Home Other Building Blocks 14459-29-1
14459-29-1,MFCD00005077
Catalog No.:AA001JQA

14459-29-1 | Hematoporphyrin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
≥98%
in stock  
$2,143.00   $1,500.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001JQA
Chemical Name:
Hematoporphyrin
CAS Number:
14459-29-1
Molecular Formula:
C34H38N4O6
Molecular Weight:
598.6887
MDL Number:
MFCD00005077
SMILES:
OC(=O)CCC1=C(C)C2=N/C/1=C\c1[nH]c(c(c1CCC(=O)O)C)/C=C/1\N=C(/C=c/3\[nH]/c(=C\2)/c(C)c3C(O)C)C(=C1C(O)C)C
Properties
Properties
 
BP:
1192.7°C at 760 mmHg  
Form:
Solid  
MP:
172.5℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
1020  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
2  
XLogP3:
2.1  

Literature

Title: Mitochondrial reactive oxygen species accelerate the expression of heme carrier protein 1 and enhance photodynamic cancer therapy effect.

Journal: Journal of clinical biochemistry and nutrition 20140701

Title: Photoinactivation of cell-free human immunodeficiency virus by hematoporphyrin monomethyl ether.

Journal: Lasers in medical science 20120901

Title: Optical properties of hematoporphyrin monomethyl ether (HMME), a PDT photosensitizer.

Journal: Photodiagnosis and photodynamic therapy 20120901

Title: Study of interaction between PEG carrier and three relevant drug molecules: piroxicam, paclitaxel, and hematoporphyrin.

Journal: The journal of physical chemistry. B 20120621

Title: Research progress of Hemoporfin--part one: preclinical study.

Journal: Photodiagnosis and photodynamic therapy 20120601

Title: Synthesis, radiolabeling, biodistribution and fluorescent imaging of histidine-coupled hematoporphyrin.

Journal: Nuclear medicine and biology 20120501

Title: Effective treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical photosan-mediated photodynamic therapy.

Journal: Head & neck 20120401

Title: Fluorescence examination and photodynamic therapy of facial squamous cell carcinoma--a case report.

Journal: Photodiagnosis and photodynamic therapy 20120301

Title: Hematoporphyrin encapsulated PLGA microbubble for contrast enhanced ultrasound imaging and sonodynamic therapy.

Journal: Journal of microencapsulation 20120101

Title: Haematoporphyrin based photodynamic therapy combined with hyperthermia provided effective therapeutic vaccine effect against colon cancer growth in mice.

Journal: International journal of medical sciences 20120101

Title: Effectiveness of photodynamic therapy for the inactivation of Candida spp. on dentures: in vitro study.

Journal: Photomedicine and laser surgery 20111201

Title: Tolerance and pharmacokinetics of single-dose intravenous hemoporfin in healthy volunteers.

Journal: Acta pharmacologica Sinica 20111201

Title: HMME-based PDT restores expression and function of transporter associated with antigen processing 1 (TAP1) and surface presentation of MHC class I antigen in human glioma.

Journal: Journal of neuro-oncology 20111101

Title: Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy.

Journal: International journal of radiation biology 20111001

Title: Intracellular metabolism, subcellular localization and phototoxicity of HMME/HB in ovarian cancer cells.

Journal: Anticancer research 20111001

Title: Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres.

Journal: Physical chemistry chemical physics : PCCP 20110907

Title: Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

Journal: Free radical biology & medicine 20110901

Title: Choosing optimal wavelength for photodynamic therapy of port wine stains by mathematic simulation.

Journal: Journal of biomedical optics 20110901

Title: Anticancer potency of cytotoxic drugs after exposure to high-intensity focused ultrasound in the presence of microbubbles and hematoporphyrin.

Journal: Molecular pharmaceutics 20110801

Title: Apoptosis induced by hematoporphyrin monomethyl ether combined with He-Ne laser irradiation in vitro on canine breast cancer cells.

Journal: Veterinary journal (London, England : 1997) 20110601

Title: Effect of hematoporphyrin monomethyl ether-mediated photodynamic therapy on hypertrophic scar fibroblasts.

