuroscience 20060101
Title: Inhibition by endomorphin-1 and endomorphin-2 of excitatory transmission in adult rat substantia gelatinosa neurons.
Journal: Neuroscience 20060101
Title: Endomorphins restored the endothelium-dependent relaxation of the rabbit aorta rings exposed to high D-glucose condition via NO-cGMP pathway.
Journal: Protein and peptide letters 20060101
Title: Endomorphin-1 is more potent than endomorphin-2 in inhibition of synaptic transmission in substantia gelatinosa of adult rat spinal cord.
Journal: The International journal of neuroscience 20051101
Title: Vasorelaxant responses to endomorphin1[psi] and endomorphin2[psi], analogues of endomorphins, in rat aorta rings.
Journal: Die Pharmazie 20051101
Title: Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine.
Journal: Brain research 20051019
Title: Structural function of C-terminal amidation of endomorphin. Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid, studied by 1H-NMR spectroscopy, molecular calculation, and X-ray crystallography.
Journal: The FEBS journal 20051001
Title: Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.
Journal: The journal of peptide research : official journal of the American Peptide Society 20050901
Title: Reduced kappa-opioid activity in a rat model of cholestasis.
Journal: European journal of pharmacology 20050822
Title: Attenuation of aortic baroreflex responses by microinjections of endomorphin-2 into the rostral ventrolateral medullary pressor area of the rat.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050701
Title: Aromatic-aromatic and proline-aromatic interactions in endomorphin-1 and endomorphin-2.
Journal: European journal of medicinal chemistry 20050701
Title: 6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.
Journal: Bioorganic & medicinal chemistry letters 20050516
Title: [TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings.
Journal: Protein and peptide letters 20050501
Title: Cardiovascular effects of endomorphins in alloxan-induced diabetic rats.
Journal: Peptides 20050401
Title: Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2.
Journal: Bioorganic & medicinal chemistry letters 20050401
Title: Differential mechanisms of antianalgesia induced by endomorphin-1 and endomorphin-2 in the ventral periaqueductal gray of the rat.
Journal: The Journal of pharmacology and experimental therapeutics 20050301
Title: Substance P and opioid peptidergic innervation of the anterior eye segment of the rat: an immunohistochemical study.
Journal: Journal of anatomy 20050301
Title: Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by mu and kappa opioid receptors.
Journal: Brain research 20050221
Title: Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
Journal: European journal of pharmacology 20050210
Title: Development of potent mu-opioid receptor ligands using unique tyrosine analogues of endomorphin-2.
Journal: Journal of medicinal chemistry 20050127
Title: Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.
Journal: Biochemical pharmacology 20050101
Title: Effects of morphine and endomorphins on the polysynaptic reflex in the isolated rat spinal cord.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050101
Title: Postnatal development of ectopic sensory fibers containing endomorphin-2 in the white matter of the spinal cord of a transgenic mouse expressing nerve growth factor in oligodendrocytes.
Journal: Neuroscience 20050101
Title: Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells.
Journal: Brain research 20041203
Title: Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001
Title: Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice.
Journal: Neuroscience letters 20040812
Title: [Development of a new analgesic based on metabolism of endomorphin, an endogenous opioid peptide].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801
Title: Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse.
Journal: Neuroscience letters 20040729
Title: Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Journal: The Journal of pharmacology and experimental therapeutics 20040701
Title: Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Journal: Journal of medicinal chemistry 20040701
Title: Differential conditioned place preference responses to endomorphin-1 and endomorphin-2 microinjected into the posterior nucleus accumbens shell and ventral tegmental area in the rat.
Journal: The Journal of pharmacology and experimental therapeutics 20040501
Title: Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells.
Journal: Experimental brain research 20040501
Title: Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat.
Journal: The European journal of neuroscience 20040401
Title: Supraspinal anti-allodynic and rewarding effects of endomorphins in rats.
Journal: Peptides 20040401
Title: Dynorphinergic mechanism mediating endomorphin-2-induced antianalgesia in the mouse spinal cord.
Journal: The Journal of pharmacology and experimental therapeutics 20031201
Title: Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.
