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144875-48-9,MFCD00937759
Catalog No.:AA001K7C

144875-48-9 | Resiquimod

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1mg
98%
in stock  
$11.00   $8.00
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25mg
≥ 98%
in stock  
$101.00   $71.00
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100mg
98%
in stock  
$107.00   $75.00
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250mg
98%
in stock  
$195.00   $137.00
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500mg
97%
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$285.00   $199.00
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1g
≥98%
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$437.00   $306.00
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5g
98%
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$1,420.00   $994.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001K7C
Chemical Name:
Resiquimod
CAS Number:
144875-48-9
Molecular Formula:
C17H22N4O2
Molecular Weight:
314.3822
MDL Number:
MFCD00937759
SMILES:
CCOCc1nc2c(n1CC(O)(C)C)c1ccccc1nc2N
Properties
Properties
 
BP:
553.6°C at 760 mmHg  
Form:
Solid  
MP:
190-193°  
Solubility:
DMSO: soluble10mg/mL, clear (warmed to 60 °C)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
406  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
1.3  

Literature

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Journal: Toxicology and applied pharmacology 20180101

Title: IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.

Journal: The Journal of biological chemistry 20171110

Title: Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human.

Journal: Blood 20130418

Title: A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

Journal: PloS one 20130101

Title: Differential control of hypoxia-inducible factor 1 activity during pro-inflammatory reactions of human haematopoietic cells of myeloid lineage.

Journal: The international journal of biochemistry & cell biology 20121101

Title: Therapy with TLR7 agonists induces lymphopenia: correlating pharmacology to mechanism in a mouse model.

Journal: Journal of clinical immunology 20121001

Title: Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN.

Journal: Biomaterials 20120601

Title: TLR3 but not TLR7/8 ligand induces allergic sensitization to inhaled allergen.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20120515

Title: R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts.

Journal: Cytotechnology 20120501

Title: Bacterial immunotherapy of gastrointestinal tumors.

Journal: Langenbeck's archives of surgery 20120401

Title: MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20120401

Title: Characterisation and expression analysis of the Atlantic halibut (Hippoglossus hippoglossus L.) cytokines: IL-1β, IL-6, IL-11, IL-12β and IFNγ.

Journal: Molecular biology reports 20120301

Title: R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes.

Journal: BMC infectious diseases 20120101

Title: Vaxjo: a web-based vaccine adjuvant database and its application for analysis of vaccine adjuvants and their uses in vaccine development.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system.

Journal: Frontiers in physiology 20120101

Title: Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol.

Journal: PloS one 20120101

Title: High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery.

Journal: PloS one 20120101

Title: Vaccine Development Against Leishmania donovani.

Journal: Frontiers in immunology 20120101

Title: Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms.

Journal: Frontiers in physiology 20120101

Title: Adjuvants for Leishmania vaccines: from models to clinical application.

Journal: Frontiers in immunology 20120101

Title: Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants.

Journal: BMC immunology 20120101

Title: Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.

Journal: Journal of immunological methods 20111028

Title: The innate antiviral immune system of the cat: molecular tools for the measurement of its state of activation.

Journal: Veterinary immunology and immunopathology 20111015

Title: Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110715

Title: Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms.

Journal: European journal of immunology 20110701

Title: Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4.

Journal: Arthritis and rheumatism 20110601

Title: CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer.

Journal: Expert review of vaccines 20110601

Title: Pattern recognition receptors and the innate immune response to viral infection.

Journal: Viruses 20110601

Title: Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.

Journal: Blood 20110526

Title: Targeting the Toll-like receptor 7 pathway in asthma: a potential immunomodulatory approach?

Journal: Expert opinion on therapeutic targets 20110501

Title: Toll-like receptor 7/8 agonist resiquimod induces late preconditioning in neonatal cardiac myocytes.

Journal: Acta pharmacologica Sinica 20110501

Title: Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110415

Title: Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110401

Title: A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110401

Title: Stimulation of TLR7 prior to polymicrobial sepsis improves the immune control of the inflammatory response in adult mice.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110301

Title: The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation.

Journal: PLoS pathogens 20110301

Title: Toll-like receptor 7 activation reduces the contractile response of airway smooth muscle.

Journal: European journal of pharmacology 20110210

Title: Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β.

Journal: Cellular and molecular life sciences : CMLS 20110101

Title: Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation.

Journal: Cancer immunology, immunotherapy : CII 20110101

Title: The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110101

Title: TLR3 and TLR7 modulate IgE production in antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs.

Journal: PloS one 20110101

Title: Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.