Journal: Photodermatology, photoimmunology & photomedicine 20110401

Title: Establishing an experimental model of photodynamically induced anterior ischemic optic neuropathy.

Journal: Visual neuroscience 20110301

Title: Inhalable, bioresponsive microparticles for targeted drug delivery in the lungs.

Journal: The Journal of pharmacy and pharmacology 20110301

Title: Efficacy and safety of hemoporfin in photodynamic therapy for port-wine stain: a multicenter and open-labeled phase IIa study.

Journal: Photodermatology, photoimmunology & photomedicine 20110201

Title: Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting.

Journal: Science translational medicine 20110105

Title: Sonodynamic effects of hematoporphyrin monomethyl ether on CNE-2 cells detected by atomic force microscopy.

Journal: Journal of cellular biochemistry 20110101

Title: In vitro and in vivo targeted delivery of photosensitizers to the tumor cells for enhanced photodynamic effects.

Journal: Journal of cancer research and therapeutics 20110101

Title: Hematoporphyrin monomethyl ether enhances the killing of ultrasound on osteosarcoma cells involving intracellular reactive oxygen species and calcium ion elevation.

Journal: Integrative cancer therapies 20101201

Title: Study on the interaction between hematoporphyrin monomethyl ether and DNA and the determination of hematoporphyrin monomethyl ether using the resonance light scattering technique.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20101015

Title: Hematoporphyrin monomethyl ether-mediated photodynamic effects on THP-1 cell-derived macrophages.

Journal: Journal of photochemistry and photobiology. B, Biology 20101005

Title: Photoinactivation effects of hematoporphyrin monomethyl ether on Gram-positive and -negative bacteria detected by atomic force microscopy.

Journal: Applied microbiology and biotechnology 20101001

Title: In vitro photosensitization initiated by camphorquinone and phenyl propanedione in dental polymeric materials.

Journal: Journal of photochemistry and photobiology. B, Biology 20100902

Title: Differences in sensitivity to HMME-mediated photodynamic therapy between EBV+ C666-1 and EBV- CNE2 cells.

Journal: Photodiagnosis and photodynamic therapy 20100901

Title: Spray-dried microparticles containing polymeric micelles encapsulating hematoporphyrin.

Journal: The AAPS journal 20100601

Title: Susceptibility of Candida albicans to photodynamic therapy in a murine model of oral candidosis.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20100301

Title: Excited state absorption study in hematoporphyrin IX.

Journal: Journal of fluorescence 20100101

Title: Therapeutic effect of photodynamic therapy using hematoporphyrin monomethyl ether (HMME) on human cholangiocarcinoma cell line QBC939.

Journal: Neoplasma 20100101

Title: Combination of bilateral metal stenting and trans-stent photodynamic therapy for palliative treatment of hilar cholangiocarcinoma.

Journal: Zeitschrift fur Gastroenterologie 20100101

Title: Photosensitizing effect of hematoporphyrin IX on immature stages of Ceratitis capitata (Diptera: Tephritidae).

Journal: Photochemistry and photobiology 20100101

Title: Effects of photodynamic therapy using hematoporphyrin monomethyl ether on experimental choroidal neovascularization.

Journal: Photochemistry and photobiology 20100101

Title: Apoptotic effect of sonodynamic therapy mediated by hematoporphyrin monomethyl ether on C6 glioma cells in vitro.

Journal: Acta neurochirurgica 20091201

Title: Hematoporphyrin monomethyl ether enhances the killing action of ultrasound on osteosarcoma in vivo.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20091201

Title: Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT.

Journal: Bioorganic & medicinal chemistry 20091115

Title: Interaction of porphyrins with human organic anion transporting polypeptide 1B1.

Journal: Chemico-biological interactions 20091110

Title: Combination of 10% EDTA, Photosan, and a blue light hand-held photopolymerizer to inactivate leading oral bacteria in dentistry in vitro.

Journal: Journal of applied microbiology 20091101

Title: The binding of analogs of porphyrins and chlorins with elongated side chains to albumin.