Journal: Journal of pharmacological sciences 20031201
Title: Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage.
Journal: Biochimica et biophysica acta 20031120
Title: Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices.
Journal: British journal of pharmacology 20031101
Title: Intrathecal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine blocks the antinociception induced by endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse.
Journal: Journal of pharmacological sciences 20031101
Title: Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study.
Journal: Biochemical pharmacology 20030815
Title: Morphine and endomorphins differentially regulate micro-opioid receptor mRNA in SHSY-5Y human neuroblastoma cells.
Journal: The Journal of pharmacology and experimental therapeutics 20030801
Title: Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord.
Journal: Life sciences 20030613
Title: Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.
Journal: Bioorganic & medicinal chemistry 20030501
Title: The antitussive effects of endomorphin-1 and endomorphin-2 in mice.
Journal: European journal of pharmacology 20030425
Title: The effect of endomorphins on the release of 3H-norepinephrine from rat nucleus tractus solitarii slices.
Journal: Regulatory peptides 20030328
Title: Endomorphin 2 analogues containing Dmp residue as an aromatic amino acid surrogate with high mu-opioid receptor affinity and selectivity.
Journal: Bioorganic & medicinal chemistry 20030306
Title: Endomorphin-1 and -2 induce naloxone-precipitated withdrawal syndromes in rats.
Journal: Peptides 20030301
Title: Synthesis and evaluation of potential affinity labels derived from endomorphin-2.
Journal: The journal of peptide research : official journal of the American Peptide Society 20030201
Title: Loss of mu-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of mu-opioid receptor gene.
Journal: Neuroscience letters 20021225
Title: Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area.
Journal: The Journal of comparative neurology 20021216
Title: Cross-tolerance between the different mu-opioid receptor agonists endomorphin-1, endomorphin-2 and morphine at the spinal level in the rat.
Journal: Neuroscience letters 20021213
Title: Endomorphin analogues containing D-Pro2 discriminate different mu-opioid receptor mediated antinociception in mice.
Journal: British journal of pharmacology 20021201
Title: Spinal pretreatment with antisense oligodeoxynucleotides against exon-1, -4, or -8 of mu-opioid receptor clone leads to differential loss of spinal endomorphin-1-and endomorphin-2-induced antinociception in the mouse.
Journal: The Journal of pharmacology and experimental therapeutics 20021101
Title: Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.
Journal: Journal of pharmaceutical sciences 20021001
Title: Endomorphins suppress nociception-induced c-Fos and Zif/268 expression in the rat spinal dorsal horn.
Journal: European journal of pharmacology 20020906
Title: Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells.
Journal: Scandinavian journal of immunology 20020901
Title: In vitro quantitative study of the degradation of endomorphins.
Journal: Peptides 20020901
Title: Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants.
Journal: The European journal of neuroscience 20020901
Title: The antinociceptive properties of endomorphin-1 and endomorphin-2 in the mouse.
Journal: Japanese journal of pharmacology 20020701
Title: Differential antinociceptive effects induced by intrathecally-administered endomorphin-1 and endomorphin-2 in mice.
Journal: Japanese journal of pharmacology 20020701
Title: Endomorphin-induced motivational effect: differential mechanism of endomorphin-1 and endomorphin-2.
Journal: Japanese journal of pharmacology 20020701
Title: Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin.
Journal: Japanese journal of pharmacology 20020701
Title: Endomorphins 1 and 2 induce amnesia via selective modulation of dopamine receptors in mice.
Journal: European journal of pharmacology 20020620
Title: Opioid peptides endomorphin-1 and endomorphin-2 in the immune system in humans and in a rodent model of inflammation.
Journal: Annals of the New York Academy of Sciences 20020601
Title: Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.
Journal: Peptides 20020501
Title: Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301
Title: Responses to microinjections of endomorphin and nociceptin into the medullary cardiovascular areas.
Journal: Clinical and experimental pharmacology & physiology 20020301
Title: Involvement of mu(1)-opioid receptors and cholinergic neurotransmission in the endomorphins-induced impairment of passive avoidance learning in mice.