Journal: Clinical & developmental immunology 20110101

Title: Poly(I:C) enhances the susceptibility of leukemic cells to NK cell cytotoxicity and phagocytosis by DC.

Journal: PloS one 20110101

Title: Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells.

Journal: PloS one 20110101

Title: The transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans.

Journal: PloS one 20110101

Title: The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation.

Journal: Cellular immunology 20110101

Title: A common path to innate immunity to HIV-1 induced by Toll-like receptor ligands in primary human macrophages.

Journal: PloS one 20110101

Title: Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.

Journal: Journal of translational medicine 20110101

Title: Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis.

Journal: PloS one 20110101

Title: Toll-like receptors and myocardial inflammation.

Journal: International journal of inflammation 20110101

Title: Systemic administration of CpG oligodeoxynucleotide and levamisole as adjuvants for gene-gun-delivered antitumor DNA vaccines.

Journal: Clinical & developmental immunology 20110101

Title: Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

Journal: PloS one 20110101

Title: Signatures of positive selection in Toll-like receptor (TLR) genes in mammals.

Journal: BMC evolutionary biology 20110101

Title: The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses.

Journal: PloS one 20110101

Title: Predicting antitumor activity of peptides by consensus of regression models trained on a small data sample.

Journal: International journal of molecular sciences 20110101

Title: An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles.

Journal: Clinical and vaccine immunology : CVI 20101201

Title: Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice.

Journal: European journal of applied physiology 20101101

Title: Inhibition of the type I interferon antiviral response during arenavirus infection.

Journal: Viruses 20101101

Title: Protective effects of Sm-p80 in the presence of resiquimod as an adjuvant against challenge infection with Schistosoma mansoni in mice.

Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20100901

Title: TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.

Journal: Vaccine 20100831

Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated suppression of toll-like receptor stimulated B-lymphocyte activation and initiation of plasmacytic differentiation.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100701

Title: Dendritic cells in uninfected infants born to hepatitis B virus-positive mothers.

Journal: Clinical and vaccine immunology : CVI 20100701

Title: Herpes simplex virus and human papillomavirus genital infections: new and investigational therapeutic options.

Journal: International journal of dermatology 20100701

Title: Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.

Journal: Journal of medicinal chemistry 20100408

Title: Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.

Journal: Blood 20100311

Title: The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1 alpha prolyl hydroxylation.

Journal: Immunology and cell biology 20100201

Title: The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells.

Journal: Cancer immunology, immunotherapy : CII 20100101

Title: Topical resiquimod: a promising adjuvant for vaccine development?

Journal: Expert review of vaccines 20100101

Title: Toll-like receptor-mediated recognition of herpes simplex virus.

Journal: Frontiers in bioscience (Scholar edition) 20100101

Title: Molecular modulation of intestinal epithelial barrier: contribution of microbiota.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Immune mechanisms of protection: can adjuvants rise to the challenge?

Journal: BMC biology 20100101

Title: Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice.

Journal: PloS one 20100101

Title: Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists.

Journal: PloS one 20100101

Title: Toll-like receptors: role in dermatological disease.

Journal: Mediators of inflammation 20100101

Title: Targeting Toll-like receptors for treatment of SLE.

Journal: Mediators of inflammation 20100101

Title: Cellular and molecular mechanisms underlying the strong neonatal IL-12 response of lamb mesenteric lymph node cells to R-848.

Journal: PloS one 20100101

Title: Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-κB-dependent transcription of TNF-α and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA.

Journal: Journal of inflammation (London, England) 20100101

Title: Pharmacotherapy of actinic keratosis.

Journal: Expert opinion on pharmacotherapy 20091201

Title: Topical resiquimod promotes priming of CTL to parenteral antigens.

Journal: Vaccine 20090925

Title: Modulation of the allergic asthma transcriptome following resiquimod treatment.

Journal: Physiological genomics 20090807

Title: Flow cytometric investigation of neutrophil oxidative burst and apoptosis in physiological and pathological situations.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20090601

Title: Do postsurgical interventions optimize ultimate scar cosmesis.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20090601

Title: TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.

Journal: Vaccine 20090518

Title: 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Rectal and vaginal immunization of mice with human papillomavirus L1 virus-like particles.

Journal: Vaccine 20090414

Title: Reversal of human papillomavirus-specific T cell immune suppression through TLR agonist treatment of Langerhans cells exposed to human papillomavirus type 16.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090301

Title: Expression and activity of Toll-like receptors 1-9 in the human term placenta and changes associated with labor at term.

Journal: Biology of reproduction 20090201

Title: Toll-like receptor 7-induced naive human B-cell differentiation and immunoglobulin production.