Journal: European biophysics journal : EBJ 20090901

Title: Photodynamic therapy for cholangiocarcinoma: overview and new developments.

Journal: Current opinion in gastroenterology 20090901

Title: [Effect of ultrasound activating hematoporphyrin on the activities of antioxidative enzymes in mouse hepatoma 22].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20090801

Title: Attempt of photodynamic therapy on esophageal varices.

Journal: Lasers in medical science 20090301

Title: Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro.

Journal: Pharmaceutical research 20090201

Title: [Role of erythrocyte cytoplasmic structures in changes in the affinity of haemoglobin for oxygen].

Journal: Biofizika 20090101

Title: Early events in photodynamic therapy: chemical and physical changes in a POPC:cholesterol bilayer due to hematoporphyrin IX-mediated photosensitization.

Journal: Photochemistry and photobiology 20090101

Title: Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma.

Journal: Experimental oncology 20081201

Title: [Observation of bacteria photodynamic inactivation induced by hematoporphvrin monomethyl ether by atomic force microscope].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20081001

Title: Sonodynamically induced antitumor effect of hematoporphyrin on Hepatoma 22.

Journal: Ultrasonics sonochemistry 20080901

Title: In vitro study of haematoporphyrin monomethyl ether-mediated sonodynamic effects on C6 glioma cells.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20080901

Title: Ultrasound exposure in the presence of hematoporphyrin induced loss of membrane integral proteins and inactivity of cell proliferation associated enzymes in sarcoma 180 cells in vitro.

Journal: Ultrasonics sonochemistry 20080701

Title: Investigation on damage of DNA molecules under irradiation of low frequency ultrasound in the presence of hematoporphyrin-gallium (HP-Ga) complex.

Journal: Ultrasonics sonochemistry 20080701

Title: Involvement of caspase 8 in apoptosis induced by ultrasound-activated hematoporphyrin in sarcoma 180 cells in vitro.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20080401

Title: Membrane fluidity altering and enzyme inactivating in sarcoma 180 cells post the exposure to sonoactivated hematoporphyrin in vitro.

Journal: Ultrasonics 20080301

Title: Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents.

Journal: Bioorganic & medicinal chemistry letters 20080101

Title: Study of the synergistic effect on hepatoma 22 tumor cells by focused ultrasound activation of hematoporphyrin.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20080101

Title: Enhancement of ultrasonically induced cytotoxic effect by hematoporphyrin in vitro.

Journal: Chemotherapy 20080101

Title: Intraperitoneal photodynamic therapy for an ovarian cancer ascite model in Fischer 344 rat using hematoporphyrin monomethyl ether.

Journal: Cancer science 20071201

Title: Towards environmentally and human friendly insect pest control technologies: photosensitization of leafminer flies Liriomyza bryoniae.

Journal: Journal of photochemistry and photobiology. B, Biology 20071112

Title: Combination of TLC blotting and gas chromatography-mass spectrometry for analysis of peroxidized cholesterol.

Journal: Lipids 20071101

Title: [Fluorescence spectroscopy study on photobleaching properties of photosensitizers in photodynamic therapy].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20071001

Title: [Effect of HMME-PDT on hyperplastic scar in rabbit ear model].

Journal: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20070901

Title: Catalytic activity of silica gels bound manganese(III)-porphyrin on oxidative reaction of adrenaline.

Journal: Chemical & pharmaceutical bulletin 20070301

Title: [Photodynamic therapy of pigmented choroidal melanomas in rabbits using hematoporphyrin monomethyl ether].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20070301

Title: Sonodynamic therapy of cancer using novel sonosensitizers.

Journal: Anticancer research 20070101

Title: Involvement of mitochondria-caspase pathway in Hemoporfin-mediated cell death.

Journal: Photochemistry and photobiology 20070101

Title: Active photosensitizers in butter detected by fluorescence spectroscopy and multivariate curve resolution.

Journal: Journal of agricultural and food chemistry 20061227

Title: Development and validation of a sensitive quantification method for hematoporphyrin monomethyl ether in plasma using high-performance liquid chromatography with fluorescence detection.