Journal: Behavioural brain research 20020201
Title: Activation of mu-opioid receptors inhibits lordosis behavior in estrogen and progesterone-primed female rats.
Journal: Hormones and behavior 20020201
Title: Endomorphins inhibit contractile responses of rat thoracic aorta rings induced by phenylephrine and angiotensin II in vitro.
Journal: Acta pharmacologica Sinica 20020101
Title: Endomorphin-2 inhibits GABAergic inputs to cardiac parasympathetic neurons in the nucleus ambiguus.
Journal: Neuroscience 20020101
Title: Release of [Met5]enkephalin from the spinal cord by intraventricularly administered endomorphin-2, but not endomorphin-1 in the anesthetized rat.
Journal: Neuroscience letters 20011204
Title: Endomorphin-1 improves scopolamine-induced impairment of short-term memory via mu1-opioid receptor in mice.
Journal: Neuroreport 20011204
Title: Acute antinociceptive tolerance and asymmetric cross-tolerance between endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse.
Journal: The Journal of pharmacology and experimental therapeutics 20011201
Title: Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Journal: Journal of medicinal chemistry 20011108
Title: Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid in DMSO solution, by 1H NMR spectroscopy and molecular modeling calculation.
Journal: The journal of peptide research : official journal of the American Peptide Society 20011101
Title: Up-regulation of spinal mu-opioid receptor function to activate G-protein by chronic naloxone treatment.
Journal: Brain research 20010921
Title: Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Journal: European journal of pharmacology 20010921
Title: Changes in brain content of nociceptin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain.
Journal: Neuroscience letters 20010921
Title: Partial agonistic action of endomorphins in the mouse spinal cord.
Journal: Neuroscience letters 20010907
Title: Endomorphins 1 and 2 modulate chemotaxis, phagocytosis and superoxide anion production by microglia.
Journal: Journal of neuroimmunology 20010903
Title: Behavioral and neuroendocrine actions of endomorphin-2.
Journal: Peptides 20010901
Title: Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse.
Journal: The Journal of pharmacology and experimental therapeutics 20010801
Title: Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells.
Journal: Neuroendocrinology 20010801
Title: Lack of the involvement of mu1-opioid receptor subtype on motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse.
Journal: Neuroscience letters 20010727
Title: Saturable brain-to-blood transport of endomorphins.
Journal: Experimental brain research 20010701
Title: Endomorphins 1 and 2, endogenous mu-opioid receptor agonists, impair passive avoidance learning in mice.
Journal: European journal of pharmacology 20010608
Title: Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601
Title: Receptor constants for endomorphin-1 and endomorphin-1-ol indicate differences in efficacy and receptor occupancy.
Journal: European journal of pharmacology 20010601
Title: Endomorphins and activation of the hypothalamo-pituitary-adrenal axis.
Journal: The Journal of endocrinology 20010401
Title: Role of cholecystokinin in the reduction of endomorphin-2-induced antinociception in diabetic mice.
Journal: European journal of pharmacology 20010323
Title: Differential effects of endomorphin-1 and -2 on amphetamine sensitization: neurochemical and behavioral aspects.
Journal: Synapse (New York, N.Y.) 20010301
Title: Different motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse.
Journal: Neuroscience 20010101
Title: Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz electroacupuncture stimulation.
Journal: Neuroscience letters 20001124
Title: Differential cardiorespiratory effects of endomorphin 1, endomorphin 2, DAMGO, and morphine.
Journal: American journal of respiratory and critical care medicine 20000901
Title: G protein activation by endomorphins in the mouse periaqueductal gray matter.
Journal: Journal of biomedical science 20000101
Title: Endomorphin-1 and endomorphin-2 activate mu-opioid receptors in myenteric neurons of the guinea-pig small intestine.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 19981201
Title: Endomorphins fully activate a cloned human mu opioid receptor.
Journal: FEBS letters 19981113
Title: A potent and selective endogenous agonist for the mu-opiate receptor.
Journal: Nature 19970403
Title: Goldberg IE, et al. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J Pharmacol Exp Ther. 1998 Aug;286(2):1007-13.