Journal: The Journal of allergy and clinical immunology 20090101

Title: Hepatitis C virus is a weak inducer of interferon alpha in plasmacytoid dendritic cells in comparison with influenza and human herpesvirus type-1.

Journal: PloS one 20090101

Title: TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.

Journal: Immunobiology 20090101

Title: Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects.

Journal: Respiratory research 20090101

Title: Sequence determinants of innate immune activation by short interfering RNAs.

Journal: BMC immunology 20090101

Title: Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma.

Journal: PloS one 20090101

Title: Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.

Journal: BMC cancer 20090101

Title: Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

Journal: PloS one 20090101

Title: Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties.

Journal: Journal of translational medicine 20090101

Title: Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration.

Journal: Cancer immunology, immunotherapy : CII 20081101

Title: Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function.

Journal: Experimental biology and medicine (Maywood, N.J.) 20080801

Title: A phase II dose-ranging study of topical resiquimod to treat actinic keratosis.

Journal: The British journal of dermatology 20080701

Title: Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells.

Journal: The Journal of experimental medicine 20080609

Title: Plasticity of dendritic cell function in response to prostaglandin E2 (PGE2) and interferon-gamma (IFN-gamma).

Journal: Journal of leukocyte biology 20080401

Title: Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice.

Journal: Biochemical and biophysical research communications 20080307

Title: TLR7 and TLR8 as targets in cancer therapy.

Journal: Oncogene 20080107

Title: Comparison of human B cell activation by TLR7 and TLR9 agonists.

Journal: BMC immunology 20080101

Title: Toll-like receptors and viruses: induction of innate antiviral immune responses.

Journal: The open microbiology journal 20080101

Title: Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.

Journal: The Journal of biological chemistry 20071221

Title: TLR agonists induce the differentiation of human bone marrow CD34+ progenitors into CD11c+ CD80/86+ DC capable of inducing a Th1-type response.

Journal: European journal of immunology 20071001

Title: Resiquimod and other immune response modifiers as vaccine adjuvants.

Journal: Expert review of vaccines 20071001

Title: Impaired CCR7 expression on plasmacytoid dendritic cells of HIV-infected children and adolescents with immunologic and virologic failure.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070815

Title: Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies.

Journal: Journal of hepatology 20070801

Title: The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070501

Title: Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial.

Journal: The Journal of infectious diseases 20070501

Title: Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070401

Title: Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects.

Journal: Journal of molecular biology 20070105

Title: TLR7/8 agonists impair monocyte-derived dendritic cell differentiation and maturation.

Journal: Journal of leukocyte biology 20070101

Title: Therapeutic use of Aldara in chronic myeloid leukemia.

Journal: Journal of translational medicine 20070101

Title: Toll-like receptor activation enhances cell-mediated immunity induced by an antibody vaccine targeting human dendritic cells.

Journal: Journal of translational medicine 20070101

Title: Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream.

Journal: Journal of translational medicine 20070101

Title: Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70.

Journal: Journal of translational medicine 20070101

Title: Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists.

Journal: BMC immunology 20070101

Title: HIV-1/HSV-2 co-infected adults in early HIV-1 infection have elevated CD4+ T cell counts.

Journal: PloS one 20070101

Title: Primary prevention of allergic diseases: current concepts and mechanisms.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

Title: Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20061201

Title: A distinct subset of intestinal dendritic cells responds selectively to oral TLR7/8 stimulation.

Journal: European journal of immunology 20061001

Title: Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling.

Journal: The Journal of biological chemistry 20060915

Title: Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801

Title: Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages.

Journal: FEMS immunology and medical microbiology 20060801

Title: Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.

Journal: European journal of immunology 20060701

Title: Toll-like receptors mediate proliferation and survival of multiple myeloma cells.

Journal: Leukemia 20060601

Title: [Application of imiquimod and resiquimod in dermatology].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20060601

Title: TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060501

Title: Regulation of intestinal dendritic cell migration and activation by plasmacytoid dendritic cells, TNF-alpha and type 1 IFNs after feeding a TLR7/8 ligand.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060501

Title: Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers.

Journal: Journal of medicinal chemistry 20060323

Title: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.

Journal: Nature 20060309

Title: Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848).

Journal: Antiviral research 20060201

Title: New approaches to vaccine adjuvants: inhibiting the inhibitor.

Journal: PLoS medicine 20060101

Title: The role of topical immune response modifiers in skin cancer.

Journal: Drugs 20060101

Title: Innate immunity for biodefense: a strategy whose time has come.