Journal: Biomedical chromatography : BMC 20061201

Title: [Photodynamic effect of hematoporphyrin monomethyl ether on ovarian cancer cell line SKOV3].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060901

Title: Intracellular chemiluminescence activates targeted photodynamic destruction of leukaemic cells.

Journal: British journal of cancer 20060717

Title: Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.

Journal: Molecular pharmacology 20060701

Title: Inactivation of methicillin-resistant Staphylococcus aureus (MRSA) by liposome-delivered photosensitising agents.

Journal: Journal of photochemistry and photobiology. B, Biology 20060501

Title: Radiosensitization of tumours by porphyrins.

Journal: Cancer letters 20060408

Title: Cellular and antitumor activity of a new diethylene glycol benzoporphyrin derivative (lemuteporfin).

Journal: Photochemistry and photobiology 20060101

Title: Mechanism of radiosensitization by porphyrins.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20060101

Title: Phototoxicity of Hemoporfin to ovarian cancer.

Journal: Biochemical and biophysical research communications 20051111

Title: Role of viscosity and permeability of the erythrocyte plasma membrane in changes in oxygen-binding properties of hemoglobin during diabetes mellitus.

Journal: Bulletin of experimental biology and medicine 20051101

Title: Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20051001

Title: Discrimination between two steps in the mitochondrial permeability transition process.

Journal: The international journal of biochemistry & cell biology 20050901

Title: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin. Optical and NMR spectroscopy characterization.

Journal: The FEBS journal 20050901

Title: pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential.

Journal: Cancer letters 20050510

Title: Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis.

Journal: The Journal of investigative dermatology 20050401

Title: Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation.

Journal: Cancer letters 20041208

Title: Tissue retention and adverse reaction after intravenous injection of hematoporphyrin derivatives in dogs.

Journal: The Journal of veterinary medical science 20041201

Title: Photodynamic therapy of brain tumours: evaluation of porphyrin uptake versus clinical outcome.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20040801

Title: Synthesis and biological activity of novel platinum(II) complexes of glutamate tethered to hydrophilic hematoporphyrin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20040607

Title: The antibody-catalyzed water oxidation pathway--a new chemical arm to immune defense?

Journal: Trends in biochemical sciences 20040501

Title: Development of a test system for mutagenicity of photosensitizers using Drosophila melanogaster.

Journal: Photochemistry and photobiology 20040401

Title: pH-dependent modification of lipophilicity of porphyrin-type photosensitizers.

Journal: Photochemistry and photobiology 20040301

Title: Preparation and mass spectrometry of 14 pure and 18O(2)-labeled oxidation products from the phytosterols beta-sitosterol and stigmasterol.

Journal: Analytical biochemistry 20040201

Title: [The simultaneous measurements of time-dependent laser-induced fluorescence intensity of hematoporphyrin monomethyl ether in animal tissues with rheumatoid arthritis].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20040201

Title: Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates.

Journal: Cancer letters 20040120

Title: Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression.

Journal: Arthritis and rheumatism 20040101

Title: Effect of chloroquine wash-out period of photosensitizers in the skin and selected organs in rats.

Journal: Physiological research 20040101

Title: Synthesis and evaluation of a hematoporphyrin derivative in a folate receptor-targeted solid-lipid nanoparticle formulation.

Journal: Anticancer research 20040101

Title: Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck.

Journal: Lasers in surgery and medicine 20040101

Title: Experimental evidence on possibility to radiosensitize aggressive tumors by porphyrins.

Journal: Medicina (Kaunas, Lithuania) 20040101

Title: Photodynamic therapy of esophageal varices: experimental studies in animal veins, and first clinical cases.

Journal: Endoscopy 20031201

Title: pH effects on the cellular uptake of four photosensitizing drugs evaluated for use in photodynamic therapy of cancer.

Journal: Cancer letters 20030530

Title: Synthesis, biodistribution and antitumor activity of hematoporphyrin-platinum(II) conjugates.

