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1443437-74-8,MFCD28166491
Catalog No.:AA001JAL

1443437-74-8 | 3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$13.00   $9.00
- +
10mg
97%
in stock  
$47.00   $33.00
- +
25mg
97%
in stock  
$70.00   $49.00
- +
50mg
97%
in stock  
$104.00   $73.00
- +
100mg
97%
in stock  
$155.00   $109.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001JAL
Chemical Name:
3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-
CAS Number:
1443437-74-8
Molecular Formula:
C23H21ClN2O3
Molecular Weight:
408.8774
MDL Number:
MFCD28166491
SMILES:
Clc1ccc(cc1)NC(=O)C1CCCN(C1)C(=O)c1cccc(c1)c1ccco1
Properties
Computed Properties
 
Complexity:
579  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.1  

Literature

Title: Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Journal: The Journal of pharmacology and experimental therapeutics 20140601

Title: Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Journal: Bioorganic & medicinal chemistry letters 20130701

Title: Bell JL, et al. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32.

Title: Johnson LA, et al. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflamm Bowel Dis. 2014 Jan;20(1):154-65.

Title: Haak AJ, et al. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6.

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SDS
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Tags:1443437-74-8 Molecular Formula|1443437-74-8 MDL|1443437-74-8 SMILES|1443437-74-8 3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-