Journal: The Journal of allergy and clinical immunology 20051201

Title: TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).

Journal: Vaccine 20051101

Title: TLR and NOD2 ligands induce cell proliferation in the rat intact spinal cord.

Journal: Journal of neuropathology and experimental neurology 20051101

Title: Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7/8 agonists.

Journal: Journal of neuroimmunology 20050701

Title: A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.

Journal: The Journal of experimental medicine 20050502

Title: Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050401

Title: Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens.

Journal: Immunology 20050401

Title: Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes.

Journal: Immunology 20050401

Title: Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050201

Title: Toll-like receptor downstream signaling.

Journal: Arthritis research & therapy 20050101

Title: Generation and maturation of dendritic cells for clinical application under serum-free conditions.

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101

Title: Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responses.

Journal: Antiviral research 20041101

Title: Emerging therapies for herpes viral infections (types 1 - 8).

Journal: Expert opinion on emerging drugs 20041101

Title: Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20041001

Title: Topical immunomodulation in dermatology: potential of toll-like receptor agonists.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20040801

Title: Resiquimod, a new immune response modifier from the family of imidazoquinolinamines, inhibits allergen-induced Th2 responses, airway inflammation and airway hyper-reactivity in mice.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

Title: Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040615

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20040601

Title: Death receptor-independent apoptosis in malignant melanoma induced by the small-molecule immune response modifier imiquimod.

Journal: The Journal of investigative dermatology 20040501

Title: Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod.

Journal: Apoptosis : an international journal on programmed cell death 20040501

Title: Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model.

Journal: Vaccine 20040416

Title: Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery.

Journal: Vaccine 20040416

Title: Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040415

Title: The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.

Journal: European journal of immunology 20031101

Title: Induction of apoptosis by Toll-like receptor-7 agonist in tissue cultures.

Journal: The British journal of dermatology 20031101

Title: Expression and function of Toll-like receptors in eosinophils: activation by Toll-like receptor 7 ligand.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031015

Title: Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod.

Journal: Journal of the National Cancer Institute 20030806

Title: An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors.

Journal: The American journal of pathology 20030801

Title: [Topical immunomodulators in dermatology].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20030701

Title: The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells.

Journal: The Journal of allergy and clinical immunology 20030201

Title: Resiquimod 3M.

Journal: Current opinion in investigational drugs (London, England : 2000) 20030201

Title: Recurrent genital herpes treatments and their impact on quality of life.

Journal: PharmacoEconomics 20030101

Title: [Imiquimod and resiquimod. The onset of a new pharmaco-therapeutic class?].

Journal: Annales de dermatologie et de venereologie 20030101

Title: Inhibition of IgE production by the imidazoquinoline resiquimod in nonallergic and allergic donors.

Journal: The Journal of investigative dermatology 20021101

Title: Current treatments and perceptions of genital herpes: a European-wide view.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20021101

Title: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.

Journal: Nature immunology 20020601

Title: The clinical management of recurrent genital herpes: current issues and future prospects.

Journal: Herpes : the journal of the IHMF 20020401

Title: Herpes simplex viruses 1 and 2.

Journal: Dermatologic clinics 20020401

Title: Immunomodulation as a treatment strategy for genital herpes: review of the evidence.

Journal: International immunopharmacology 20020301

Title: Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.

Journal: Nature immunology 20020201

Title: Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod.

Journal: Cellular immunology 20020101

Title: Imiquimod and resiquimod as novel immunomodulators.

Journal: The Journal of antimicrobial chemotherapy 20011201

Title: Topical immunomodulators--progress towards treating inflammation, infection, and cancer.

Journal: The Lancet. Infectious diseases 20011001

Title: Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: a pilot study.

Journal: The Journal of infectious diseases 20010715

Title: Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment.

Journal: The Journal of infectious diseases 20010315

Title: The immune response modifier resiquimod mimics CD40-induced B cell activation.

Journal: Cellular immunology 20010225

Title: Immunomodulating and antiviral activities of the imidazoquinoline S-28463.

Journal: Antiviral research 19951101

Title: Editorials: More health care with less.

Journal: Dimensions in health service 19751201

Title: Sachan S, et al. Adjuvant potential of resiquimod with inactivated Newcastle disease vaccine and its mechanism of action in chicken. Vaccine. 2015 Aug 26;33(36):4526-32.

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Title: Zhou ZX, et al. Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-κB-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus). Dev Comp Immunol. 2015 Mar;49(1):113-20.

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Tags:144875-48-9 Molecular Formula|144875-48-9 MDL|144875-48-9 SMILES|144875-48-9 Resiquimod