Journal: Bioorganic & medicinal chemistry 20030417

Title: [Time-resolved fluorescence studies of hematoporphyrin monomethyl ether for photodynamic diagnosis].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20030401

Title: Structural modifications of the permeability transition pore complex in resealed mitochondria induced by matrix-entrapped disaccharides.

Journal: Archives of biochemistry and biophysics 20030201

Title: Cellular uptake, localization and photodynamic effects of haematoporphyrin derivative in human glioma and squamous carcinoma cell lines.

Journal: Journal of photochemistry and photobiology. B, Biology 20030201

Title: Collagen secretion after photodynamic therapy versus scar-inducing anti-cancer modalities: an in vitro study.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20020901

Title: Experimental study on photodynamic diagnosis of cancer mediated by chemiluminescence probe.

Journal: FEBS letters 20020717

Title: Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity.

Journal: Journal of medicinal chemistry 20020509

Title: Enhanced antitumor effect of ultrasound in the presence of piroxicam in a mouse air pouch model.

Journal: Japanese journal of cancer research : Gann 20020201

Title: Low-density lipoprotein receptors in the uptake of tumour photosensitizers by human and rat transformed fibroblasts.

Journal: The international journal of biochemistry & cell biology 20020101

Title: Photodynamic therapy in head and neck cancer.

Journal: Current oncology reports 20020101

Title: Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study.

Journal: Lasers in surgery and medicine 20020101

Title: [Diagnosis and treatment of bladder tumors by photodynamic therapy].

Journal: Pathologie-biologie 20011201

Title: Photodynamic therapy for superficial bladder cancer.

Journal: Expert review of anticancer therapy 20011201

Title: The history of photodetection and photodynamic therapy.

Journal: Photochemistry and photobiology 20011101

Title: Photoradiation of perfused placental tissue--a suitable in vitro model for photodynamic therapy?

Journal: Archives of gynecology and obstetrics 20011101

Title: Photodynamic activity of the haematoporphyrin derivative with rutin and arginine substituents (HpD-Rut(2)-Arg(2)) against Staphylococcus aureus and Pseudomonas aeruginosa.

Journal: Pharmacological research 20010901

Title: pH-dependent spectral properties of HpIX, TPPS2a, mTHPP and mTHPC.

Journal: Photochemistry and photobiology 20010801

Title: On-line incorporation of cloud point extraction to flow injection analysis.

Journal: Analytical chemistry 20010715

Title: Photosensitive chemical and laser light treatments decrease epizootic hemorrhagic disease virus associated with in vitro produced bovine embryos.

Journal: Theriogenology 20010501

Title: Photodynamic effect of deuteroporphyrin IX and hematoporphyrin derivatives on single neuron.

Journal: Biochemical and biophysical research communications 20010301

Title: The effects of singlet oxygen produced by photodynamic action on the mitochondrial permeability transition differ in accordance with the localization of the sensitizer.

Journal: Archives of biochemistry and biophysics 20010215

Title: An unusual photohaemolytic property of riboflavin.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010101

Title: The influence of photodynamic therapy on the wound healing process in rats.

Journal: Journal of biomaterials applications 20010101

Title: Embryotoxicity of TPPS4 and PS 3 photosensitizers in chicken embryo under different light conditions.

Journal: Neoplasma 20010101

Title: Does new photosensitizer improve photodynamic therapy in advanced esophageal carcinoma?

Journal: Lasers in surgery and medicine 20010101

Title: [Photoinactivation of microorganisms in the presence of photosensitizers].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20010101

Title: Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.

Journal: British journal of cancer 19970101

Title: Phototherapy of bladder cancer: dose/effect relationships.

Journal: The Journal of urology 19860801

Title: Experimental porphyric neuropathy: a preliminary report.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 19810501

Title: Charge-transfer complexes of hematoporphyrin having a pharmacological interest.

Journal: Arzneimittel-Forschung 19770101

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:14459-29-1 Molecular Formula|14459-29-1 MDL|14459-29-1 SMILES|14459-29-1 Hematoporphyrin