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Home Other Building Blocks 1450881-55-6
1450881-55-6,MFCD28502117
Catalog No.:AA001KGE

1450881-55-6 | SAR-20347

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$25.00   $18.00
- +
5mg
98%
in stock  
$62.00   $43.00
- +
10mg
98%
in stock  
$91.00   $64.00
- +
25mg
98%
in stock  
$154.00   $108.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001KGE
Chemical Name:
SAR-20347
CAS Number:
1450881-55-6
Molecular Formula:
C21H18ClFN4O4
Molecular Weight:
444.8434
MDL Number:
MFCD28502117
SMILES:
O=C(c1ccc(cc1)Nc1oc(nc1C(=O)N)c1c(F)cccc1Cl)N1CCOCC1
Properties
Computed Properties
 
Complexity:
645  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.5  

Downstream Synthesis Route
Literature

Title: Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20141001

Title: Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.

Journal: Biochimica et biophysica acta 20110801

Title: Works MG, et al. Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. J Immunol. 2014 Oct 1;193(7):3278-87.

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Additional Info:
SDS
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